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The map label for this gene is ponA [H]

Identifier: 78042905

GI number: 78042905

Start: 1400287

End: 1402683

Strand: Direct

Name: ponA [H]

Synonym: CHY_1563

Alternate gene names: 78042905

Gene position: 1400287-1402683 (Clockwise)

Preceding gene: 78044783

Following gene: 78044531

Centisome position: 58.31

GC content: 41.47

Gene sequence:

>2397_bases
ATGCCAAAGTGGCTTTTAGTTTCCCTGCTGGTATTTACTCTATTATTTTTTATTGGAACAATTGCCGTGGGTAGTTATAT
TTATTATTGTTTAAAAGACGTACCCTCTTTCTCTCCCAAAATGCTGGAGTTGTCTGGAACCACTTTAATTTTTGATAAAG
ACAATAATATAATTGCTGAAGTCCATGGCAGTGAAAATCGGATACCTGTAAAAATAAAAGAAGTTCCGGAGGTTGTTAAG
AAAGCAATAATCGGTGCTGAAGATGCCCGCTTTTACCAACATCACGGTATTGATTTAAAAGCTATTTTAAGAGCAGCCCT
GGAAGATTTAAAATATGGAGCTCCGAAAGAGGGAGCAAGCACAATTACCCAGCAGTTAGTTAAACTTACCTTTTTAACCT
CAGAAAAAACCCTAAAAAGAAAAATTCAAGAGGCATATTTAGCTATCCAGCTCGAAAGAGCTTTTACCAAAGATGAAATC
CTCGAAATGTATTTAAACCGTAGTTATTTCGGTGAAGGCGCTTACGGAATAAAGGCCGCCGCCCAAACTTACTTTGGCAA
AGATTTAGATGAATTAACTTTAAGTGAAGCAGCTCTTTTAGCAGGCCTACTTCCAGCACCAAGTCGTTATTCTCCTTTAA
ACAACAAGGAGCTGGCGCTAAACCGGCGCAACATTGTCTTAAATAAAATGGTTCGAGCAGGCTTGATAACTGAAGACCAA
GCCAGAAAAGCTAAAAGCGAACCTTTAATCTTAAACCCCAATCTTATAGACAAAAGTCACCATAAATATAAATATCCCTA
TTTTGTAGAATATGTAATCGAACAGCTTACAGAAAAGTTTGGAAGTGACCGGGTTTTTCGCGGTGGACTTAGAGTTTATA
CAACCTTAGACCCCAAAATTCAAGAAGCTGCAGAAAAAGCGTTATCAGATCCCAAGAACTTCCCCAAATCCAAGCGGGAT
AAAGATGGAATTTTACAACCTCAGGGTGCAGTGGTAGTTCTTGATCCTAAAACAGGTGAAATTAAAGCAATCGTTGGAGG
GCGTGAACATAATCAGCTACGGCAGTGGAATAGAGCTACCAGGACCAAAAGGCAACCGGGTTCAGCCTTTAAGCCAATCA
TTGCCTACGGTCCGGCCATTGAAAACGGCATGTCTCCGGCTACAGTAATTGATGATAGACCTATTAAATACGGCAAACAT
TCTTTTGTCAATTCCAATGGCAAATATCGGGGATTAATCACTTTAAGGACTGCTCTTACTTATTCAGTAAATACCGTTGC
CGTACAACTTCTCGATAAAGTTGGCTTTGCTGAAGCATTTAAATTTGCAAAAAAGCTTGGCATTGAGCTAAATCCTAAGC
TTGAATCAAACCTCGGGGTTGCCCTTGGCGGTCTTACGGACGGAGTTACCCCTCTTCAAATGGCAGCCGCTTACGGAGCC
TTTGCCAATAATGGAATTTATGTAGAACCATCGGCGATAATCAAAGTCGAATCAGCCACCGGCGAAATACTCTATGAAAA
TAAACCCAAAAAGCGGATAGCCATGAAACCGGAAACCGCTTTTATGATTACTTCAATGCTCGAAGACGTTATTTTTAAAC
CGGGAGGTACTGGTTCCGCTGCACGGTTAGACCGACCGGTTGCCGGAAAAACGGGTACAACCGATGAAGGAAAAGACCTC
TGGTTTGTGGGTTATACTCCCGATTTAGTCGCTGCCGTCTGGGTTGGCCATGATAAACCTCAACCGATTCCCGGAGGATT
CGGCGGTATCTATCCAGCCAGAATTTTTAAAGCAATAATGACTGAAGCTTTAAAAGGAGTACCAAAATCTGACTTCGAAA
AGCCCAACGGTATTATCAAAGCCACTGTATGTGGAAAATCAGGACTTTTACCGAGTAGTGACTGCCCTCAGAACCAGTTG
GTTTATGATTATTTTGCCAAAGGAACAGTACCAACCAAAATTTGTAATGTCCATGTAAAAGCAGAAATTTGCGCTGATTC
CCATTTGCTGGCAACAGAGTATTGTCCCAATAAGCTGACCGTCAGCTTAATTGATCTACCCTATGAAGTTCCGAGTTACG
TTTTAGACTACTCATTAAGGTTACCCAAAGAAAAATGTAATATTCACGGTCCGGGAAGCCAGTCTTCAACTCAAGAGGTA
GAAGTGCCCATTTGCACCGATCCATCCCACAACGGTCAGGACTTCTTGGCTCTAATTCCCAAAGCCGGTGAAAGCGGAGG
TTGTCCACCCCAATATGTTACCGTTAAAAAGTTTCCCAAAGATAAGGTACCAAAAGTTTACTGTGATATACCGGAACATC
AAATAAAACCTGCCCAAGGTAATGACAATCAAACAACACCTCCCGGCAATAATCAAACAACCCCTCCTAACAATTAG

Upstream 100 bases:

>100_bases
TTCCGTCAAGGTAAAACTTTTTCAATACATCTTTCCCAAGATATGTTATAATTTTTTTTAAGTAAAAGGAGGTCTTAAAG
TGGAAAAACAACGAAAAAGA

Downstream 100 bases:

>100_bases
GAGGGGTTTACTTTAAATATACCTCCGTTGCTTAATTTTCTCTTGTTGTAGGGCAATTTAGAGGCCTTGAGGGGTTTACT
TTAAATATACCTCCGTTGCA

Product: 1A family penicillin-binding protein

Products: NA

Alternate protein names: PBP1; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 798; Mature: 797

Protein sequence:

>798_residues
MPKWLLVSLLVFTLLFFIGTIAVGSYIYYCLKDVPSFSPKMLELSGTTLIFDKDNNIIAEVHGSENRIPVKIKEVPEVVK
KAIIGAEDARFYQHHGIDLKAILRAALEDLKYGAPKEGASTITQQLVKLTFLTSEKTLKRKIQEAYLAIQLERAFTKDEI
LEMYLNRSYFGEGAYGIKAAAQTYFGKDLDELTLSEAALLAGLLPAPSRYSPLNNKELALNRRNIVLNKMVRAGLITEDQ
ARKAKSEPLILNPNLIDKSHHKYKYPYFVEYVIEQLTEKFGSDRVFRGGLRVYTTLDPKIQEAAEKALSDPKNFPKSKRD
KDGILQPQGAVVVLDPKTGEIKAIVGGREHNQLRQWNRATRTKRQPGSAFKPIIAYGPAIENGMSPATVIDDRPIKYGKH
SFVNSNGKYRGLITLRTALTYSVNTVAVQLLDKVGFAEAFKFAKKLGIELNPKLESNLGVALGGLTDGVTPLQMAAAYGA
FANNGIYVEPSAIIKVESATGEILYENKPKKRIAMKPETAFMITSMLEDVIFKPGGTGSAARLDRPVAGKTGTTDEGKDL
WFVGYTPDLVAAVWVGHDKPQPIPGGFGGIYPARIFKAIMTEALKGVPKSDFEKPNGIIKATVCGKSGLLPSSDCPQNQL
VYDYFAKGTVPTKICNVHVKAEICADSHLLATEYCPNKLTVSLIDLPYEVPSYVLDYSLRLPKEKCNIHGPGSQSSTQEV
EVPICTDPSHNGQDFLALIPKAGESGGCPPQYVTVKKFPKDKVPKVYCDIPEHQIKPAQGNDNQTTPPGNNQTTPPNN

Sequences:

>Translated_798_residues
MPKWLLVSLLVFTLLFFIGTIAVGSYIYYCLKDVPSFSPKMLELSGTTLIFDKDNNIIAEVHGSENRIPVKIKEVPEVVK
KAIIGAEDARFYQHHGIDLKAILRAALEDLKYGAPKEGASTITQQLVKLTFLTSEKTLKRKIQEAYLAIQLERAFTKDEI
LEMYLNRSYFGEGAYGIKAAAQTYFGKDLDELTLSEAALLAGLLPAPSRYSPLNNKELALNRRNIVLNKMVRAGLITEDQ
ARKAKSEPLILNPNLIDKSHHKYKYPYFVEYVIEQLTEKFGSDRVFRGGLRVYTTLDPKIQEAAEKALSDPKNFPKSKRD
KDGILQPQGAVVVLDPKTGEIKAIVGGREHNQLRQWNRATRTKRQPGSAFKPIIAYGPAIENGMSPATVIDDRPIKYGKH
SFVNSNGKYRGLITLRTALTYSVNTVAVQLLDKVGFAEAFKFAKKLGIELNPKLESNLGVALGGLTDGVTPLQMAAAYGA
FANNGIYVEPSAIIKVESATGEILYENKPKKRIAMKPETAFMITSMLEDVIFKPGGTGSAARLDRPVAGKTGTTDEGKDL
WFVGYTPDLVAAVWVGHDKPQPIPGGFGGIYPARIFKAIMTEALKGVPKSDFEKPNGIIKATVCGKSGLLPSSDCPQNQL
VYDYFAKGTVPTKICNVHVKAEICADSHLLATEYCPNKLTVSLIDLPYEVPSYVLDYSLRLPKEKCNIHGPGSQSSTQEV
EVPICTDPSHNGQDFLALIPKAGESGGCPPQYVTVKKFPKDKVPKVYCDIPEHQIKPAQGNDNQTTPPGNNQTTPPNN
>Mature_797_residues
PKWLLVSLLVFTLLFFIGTIAVGSYIYYCLKDVPSFSPKMLELSGTTLIFDKDNNIIAEVHGSENRIPVKIKEVPEVVKK
AIIGAEDARFYQHHGIDLKAILRAALEDLKYGAPKEGASTITQQLVKLTFLTSEKTLKRKIQEAYLAIQLERAFTKDEIL
EMYLNRSYFGEGAYGIKAAAQTYFGKDLDELTLSEAALLAGLLPAPSRYSPLNNKELALNRRNIVLNKMVRAGLITEDQA
RKAKSEPLILNPNLIDKSHHKYKYPYFVEYVIEQLTEKFGSDRVFRGGLRVYTTLDPKIQEAAEKALSDPKNFPKSKRDK
DGILQPQGAVVVLDPKTGEIKAIVGGREHNQLRQWNRATRTKRQPGSAFKPIIAYGPAIENGMSPATVIDDRPIKYGKHS
FVNSNGKYRGLITLRTALTYSVNTVAVQLLDKVGFAEAFKFAKKLGIELNPKLESNLGVALGGLTDGVTPLQMAAAYGAF
ANNGIYVEPSAIIKVESATGEILYENKPKKRIAMKPETAFMITSMLEDVIFKPGGTGSAARLDRPVAGKTGTTDEGKDLW
FVGYTPDLVAAVWVGHDKPQPIPGGFGGIYPARIFKAIMTEALKGVPKSDFEKPNGIIKATVCGKSGLLPSSDCPQNQLV
YDYFAKGTVPTKICNVHVKAEICADSHLLATEYCPNKLTVSLIDLPYEVPSYVLDYSLRLPKEKCNIHGPGSQSSTQEVE
VPICTDPSHNGQDFLALIPKAGESGGCPPQYVTVKKFPKDKVPKVYCDIPEHQIKPAQGNDNQTTPPGNNQTTPPNN

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein. Note=Probably found all over the whole cell at low concentrations. Also localizes to the division site in vegetative cells [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 fibronectin type-III domain [H]

Homologues:

Organism=Escherichia coli, GI1786343, Length=534, Percent_Identity=33.3333333333333, Blast_Score=236, Evalue=4e-63,
Organism=Escherichia coli, GI87082258, Length=313, Percent_Identity=41.2140575079872, Blast_Score=230, Evalue=3e-61,
Organism=Escherichia coli, GI1788867, Length=600, Percent_Identity=29.1666666666667, Blast_Score=202, Evalue=7e-53,
Organism=Escherichia coli, GI1789601, Length=234, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR008957
- InterPro:   IPR003961
- InterPro:   IPR001264
- InterPro:   IPR013783
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00041 fn3; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 87692; Mature: 87561

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKWLLVSLLVFTLLFFIGTIAVGSYIYYCLKDVPSFSPKMLELSGTTLIFDKDNNIIAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCEEEE
VHGSENRIPVKIKEVPEVVKKAIIGAEDARFYQHHGIDLKAILRAALEDLKYGAPKEGAS
ECCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHH
TITQQLVKLTFLTSEKTLKRKIQEAYLAIQLERAFTKDEILEMYLNRSYFGEGAYGIKAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
AQTYFGKDLDELTLSEAALLAGLLPAPSRYSPLNNKELALNRRNIVLNKMVRAGLITEDQ
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCHH
ARKAKSEPLILNPNLIDKSHHKYKYPYFVEYVIEQLTEKFGSDRVFRGGLRVYTTLDPKI
HHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCEEEEEECCHHH
QEAAEKALSDPKNFPKSKRDKDGILQPQGAVVVLDPKTGEIKAIVGGREHNQLRQWNRAT
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHH
RTKRQPGSAFKPIIAYGPAIENGMSPATVIDDRPIKYGKHSFVNSNGKYRGLITLRTALT
HCCCCCCCCCCCHHEECCHHHCCCCCCEEECCCCCCCCCCCEECCCCCEEEEEEEEEHHH
YSVNTVAVQLLDKVGFAEAFKFAKKLGIELNPKLESNLGVALGGLTDGVTPLQMAAAYGA
HHHHHHHHHHHHHHCHHHHHHHHHHHCCEECCCCCCCCCEEECCCCCCCCHHHHHHHHHH
FANNGIYVEPSAIIKVESATGEILYENKPKKRIAMKPETAFMITSMLEDVIFKPGGTGSA
HCCCCEEECCCEEEEEECCCCCEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCH
ARLDRPVAGKTGTTDEGKDLWFVGYTPDLVAAVWVGHDKPQPIPGGFGGIYPARIFKAIM
HHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHH
TEALKGVPKSDFEKPNGIIKATVCGKSGLLPSSDCPQNQLVYDYFAKGTVPTKICNVHVK
HHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHCCCCCCEEEEEEEE
AEICADSHLLATEYCPNKLTVSLIDLPYEVPSYVLDYSLRLPKEKCNIHGPGSQSSTQEV
EEECCCCCEEEHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEE
EVPICTDPSHNGQDFLALIPKAGESGGCPPQYVTVKKFPKDKVPKVYCDIPEHQIKPAQG
EEEEECCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCEEEECCCHHHCCCCCC
NDNQTTPPGNNQTTPPNN
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKWLLVSLLVFTLLFFIGTIAVGSYIYYCLKDVPSFSPKMLELSGTTLIFDKDNNIIAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCEEEE
VHGSENRIPVKIKEVPEVVKKAIIGAEDARFYQHHGIDLKAILRAALEDLKYGAPKEGAS
ECCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHH
TITQQLVKLTFLTSEKTLKRKIQEAYLAIQLERAFTKDEILEMYLNRSYFGEGAYGIKAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
AQTYFGKDLDELTLSEAALLAGLLPAPSRYSPLNNKELALNRRNIVLNKMVRAGLITEDQ
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCHH
ARKAKSEPLILNPNLIDKSHHKYKYPYFVEYVIEQLTEKFGSDRVFRGGLRVYTTLDPKI
HHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCEEEEEECCHHH
QEAAEKALSDPKNFPKSKRDKDGILQPQGAVVVLDPKTGEIKAIVGGREHNQLRQWNRAT
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHH
RTKRQPGSAFKPIIAYGPAIENGMSPATVIDDRPIKYGKHSFVNSNGKYRGLITLRTALT
HCCCCCCCCCCCHHEECCHHHCCCCCCEEECCCCCCCCCCCEECCCCCEEEEEEEEEHHH
YSVNTVAVQLLDKVGFAEAFKFAKKLGIELNPKLESNLGVALGGLTDGVTPLQMAAAYGA
HHHHHHHHHHHHHHCHHHHHHHHHHHCCEECCCCCCCCCEEECCCCCCCCHHHHHHHHHH
FANNGIYVEPSAIIKVESATGEILYENKPKKRIAMKPETAFMITSMLEDVIFKPGGTGSA
HCCCCEEECCCEEEEEECCCCCEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCH
ARLDRPVAGKTGTTDEGKDLWFVGYTPDLVAAVWVGHDKPQPIPGGFGGIYPARIFKAIM
HHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHH
TEALKGVPKSDFEKPNGIIKATVCGKSGLLPSSDCPQNQLVYDYFAKGTVPTKICNVHVK
HHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHCCCCCCEEEEEEEE
AEICADSHLLATEYCPNKLTVSLIDLPYEVPSYVLDYSLRLPKEKCNIHGPGSQSSTQEV
EEECCCCCEEEHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEE
EVPICTDPSHNGQDFLALIPKAGESGGCPPQYVTVKKFPKDKVPKVYCDIPEHQIKPAQG
EEEEECCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCEEEECCCHHHCCCCCC
NDNQTTPPGNNQTTPPNN
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7814321; 8760912; 9384377; 9721295; 10322023 [H]