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The map label for this gene is ilvC

Identifier: 78042750

GI number: 78042750

Start: 450178

End: 451170

Strand: Direct

Name: ilvC

Synonym: CHY_0519

Alternate gene names: 78042750

Gene position: 450178-451170 (Clockwise)

Preceding gene: 78043291

Following gene: 78043014

Centisome position: 18.75

GC content: 43.61

Gene sequence:

>993_bases
ATGAAAAAAGTTTATTATGATCAGGACGCTAATTTAGAGCTTTTACGGGAGAAAAAAATTGCGATTATTGGCTACGGTAG
CCAGGGGCATGCTCAGGCCCAGAACTTAAAAGATAGCGGCTTAAATGTGGTGGTAGGTCTTCATAAAAAAAGTAAAAGCC
GGGAAAAAGCCGAAGCTGATGGTTTTACGGTAATGAAAGTGGATGAAGCGGCCCAGTGGGCTGATATCATTCAAATTTTG
GTTCCCGACCAAATTCAGGGAGAATTATACCGGGATAAAATCGAGGAACATTTAAAACCGGGTAAGGCCTTAATGTTTTC
CCACGGTTTTAACATTCATTACGGACAAATAGTGCCGCCGCCGGATGTCGATGTCTTCTTAGTTGCCCCTAAAAGTCCCG
GTCACCTGGTAAGGCGGATGTATTTAGAAGGCAAAGGGGTGCCGGGTTTAATTGCCGTCTATCAGGATGCTACCGGAAAA
GCCAAGGATTTAGCTTTGGCCTATGCTAAAGGTATTGGCTGCACCCGGGCGGGAGTTTTTGAAACTACTTTTAAAGAAGA
AACGGAAACGGATCTTTTTGGTGAACAGGCGGTGTTATGCGGTGGGGTAACCCACTTAATTAAAGCCGGTTTTGAAACTT
TAGTAGAAGCGGGCTATGCTCCGGAAATGGCTTATTTTGAATGTCTCCATGAAATGAAGTTAATTGTCGATTTAATTTAT
GAAGGTGGCTTTTCGTTAATGCGGTATTCCATATCCGATACTGCCGAGTATGGTGACTACATGGTAGGTCCCCGGATTAT
TACCGAAGAGACCAAAAAAGAGATGAAAAAGGTCTTGGAAGAAATTCAAAACGGAACTTTTGCCAAAAACTGGATATTAG
AGAACATGGCCGGTCGTCCGGTTTATAACGCCATCAAGCGTCGGGAACAGGAACATTTAATTGAAAAGGTGGGGGCAGAA
TTACGGCAGATGATGCCATGGCTGAAAAAGTAG

Upstream 100 bases:

>100_bases
GGCCTTTTGGTATTAAAGAGCTGGTACGCACCGGAAAAATTGCCCTGCTGCGGGGCTCCAGAACTTCAAATATAAATGGA
GTAAAGGAGGAGGAATAAAA

Downstream 100 bases:

>100_bases
GGGGGATGTCTTTTGGAGATAACTGGTGCTCAGGCTTTGGTAAAAGCGTTAGAACTGGAGGGGGTAACTACTATCTTCGG
TTACCCTGGAGGAGCGGTTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKKVYYDQDANLELLREKKIAIIGYGSQGHAQAQNLKDSGLNVVVGLHKKSKSREKAEADGFTVMKVDEAAQWADIIQIL
VPDQIQGELYRDKIEEHLKPGKALMFSHGFNIHYGQIVPPPDVDVFLVAPKSPGHLVRRMYLEGKGVPGLIAVYQDATGK
AKDLALAYAKGIGCTRAGVFETTFKEETETDLFGEQAVLCGGVTHLIKAGFETLVEAGYAPEMAYFECLHEMKLIVDLIY
EGGFSLMRYSISDTAEYGDYMVGPRIITEETKKEMKKVLEEIQNGTFAKNWILENMAGRPVYNAIKRREQEHLIEKVGAE
LRQMMPWLKK

Sequences:

>Translated_330_residues
MKKVYYDQDANLELLREKKIAIIGYGSQGHAQAQNLKDSGLNVVVGLHKKSKSREKAEADGFTVMKVDEAAQWADIIQIL
VPDQIQGELYRDKIEEHLKPGKALMFSHGFNIHYGQIVPPPDVDVFLVAPKSPGHLVRRMYLEGKGVPGLIAVYQDATGK
AKDLALAYAKGIGCTRAGVFETTFKEETETDLFGEQAVLCGGVTHLIKAGFETLVEAGYAPEMAYFECLHEMKLIVDLIY
EGGFSLMRYSISDTAEYGDYMVGPRIITEETKKEMKKVLEEIQNGTFAKNWILENMAGRPVYNAIKRREQEHLIEKVGAE
LRQMMPWLKK
>Mature_330_residues
MKKVYYDQDANLELLREKKIAIIGYGSQGHAQAQNLKDSGLNVVVGLHKKSKSREKAEADGFTVMKVDEAAQWADIIQIL
VPDQIQGELYRDKIEEHLKPGKALMFSHGFNIHYGQIVPPPDVDVFLVAPKSPGHLVRRMYLEGKGVPGLIAVYQDATGK
AKDLALAYAKGIGCTRAGVFETTFKEETETDLFGEQAVLCGGVTHLIKAGFETLVEAGYAPEMAYFECLHEMKLIVDLIY
EGGFSLMRYSISDTAEYGDYMVGPRIITEETKKEMKKVLEEIQNGTFAKNWILENMAGRPVYNAIKRREQEHLIEKVGAE
LRQMMPWLKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=36.8600682593857, Blast_Score=141, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=327, Percent_Identity=34.8623853211009, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CARHZ (Q3AEQ7)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359377.1
- ProteinModelPortal:   Q3AEQ7
- SMR:   Q3AEQ7
- STRING:   Q3AEQ7
- GeneID:   3726922
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0519
- NMPDR:   fig|246194.3.peg.1086
- TIGR:   CHY_0519
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   AMKQCLK
- ProtClustDB:   PRK05479
- BioCyc:   CHYD246194:CHY_0519-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37048; Mature: 37048

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVYYDQDANLELLREKKIAIIGYGSQGHAQAQNLKDSGLNVVVGLHKKSKSREKAEAD
CCCEEECCCCCHHHEECCCEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHCC
GFTVMKVDEAAQWADIIQILVPDQIQGELYRDKIEEHLKPGKALMFSHGFNIHYGQIVPP
CEEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCC
PDVDVFLVAPKSPGHLVRRMYLEGKGVPGLIAVYQDATGKAKDLALAYAKGIGCTRAGVF
CCCCEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCH
ETTFKEETETDLFGEQAVLCGGVTHLIKAGFETLVEAGYAPEMAYFECLHEMKLIVDLIY
HHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGFSLMRYSISDTAEYGDYMVGPRIITEETKKEMKKVLEEIQNGTFAKNWILENMAGRP
HCCHHHEEECHHHHHHHCCEECCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
VYNAIKRREQEHLIEKVGAELRQMMPWLKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKVYYDQDANLELLREKKIAIIGYGSQGHAQAQNLKDSGLNVVVGLHKKSKSREKAEAD
CCCEEECCCCCHHHEECCCEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHCC
GFTVMKVDEAAQWADIIQILVPDQIQGELYRDKIEEHLKPGKALMFSHGFNIHYGQIVPP
CEEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCC
PDVDVFLVAPKSPGHLVRRMYLEGKGVPGLIAVYQDATGKAKDLALAYAKGIGCTRAGVF
CCCCEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCH
ETTFKEETETDLFGEQAVLCGGVTHLIKAGFETLVEAGYAPEMAYFECLHEMKLIVDLIY
HHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGFSLMRYSISDTAEYGDYMVGPRIITEETKKEMKKVLEEIQNGTFAKNWILENMAGRP
HCCHHHEEECHHHHHHHCCEECCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
VYNAIKRREQEHLIEKVGAELRQMMPWLKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA