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The map label for this gene is trpF [H]

Identifier: 77465588

GI number: 77465588

Start: 680191

End: 680829

Strand: Reverse

Name: trpF [H]

Synonym: RSP_3587

Alternate gene names: 77465588

Gene position: 680829-680191 (Counterclockwise)

Preceding gene: 77465589

Following gene: 77465587

Centisome position: 72.2

GC content: 71.36

Gene sequence:

>639_bases
ATGGCAGGAGTCCGCGTCAAGATCTGCGGACTGCGGACGGAGTCGGATGTGAAGGCGGCCGCGTCCTCGGGCGCGGCCTA
TGTCGGTCTGGTGTTCTTCCCGAAATCGCCGCGCCATCTGGAGCTTGCGCAGGCGCAGCGGCTCGCGCTCGCCGCGCCGC
CGGGGGTGGCCAAGGTGGCGCTGACGGTCGACGCCAGTGACGAGACGCTCGACGCCATCGTCGAGGCGGTGCCGCTCGAC
ATGCTGCAGCTTCACGGCGGCGAGAGCCCCGAGCGGGTGGCCGAGGTGCGGGCGCGCTACGGGCTGCCGGTCATGAAGGC
CGTGGGGGTGGCGGACGAAGGCGACCTGCCGCAGATTCTCGAACAGTCGCTGGCCGCCGACCAGATCCTGATCGATGCAA
AACCGCCGAAGGGCGCGGCGCTGCCCGGCGGCAATGGCCTCTCCTTCGACTGGCGGCTGATCTCGGGGCGGCACTGGATC
AGGCCCTGGATGCTGGCGGGGGGGCTGACGGTCGAAAATCTGGCCGAGGCCGTCCGGCGCACGGGGGCGTCGCAGGTCGA
TGTCTCCTCGGGCGTCGAATCGGCGCCGGGCGTCAAGGATCCGGCCCGGATCGCGGCCTTCCTGCAGGCCGCCCGGTGA

Upstream 100 bases:

>100_bases
TCCAGCGCGAAGTCTCCACGCTCAGATCCAAGGTCGAGACCGGCACCGCCGTCGGCGTGCCGAAGAACGACGTTCTGACC
GCGCTCTCGAAATCGGCCTG

Downstream 100 bases:

>100_bases
TCCGCTTCCGCGACGCGCGACGCGAGGATGTGGCGGCCATCCTGGCGCTGCTCGCCGACGATGCGCTGGGGGCTCAGCGC
GAGACGGCCCCGCTCGAGAC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MAGVRVKICGLRTESDVKAAASSGAAYVGLVFFPKSPRHLELAQAQRLALAAPPGVAKVALTVDASDETLDAIVEAVPLD
MLQLHGGESPERVAEVRARYGLPVMKAVGVADEGDLPQILEQSLAADQILIDAKPPKGAALPGGNGLSFDWRLISGRHWI
RPWMLAGGLTVENLAEAVRRTGASQVDVSSGVESAPGVKDPARIAAFLQAAR

Sequences:

>Translated_212_residues
MAGVRVKICGLRTESDVKAAASSGAAYVGLVFFPKSPRHLELAQAQRLALAAPPGVAKVALTVDASDETLDAIVEAVPLD
MLQLHGGESPERVAEVRARYGLPVMKAVGVADEGDLPQILEQSLAADQILIDAKPPKGAALPGGNGLSFDWRLISGRHWI
RPWMLAGGLTVENLAEAVRRTGASQVDVSSGVESAPGVKDPARIAAFLQAAR
>Mature_211_residues
AGVRVKICGLRTESDVKAAASSGAAYVGLVFFPKSPRHLELAQAQRLALAAPPGVAKVALTVDASDETLDAIVEAVPLDM
LQLHGGESPERVAEVRARYGLPVMKAVGVADEGDLPQILEQSLAADQILIDAKPPKGAALPGGNGLSFDWRLISGRHWIR
PWMLAGGLTVENLAEAVRRTGASQVDVSSGVESAPGVKDPARIAAFLQAAR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=210, Percent_Identity=35.7142857142857, Blast_Score=95, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320210, Length=226, Percent_Identity=31.858407079646, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 22143; Mature: 22011

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGVRVKICGLRTESDVKAAASSGAAYVGLVFFPKSPRHLELAQAQRLALAAPPGVAKVA
CCCCEEEEEECCCCHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHEEECCCCCEEEE
LTVDASDETLDAIVEAVPLDMLQLHGGESPERVAEVRARYGLPVMKAVGVADEGDLPQIL
EEECCCHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHH
EQSLAADQILIDAKPPKGAALPGGNGLSFDWRLISGRHWIRPWMLAGGLTVENLAEAVRR
HHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHH
TGASQVDVSSGVESAPGVKDPARIAAFLQAAR
CCCCCEEHHCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AGVRVKICGLRTESDVKAAASSGAAYVGLVFFPKSPRHLELAQAQRLALAAPPGVAKVA
CCCEEEEEECCCCHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHEEECCCCCEEEE
LTVDASDETLDAIVEAVPLDMLQLHGGESPERVAEVRARYGLPVMKAVGVADEGDLPQIL
EEECCCHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHH
EQSLAADQILIDAKPPKGAALPGGNGLSFDWRLISGRHWIRPWMLAGGLTVENLAEAVRR
HHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHH
TGASQVDVSSGVESAPGVKDPARIAAFLQAAR
CCCCCEEHHCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA