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The map label for this gene is hutH [H]

Identifier: 77465572

GI number: 77465572

Start: 668567

End: 670138

Strand: Reverse

Name: hutH [H]

Synonym: RSP_3574

Alternate gene names: 77465572

Gene position: 670138-668567 (Counterclockwise)

Preceding gene: 77465573

Following gene: 77465568

Centisome position: 71.06

GC content: 68.89

Gene sequence:

>1572_bases
ATGCTCGCCATGAGCCCCCCGAAGCCGGCCGTCGAGCTGGATCGCCACATCGATCTGGACCAGGCCCATGCCGTGGCGAG
CGGCGGCGCGCGGATTGTCCTTGCCCCTCCGGCGCGCGACCGGTGCCGTGCGTCCGAAGCGCGGCTCGGCGCTGTCATCC
GCGAGGCGCGCCATGTCTACGGACTGACAACCGGCTTCGGTCCCCTTGCGAACCGCCTGATCTCAGGTGAGAATGTCCGA
ACGCTGCAGGCCAATCTTGTCCATCATCTGGCCAGCGGCGTGGGACCGGTGCTTGACTGGACGACGGCGCGCGCCATGGT
TCTGGCGCGTCTGGTGTCGATCGCTCAGGGAGCCTCCGGTGCCAGCGAGGGGACCATCGCTCGCCTGATCGACCTGCTCA
ATTCCGAGCTCGCTCCGGCCGTTCCCAGCCGCGGCACGGTGGGCGCGTCGGGTGACCTGACACCGCTTGCGCATATGGTG
CTCTGCCTCCAGGGCCGGGGAGACTTCCTGGACCGGGACGGGACGCGGCTTGACGGCGCAGAAGGGCTCCGGCGCGGACG
GCTGCAACCGCTCGATCTCTCCCATCGCGATGCACTGGCGCTGGTCAACGGGACCTCCGCCATGACCGGGATCGCGCTGG
TGAATGCTCACGCCTGCCGCCATCTCGGCAACTGGGCGGTGGCGTTGACGGCCCTGCTTGCGGAATGTCTGAGAGGCCGG
ACCGAGGCATGGGCCGCGGCACTGTCCGACCTGCGGCCGCATCCCGGACAGAAGGACGCCGCAGCGAGGCTGCGCGCCCG
CGTGGACGGCAGCGCGCGGGTGGTCCGGCACGTCATTGCCGAGCGGAGGCTCGACGCCGGCGATATCGGGACGGAGCCGG
AGGCGGGGCAGGATGCCTACAGCCTGCGCTGCGCTCCGCAGGTTCTCGGGGCGGGCTTCGACACGCTCGCATGGCATGAC
CGGGTGCTGACGATCGAGCTGAACGCGGTGACCGACAATCCGGTGTTTCCGCCCGATGGCAGCGTGCCCGCCCTGCACGG
GGGCAATTTCATGGGCCAGCATGTGGCGCTGACGTCCGATGCGCTCGCCACGGCCGTCACCGTTCTGGCGGGCCTTGCGG
AGCGCCAGATTGCACGTCTGACAGATGAAAGGCTGAACCGTGGGCTGCCCCCCTTCCTCCACCGGGGCCCCGCCGGGTTG
AATTCCGGCTTCATGGGCGCACAGGTGACGGCGACCGCGCTCCTGGCCGAGATGCGAGCCACGGGACCTGCCTCGATCCA
TTCGATCTCCACGAACGCCGCCAATCAGGATGTGGTCTCGCTTGGGACCATCGCCGCGCGCCTCTGCCGCGAGAAGATCG
ACCGTTGGGCGGAGATCCTTGCGATCCTCGCTCTCTGTCTTGCACAAGCTGCGGAGCTGCGCTGCGGCAGCGGCCTAGAC
GGGGTGTCTCCCGCGGGGAAGAAGCTGGTGCAGGCCCTGCGCGAGCAGTTCCCGCCGCTTGAGACGGACCGGCCCCTGGG
ACAGGAAATTGCCGCGCTTGCTACGCACCTCTTGCAGCAATCTCCCGTCTGA

Upstream 100 bases:

>100_bases
CTCGCTCGATCTGGGCCCGCTGGGGCGGACGATCTGAAGCAAGAAACTCTGCATTAACCAGCTTCCACTACCTTCGGCGA
GAAGACAGGGAGTGAAGCCA

Downstream 100 bases:

>100_bases
GCGCGGCCTCAGGTCGTGGCGGGATCCACCGTGAGGCCTACAGCCTCGGCATATTTGAGCCAGGTCTCGATCGACGCCAC
GACGGCACGGACCTCGATGG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MLAMSPPKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVR
TLQANLVHHLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGASGDLTPLAHMV
LCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGR
TEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHD
RVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGL
NSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLD
GVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV

Sequences:

>Translated_523_residues
MLAMSPPKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVR
TLQANLVHHLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGASGDLTPLAHMV
LCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGR
TEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHD
RVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGL
NSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLD
GVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
>Mature_523_residues
MLAMSPPKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVR
TLQANLVHHLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGASGDLTPLAHMV
LCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGR
TEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHD
RVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGL
NSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLD
GVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=518, Percent_Identity=36.1003861003861, Blast_Score=267, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17567831, Length=488, Percent_Identity=35.8606557377049, Blast_Score=234, Evalue=6e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54915; Mature: 54915

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAMSPPKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVY
CCCCCCCCCHHHHHHCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
GLTTGFGPLANRLISGENVRTLQANLVHHLASGVGPVLDWTTARAMVLARLVSIAQGASG
HCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
ASEGTIARLIDLLNSELAPAVPSRGTVGASGDLTPLAHMVLCLQGRGDFLDRDGTRLDGA
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCH
EGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGR
HHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAY
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
SLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSD
HHCCHHHHHCCCCHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHC
TGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLD
CCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLAMSPPKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVY
CCCCCCCCCHHHHHHCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
GLTTGFGPLANRLISGENVRTLQANLVHHLASGVGPVLDWTTARAMVLARLVSIAQGASG
HCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
ASEGTIARLIDLLNSELAPAVPSRGTVGASGDLTPLAHMVLCLQGRGDFLDRDGTRLDGA
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCH
EGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGR
HHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAY
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
SLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSD
HHCCHHHHHCCCCHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHC
TGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLD
CCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]