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The map label for this gene is fdh [H]

Identifier: 77465117

GI number: 77465117

Start: 147887

End: 149071

Strand: Direct

Name: fdh [H]

Synonym: RSP_3104

Alternate gene names: 77465117

Gene position: 147887-149071 (Clockwise)

Preceding gene: 77465116

Following gene: 77465123

Centisome position: 15.68

GC content: 67.0

Gene sequence:

>1185_bases
ATGCGCGCACTCACCTGGCACGGAAAGCACGATGTCCGCGTCGAGACCCATCCCGACCCCGAGATCGTCAATCCGCGCGA
CGCGATCATCGAGGTGACGGCCACGGCGATCTGCGGCTCGGATCTGCATCTCTACGACGGGGTGATCCCGGGGCTGATGT
CGGGCGACATCCTCGGGCACGAGTTCATGGGCCGCGTCGTCGAGACCGGGCCGAAAAGCACGCTGAAGAAGGGCCAGCGG
GTCGTGGTGCCCTTCACGATCTCCTGCGGGCAGTGCTTCTTCTGCGAGCATCAGCTCTTTTCCGCCTGCGACAATTCCAA
CCCCGCGGAGAAGCAGGACCTGTCCGAGCCGCTCTATGGCCATGCGGTGTCGGGGCTGTTCGGCTATTCGCATCTGACGG
GCGGCTATCCGGGCGGGCAGGCGGAATATGTGCGTGTGCCCTATTCGGACGTGGGACCGATCGTGATCCCGGACGGGCTC
GAGGACGAGCAGGTGCTGTTCCTGTCTGACATTCTCCCGACGGGCTGGATGGCCGCCGAGAATGCCGGGATCGAGGAGGG
CGACACGGTCGCCGTCTGGGGCTGCGGCCCGGTCGGCCTCTTCGCGATCCAGTCGGCCCTGCTGATGGGGGCGGGCAAGG
TCATTGCCATCGACGAATATCCCAAGCGGCTGGCGCTGGCGCGCAGGCTCGGGGCCGAGGTGATCGACTTCCGGCGCACG
AAGGTGCTCGAGGCGCTGATGGAGATGTCGGGGGGCCTCGGCCCCGATGCGGTGATCGATGCCGTGGGGATGGAGGCGCA
TGGCTTCATGCCCGACACGCTGATGGACAACATGAAGCAGCGCGTGGGGATCGGCGCGGACAGCGGCCACGCGCTGCGCG
AGGCGATCCTTGCGGTGCGCAAGGGCGGCCGCGTCTCGGTGCCCGGCGTCTACGGCGGCTTCCTCGACAAGTTTCCGCTC
GGCGCGCTGATGGAGAAGGGCCTGACCGTGAAGACCGGCCAGACCCATGTGCAGCGATACACCGAGGAGCTTCTGCGCCG
GATCGGCGAGGGCGAGATCGACACGACCTTCCTGATCTCGCACCGCCTGCCGCTCGAGGAGGCGGCGCGGGGCTACGAGA
ACTTCCGCTTCAACCAGAACGAGTGGACCAAGGTGGTGCTGAAGCCGGGCCTGACCGGCGCCTGA

Upstream 100 bases:

>100_bases
TCTCGCGCCCGCGATGCAGGGGCGGCGCGAGCTGCGCCGCTTCAAGATGCTGATGGAGGCCGGCGAGATCGCCACCTCCC
GCAACCGGAAGGATTGATCG

Downstream 100 bases:

>100_bases
CGGAAGGCGGGCGGCGCAGCCGCCCGCTTCACTCCACCCGCAGCCCGGGCTCGGGGCGGATGGGCACCTCGATCTCGCAG
CGTACCCCTTCGGGGCGGAA

Product: putative glutathione-dependent formaldehyde dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRALTWHGKHDVRVETHPDPEIVNPRDAIIEVTATAICGSDLHLYDGVIPGLMSGDILGHEFMGRVVETGPKSTLKKGQR
VVVPFTISCGQCFFCEHQLFSACDNSNPAEKQDLSEPLYGHAVSGLFGYSHLTGGYPGGQAEYVRVPYSDVGPIVIPDGL
EDEQVLFLSDILPTGWMAAENAGIEEGDTVAVWGCGPVGLFAIQSALLMGAGKVIAIDEYPKRLALARRLGAEVIDFRRT
KVLEALMEMSGGLGPDAVIDAVGMEAHGFMPDTLMDNMKQRVGIGADSGHALREAILAVRKGGRVSVPGVYGGFLDKFPL
GALMEKGLTVKTGQTHVQRYTEELLRRIGEGEIDTTFLISHRLPLEEAARGYENFRFNQNEWTKVVLKPGLTGA

Sequences:

>Translated_394_residues
MRALTWHGKHDVRVETHPDPEIVNPRDAIIEVTATAICGSDLHLYDGVIPGLMSGDILGHEFMGRVVETGPKSTLKKGQR
VVVPFTISCGQCFFCEHQLFSACDNSNPAEKQDLSEPLYGHAVSGLFGYSHLTGGYPGGQAEYVRVPYSDVGPIVIPDGL
EDEQVLFLSDILPTGWMAAENAGIEEGDTVAVWGCGPVGLFAIQSALLMGAGKVIAIDEYPKRLALARRLGAEVIDFRRT
KVLEALMEMSGGLGPDAVIDAVGMEAHGFMPDTLMDNMKQRVGIGADSGHALREAILAVRKGGRVSVPGVYGGFLDKFPL
GALMEKGLTVKTGQTHVQRYTEELLRRIGEGEIDTTFLISHRLPLEEAARGYENFRFNQNEWTKVVLKPGLTGA
>Mature_394_residues
MRALTWHGKHDVRVETHPDPEIVNPRDAIIEVTATAICGSDLHLYDGVIPGLMSGDILGHEFMGRVVETGPKSTLKKGQR
VVVPFTISCGQCFFCEHQLFSACDNSNPAEKQDLSEPLYGHAVSGLFGYSHLTGGYPGGQAEYVRVPYSDVGPIVIPDGL
EDEQVLFLSDILPTGWMAAENAGIEEGDTVAVWGCGPVGLFAIQSALLMGAGKVIAIDEYPKRLALARRLGAEVIDFRRT
KVLEALMEMSGGLGPDAVIDAVGMEAHGFMPDTLMDNMKQRVGIGADSGHALREAILAVRKGGRVSVPGVYGGFLDKFPL
GALMEKGLTVKTGQTHVQRYTEELLRRIGEGEIDTTFLISHRLPLEEAARGYENFRFNQNEWTKVVLKPGLTGA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=278, Percent_Identity=29.8561151079137, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71565154, Length=275, Percent_Identity=28.7272727272727, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4501939, Length=268, Percent_Identity=28.3582089552239, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156523966, Length=268, Percent_Identity=28.3582089552239, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786825, Length=398, Percent_Identity=51.2562814070352, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI226510992, Length=363, Percent_Identity=26.9972451790634, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788075, Length=390, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790718, Length=216, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082125, Length=268, Percent_Identity=29.4776119402985, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788073, Length=376, Percent_Identity=23.4042553191489, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787863, Length=368, Percent_Identity=25.2717391304348, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786552, Length=219, Percent_Identity=32.4200913242009, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081918, Length=257, Percent_Identity=29.5719844357977, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788407, Length=230, Percent_Identity=28.2608695652174, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319258, Length=421, Percent_Identity=28.5035629453682, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=380, Percent_Identity=27.3684210526316, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17137530, Length=394, Percent_Identity=26.1421319796954, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17737895, Length=241, Percent_Identity=30.2904564315353, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42644; Mature: 42644

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALTWHGKHDVRVETHPDPEIVNPRDAIIEVTATAICGSDLHLYDGVIPGLMSGDILGH
CCCEEECCCCCEEEECCCCCCCCCCHHHHEEEEHHHHCCCCCHHHHCCCCHHHCCCHHHH
EFMGRVVETGPKSTLKKGQRVVVPFTISCGQCFFCEHQLFSACDNSNPAEKQDLSEPLYG
HHHHHHHHCCCHHHHHCCCEEEEEEEECCCCEEEHHHHHHHHHCCCCCCCHHHHCCCHHH
HAVSGLFGYSHLTGGYPGGQAEYVRVPYSDVGPIVIPDGLEDEQVLFLSDILPTGWMAAE
HHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEECCCCCCCCEEEEHHHCCCCCCHHC
NAGIEEGDTVAVWGCGPVGLFAIQSALLMGAGKVIAIDEYPKRLALARRLGAEVIDFRRT
CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
KVLEALMEMSGGLGPDAVIDAVGMEAHGFMPDTLMDNMKQRVGIGADSGHALREAILAVR
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KGGRVSVPGVYGGFLDKFPLGALMEKGLTVKTGQTHVQRYTEELLRRIGEGEIDTTFLIS
CCCCEECCCHHHHHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEE
HRLPLEEAARGYENFRFNQNEWTKVVLKPGLTGA
CCCCHHHHHCCHHHCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MRALTWHGKHDVRVETHPDPEIVNPRDAIIEVTATAICGSDLHLYDGVIPGLMSGDILGH
CCCEEECCCCCEEEECCCCCCCCCCHHHHEEEEHHHHCCCCCHHHHCCCCHHHCCCHHHH
EFMGRVVETGPKSTLKKGQRVVVPFTISCGQCFFCEHQLFSACDNSNPAEKQDLSEPLYG
HHHHHHHHCCCHHHHHCCCEEEEEEEECCCCEEEHHHHHHHHHCCCCCCCHHHHCCCHHH
HAVSGLFGYSHLTGGYPGGQAEYVRVPYSDVGPIVIPDGLEDEQVLFLSDILPTGWMAAE
HHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEECCCCCCCCEEEEHHHCCCCCCHHC
NAGIEEGDTVAVWGCGPVGLFAIQSALLMGAGKVIAIDEYPKRLALARRLGAEVIDFRRT
CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
KVLEALMEMSGGLGPDAVIDAVGMEAHGFMPDTLMDNMKQRVGIGADSGHALREAILAVR
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KGGRVSVPGVYGGFLDKFPLGALMEKGLTVKTGQTHVQRYTEELLRRIGEGEIDTTFLIS
CCCCEECCCHHHHHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEE
HRLPLEEAARGYENFRFNQNEWTKVVLKPGLTGA
CCCCHHHHHCCHHHCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]