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The map label for this gene is dorR [H]

Identifier: 77465059

GI number: 77465059

Start: 80695

End: 81393

Strand: Reverse

Name: dorR [H]

Synonym: RSP_3045

Alternate gene names: 77465059

Gene position: 81393-80695 (Counterclockwise)

Preceding gene: 77465066

Following gene: 77465054

Centisome position: 8.63

GC content: 66.09

Gene sequence:

>699_bases
ATGAAGAAGAACTACCACATGCTTGTCGTCGAGGACGATCCGGTCAGCCGCCAGACGCTCGCGATGTATCTGCGCAAGGA
AAATCACGAGGTCAGCGAGGCGCGCGACGGCGAGCAGATGCGCCGCGTCTTCGCCAAGGGCGACGTGGATGTGGTGATGC
TCGACATCAACATGCCGGGCGAGGACGGGCTGTCGATTCTGCGGGAACTGCGCCGGCAGTCCGAGGTCGGCATCATCATG
GTGACGAGCCGGAAGGAGGATGTGGACCGGATCGTGGCGCTGGAGCTCGGCGCGGACGATTATGTGACCAAGCCCTACAA
CATGCGCGAGATCCTGCCGCGGGCAAAGAATCTCGCCCGGCGGGTGGCGGCCCTGCGGCTGGTGCGGCCGGACCAGCCGG
CGACGACCTTCGACGGCTGGACCCTCGACGCGGCCCATTGGGCGCTGACCGATCCCGCGGGCAATCATGTCAAACTGACA
CGGGCCGAGTTCGAGCTGCTGGCCACCTTCGTGGCCCATCCCGGGCAGGTCCTGACCCGCGACCAGCTGATGAACCATGT
CGGCCGCCGCGGGCACGAGACCTTCGACCGGACCATCGACGTGCTAGTGCGCCGCATCCGCCGCAAGATCGAGGCGGACC
CTTCCGACCCGCGGCTGATCGTGACCGTTCACGGCATCGGCTACGTCTTCCAGGCCTGA

Upstream 100 bases:

>100_bases
GAACAGGATGTTAACAGCGGCCAAGTGAATGAGTTGCCGTTGAAATCGGGGCGCGAAAGGGTGCATTAGGTCCAACCGGC
CGCAGGAGACCTCGCGCGTC

Downstream 100 bases:

>100_bases
CGCCGGAAGAGACCGCCTCAGCTCTCGGCCACTCCGGCACTGGCTTCGGCCCAGGCGAGATCGGCCAGCGCCGGAGCGGC
GCGGCAGTCGGAGACCAGCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKKNYHMLVVEDDPVSRQTLAMYLRKENHEVSEARDGEQMRRVFAKGDVDVVMLDINMPGEDGLSILRELRRQSEVGIIM
VTSRKEDVDRIVALELGADDYVTKPYNMREILPRAKNLARRVAALRLVRPDQPATTFDGWTLDAAHWALTDPAGNHVKLT
RAEFELLATFVAHPGQVLTRDQLMNHVGRRGHETFDRTIDVLVRRIRRKIEADPSDPRLIVTVHGIGYVFQA

Sequences:

>Translated_232_residues
MKKNYHMLVVEDDPVSRQTLAMYLRKENHEVSEARDGEQMRRVFAKGDVDVVMLDINMPGEDGLSILRELRRQSEVGIIM
VTSRKEDVDRIVALELGADDYVTKPYNMREILPRAKNLARRVAALRLVRPDQPATTFDGWTLDAAHWALTDPAGNHVKLT
RAEFELLATFVAHPGQVLTRDQLMNHVGRRGHETFDRTIDVLVRRIRRKIEADPSDPRLIVTVHGIGYVFQA
>Mature_232_residues
MKKNYHMLVVEDDPVSRQTLAMYLRKENHEVSEARDGEQMRRVFAKGDVDVVMLDINMPGEDGLSILRELRRQSEVGIIM
VTSRKEDVDRIVALELGADDYVTKPYNMREILPRAKNLARRVAALRLVRPDQPATTFDGWTLDAAHWALTDPAGNHVKLT
RAEFELLATFVAHPGQVLTRDQLMNHVGRRGHETFDRTIDVLVRRIRRKIEADPSDPRLIVTVHGIGYVFQA

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=41.2280701754386, Blast_Score=197, Evalue=5e-52,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=44.017094017094, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=42.4892703862661, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=37.117903930131, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=33.4801762114537, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=34.2222222222222, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=31.6017316017316, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=32.15859030837, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=34.070796460177, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=28.7610619469027, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI2367329, Length=242, Percent_Identity=32.2314049586777, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1789402, Length=234, Percent_Identity=29.4871794871795, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=26.9565217391304, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=33.0188679245283, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26530; Mature: 26530

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNYHMLVVEDDPVSRQTLAMYLRKENHEVSEARDGEQMRRVFAKGDVDVVMLDINMPG
CCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCCCEEEEEEECCCC
EDGLSILRELRRQSEVGIIMVTSRKEDVDRIVALELGADDYVTKPYNMREILPRAKNLAR
CHHHHHHHHHHHHCCCCEEEEECCCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
RVAALRLVRPDQPATTFDGWTLDAAHWALTDPAGNHVKLTRAEFELLATFVAHPGQVLTR
HHHHHHHCCCCCCCCCCCCEEECCCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCHHHH
DQLMNHVGRRGHETFDRTIDVLVRRIRRKIEADPSDPRLIVTVHGIGYVFQA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEECC
>Mature Secondary Structure
MKKNYHMLVVEDDPVSRQTLAMYLRKENHEVSEARDGEQMRRVFAKGDVDVVMLDINMPG
CCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCCCEEEEEEECCCC
EDGLSILRELRRQSEVGIIMVTSRKEDVDRIVALELGADDYVTKPYNMREILPRAKNLAR
CHHHHHHHHHHHHCCCCEEEEECCCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
RVAALRLVRPDQPATTFDGWTLDAAHWALTDPAGNHVKLTRAEFELLATFVAHPGQVLTR
HHHHHHHCCCCCCCCCCCCEEECCCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCHHHH
DQLMNHVGRRGHETFDRTIDVLVRRIRRKIEADPSDPRLIVTVHGIGYVFQA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]