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The map label for this gene is pyrC [H]

Identifier: 77461883

GI number: 77461883

Start: 6343000

End: 6344337

Strand: Direct

Name: pyrC [H]

Synonym: Pfl01_5663

Alternate gene names: 77461883

Gene position: 6343000-6344337 (Clockwise)

Preceding gene: 77461882

Following gene: 77461885

Centisome position: 98.52

GC content: 61.06

Gene sequence:

>1338_bases
ATGAGCAGTGTGCTGATTCGCAATGCGCGGCTGGTGAACGAAGGGCGTGAGTTCGATGCCGATCTGTTGGTCAGCCACGG
ACGCATCGTCAAGATCGCCGGCAGCATCGAAGGTGAAAACGCGACCCGGGAAATCGACGCCACCGGCCAATGGCTGCTGC
CGGGGATGATTGATGACCAGGTGCATTTCCGTGAGCCGGGTGCGCCGGCCAAGGGCAGCGTCCACACCGAGTCCCGGGCA
GCCGTGGCCGGTGGCATCACCAGTTTTATGGACATGCCCAACACCCACCCTGCCACCCTCACCCTTGAAGCGCTGGCCGA
CAAAAAACGCCGGGCAGCAATCAACTCGGTGGCCAACTACGGTTTTCACTTTGGCGTCAGTCACGACAATCTGGACACGG
TCGCAGCACTCAACCCGAGCGAAGTGGCCGGGGTCAAAGTGTTCATGGGCGCGTCCACCGGCAACATGCTGGTGGACGAC
CCGCACACCCTCGAGCGCCTGTTCGCTGAAGTGCCGACGATTCTGCTGGCCCACTGTGAACACACGCCGAGCATCGAAGC
GAATGCCGCGAACCTGCGTGAGCGGTACGGCAACCAACTGCCACCCGATGCCCATGCGCAGATCCGCAATGCCGACAGCT
GCTTTCGCTCATCGTCTCTGGCAGTGGATCTGGCCAAACGTCACGGCACTCGCCTGCACGTCCTGCACCTGACCACGGCC
CGCGAACTGGCCCTGTTTGAAGATAAACCGCTGACGCAAAAACGCATCACCGCCGAAGTCTGCCTGCACCATTTACTGTT
CGATGAACGTGACTATCCGAACCTCGGCAACCTGATCAAATGCAACCCGGCGATCAAGTCCCGGAGCGATCGTGACGCCC
TGCGCCAGGCACTGCTGAGCAATCGACTGGACGTGATCGGCAGCGATCACGCACCGCACACCTGGGCGGAAAAACAGCAA
GCGTATGAACAGGCACCGTCCGGGCTGCCACTGGTACAGCACGCTCTGCCGGCGTTGTTGGAACTGGTGGCGGATGGCGT
GCTGCCGATCACCACGCTGGTGGCCAAGACCAGTCACCGGGTGGCAGATCTGTTTGCCATTCCGGATCGGGGTTATTTGC
GTGAGGGATATTGGGCGGATCTGGTGTTGATTCAACCGGAGCCCAAAGGCGTCGCGGTGTCACGCCAGCCGGTTCTGTCG
CAATGCGGCTGGACGCCGTTCGCTCAGCGCAGCTTTCGGCATAGGGTCAGCACGACGATAGTGTCGGGGCAGATTGCATG
GCATGACCACCGGATTCATGACAGTTGTCAGGGCTTGCCACTGCGGTTCATGCGTTGA

Upstream 100 bases:

>100_bases
GCCAGTGAGCGTCAGCGCTTCGGAGTTTTCCGAAGACGTGGCGCGCACCAACGTCGACCTGGTGCGCGGCTACAAAGCCT
TGCAGAACGAGTTCTGAATC

Downstream 100 bases:

>100_bases
AAAAAAACCGCCTCCACTCGACGTGGAGGCGGTTTCGATAAAGACGTTACGCTCTCGGTTTGACTGTGCCGCAATCCTGA
CCCAACCAGACTGCCCGGGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSSVLIRNARLVNEGREFDADLLVSHGRIVKIAGSIEGENATREIDATGQWLLPGMIDDQVHFREPGAPAKGSVHTESRA
AVAGGITSFMDMPNTHPATLTLEALADKKRRAAINSVANYGFHFGVSHDNLDTVAALNPSEVAGVKVFMGASTGNMLVDD
PHTLERLFAEVPTILLAHCEHTPSIEANAANLRERYGNQLPPDAHAQIRNADSCFRSSSLAVDLAKRHGTRLHVLHLTTA
RELALFEDKPLTQKRITAEVCLHHLLFDERDYPNLGNLIKCNPAIKSRSDRDALRQALLSNRLDVIGSDHAPHTWAEKQQ
AYEQAPSGLPLVQHALPALLELVADGVLPITTLVAKTSHRVADLFAIPDRGYLREGYWADLVLIQPEPKGVAVSRQPVLS
QCGWTPFAQRSFRHRVSTTIVSGQIAWHDHRIHDSCQGLPLRFMR

Sequences:

>Translated_445_residues
MSSVLIRNARLVNEGREFDADLLVSHGRIVKIAGSIEGENATREIDATGQWLLPGMIDDQVHFREPGAPAKGSVHTESRA
AVAGGITSFMDMPNTHPATLTLEALADKKRRAAINSVANYGFHFGVSHDNLDTVAALNPSEVAGVKVFMGASTGNMLVDD
PHTLERLFAEVPTILLAHCEHTPSIEANAANLRERYGNQLPPDAHAQIRNADSCFRSSSLAVDLAKRHGTRLHVLHLTTA
RELALFEDKPLTQKRITAEVCLHHLLFDERDYPNLGNLIKCNPAIKSRSDRDALRQALLSNRLDVIGSDHAPHTWAEKQQ
AYEQAPSGLPLVQHALPALLELVADGVLPITTLVAKTSHRVADLFAIPDRGYLREGYWADLVLIQPEPKGVAVSRQPVLS
QCGWTPFAQRSFRHRVSTTIVSGQIAWHDHRIHDSCQGLPLRFMR
>Mature_444_residues
SSVLIRNARLVNEGREFDADLLVSHGRIVKIAGSIEGENATREIDATGQWLLPGMIDDQVHFREPGAPAKGSVHTESRAA
VAGGITSFMDMPNTHPATLTLEALADKKRRAAINSVANYGFHFGVSHDNLDTVAALNPSEVAGVKVFMGASTGNMLVDDP
HTLERLFAEVPTILLAHCEHTPSIEANAANLRERYGNQLPPDAHAQIRNADSCFRSSSLAVDLAKRHGTRLHVLHLTTAR
ELALFEDKPLTQKRITAEVCLHHLLFDERDYPNLGNLIKCNPAIKSRSDRDALRQALLSNRLDVIGSDHAPHTWAEKQQA
YEQAPSGLPLVQHALPALLELVADGVLPITTLVAKTSHRVADLFAIPDRGYLREGYWADLVLIQPEPKGVAVSRQPVLSQ
CGWTPFAQRSFRHRVSTTIVSGQIAWHDHRIHDSCQGLPLRFMR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=381, Percent_Identity=27.2965879265092, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4503379, Length=452, Percent_Identity=23.8938053097345, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4503051, Length=451, Percent_Identity=21.9512195121951, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI62422571, Length=451, Percent_Identity=21.9512195121951, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI190194363, Length=449, Percent_Identity=23.162583518931, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI19923821, Length=413, Percent_Identity=21.0653753026634, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI4503375, Length=414, Percent_Identity=22.9468599033816, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI4503377, Length=447, Percent_Identity=21.7002237136465, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786722, Length=452, Percent_Identity=25.2212389380531, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI87082175, Length=399, Percent_Identity=26.3157894736842, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=382, Percent_Identity=29.5811518324607, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71989490, Length=463, Percent_Identity=23.5421166306695, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17539558, Length=413, Percent_Identity=24.2130750605327, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=397, Percent_Identity=25.6926952141058, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642586, Length=383, Percent_Identity=28.1984334203655, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI18859883, Length=405, Percent_Identity=27.4074074074074, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=25.2747252747253, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137462, Length=415, Percent_Identity=26.9879518072289, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644287, Length=290, Percent_Identity=26.8965517241379, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24644289, Length=131, Percent_Identity=34.3511450381679, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48963; Mature: 48832

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVLIRNARLVNEGREFDADLLVSHGRIVKIAGSIEGENATREIDATGQWLLPGMIDDQ
CCCEEEECHHHHCCCCCCCHHHHCCCCEEEEEECCCCCCCCCEEECCCCCEECCCCCCCC
VHFREPGAPAKGSVHTESRAAVAGGITSFMDMPNTHPATLTLEALADKKRRAAINSVANY
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHC
GFHFGVSHDNLDTVAALNPSEVAGVKVFMGASTGNMLVDDPHTLERLFAEVPTILLAHCE
CEEECCCCCCCCEEEECCCHHHCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCC
HTPSIEANAANLRERYGNQLPPDAHAQIRNADSCFRSSSLAVDLAKRHGTRLHVLHLTTA
CCCCCCCCHHHHHHHCCCCCCCCHHHHHCCHHHHHHCCCCEEEHHHHCCCEEEEEEECCH
RELALFEDKPLTQKRITAEVCLHHLLFDERDYPNLGNLIKCNPAIKSRSDRDALRQALLS
HHHHEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHCCCCHHHHHHHHHHH
NRLDVIGSDHAPHTWAEKQQAYEQAPSGLPLVQHALPALLELVADGVLPITTLVAKTSHR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCH
VADLFAIPDRGYLREGYWADLVLIQPEPKGVAVSRQPVLSQCGWTPFAQRSFRHRVSTTI
HHHEEECCCCCCCCCCCEEEEEEECCCCCCEEECCCHHHHHCCCCHHHHHHHHHHHHHEE
VSGQIAWHDHRIHDSCQGLPLRFMR
EECEEEECCCHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SSVLIRNARLVNEGREFDADLLVSHGRIVKIAGSIEGENATREIDATGQWLLPGMIDDQ
CCEEEECHHHHCCCCCCCHHHHCCCCEEEEEECCCCCCCCCEEECCCCCEECCCCCCCC
VHFREPGAPAKGSVHTESRAAVAGGITSFMDMPNTHPATLTLEALADKKRRAAINSVANY
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHC
GFHFGVSHDNLDTVAALNPSEVAGVKVFMGASTGNMLVDDPHTLERLFAEVPTILLAHCE
CEEECCCCCCCCEEEECCCHHHCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCC
HTPSIEANAANLRERYGNQLPPDAHAQIRNADSCFRSSSLAVDLAKRHGTRLHVLHLTTA
CCCCCCCCHHHHHHHCCCCCCCCHHHHHCCHHHHHHCCCCEEEHHHHCCCEEEEEEECCH
RELALFEDKPLTQKRITAEVCLHHLLFDERDYPNLGNLIKCNPAIKSRSDRDALRQALLS
HHHHEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHCCCCHHHHHHHHHHH
NRLDVIGSDHAPHTWAEKQQAYEQAPSGLPLVQHALPALLELVADGVLPITTLVAKTSHR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCH
VADLFAIPDRGYLREGYWADLVLIQPEPKGVAVSRQPVLSQCGWTPFAQRSFRHRVSTTI
HHHEEECCCCCCCCCCCEEEEEEECCCCCCEEECCCHHHHHCCCCHHHHHHHHHHHHHEE
VSGQIAWHDHRIHDSCQGLPLRFMR
EECEEEECCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA