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The map label for this gene is phoR [H]

Identifier: 77461828

GI number: 77461828

Start: 6278680

End: 6280002

Strand: Direct

Name: phoR [H]

Synonym: Pfl01_5607

Alternate gene names: 77461828

Gene position: 6278680-6280002 (Clockwise)

Preceding gene: 77461827

Following gene: 77461829

Centisome position: 97.52

GC content: 63.11

Gene sequence:

>1323_bases
GTGAACCAAAACTGGCATGGCACCCTGATCCGCCACATGCTGTTGCTGGTCACCGGCTGCCTGGTGATCGGCCTGATCAC
CGGCTACTACGGCTGGAGTCTGGCGGCAGGCCTGGGCCTGTACCTGGCCTGGACGCTCAAGCAACTGCTGCGCCTGCACG
AATGGCTGCGCCTGCACCAACCCGATGAAGCACCGCCCGACGGCTATGGCCTGTGGGGCGAGGTGTTCGACAGCATCTAC
CACCTGCAACGCCGCGACCAACGGGTACGCGGGCGCCTGCAAGCGGTGATCGACCGCGTCCAGGAGTCCACCGCTGCGCT
GAAAGACGCGGTGATCATGCTCGACAGCGACGGCAACCTGGAATGGTGGAACCGCGCCGCCGAAACCCTGCTCGGTCTCA
AGACCCCGCAGGACAGCGGTCAACCGGTGACCAACCTCGTCCGCCATCCGCGCTTCAAGGAATACTTCGAGCAGGAAAGC
TACGCCGAACCGCTGGAAATCCCCTCGCCGACCAACGATCGCGTACGCATCCAGCTGTACCTCACGCGCTACGGCAACAA
CGAACACTTGATGCTGGTGCGCGACGTCACGCGCATCCATCAACTGGAACAGATGCGCAAAGACTTCATCGCCAACGTCT
CCCACGAGCTGCGCACCCCGCTGACGGTGATCTGCGGCTACCTGGAAACCCTGCTCGACAACGTTGAGGAAGTGAACCCG
CGCTGGAGCCGCGCCCTGCAGCAGATGCAGCAGCAGGGCGGGCGCATGCAGACCCTGCTCAACGACTTGCTGTTGCTGGC
CAAGCTGGAAGCCACCGATTACCCGTCGGACAATCAGCCGGTGCACATCGACACCCTGTTGCAGTCGATCAAGAGCGACG
CCCAGCAGCTGTCAGGTTCGAAGAATCAGAAAATCACCCTGGAAGCCGACACCAGCATTCTACTCAAGGGCAGCGAAGCG
GAACTGCGCAGTGCGTTTTCCAACCTGGTGTTCAACGCCGTCAAATACACCCCGGCCGAAGGCAATATCCGCATCCGCTG
GTGGGGCGACGATCAGGGTGCGCACCTGAGCGTGCAGGATTCCGGGATCGGCATCGACAGCAAACACCTGCCGCGCCTGA
CCGAACGCTTCTACCGCGTCGACTCCAGCCGCAACTCCAACACCGGCGGCACCGGCCTGGGCCTGGCCATCGTCAAACAC
GTGCTGCTGCGCCATCGCGCACGGATGGAGATCAGCAGCGTGCCCGGTCATGGCAGCACCTTCACCTGCCATTTCGCCCC
GGCCCAGGTCGCTCAGGCACGGGTCATCAGCGCCGCTGAGTAA

Upstream 100 bases:

>100_bases
CCTACGAAAATCTGGTACAAACCGTGCGCGGCACCGGCTACCGGTTCTCCACCAAGGCCTGAGCCGAGCGCCAGCCCCGT
AGACAAGGACCGCATTTTCC

Downstream 100 bases:

>100_bases
TGCCGGACTAGGCAATCGCCAGGTCAGCCGCTACATTGGCTGACTTGCGCCTGCCTTTCAGGTGCGGATTTTTCTTTCTT
TCGAATCACACGGAACCCGC

Product: PAS/PAC sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MNQNWHGTLIRHMLLLVTGCLVIGLITGYYGWSLAAGLGLYLAWTLKQLLRLHEWLRLHQPDEAPPDGYGLWGEVFDSIY
HLQRRDQRVRGRLQAVIDRVQESTAALKDAVIMLDSDGNLEWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFEQES
YAEPLEIPSPTNDRVRIQLYLTRYGNNEHLMLVRDVTRIHQLEQMRKDFIANVSHELRTPLTVICGYLETLLDNVEEVNP
RWSRALQQMQQQGGRMQTLLNDLLLLAKLEATDYPSDNQPVHIDTLLQSIKSDAQQLSGSKNQKITLEADTSILLKGSEA
ELRSAFSNLVFNAVKYTPAEGNIRIRWWGDDQGAHLSVQDSGIGIDSKHLPRLTERFYRVDSSRNSNTGGTGLGLAIVKH
VLLRHRARMEISSVPGHGSTFTCHFAPAQVAQARVISAAE

Sequences:

>Translated_440_residues
MNQNWHGTLIRHMLLLVTGCLVIGLITGYYGWSLAAGLGLYLAWTLKQLLRLHEWLRLHQPDEAPPDGYGLWGEVFDSIY
HLQRRDQRVRGRLQAVIDRVQESTAALKDAVIMLDSDGNLEWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFEQES
YAEPLEIPSPTNDRVRIQLYLTRYGNNEHLMLVRDVTRIHQLEQMRKDFIANVSHELRTPLTVICGYLETLLDNVEEVNP
RWSRALQQMQQQGGRMQTLLNDLLLLAKLEATDYPSDNQPVHIDTLLQSIKSDAQQLSGSKNQKITLEADTSILLKGSEA
ELRSAFSNLVFNAVKYTPAEGNIRIRWWGDDQGAHLSVQDSGIGIDSKHLPRLTERFYRVDSSRNSNTGGTGLGLAIVKH
VLLRHRARMEISSVPGHGSTFTCHFAPAQVAQARVISAAE
>Mature_440_residues
MNQNWHGTLIRHMLLLVTGCLVIGLITGYYGWSLAAGLGLYLAWTLKQLLRLHEWLRLHQPDEAPPDGYGLWGEVFDSIY
HLQRRDQRVRGRLQAVIDRVQESTAALKDAVIMLDSDGNLEWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFEQES
YAEPLEIPSPTNDRVRIQLYLTRYGNNEHLMLVRDVTRIHQLEQMRKDFIANVSHELRTPLTVICGYLETLLDNVEEVNP
RWSRALQQMQQQGGRMQTLLNDLLLLAKLEATDYPSDNQPVHIDTLLQSIKSDAQQLSGSKNQKITLEADTSILLKGSEA
ELRSAFSNLVFNAVKYTPAEGNIRIRWWGDDQGAHLSVQDSGIGIDSKHLPRLTERFYRVDSSRNSNTGGTGLGLAIVKH
VLLRHRARMEISSVPGHGSTFTCHFAPAQVAQARVISAAE

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=403, Percent_Identity=40.9429280397022, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1788393, Length=223, Percent_Identity=32.7354260089686, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI48994928, Length=269, Percent_Identity=31.9702602230483, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788549, Length=380, Percent_Identity=26.0526315789474, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786783, Length=218, Percent_Identity=28.4403669724771, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI145693157, Length=275, Percent_Identity=27.6363636363636, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=29.7872340425532, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081816, Length=244, Percent_Identity=32.3770491803279, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=246, Percent_Identity=29.6747967479675, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=26.3392857142857, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=200, Percent_Identity=33.5, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.8701298701299, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=31.7535545023697, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=226, Percent_Identity=29.646017699115, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=28.2407407407407, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789808, Length=246, Percent_Identity=29.2682926829268, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=216, Percent_Identity=24.537037037037, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=210, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=25, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49820; Mature: 49820

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNWHGTLIRHMLLLVTGCLVIGLITGYYGWSLAAGLGLYLAWTLKQLLRLHEWLRLHQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDEAPPDGYGLWGEVFDSIYHLQRRDQRVRGRLQAVIDRVQESTAALKDAVIMLDSDGNL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCH
EWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFEQESYAEPLEIPSPTNDRVRIQLY
HHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
LTRYGNNEHLMLVRDVTRIHQLEQMRKDFIANVSHELRTPLTVICGYLETLLDNVEEVNP
EEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCH
RWSRALQQMQQQGGRMQTLLNDLLLLAKLEATDYPSDNQPVHIDTLLQSIKSDAQQLSGS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCC
KNQKITLEADTSILLKGSEAELRSAFSNLVFNAVKYTPAEGNIRIRWWGDDQGAHLSVQD
CCCEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEC
SGIGIDSKHLPRLTERFYRVDSSRNSNTGGTGLGLAIVKHVLLRHRARMEISSVPGHGST
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
FTCHFAPAQVAQARVISAAE
EEEECCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQNWHGTLIRHMLLLVTGCLVIGLITGYYGWSLAAGLGLYLAWTLKQLLRLHEWLRLHQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDEAPPDGYGLWGEVFDSIYHLQRRDQRVRGRLQAVIDRVQESTAALKDAVIMLDSDGNL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCH
EWWNRAAETLLGLKTPQDSGQPVTNLVRHPRFKEYFEQESYAEPLEIPSPTNDRVRIQLY
HHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
LTRYGNNEHLMLVRDVTRIHQLEQMRKDFIANVSHELRTPLTVICGYLETLLDNVEEVNP
EEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCH
RWSRALQQMQQQGGRMQTLLNDLLLLAKLEATDYPSDNQPVHIDTLLQSIKSDAQQLSGS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCC
KNQKITLEADTSILLKGSEAELRSAFSNLVFNAVKYTPAEGNIRIRWWGDDQGAHLSVQD
CCCEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEC
SGIGIDSKHLPRLTERFYRVDSSRNSNTGGTGLGLAIVKHVLLRHRARMEISSVPGHGST
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
FTCHFAPAQVAQARVISAAE
EEEECCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]