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The map label for this gene is ppx [H]

Identifier: 77461684

GI number: 77461684

Start: 6129227

End: 6130729

Strand: Direct

Name: ppx [H]

Synonym: Pfl01_5463

Alternate gene names: 77461684

Gene position: 6129227-6130729 (Clockwise)

Preceding gene: 77461683

Following gene: 77461687

Centisome position: 95.2

GC content: 63.07

Gene sequence:

>1503_bases
ATGCCGCAATCCCAAGCCAAGAATCTGTCCCTGATCGCCGCGATCGACCTGGGCTCCAACAGCTTCCATATGGTCGTGGC
CAAGGCCCAGAACGGCGAAATCCGTATTCTCGAACGGCTCGGGGAAAAGGTTCAGCTGGCCGCCGGCATCGACGATGAGC
GCCAGCTCAACGAAGAATCCATGCAGCGCGGGCTCGACTGCCTCAAGCGCTTTGCCCAACTGATCAACGGCATGCCGCTG
GGCGCCGTGCGGATCGTCGGTACCAACGCCCTGCGCGAGGCGCGCAACCGTGGCGAATTCATCCGCCGTGCCGAAGAAAT
CCTCGGCCATCCGGTGGAAGTCATCTCCGGCCGTGAAGAGGCCCGCCTGATCTACCTCGGCGTGTCCCACACCCTCGCCG
ACACCCCGGGCAAACGCCTGGTCGCCGACATCGGCGGCGGCAGTACCGAATTCATCATCGGCCAGCGTTTCGAACCGCTG
CTGCGCGAAAGCCTGCAAATGGGCTGCGTGAGCTTCACCCAGCGCTATTTCAAGGACGGCAAAATCACCCCGGCCCGCTA
CGCCCAGGCCTACACGGCGGCGCGGCTGGAAATCATGAGCATCGAACACGCCTTGCATCGCCTGACCTGGGATGAAGCCA
TCGGCTCCTCGGGCACCATCCGCGCCATCGGCCTGGCGCTGAAGGCCGGCGGTCACGGCACCGGCGAAGTGAATGCCGAA
GGTCTGGCGTGGCTCAAGCGTCGCCTGTTCAAGCTCGGCGATGTCGACAAGATCGATTTCGAAGGCATCAAGCCGGATCG
TCGGGCGATCTTCCCGGCCGGTCTGGCGATTCTCGAAGCGATCTTCGACGCCCTCGAACTGCAACGCATGGATCACTGCG
AAGGCGCGCTGCGTGAAGGCGTACTTTACGACCTGCTCGGCCGCCATCACCACGAAGACGTGCGCGAACGTACTCTGACC
TCGCTGATGGAGCGCTACCACGTCGACCTCGAACAGGCCGCGCGGGTCGAGCGCAAAGCCCTGCACGCGTTCGATCAAGT
GGCCGTGGACTGGGAGCTGGACGACGGTATCTGGCGCGAACTGCTGGGCTGGGCGGCGAAAGTGCACGAAGTCGGGCTCG
ACATCGCTCACTATCACTACCATAAGCACGGTGCCTACCTGATCGAACACTCGGACCTCGCCGGGTTCTCCCGCGAAGAC
CAGCAGATGCTTGCGCTGCTGGTGCGTGGCCACCGCCGCAACATCCCCAAGGACAAGTTCGCCGAGTTCGGAGACGACGG
CGACAAGCTGATCCGTCTGTGTGTGCTGCTGCGTTTCGCCATCCTGTTCCACCACATTCGTGGCACCCAGGCGATGCCGC
AGGTTGCGCTGCATGCCAACGGCGACAACCTCGATGTGGAGTTTCCGGAGAACTGGCTGGATGAAAACCAGCTGACCCAG
GCGGATTTCGGGCTTGAGGCCGAATGGCTGACGCGGGTGGGGATTGTCCTGACCGTGCATTGA

Upstream 100 bases:

>100_bases
TGAGACTTTATGCGCTGAATCAAGGGTTTGAACCATGCGCGTTGGCGGCAGCGTTTGATCGTGGCACGATGTCGGGGTTA
TCGACCGAGACCCCCTGACC

Downstream 100 bases:

>100_bases
GTAACGGGCAGGCACAAAAAAGGCGATCCGGATGGATCGCCTTTTTTATGGCTATGAAACCTGCGGTCAGCTGCTCACCG
GCAGAATCGGGCTGCCCAAT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MPQSQAKNLSLIAAIDLGSNSFHMVVAKAQNGEIRILERLGEKVQLAAGIDDERQLNEESMQRGLDCLKRFAQLINGMPL
GAVRIVGTNALREARNRGEFIRRAEEILGHPVEVISGREEARLIYLGVSHTLADTPGKRLVADIGGGSTEFIIGQRFEPL
LRESLQMGCVSFTQRYFKDGKITPARYAQAYTAARLEIMSIEHALHRLTWDEAIGSSGTIRAIGLALKAGGHGTGEVNAE
GLAWLKRRLFKLGDVDKIDFEGIKPDRRAIFPAGLAILEAIFDALELQRMDHCEGALREGVLYDLLGRHHHEDVRERTLT
SLMERYHVDLEQAARVERKALHAFDQVAVDWELDDGIWRELLGWAAKVHEVGLDIAHYHYHKHGAYLIEHSDLAGFSRED
QQMLALLVRGHRRNIPKDKFAEFGDDGDKLIRLCVLLRFAILFHHIRGTQAMPQVALHANGDNLDVEFPENWLDENQLTQ
ADFGLEAEWLTRVGIVLTVH

Sequences:

>Translated_500_residues
MPQSQAKNLSLIAAIDLGSNSFHMVVAKAQNGEIRILERLGEKVQLAAGIDDERQLNEESMQRGLDCLKRFAQLINGMPL
GAVRIVGTNALREARNRGEFIRRAEEILGHPVEVISGREEARLIYLGVSHTLADTPGKRLVADIGGGSTEFIIGQRFEPL
LRESLQMGCVSFTQRYFKDGKITPARYAQAYTAARLEIMSIEHALHRLTWDEAIGSSGTIRAIGLALKAGGHGTGEVNAE
GLAWLKRRLFKLGDVDKIDFEGIKPDRRAIFPAGLAILEAIFDALELQRMDHCEGALREGVLYDLLGRHHHEDVRERTLT
SLMERYHVDLEQAARVERKALHAFDQVAVDWELDDGIWRELLGWAAKVHEVGLDIAHYHYHKHGAYLIEHSDLAGFSRED
QQMLALLVRGHRRNIPKDKFAEFGDDGDKLIRLCVLLRFAILFHHIRGTQAMPQVALHANGDNLDVEFPENWLDENQLTQ
ADFGLEAEWLTRVGIVLTVH
>Mature_499_residues
PQSQAKNLSLIAAIDLGSNSFHMVVAKAQNGEIRILERLGEKVQLAAGIDDERQLNEESMQRGLDCLKRFAQLINGMPLG
AVRIVGTNALREARNRGEFIRRAEEILGHPVEVISGREEARLIYLGVSHTLADTPGKRLVADIGGGSTEFIIGQRFEPLL
RESLQMGCVSFTQRYFKDGKITPARYAQAYTAARLEIMSIEHALHRLTWDEAIGSSGTIRAIGLALKAGGHGTGEVNAEG
LAWLKRRLFKLGDVDKIDFEGIKPDRRAIFPAGLAILEAIFDALELQRMDHCEGALREGVLYDLLGRHHHEDVRERTLTS
LMERYHVDLEQAARVERKALHAFDQVAVDWELDDGIWRELLGWAAKVHEVGLDIAHYHYHKHGAYLIEHSDLAGFSREDQ
QMLALLVRGHRRNIPKDKFAEFGDDGDKLIRLCVLLRFAILFHHIRGTQAMPQVALHANGDNLDVEFPENWLDENQLTQA
DFGLEAEWLTRVGIVLTVH

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=492, Percent_Identity=40.8536585365854, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI48994966, Length=501, Percent_Identity=39.3213572854291, Blast_Score=341, Evalue=7e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56183; Mature: 56052

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQSQAKNLSLIAAIDLGSNSFHMVVAKAQNGEIRILERLGEKVQLAAGIDDERQLNEES
CCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCHHHHHCCCCEEEECCCCHHHHCCHHH
MQRGLDCLKRFAQLINGMPLGAVRIVGTNALREARNRGEFIRRAEEILGHPVEVISGREE
HHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
ARLIYLGVSHTLADTPGKRLVADIGGGSTEFIIGQRFEPLLRESLQMGCVSFTQRYFKDG
CEEEEEECCHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
KITPARYAQAYTAARLEIMSIEHALHRLTWDEAIGSSGTIRAIGLALKAGGHGTGEVNAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHH
GLAWLKRRLFKLGDVDKIDFEGIKPDRRAIFPAGLAILEAIFDALELQRMDHCEGALREG
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLYDLLGRHHHEDVRERTLTSLMERYHVDLEQAARVERKALHAFDQVAVDWELDDGIWRE
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCHHHHHH
LLGWAAKVHEVGLDIAHYHYHKHGAYLIEHSDLAGFSREDQQMLALLVRGHRRNIPKDKF
HHHHHHHHHHHCCHHHHHEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
AEFGDDGDKLIRLCVLLRFAILFHHIRGTQAMPQVALHANGDNLDVEFPENWLDENQLTQ
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCHHHCCCCCCCH
ADFGLEAEWLTRVGIVLTVH
HHCCCCHHHHHHCCEEEEEC
>Mature Secondary Structure 
PQSQAKNLSLIAAIDLGSNSFHMVVAKAQNGEIRILERLGEKVQLAAGIDDERQLNEES
CCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCHHHHHCCCCEEEECCCCHHHHCCHHH
MQRGLDCLKRFAQLINGMPLGAVRIVGTNALREARNRGEFIRRAEEILGHPVEVISGREE
HHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
ARLIYLGVSHTLADTPGKRLVADIGGGSTEFIIGQRFEPLLRESLQMGCVSFTQRYFKDG
CEEEEEECCHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
KITPARYAQAYTAARLEIMSIEHALHRLTWDEAIGSSGTIRAIGLALKAGGHGTGEVNAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHH
GLAWLKRRLFKLGDVDKIDFEGIKPDRRAIFPAGLAILEAIFDALELQRMDHCEGALREG
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLYDLLGRHHHEDVRERTLTSLMERYHVDLEQAARVERKALHAFDQVAVDWELDDGIWRE
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCHHHHHH
LLGWAAKVHEVGLDIAHYHYHKHGAYLIEHSDLAGFSREDQQMLALLVRGHRRNIPKDKF
HHHHHHHHHHHCCHHHHHEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
AEFGDDGDKLIRLCVLLRFAILFHHIRGTQAMPQVALHANGDNLDVEFPENWLDENQLTQ
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCHHHCCCCCCCH
ADFGLEAEWLTRVGIVLTVH
HHCCCCHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]