Click here to switch to the map view.

The map label for this gene is ahcY [H]

Identifier: 77461501

GI number: 77461501

Start: 5940763

End: 5942172

Strand: Direct

Name: ahcY [H]

Synonym: Pfl01_5280

Alternate gene names: 77461501

Gene position: 5940763-5942172 (Clockwise)

Preceding gene: 77461498

Following gene: 77461502

Centisome position: 92.27

GC content: 58.72

Gene sequence:

>1410_bases
ATGAGCGCTGTTATCACGCCTGCCGATTTTAACGATTACAAAGTTGCCGACATATCCCTGGCTGCCTGGGGTCGTCGCGA
AACCATCATCGCCGAGTCGGAAATGCCGGCCCTGATGGGTCTGCGCCGCAAGTACGCTTCCGAGCAGCCTTTGAAAGGCG
CAAAAATCCTCGGCTGCATCCACATGACCATCCAGACCGCCGTGCTGATCGAAACCCTGGTTGCCCTGGGTGCCGAAGTA
CGCTGGTCGTCCTGCAACATTTTCTCGACTCAGGATCAGGCCGCTGCTTCCATCGCTGCTGCCGGCATCCCGGTTTTCGC
CTGGAAAGGCGAGACTGAAGAAGAGTACGAGTGGTGCCTGGAGCAGACCATCCTGAAGGATGGCCAGCCATGGGACGCCA
ACATGATCCTCGACGACGGCGGCGACCTGACCGAGCTGCTGCACAAGAAATACCCACAGGTTCTGGACCGTGTTCACGGC
GTGACCGAAGAAACCACCACCGGCGTGCACCGTCTGCTGGACATGCTGGCCAAGGGCGAGCTGAAAATCCCGGCCATCAA
CGTCAACGACTCGGTGACCAAGTCCAAGAACGACAACAAGTACGGCTGCCGTCACAGCCTGAACGATGCCATCAAGCGTG
GCACCGACCACCTGCTGTCCGGCAAGCAAGCGCTGGTCATCGGTTACGGTGACGTGGGCAAGGGTTCGGCCCAGTCCCTG
CGTCAGGAAGGCATGATCGTCAAAGTCTCCGAAGTTGACCCGATCTGCGCCATGCAAGCCTGCATGGACGGTTTCGAACT
GGTTTCGCCGTTCATCGACGGTATCAACGACGGCACCGAAGCGAGCATCGACAAAGCGCTGCTGGGCAAGATCGACCTGA
TCGTGACCACCACCGGTAACGTCAACGTTTGCGACGCAAACATGCTCAAAGCCCTGAAGAAGCGCGCCGTTGTCTGCAAC
ATCGGTCACTTCGACAACGAAATCGACACCGCTTTCATGCGCAAGAACTGGGCATGGGAAGAAGTGAAGCCACAGGTACA
CAAGATCCACCGTACCGGCGCTGGCTCGTTCGATCCACAGAACGACGACTACCTGATCCTGCTGGCCGAAGGCCGTCTGG
TGAACCTGGGCAACGCTACCGGTCACCCAAGCCGCATCATGGACGGTTCGTTCGCCAACCAGGTTCTGGCGCAGATCTTC
CTGTTCGGCCAGAAGTACGCCGACCTGTCGCCAGCCCAGAAAGCCGAGCGCCTGACCGTTGAAGTACTGCCGAAGAAACT
CGACGAAGAAGTGGCCCTGGAAATGGTTCGCGGCTTCGGCGGCGTGGTCACTCAACTGACCAAGCAACAGGCTGACTACA
TCGGCGTGACCGTCGAAGGTCCGTTCAAGCCACACGCTTACCGCTACTAA

Upstream 100 bases:

>100_bases
AGGTTCAACCTGTCAGGCTCGGATGGGGCGTTGACCGGCTCAGGCCGGACACTAAACGCACAACGGCGCCCATTCGCATA
CATTACGAATGGAGGCTCTC

Downstream 100 bases:

>100_bases
GAGCAGCTGCGAGCTTCAAGCTTCAAGCGGCAAGCAAGGCCACAAGCCGGGCTTGCCGCGCGAAGCCCGAAAGCTCTGCC
CCTATTTGTCAAAACAGTGT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSAVITPADFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYASEQPLKGAKILGCIHMTIQTAVLIETLVALGAEV
RWSSCNIFSTQDQAAASIAAAGIPVFAWKGETEEEYEWCLEQTILKDGQPWDANMILDDGGDLTELLHKKYPQVLDRVHG
VTEETTTGVHRLLDMLAKGELKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSL
RQEGMIVKVSEVDPICAMQACMDGFELVSPFIDGINDGTEASIDKALLGKIDLIVTTTGNVNVCDANMLKALKKRAVVCN
IGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGAGSFDPQNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIF
LFGQKYADLSPAQKAERLTVEVLPKKLDEEVALEMVRGFGGVVTQLTKQQADYIGVTVEGPFKPHAYRY

Sequences:

>Translated_469_residues
MSAVITPADFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYASEQPLKGAKILGCIHMTIQTAVLIETLVALGAEV
RWSSCNIFSTQDQAAASIAAAGIPVFAWKGETEEEYEWCLEQTILKDGQPWDANMILDDGGDLTELLHKKYPQVLDRVHG
VTEETTTGVHRLLDMLAKGELKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSL
RQEGMIVKVSEVDPICAMQACMDGFELVSPFIDGINDGTEASIDKALLGKIDLIVTTTGNVNVCDANMLKALKKRAVVCN
IGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGAGSFDPQNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIF
LFGQKYADLSPAQKAERLTVEVLPKKLDEEVALEMVRGFGGVVTQLTKQQADYIGVTVEGPFKPHAYRY
>Mature_468_residues
SAVITPADFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYASEQPLKGAKILGCIHMTIQTAVLIETLVALGAEVR
WSSCNIFSTQDQAAASIAAAGIPVFAWKGETEEEYEWCLEQTILKDGQPWDANMILDDGGDLTELLHKKYPQVLDRVHGV
TEETTTGVHRLLDMLAKGELKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSLR
QEGMIVKVSEVDPICAMQACMDGFELVSPFIDGINDGTEASIDKALLGKIDLIVTTTGNVNVCDANMLKALKKRAVVCNI
GHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGAGSFDPQNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIFL
FGQKYADLSPAQKAERLTVEVLPKKLDEEVALEMVRGFGGVVTQLTKQQADYIGVTVEGPFKPHAYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=460, Percent_Identity=55.6521739130435, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI239937451, Length=438, Percent_Identity=54.7945205479452, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI24308043, Length=461, Percent_Identity=46.6377440347072, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI298286489, Length=461, Percent_Identity=46.6377440347072, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI195539337, Length=461, Percent_Identity=46.6377440347072, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI195539349, Length=461, Percent_Identity=46.6377440347072, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI21361647, Length=461, Percent_Identity=46.4208242950108, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17506425, Length=459, Percent_Identity=57.7342047930283, Blast_Score=499, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6320882, Length=467, Percent_Identity=53.7473233404711, Blast_Score=456, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24642172, Length=461, Percent_Identity=56.1822125813449, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24656245, Length=462, Percent_Identity=46.7532467532467, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI45553387, Length=459, Percent_Identity=47.9302832244009, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI45553385, Length=458, Percent_Identity=47.8165938864629, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51419; Mature: 51288

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVITPADFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYASEQPLKGAKILGCI
CCCEECCCCCCCEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHH
HMTIQTAVLIETLVALGAEVRWSSCNIFSTQDQAAASIAAAGIPVFAWKGETEEEYEWCL
HHHHHHHHHHHHHHHCCCCEEECCCCEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
EQTILKDGQPWDANMILDDGGDLTELLHKKYPQVLDRVHGVTEETTTGVHRLLDMLAKGE
HHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
LKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSL
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCCEEEEECCCCCCCHHHHH
RQEGMIVKVSEVDPICAMQACMDGFELVSPFIDGINDGTEASIDKALLGKIDLIVTTTGN
HHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEEECCC
VNVCDANMLKALKKRAVVCNIGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGAGSFDPQ
CEECCHHHHHHHHHCEEEEECCCCCCHHHHHHHHCCCCHHHHCHHHHHHHHCCCCCCCCC
NDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIFLFGQKYADLSPAQKAERLTV
CCCEEEEEECCCEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
EVLPKKLDEEVALEMVRGFGGVVTQLTKQQADYIGVTVEGPFKPHAYRY
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SAVITPADFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYASEQPLKGAKILGCI
CCEECCCCCCCEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHH
HMTIQTAVLIETLVALGAEVRWSSCNIFSTQDQAAASIAAAGIPVFAWKGETEEEYEWCL
HHHHHHHHHHHHHHHCCCCEEECCCCEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
EQTILKDGQPWDANMILDDGGDLTELLHKKYPQVLDRVHGVTEETTTGVHRLLDMLAKGE
HHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
LKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSL
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCCEEEEECCCCCCCHHHHH
RQEGMIVKVSEVDPICAMQACMDGFELVSPFIDGINDGTEASIDKALLGKIDLIVTTTGN
HHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEEECCC
VNVCDANMLKALKKRAVVCNIGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGAGSFDPQ
CEECCHHHHHHHHHCEEEEECCCCCCHHHHHHHHCCCCHHHHCHHHHHHHHCCCCCCCCC
NDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIFLFGQKYADLSPAQKAERLTV
CCCEEEEEECCCEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
EVLPKKLDEEVALEMVRGFGGVVTQLTKQQADYIGVTVEGPFKPHAYRY
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA