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The map label for this gene is cvrA [H]

Identifier: 77461498

GI number: 77461498

Start: 5937810

End: 5939075

Strand: Direct

Name: cvrA [H]

Synonym: Pfl01_5277

Alternate gene names: 77461498

Gene position: 5937810-5939075 (Clockwise)

Preceding gene: 77461497

Following gene: 77461501

Centisome position: 92.22

GC content: 63.51

Gene sequence:

>1266_bases
ATGCTTGAACTCGTCGCCGCTTTCATCTGCCTCACCACCCTCCTCACCTTTGTGAATTTCCGCTTCATCGGCCTGCCCCC
GACCATCGGCGTGATGGTTACCGCGCTGATGTTTTCCCTGTTGCTGCAAGGCCTGAGCCTGCTCGGCTACCCCGGTCTCG
AAGAGCGCGTACAGCAACTGATCGGCCAGATCGACTTCGGCGATCTGCTGATGAACTGGATGCTCTCGTTCCTGCTGTTC
GCCGGTGCGTTGCACGTGAACCTCAACGACCTGCGCAGTTACCGCTGGCCCATCGGCCTGCTGGCGACCTTCGGCGTATT
GATCGCCACCGCCGTGATCGGCAGCCTCGCCTACTACATCTTCGCCCTGTTCGGCTGGCACGTGAGCTTCCTCTACTGCC
TGTTGTTCGGCGCGCTGATTTCCCCGACCGACCCGATCGCGGTACTCGGCGTGCTGCGTACGGCCAATGCCTCGAAGCCG
CTGAAGACCACCATCGTCGGCGAATCGCTGTTCAACGACGGCACCGCCGTGGTGGTGTTCACCGTGTTGCTGGGCATCGC
GCAACTGGGCGAAACCCCGACCGTCGGCGCCACGGCCATGCTGTTTGCCCATGAAGCCATCGGCGGCGTGCTGTTCGGCG
GGCTGATCGGTTATCTGGTGTACCTGATGATCAAGAGCATCGAGCAGCACCAGATCGAAGTCATGCTGACCCTGGCGCTG
GTGATCGGCGGTTCGGCGATGGCCACCGAGCTGCACGTCTCGGCGCCGATTGCGATGGTGGTTGCCGGGCTGATCATCGG
TAACTTGGGTCGCAACCTGGCGATGAACGACATGACCCGCAAATACCTGGACGGTTTCTGGGAATTGCTCGACGACATGC
TCAACGCCCTGCTGTTCGCGCTGATCGGGATGGAGCTGTTGCTGCTGCCGTTCAACTGGCTGCACGTGGCGGCGGCAAGC
CTGCTGGCGCTGGCGATTCTGCTGTCGCGCCTGCTCACCGTGGCCCCGGCCATCGTCTTGCTGCGGCGCTGGCGCACCGT
GCCGCGCGGCACTATCCGGATCCTGACCTGGGGTGGATTGCGCGGCGGTGTGTCGGTGGCACTGGCACTGGCCCTGCCGT
TGGGCCCGGAGCGCGATCTGCTGCTGAGCATCACCTACATCGTGGTGCTGTCATCGATCCTGTTGCAGGGCCTGACCATC
GGCAAACTGGTCAAGCACGCAACGCGCGACGAGCCGGCGAGCGCTGCCGAGCCCGCGCACCATTGA

Upstream 100 bases:

>100_bases
CGGGGGACACCATTGTGTCCCCACCCGGCGTCAGCCCATCCAACCCTTGCGTCCATGAACGGGCGCGATGTCTTTCCACC
CCCCATCCAAAGGACCCCGG

Downstream 100 bases:

>100_bases
TCATTTCTTGATCTGCTGCGGATCGGGCTTTTCGGCCTGATCCGCAGACTCTTTCGGCTTTCCGCTTTCACTGCGGATCT
GCGCATGACTGATCAGGGCG

Product: Sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MLELVAAFICLTTLLTFVNFRFIGLPPTIGVMVTALMFSLLLQGLSLLGYPGLEERVQQLIGQIDFGDLLMNWMLSFLLF
AGALHVNLNDLRSYRWPIGLLATFGVLIATAVIGSLAYYIFALFGWHVSFLYCLLFGALISPTDPIAVLGVLRTANASKP
LKTTIVGESLFNDGTAVVVFTVLLGIAQLGETPTVGATAMLFAHEAIGGVLFGGLIGYLVYLMIKSIEQHQIEVMLTLAL
VIGGSAMATELHVSAPIAMVVAGLIIGNLGRNLAMNDMTRKYLDGFWELLDDMLNALLFALIGMELLLLPFNWLHVAAAS
LLALAILLSRLLTVAPAIVLLRRWRTVPRGTIRILTWGGLRGGVSVALALALPLGPERDLLLSITYIVVLSSILLQGLTI
GKLVKHATRDEPASAAEPAHH

Sequences:

>Translated_421_residues
MLELVAAFICLTTLLTFVNFRFIGLPPTIGVMVTALMFSLLLQGLSLLGYPGLEERVQQLIGQIDFGDLLMNWMLSFLLF
AGALHVNLNDLRSYRWPIGLLATFGVLIATAVIGSLAYYIFALFGWHVSFLYCLLFGALISPTDPIAVLGVLRTANASKP
LKTTIVGESLFNDGTAVVVFTVLLGIAQLGETPTVGATAMLFAHEAIGGVLFGGLIGYLVYLMIKSIEQHQIEVMLTLAL
VIGGSAMATELHVSAPIAMVVAGLIIGNLGRNLAMNDMTRKYLDGFWELLDDMLNALLFALIGMELLLLPFNWLHVAAAS
LLALAILLSRLLTVAPAIVLLRRWRTVPRGTIRILTWGGLRGGVSVALALALPLGPERDLLLSITYIVVLSSILLQGLTI
GKLVKHATRDEPASAAEPAHH
>Mature_421_residues
MLELVAAFICLTTLLTFVNFRFIGLPPTIGVMVTALMFSLLLQGLSLLGYPGLEERVQQLIGQIDFGDLLMNWMLSFLLF
AGALHVNLNDLRSYRWPIGLLATFGVLIATAVIGSLAYYIFALFGWHVSFLYCLLFGALISPTDPIAVLGVLRTANASKP
LKTTIVGESLFNDGTAVVVFTVLLGIAQLGETPTVGATAMLFAHEAIGGVLFGGLIGYLVYLMIKSIEQHQIEVMLTLAL
VIGGSAMATELHVSAPIAMVVAGLIIGNLGRNLAMNDMTRKYLDGFWELLDDMLNALLFALIGMELLLLPFNWLHVAAAS
LLALAILLSRLLTVAPAIVLLRRWRTVPRGTIRILTWGGLRGGVSVALALALPLGPERDLLLSITYIVVLSSILLQGLTI
GKLVKHATRDEPASAAEPAHH

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=309, Percent_Identity=27.1844660194175, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI15529998, Length=307, Percent_Identity=28.3387622149837, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI194239733, Length=303, Percent_Identity=29.3729372937294, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI27734935, Length=319, Percent_Identity=23.1974921630094, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4759144, Length=288, Percent_Identity=30.9027777777778, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI294997330, Length=396, Percent_Identity=23.2323232323232, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI41872703, Length=322, Percent_Identity=23.2919254658385, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI110227626, Length=396, Percent_Identity=23.2323232323232, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI5454070, Length=319, Percent_Identity=25.3918495297806, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71990924, Length=333, Percent_Identity=24.6246246246246, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980847, Length=328, Percent_Identity=23.780487804878, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71990932, Length=333, Percent_Identity=24.6246246246246, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25150332, Length=320, Percent_Identity=24.375, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=273, Percent_Identity=25.2747252747253, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71992101, Length=273, Percent_Identity=25.2747252747253, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71993590, Length=338, Percent_Identity=24.5562130177515, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71993582, Length=338, Percent_Identity=24.5562130177515, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71999817, Length=335, Percent_Identity=24.7761194029851, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71999819, Length=335, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71999821, Length=341, Percent_Identity=24.633431085044, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25147678, Length=297, Percent_Identity=25.5892255892256, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=307, Percent_Identity=27.0358306188925, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221510740, Length=326, Percent_Identity=25.4601226993865, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585580, Length=326, Percent_Identity=25.4601226993865, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585578, Length=326, Percent_Identity=25.4601226993865, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221473222, Length=314, Percent_Identity=24.8407643312102, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221473212, Length=316, Percent_Identity=25.6329113924051, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221473215, Length=314, Percent_Identity=24.8407643312102, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281364513, Length=314, Percent_Identity=24.8407643312102, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281360447, Length=324, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221510734, Length=336, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221510738, Length=324, Percent_Identity=25.3086419753086, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221510732, Length=324, Percent_Identity=25.3086419753086, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221510736, Length=324, Percent_Identity=25.3086419753086, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 45334; Mature: 45334

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELVAAFICLTTLLTFVNFRFIGLPPTIGVMVTALMFSLLLQGLSLLGYPGLEERVQQL
CHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IGQIDFGDLLMNWMLSFLLFAGALHVNLNDLRSYRWPIGLLATFGVLIATAVIGSLAYYI
HCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FALFGWHVSFLYCLLFGALISPTDPIAVLGVLRTANASKPLKTTIVGESLFNDGTAVVVF
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHH
TVLLGIAQLGETPTVGATAMLFAHEAIGGVLFGGLIGYLVYLMIKSIEQHQIEVMLTLAL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGGSAMATELHVSAPIAMVVAGLIIGNLGRNLAMNDMTRKYLDGFWELLDDMLNALLFA
HHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGMELLLLPFNWLHVAAASLLALAILLSRLLTVAPAIVLLRRWRTVPRGTIRILTWGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCC
RGGVSVALALALPLGPERDLLLSITYIVVLSSILLQGLTIGKLVKHATRDEPASAAEPAH
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCC
H
C
>Mature Secondary Structure
MLELVAAFICLTTLLTFVNFRFIGLPPTIGVMVTALMFSLLLQGLSLLGYPGLEERVQQL
CHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IGQIDFGDLLMNWMLSFLLFAGALHVNLNDLRSYRWPIGLLATFGVLIATAVIGSLAYYI
HCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FALFGWHVSFLYCLLFGALISPTDPIAVLGVLRTANASKPLKTTIVGESLFNDGTAVVVF
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHH
TVLLGIAQLGETPTVGATAMLFAHEAIGGVLFGGLIGYLVYLMIKSIEQHQIEVMLTLAL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGGSAMATELHVSAPIAMVVAGLIIGNLGRNLAMNDMTRKYLDGFWELLDDMLNALLFA
HHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGMELLLLPFNWLHVAAASLLALAILLSRLLTVAPAIVLLRRWRTVPRGTIRILTWGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCC
RGGVSVALALALPLGPERDLLLSITYIVVLSSILLQGLTIGKLVKHATRDEPASAAEPAH
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA