Click here to switch to the map view.

The map label for this gene is fba [H]

Identifier: 77461483

GI number: 77461483

Start: 5922236

End: 5923300

Strand: Reverse

Name: fba [H]

Synonym: Pfl01_5262

Alternate gene names: 77461483

Gene position: 5923300-5922236 (Counterclockwise)

Preceding gene: 77461484

Following gene: 77461480

Centisome position: 92.0

GC content: 59.91

Gene sequence:

>1065_bases
ATGGCACTTATCAGCATGCGCCAGATGCTGGACCACGCAGCCGAGTTCGGCTACGGCGTTCCAGCCTTCAACGTCAACAA
CCTTGAGCAGATGCGCGCCATCATGGAAGCCGCTGACAAGACTGACTCCCCGGTGATCGTTCAGGCTTCGGCCGGTGCCC
GCAAATACGCCGGCGCCCCGTTCCTGCGTCACCTGATCCTGGCGGCGATCGAAGAATTCCCGCACATCCCGGTGTGCATG
CACCAGGACCACGGCACCAGCCCTGACGTCTGCCAGCGCTCGATCCAGCTGGGCTTCAGCTCGGTCATGATGGATGGCTC
CCTCGGCGAAGACGGCAAGACCCCGACCGACTACGAATACAACGTCCGCGTGACCCAACAAACGGTAGCCATGGCTCACG
CCTGCGGCGTTTCGGTAGAAGGCGAGCTGGGCTGCCTGGGTTCGCTGGAAACCGGCATGGCCGGTGAAGAAGACGGCATC
GGCGCCGAAGGCGTTCTGGATCACAGCCAGATGCTGACCGACCCGGAAGAAGCCGCCGACTTCGTCAAGAAGACCCAGGT
TGATGCCCTGGCCATCGCCATCGGCACCAGCCACGGCGCCTACAAGTTCACCAAGCCGCCTACCGGTGACGTGCTGGCGA
TCGACCGCATCAAGGAAATCCACAAACGCATCCCGAACACCCACCTGGTGATGCACGGTTCCTCGTCGGTTCCGCAAGAG
TGGCTGGCGATCATCAACCAGTACGGCGGCGACATCAAAGAAACCTACGGCGTACCGGTTGAAGAAATCGTCGAAGGCAT
CAAGCACGGCGTGCGCAAGGTCAACATCGACACCGACCTGCGTCTGGCATCCACTGGCGCCATGCGTCGCCTGATGGCCA
CCAACCCGAGCGAATTCGACCCACGTAAATTCTTCGGCGAAACCGTGAAGGCGATGCGCGATGTATGTATCGCTCGTTAC
GAAGCTTTCGGTACTGCCGGCAACGCTTCGAAGATCAAACCGATCTCGTTGGAAGCAATGTTTCAGCGTTACCTCAAAGG
TGAGTTGAACGCTAAGGTGAACTAA

Upstream 100 bases:

>100_bases
CAGGCCGGGCCTCAACCCCCGATCTGCAATCACTTGAATAGCCGCCGCCGCTCCGGCAGGCTGGCACGATTAACGACCCA
AACCGGGAGAGAGACACACA

Downstream 100 bases:

>100_bases
GTCTCAGGCGTTTATAAAAAAACCCGCAGCGATGCGGGTTTTTTGTGATGATTGAACTAATATTGTTTCATGTTTCATGT
TTCATGTTTTTCTGGTGTAG

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MALISMRQMLDHAAEFGYGVPAFNVNNLEQMRAIMEAADKTDSPVIVQASAGARKYAGAPFLRHLILAAIEEFPHIPVCM
HQDHGTSPDVCQRSIQLGFSSVMMDGSLGEDGKTPTDYEYNVRVTQQTVAMAHACGVSVEGELGCLGSLETGMAGEEDGI
GAEGVLDHSQMLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTKPPTGDVLAIDRIKEIHKRIPNTHLVMHGSSSVPQE
WLAIINQYGGDIKETYGVPVEEIVEGIKHGVRKVNIDTDLRLASTGAMRRLMATNPSEFDPRKFFGETVKAMRDVCIARY
EAFGTAGNASKIKPISLEAMFQRYLKGELNAKVN

Sequences:

>Translated_354_residues
MALISMRQMLDHAAEFGYGVPAFNVNNLEQMRAIMEAADKTDSPVIVQASAGARKYAGAPFLRHLILAAIEEFPHIPVCM
HQDHGTSPDVCQRSIQLGFSSVMMDGSLGEDGKTPTDYEYNVRVTQQTVAMAHACGVSVEGELGCLGSLETGMAGEEDGI
GAEGVLDHSQMLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTKPPTGDVLAIDRIKEIHKRIPNTHLVMHGSSSVPQE
WLAIINQYGGDIKETYGVPVEEIVEGIKHGVRKVNIDTDLRLASTGAMRRLMATNPSEFDPRKFFGETVKAMRDVCIARY
EAFGTAGNASKIKPISLEAMFQRYLKGELNAKVN
>Mature_353_residues
ALISMRQMLDHAAEFGYGVPAFNVNNLEQMRAIMEAADKTDSPVIVQASAGARKYAGAPFLRHLILAAIEEFPHIPVCMH
QDHGTSPDVCQRSIQLGFSSVMMDGSLGEDGKTPTDYEYNVRVTQQTVAMAHACGVSVEGELGCLGSLETGMAGEEDGIG
AEGVLDHSQMLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTKPPTGDVLAIDRIKEIHKRIPNTHLVMHGSSSVPQEW
LAIINQYGGDIKETYGVPVEEIVEGIKHGVRKVNIDTDLRLASTGAMRRLMATNPSEFDPRKFFGETVKAMRDVCIARYE
AFGTAGNASKIKPISLEAMFQRYLKGELNAKVN

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=330, Percent_Identity=34.2424242424242, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082041, Length=315, Percent_Identity=32.3809523809524, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1788072, Length=333, Percent_Identity=27.6276276276276, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789293, Length=366, Percent_Identity=24.5901639344262, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38453; Mature: 38322

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALISMRQMLDHAAEFGYGVPAFNVNNLEQMRAIMEAADKTDSPVIVQASAGARKYAGAP
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHCCCH
FLRHLILAAIEEFPHIPVCMHQDHGTSPDVCQRSIQLGFSSVMMDGSLGEDGKTPTDYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCEEE
NVRVTQQTVAMAHACGVSVEGELGCLGSLETGMAGEEDGIGAEGVLDHSQMLTDPEEAAD
EEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHH
FVKKTQVDALAIAIGTSHGAYKFTKPPTGDVLAIDRIKEIHKRIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCHHH
WLAIINQYGGDIKETYGVPVEEIVEGIKHGVRKVNIDTDLRLASTGAMRRLMATNPSEFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHCCCCCCC
PRKFFGETVKAMRDVCIARYEAFGTAGNASKIKPISLEAMFQRYLKGELNAKVN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ALISMRQMLDHAAEFGYGVPAFNVNNLEQMRAIMEAADKTDSPVIVQASAGARKYAGAP
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHCCCH
FLRHLILAAIEEFPHIPVCMHQDHGTSPDVCQRSIQLGFSSVMMDGSLGEDGKTPTDYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCEEE
NVRVTQQTVAMAHACGVSVEGELGCLGSLETGMAGEEDGIGAEGVLDHSQMLTDPEEAAD
EEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHH
FVKKTQVDALAIAIGTSHGAYKFTKPPTGDVLAIDRIKEIHKRIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCHHH
WLAIINQYGGDIKETYGVPVEEIVEGIKHGVRKVNIDTDLRLASTGAMRRLMATNPSEFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHCCCCCCC
PRKFFGETVKAMRDVCIARYEAFGTAGNASKIKPISLEAMFQRYLKGELNAKVN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]