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The map label for this gene is betA [H]

Identifier: 77461465

GI number: 77461465

Start: 5901967

End: 5903670

Strand: Direct

Name: betA [H]

Synonym: Pfl01_5244

Alternate gene names: 77461465

Gene position: 5901967-5903670 (Clockwise)

Preceding gene: 77461464

Following gene: 77461466

Centisome position: 91.67

GC content: 62.32

Gene sequence:

>1704_bases
ATGTCCCAAGAATTCGATTACATCATCGTCGGTGCCGGCTCTGCCGGTAACACCCTGGCGACCCGTCTGACTGAAGACGA
AGGCGTCACCGTCCTGCTGCTTGAAGCCGGCGGCCCGGACTATCGTTTCGACTTCCGTACGCAAATGCCGGCCGCTCTGG
CATTCCCGCTGCAAGGTCGTCGCTACAACTGGGCGTACGAAACCGATCCGGAGCCACACATGGACGGTCGCCGGATGGAA
TGCGGTCGCGGCAAGGGCCTCGGCGGTTCCTCGCTGATCAACGGCATGTGCTACATCCGCGGCAACGCAATGGACTACGA
CGGCTGGGCCAAACTGCCAGGCCTGGAAGACTGGTCCTACCTCGACTGCCTGCCGTATTTCCGAAAAGCGGAAACCCGCG
ACATCGGCCCGAACGACTACCACGGTGGCGACGGCCCGGTCAGCGTGACCACGCCGAAAGCGGGCAACAACCCGCTGTTC
CACGCCATGGTTGAAGCTGGCGTGCAGGCCGGTTACCCGCGCACCGAAGACTTGAACGGCTATCAGCAGGAAGGCTTTGG
CCCGATGGACCGCACCGTGACGCCGAATGGCCGTCGTGCTTCCACCGCCCGTGGTTACCTGGACGTGGCCAAGAAGCGTT
CGACCCTGACCATCGTTACTCACGCCCTGACCGACAAGGTTCTGTTCGAAGGCAAGCGTGCCGTTGGAGTGCGTTACCTG
GTCGGCGCCGCTGAAGAGCGCGTCGAAGCCCGCGCCCGCAAAGAAGTCATCGTCTGCTCCGGCGCGATCGCTTCGCCGCA
ACTGCTGCAACGCTCCGGTGTCGGCCCGGCGAAACTGCTGGAAAGCCTCGACATCCCAGTGGTTCACGATCTGCCAGGCG
TTGGCGAAAACCTGCAGGATCACCTTGAGCTGTACCTGCAATACGCTTGCACCCAACCGGTCTCGCTGTACCCGTCGCTG
CTCTGGTACAACCAGCCGGCCATCGGTGCCGAGTGGCTGTTCAACGGCACCGGCATTGGCGCCAGCAACCAGTTCGAAGC
CGGCGGTTTCATCCGTACCCGTCCGGAATTCGAGTGGCCGAACATCCAGTATCACTTCCTGCCGGTGGCGATTAACTACA
ACGGCAGCAACGGTGTGAAAGAGCACGGTTTCCAGGCGCACATGGGTTCCATGCGTTCGCCGAGCCGCGGTCGCGTCCAG
GTCAAATCCAAGGATCCGCGCCAGCACCCGAGCATCCTGTTCAACTACATGGCCACCGAGCAGGACTGGCAGGAATTTCG
CGACGGCATCCGCCTGACCCGTGAAATCATGCAACAGCCTGCACTGGACGCCTTCCGTGGCCGCGAAATCAGCCCGGGCA
TCGAAGTGCAAACCGATGAGCAGCTGGACAAGTTCATCCGCGAGCACGCCGAAACCGCGTTCCACCCGTCCTGCTCGTGC
AAGATGGGCACCGACGACATGGCCGTAGTGGATGGCGAAGGCCGCGTGCATGGCATGCAGGGTCTGCGTGTGGTCGATGC
GTCGATCATGCCGATCATCACCACCGGCAACCTGAACGCGCCGACGATCATGATGGCCGAGAAAATCGCCGACAAGATCC
GTGGCCGTCAGCCGCTGCCGCGCAGCAAGGCGCCGTACTACGTCGCTGGCGATGCGCCAGTGAAAGGCAAGGCGATGCGT
GATGTGAGCGCTGTTGCTCAGTAA

Upstream 100 bases:

>100_bases
CATTGTGTGCTGCCCGCGAAGCCGCCTTCGCGGGCAAGCCCGTTCCCACTAGGGAAGCGCTGGCTGTCTGACCTGACCAA
CTTCAAAGAGGGTGCATTCA

Downstream 100 bases:

>100_bases
GTTGTAATACCGGGCGGTGATCGTTCCCATGCAATGTGGGAACGATCAGCCTACTCAAAGCAGCAAATCCCCCTACACCC
CCTCTTCACTTGATCCTACC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MSQEFDYIIVGAGSAGNTLATRLTEDEGVTVLLLEAGGPDYRFDFRTQMPAALAFPLQGRRYNWAYETDPEPHMDGRRME
CGRGKGLGGSSLINGMCYIRGNAMDYDGWAKLPGLEDWSYLDCLPYFRKAETRDIGPNDYHGGDGPVSVTTPKAGNNPLF
HAMVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPNGRRASTARGYLDVAKKRSTLTIVTHALTDKVLFEGKRAVGVRYL
VGAAEERVEARARKEVIVCSGAIASPQLLQRSGVGPAKLLESLDIPVVHDLPGVGENLQDHLELYLQYACTQPVSLYPSL
LWYNQPAIGAEWLFNGTGIGASNQFEAGGFIRTRPEFEWPNIQYHFLPVAINYNGSNGVKEHGFQAHMGSMRSPSRGRVQ
VKSKDPRQHPSILFNYMATEQDWQEFRDGIRLTREIMQQPALDAFRGREISPGIEVQTDEQLDKFIREHAETAFHPSCSC
KMGTDDMAVVDGEGRVHGMQGLRVVDASIMPIITTGNLNAPTIMMAEKIADKIRGRQPLPRSKAPYYVAGDAPVKGKAMR
DVSAVAQ

Sequences:

>Translated_567_residues
MSQEFDYIIVGAGSAGNTLATRLTEDEGVTVLLLEAGGPDYRFDFRTQMPAALAFPLQGRRYNWAYETDPEPHMDGRRME
CGRGKGLGGSSLINGMCYIRGNAMDYDGWAKLPGLEDWSYLDCLPYFRKAETRDIGPNDYHGGDGPVSVTTPKAGNNPLF
HAMVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPNGRRASTARGYLDVAKKRSTLTIVTHALTDKVLFEGKRAVGVRYL
VGAAEERVEARARKEVIVCSGAIASPQLLQRSGVGPAKLLESLDIPVVHDLPGVGENLQDHLELYLQYACTQPVSLYPSL
LWYNQPAIGAEWLFNGTGIGASNQFEAGGFIRTRPEFEWPNIQYHFLPVAINYNGSNGVKEHGFQAHMGSMRSPSRGRVQ
VKSKDPRQHPSILFNYMATEQDWQEFRDGIRLTREIMQQPALDAFRGREISPGIEVQTDEQLDKFIREHAETAFHPSCSC
KMGTDDMAVVDGEGRVHGMQGLRVVDASIMPIITTGNLNAPTIMMAEKIADKIRGRQPLPRSKAPYYVAGDAPVKGKAMR
DVSAVAQ
>Mature_566_residues
SQEFDYIIVGAGSAGNTLATRLTEDEGVTVLLLEAGGPDYRFDFRTQMPAALAFPLQGRRYNWAYETDPEPHMDGRRMEC
GRGKGLGGSSLINGMCYIRGNAMDYDGWAKLPGLEDWSYLDCLPYFRKAETRDIGPNDYHGGDGPVSVTTPKAGNNPLFH
AMVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPNGRRASTARGYLDVAKKRSTLTIVTHALTDKVLFEGKRAVGVRYLV
GAAEERVEARARKEVIVCSGAIASPQLLQRSGVGPAKLLESLDIPVVHDLPGVGENLQDHLELYLQYACTQPVSLYPSLL
WYNQPAIGAEWLFNGTGIGASNQFEAGGFIRTRPEFEWPNIQYHFLPVAINYNGSNGVKEHGFQAHMGSMRSPSRGRVQV
KSKDPRQHPSILFNYMATEQDWQEFRDGIRLTREIMQQPALDAFRGREISPGIEVQTDEQLDKFIREHAETAFHPSCSCK
MGTDDMAVVDGEGRVHGMQGLRVVDASIMPIITTGNLNAPTIMMAEKIADKIRGRQPLPRSKAPYYVAGDAPVKGKAMRD
VSAVAQ

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=551, Percent_Identity=49.546279491833, Blast_Score=518, Evalue=1e-147,
Organism=Escherichia coli, GI1786503, Length=554, Percent_Identity=78.158844765343, Blast_Score=928, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=557, Percent_Identity=46.3195691202873, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45549471, Length=575, Percent_Identity=35.1304347826087, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI45551458, Length=575, Percent_Identity=35.1304347826087, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24642048, Length=589, Percent_Identity=35.1443123938879, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24642059, Length=571, Percent_Identity=34.6760070052539, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI24642042, Length=572, Percent_Identity=35.6643356643357, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24642055, Length=588, Percent_Identity=35.0340136054422, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI17137792, Length=553, Percent_Identity=34.3580470162749, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI24642039, Length=581, Percent_Identity=35.4561101549053, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24650267, Length=579, Percent_Identity=33.6787564766839, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI18859995, Length=572, Percent_Identity=33.5664335664336, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642051, Length=576, Percent_Identity=31.9444444444444, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24642037, Length=578, Percent_Identity=32.8719723183391, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24642035, Length=575, Percent_Identity=32.1739130434783, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI18859993, Length=582, Percent_Identity=32.6460481099656, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24645930, Length=580, Percent_Identity=27.5862068965517, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24642057, Length=594, Percent_Identity=28.956228956229, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 62523; Mature: 62391

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEFDYIIVGAGSAGNTLATRLTEDEGVTVLLLEAGGPDYRFDFRTQMPAALAFPLQGR
CCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCC
RYNWAYETDPEPHMDGRRMECGRGKGLGGSSLINGMCYIRGNAMDYDGWAKLPGLEDWSY
EECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCH
LDCLPYFRKAETRDIGPNDYHGGDGPVSVTTPKAGNNPLFHAMVEAGVQAGYPRTEDLNG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
YQQEGFGPMDRTVTPNGRRASTARGYLDVAKKRSTLTIVTHALTDKVLFEGKRAVGVRYL
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHCCCHHHCCCEE
VGAAEERVEARARKEVIVCSGAIASPQLLQRSGVGPAKLLESLDIPVVHDLPGVGENLQD
HHHHHHHHHHHHHCEEEEECCCCCCHHHHHHCCCCHHHHHHHCCCCEEECCCCCCCCHHH
HLELYLQYACTQPVSLYPSLLWYNQPAIGAEWLFNGTGIGASNQFEAGGFIRTRPEFEWP
HHHHHHHHHCCCCHHHCCHHHEECCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCCCC
NIQYHFLPVAINYNGSNGVKEHGFQAHMGSMRSPSRGRVQVKSKDPRQHPSILFNYMATE
CEEEEEEEEEEEECCCCCHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCH
QDWQEFRDGIRLTREIMQQPALDAFRGREISPGIEVQTDEQLDKFIREHAETAFHPSCSC
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCE
KMGTDDMAVVDGEGRVHGMQGLRVVDASIMPIITTGNLNAPTIMMAEKIADKIRGRQPLP
EECCCCEEEECCCCCEECCCCCEEECCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
RSKAPYYVAGDAPVKGKAMRDVSAVAQ
CCCCCEEEECCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SQEFDYIIVGAGSAGNTLATRLTEDEGVTVLLLEAGGPDYRFDFRTQMPAALAFPLQGR
CCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCC
RYNWAYETDPEPHMDGRRMECGRGKGLGGSSLINGMCYIRGNAMDYDGWAKLPGLEDWSY
EECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCH
LDCLPYFRKAETRDIGPNDYHGGDGPVSVTTPKAGNNPLFHAMVEAGVQAGYPRTEDLNG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
YQQEGFGPMDRTVTPNGRRASTARGYLDVAKKRSTLTIVTHALTDKVLFEGKRAVGVRYL
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHCCCHHHCCCEE
VGAAEERVEARARKEVIVCSGAIASPQLLQRSGVGPAKLLESLDIPVVHDLPGVGENLQD
HHHHHHHHHHHHHCEEEEECCCCCCHHHHHHCCCCHHHHHHHCCCCEEECCCCCCCCHHH
HLELYLQYACTQPVSLYPSLLWYNQPAIGAEWLFNGTGIGASNQFEAGGFIRTRPEFEWP
HHHHHHHHHCCCCHHHCCHHHEECCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCCCC
NIQYHFLPVAINYNGSNGVKEHGFQAHMGSMRSPSRGRVQVKSKDPRQHPSILFNYMATE
CEEEEEEEEEEEECCCCCHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCH
QDWQEFRDGIRLTREIMQQPALDAFRGREISPGIEVQTDEQLDKFIREHAETAFHPSCSC
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCE
KMGTDDMAVVDGEGRVHGMQGLRVVDASIMPIITTGNLNAPTIMMAEKIADKIRGRQPLP
EECCCCEEEECCCCCEECCCCCEEECCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
RSKAPYYVAGDAPVKGKAMRDVSAVAQ
CCCCCEEEECCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA