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The map label for this gene is 77461455

Identifier: 77461455

GI number: 77461455

Start: 5888874

End: 5890037

Strand: Direct

Name: 77461455

Synonym: Pfl01_5234

Alternate gene names: NA

Gene position: 5888874-5890037 (Clockwise)

Preceding gene: 77461454

Following gene: 77461456

Centisome position: 91.46

GC content: 62.37

Gene sequence:

>1164_bases
ATGCAAACCGCCGCTGCAGTTGCCGATTTCCGTACTTATCCGTTGATCAGCGCGCTGAACGGCGTGCAGAACCTGGCGGA
TCGCGTCCTGATTGAATGGGCCGACGGGCGTGTCAGCCCGTTTCACCACGTGTGGCTGCGTGACAACTGTCCGTGTCCGC
ACTGCGTCTACAGCGTCACCCGTGAGCAGGTGTTCGAGATCATCGATGCGGCTCCCGACCTGACGCCATCCGCGGTGCAC
ATCGACACCGATGGCTGCCTGCGTATCGACTGGCAGGACGGCCACCTCAGCCGCTTCGATGCCGGCTGGTTGCGCGCCCA
CGCCTACGATGATGAATCCCGCGCCGAACGCCTCGCCGCCAAGCCGAAACCCTTCCTGTGGCGCAGTGATTTGCAGTTGC
CGGTGTTCGACTATGCAGCCCTGATGAACGACAACGCCGCGTTGCTGCAATGGTTGCTGGCAGTACGCGATATCGGTCTG
ACTCAGGTGCGTGGCGTGCCCACCGAACCCGGTTCGCTGAAGCTGATCGCCCAGCGCATTTCGTTCATCCGCGAGAGCAA
CTTCGGTGTGCTGTTCAACGTGCAATCCAGGGCCGACGCCGACAGCAATGCCTACACCGCTTTCAACCTGCCATTGCACA
CCGACCTGCCGACCCGCGAGCTGCAACCGGGCCTGCAATTTCTGCATTGCCTGGTGAACGACGCCGAGGGTGGCGAAAGC
ATTTTCGTCGACGGTTTTGCGATTGCCGAAGCGTTGCGTCAGGAAGATCCCGCATCATTCAAGGCCCTGTGCGAGATCCC
GGTGGAGTTTCGCAACAAGGATCGCCACAGCGACTATCGCTGCCTGGCGCCGATCATCGCCCTGGACGCGTTGGGCCGGG
TCGCGGAAATCCGCATGGCCAACTTCTTGCGCGGCGCGTTCGACACGTCCGTGGAGCAAATGCCCCTGCTGTATCGCGCT
TACCGACGCTTCATCGCCATGACCCGCGAGCTACGTTTCCGGGTCATGCAGCGGCTCAATCCGGGCGAGCTGTGGTGCTT
CGACAACCGCCGCACCCTGCACGCGCGCAATGCGTTCGACCCGGCCACCGGGGCCCGACATTTTCAGGGCTGCTACATCG
ACCGGGATGAGCTGCTGTCGCGGATTCTGGTGTTGCAACGCTAG

Upstream 100 bases:

>100_bases
CATCGTCGCCGAGCAGGCCGATCTGCCCGCTCCCGCTTACATCGGCCGGGTCATCGCCCTGCCCCCAGCCCGGTAAATCC
ATCCCTCACAAGGAGCCGCC

Downstream 100 bases:

>100_bases
ACCGCGTCAGCCTTATTCGCGAGCAAGCCCGCTCCCACATTTCACCGCGTTCCCATGAATGAACGCGATCACCTGTGGGA
GCGGGCTTGCTCCGGGCGGC

Product: gamma-butyrobetaine hydroxylase

Products: NA

Alternate protein names: Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MQTAAAVADFRTYPLISALNGVQNLADRVLIEWADGRVSPFHHVWLRDNCPCPHCVYSVTREQVFEIIDAAPDLTPSAVH
IDTDGCLRIDWQDGHLSRFDAGWLRAHAYDDESRAERLAAKPKPFLWRSDLQLPVFDYAALMNDNAALLQWLLAVRDIGL
TQVRGVPTEPGSLKLIAQRISFIRESNFGVLFNVQSRADADSNAYTAFNLPLHTDLPTRELQPGLQFLHCLVNDAEGGES
IFVDGFAIAEALRQEDPASFKALCEIPVEFRNKDRHSDYRCLAPIIALDALGRVAEIRMANFLRGAFDTSVEQMPLLYRA
YRRFIAMTRELRFRVMQRLNPGELWCFDNRRTLHARNAFDPATGARHFQGCYIDRDELLSRILVLQR

Sequences:

>Translated_387_residues
MQTAAAVADFRTYPLISALNGVQNLADRVLIEWADGRVSPFHHVWLRDNCPCPHCVYSVTREQVFEIIDAAPDLTPSAVH
IDTDGCLRIDWQDGHLSRFDAGWLRAHAYDDESRAERLAAKPKPFLWRSDLQLPVFDYAALMNDNAALLQWLLAVRDIGL
TQVRGVPTEPGSLKLIAQRISFIRESNFGVLFNVQSRADADSNAYTAFNLPLHTDLPTRELQPGLQFLHCLVNDAEGGES
IFVDGFAIAEALRQEDPASFKALCEIPVEFRNKDRHSDYRCLAPIIALDALGRVAEIRMANFLRGAFDTSVEQMPLLYRA
YRRFIAMTRELRFRVMQRLNPGELWCFDNRRTLHARNAFDPATGARHFQGCYIDRDELLSRILVLQR
>Mature_387_residues
MQTAAAVADFRTYPLISALNGVQNLADRVLIEWADGRVSPFHHVWLRDNCPCPHCVYSVTREQVFEIIDAAPDLTPSAVH
IDTDGCLRIDWQDGHLSRFDAGWLRAHAYDDESRAERLAAKPKPFLWRSDLQLPVFDYAALMNDNAALLQWLLAVRDIGL
TQVRGVPTEPGSLKLIAQRISFIRESNFGVLFNVQSRADADSNAYTAFNLPLHTDLPTRELQPGLQFLHCLVNDAEGGES
IFVDGFAIAEALRQEDPASFKALCEIPVEFRNKDRHSDYRCLAPIIALDALGRVAEIRMANFLRGAFDTSVEQMPLLYRA
YRRFIAMTRELRFRVMQRLNPGELWCFDNRRTLHARNAFDPATGARHFQGCYIDRDELLSRILVLQR

Specific function: Catalyzes the formation of L-carnitine from gamma- butyrobetaine [H]

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-BBH/TMLD family [H]

Homologues:

Organism=Homo sapiens, GI4502369, Length=374, Percent_Identity=31.8181818181818, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI8922625, Length=376, Percent_Identity=28.1914893617021, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI296317249, Length=320, Percent_Identity=25.9375, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17534641, Length=411, Percent_Identity=30.9002433090024, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71992672, Length=370, Percent_Identity=25.9459459459459, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321766, Length=412, Percent_Identity=24.7572815533981, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639015, Length=379, Percent_Identity=33.245382585752, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI221329931, Length=371, Percent_Identity=30.9973045822102, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19922166, Length=394, Percent_Identity=32.48730964467, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24648401, Length=355, Percent_Identity=27.6056338028169, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012775
- InterPro:   IPR010376
- InterPro:   IPR003819 [H]

Pfam domain/function: PF06155 DUF971; PF02668 TauD [H]

EC number: =1.14.11.1 [H]

Molecular weight: Translated: 44027; Mature: 44027

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTAAAVADFRTYPLISALNGVQNLADRVLIEWADGRVSPFHHVWLRDNCPCPHCVYSVT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCCCCCHHHHHHH
REQVFEIIDAAPDLTPSAVHIDTDGCLRIDWQDGHLSRFDAGWLRAHAYDDESRAERLAA
HHHHHHHHHCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCHHEEECCCCHHHHHHHHC
KPKPFLWRSDLQLPVFDYAALMNDNAALLQWLLAVRDIGLTQVRGVPTEPGSLKLIAQRI
CCCCCEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHH
SFIRESNFGVLFNVQSRADADSNAYTAFNLPLHTDLPTRELQPGLQFLHCLVNDAEGGES
HHHHCCCCEEEEEECCCCCCCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHCCCCCCCE
IFVDGFAIAEALRQEDPASFKALCEIPVEFRNKDRHSDYRCLAPIIALDALGRVAEIRMA
EEECHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NFLRGAFDTSVEQMPLLYRAYRRFIAMTRELRFRVMQRLNPGELWCFDNRRTLHARNAFD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCC
PATGARHFQGCYIDRDELLSRILVLQR
CCCCCHHHCCCEECHHHHHHHHHHHCC
>Mature Secondary Structure
MQTAAAVADFRTYPLISALNGVQNLADRVLIEWADGRVSPFHHVWLRDNCPCPHCVYSVT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCCCCCHHHHHHH
REQVFEIIDAAPDLTPSAVHIDTDGCLRIDWQDGHLSRFDAGWLRAHAYDDESRAERLAA
HHHHHHHHHCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCHHEEECCCCHHHHHHHHC
KPKPFLWRSDLQLPVFDYAALMNDNAALLQWLLAVRDIGLTQVRGVPTEPGSLKLIAQRI
CCCCCEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHH
SFIRESNFGVLFNVQSRADADSNAYTAFNLPLHTDLPTRELQPGLQFLHCLVNDAEGGES
HHHHCCCCEEEEEECCCCCCCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHCCCCCCCE
IFVDGFAIAEALRQEDPASFKALCEIPVEFRNKDRHSDYRCLAPIIALDALGRVAEIRMA
EEECHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NFLRGAFDTSVEQMPLLYRAYRRFIAMTRELRFRVMQRLNPGELWCFDNRRTLHARNAFD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCC
PATGARHFQGCYIDRDELLSRILVLQR
CCCCCHHHCCCEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504802 [H]