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The map label for this gene is etfA [H]

Identifier: 77461442

GI number: 77461442

Start: 5874910

End: 5876130

Strand: Reverse

Name: etfA [H]

Synonym: Pfl01_5221

Alternate gene names: 77461442

Gene position: 5876130-5874910 (Counterclockwise)

Preceding gene: 77461443

Following gene: 77461441

Centisome position: 91.27

GC content: 66.83

Gene sequence:

>1221_bases
ATGAGCGACATTATCCGCCGCGATCCCCGCGCCGAATGGATCGCACGCAACCGTCTGCACCCGCTGCACGCGGCCATGCA
GCCGGCGCAACACAGCTGGATGGGCCCCAACGGGATCATCCGCAAGAACCTGCACGGCATCGGCTTCATCGGGCCGAACG
GCATCAAGCGTATCGACCGCAGCGGCGCCCAGCAGGGCGGGGCGGTCAAACGCTCGGCCGCGGTCGAAGTGCAGTTGCCG
CTGCATCAGGTGCCGGCGCCGGCGTTCTACATCAGCGTGGTGCCGGACATGGTCGGCGGCCGCTTGAGCAGCCACGACCG
CGACCTGCTTGGTCTGGCTCATCAGCTGGCCGGCAGCGACGGCGCGGTGCTGGCCGTGGTGTTCGGTGAGCACAAGGAAA
ACGCTTTCGCCACCGCAGGCGTTGACCGCTTGCTGGTGCTGGAAGGCGAAGAATTCAGCGGTTATGCACCGGAGCAACGG
ATCCAGGGCCTGCGGGCTGTGGATAACCAGTTCACCCCGCGTCACTGGCTGCTGCCGGACAGCCGCAGCGGTGGCGGCGA
ACTCGGGCGGCGCTTTGCTGCCGCACTGGGTGAACGCCCGGCGACACGGGTGTGGCAGGTCAAGGATCAGGAGTGCATCG
GCCGCGCCGGTGCTGGTCTGCAGGATCTGGCCCGTCCGGTGGCGCGGTTGATTCTGGCGTCCGCCGAATGTGCCGAACCG
GTCAGCGAAACCCGTCACGAAGCGCTGCCGGTGGAGTTATCCACACCCGTCGCACGCAGCCTGTCGCGGATCGAGGATCT
GGGTGCGGTGGCGGTGGATCCGGCAGCGATTCCGATGGCCGAAGCCGAGTTCATCTTCTCAGGTGGTAACGGGGTCAAGG
ACTGGGAGCTTTTCCACAGGACCGCCGCCGCCCTCGGCGCCACCGAAGGCGCCTCGCGGGTGGCAGTGGACGATGGCTTC
ATGGCCCGCGACCGCCAGGTCGGCGCGTCCGGCACCTGGGTTACGGCGCGGGTTTACGTGGCCGTGGGGATTTCCGGGGC
GATCCAGCACCTGCAGGGCATCGGTGCCTGCGACAAAGTGGTGGCGATCAACCTCGATCCGGGCTGCGACATGATCAAGC
GTGCCGACCTGTCGGTGATCGGTGAGAGCGCGGAAATTCTTCAGGCCTTGATCGCGGCGGTAGAGGCTTACCGCAACGAA
GCCAAGCGCGATGCGGCTTAA

Upstream 100 bases:

>100_bases
TCAAGGACATTGCCGAACTGGTGGCCGACGCGCTGCTCGAAGACGCCGCGCCGAACAAGCCTGCCACCCCGGCCAAGCGT
GAACCTGCGGAGGCCCACTG

Downstream 100 bases:

>100_bases
GGAACGGTTATGAGCACAAAGATCATCAGTCTGGTTTCAATCGGCGCCCACCCGACCTCCGGCCGCCCTCGCCGCGCCGA
TCAGGACGCCCGCGCGGTAG

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSDIIRRDPRAEWIARNRLHPLHAAMQPAQHSWMGPNGIIRKNLHGIGFIGPNGIKRIDRSGAQQGGAVKRSAAVEVQLP
LHQVPAPAFYISVVPDMVGGRLSSHDRDLLGLAHQLAGSDGAVLAVVFGEHKENAFATAGVDRLLVLEGEEFSGYAPEQR
IQGLRAVDNQFTPRHWLLPDSRSGGGELGRRFAAALGERPATRVWQVKDQECIGRAGAGLQDLARPVARLILASAECAEP
VSETRHEALPVELSTPVARSLSRIEDLGAVAVDPAAIPMAEAEFIFSGGNGVKDWELFHRTAAALGATEGASRVAVDDGF
MARDRQVGASGTWVTARVYVAVGISGAIQHLQGIGACDKVVAINLDPGCDMIKRADLSVIGESAEILQALIAAVEAYRNE
AKRDAA

Sequences:

>Translated_406_residues
MSDIIRRDPRAEWIARNRLHPLHAAMQPAQHSWMGPNGIIRKNLHGIGFIGPNGIKRIDRSGAQQGGAVKRSAAVEVQLP
LHQVPAPAFYISVVPDMVGGRLSSHDRDLLGLAHQLAGSDGAVLAVVFGEHKENAFATAGVDRLLVLEGEEFSGYAPEQR
IQGLRAVDNQFTPRHWLLPDSRSGGGELGRRFAAALGERPATRVWQVKDQECIGRAGAGLQDLARPVARLILASAECAEP
VSETRHEALPVELSTPVARSLSRIEDLGAVAVDPAAIPMAEAEFIFSGGNGVKDWELFHRTAAALGATEGASRVAVDDGF
MARDRQVGASGTWVTARVYVAVGISGAIQHLQGIGACDKVVAINLDPGCDMIKRADLSVIGESAEILQALIAAVEAYRNE
AKRDAA
>Mature_405_residues
SDIIRRDPRAEWIARNRLHPLHAAMQPAQHSWMGPNGIIRKNLHGIGFIGPNGIKRIDRSGAQQGGAVKRSAAVEVQLPL
HQVPAPAFYISVVPDMVGGRLSSHDRDLLGLAHQLAGSDGAVLAVVFGEHKENAFATAGVDRLLVLEGEEFSGYAPEQRI
QGLRAVDNQFTPRHWLLPDSRSGGGELGRRFAAALGERPATRVWQVKDQECIGRAGAGLQDLARPVARLILASAECAEPV
SETRHEALPVELSTPVARSLSRIEDLGAVAVDPAAIPMAEAEFIFSGGNGVKDWELFHRTAAALGATEGASRVAVDDGFM
ARDRQVGASGTWVTARVYVAVGISGAIQHLQGIGACDKVVAINLDPGCDMIKRADLSVIGESAEILQALIAAVEAYRNEA
KRDAA

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI189181759, Length=281, Percent_Identity=29.8932384341637, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4503607, Length=281, Percent_Identity=29.8932384341637, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1786226, Length=234, Percent_Identity=30.3418803418803, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787990, Length=176, Percent_Identity=28.9772727272727, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506929, Length=259, Percent_Identity=32.8185328185328, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325261, Length=278, Percent_Identity=24.8201438848921, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136898, Length=250, Percent_Identity=32.8, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24652801, Length=250, Percent_Identity=32.8, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 43263; Mature: 43131

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIIRRDPRAEWIARNRLHPLHAAMQPAQHSWMGPNGIIRKNLHGIGFIGPNGIKRIDR
CCCHHHCCCCHHHHHHCCCCHHHHHHCCHHHCCCCCCCHHHHCCCEEEEECCHHHHHHHH
SGAQQGGAVKRSAAVEVQLPLHQVPAPAFYISVVPDMVGGRLSSHDRDLLGLAHQLAGSD
HCCCCCCCEECCCEEEEEECHHHCCCCEEEEEECHHHHCCCCCCCCHHHHHHHHHHCCCC
GAVLAVVFGEHKENAFATAGVDRLLVLEGEEFSGYAPEQRIQGLRAVDNQFTPRHWLLPD
CCEEEEEECCCCCCCEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEECCC
SRSGGGELGRRFAAALGERPATRVWQVKDQECIGRAGAGLQDLARPVARLILASAECAEP
CCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VSETRHEALPVELSTPVARSLSRIEDLGAVAVDPAAIPMAEAEFIFSGGNGVKDWELFHR
HHHHHHHCCCEEECCHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCHHHHHHH
TAAALGATEGASRVAVDDGFMARDRQVGASGTWVTARVYVAVGISGAIQHLQGIGACDKV
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEEEECHHHHHHHHHCCCCCCEE
VAINLDPGCDMIKRADLSVIGESAEILQALIAAVEAYRNEAKRDAA
EEEECCCCCCHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDIIRRDPRAEWIARNRLHPLHAAMQPAQHSWMGPNGIIRKNLHGIGFIGPNGIKRIDR
CCHHHCCCCHHHHHHCCCCHHHHHHCCHHHCCCCCCCHHHHCCCEEEEECCHHHHHHHH
SGAQQGGAVKRSAAVEVQLPLHQVPAPAFYISVVPDMVGGRLSSHDRDLLGLAHQLAGSD
HCCCCCCCEECCCEEEEEECHHHCCCCEEEEEECHHHHCCCCCCCCHHHHHHHHHHCCCC
GAVLAVVFGEHKENAFATAGVDRLLVLEGEEFSGYAPEQRIQGLRAVDNQFTPRHWLLPD
CCEEEEEECCCCCCCEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEECCC
SRSGGGELGRRFAAALGERPATRVWQVKDQECIGRAGAGLQDLARPVARLILASAECAEP
CCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VSETRHEALPVELSTPVARSLSRIEDLGAVAVDPAAIPMAEAEFIFSGGNGVKDWELFHR
HHHHHHHCCCEEECCHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCHHHHHHH
TAAALGATEGASRVAVDDGFMARDRQVGASGTWVTARVYVAVGISGAIQHLQGIGACDKV
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEEEECHHHHHHHHHCCCCCCEE
VAINLDPGCDMIKRADLSVIGESAEILQALIAAVEAYRNEAKRDAA
EEEECCCCCCHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]