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The map label for this gene is folB [H]

Identifier: 77461365

GI number: 77461365

Start: 5780849

End: 5781205

Strand: Reverse

Name: folB [H]

Synonym: Pfl01_5144

Alternate gene names: 77461365

Gene position: 5781205-5780849 (Counterclockwise)

Preceding gene: 77461367

Following gene: 77461364

Centisome position: 89.79

GC content: 61.34

Gene sequence:

>357_bases
TTGGACAGAGTGTTTATCGAGGGCCTGGAAGTCGACACCGTGATCGGTGCCTACGACTGGGAGCGCGGCATCCGACAGTG
CCTGCGTCTTGATTTGAGCTTCGCCTGGGACAATCGCCCGGCCGCCGCCGGTGACGACCTGACCCTGGCGCTCGATTACG
CCAGTGTGTCCACACGGATCCAGGCCTTTGCCGAGCAATCCCAGTATCAACTGGTCGAGACCTTCGCCGAGCGTCTGGTT
GAAGTGCTGATGAATGAATTCAAGATCACCTGGGTGCGCCTGAAGCTGACCAAGCCAGGTGCCGTACCGGCCGCCAAGGG
TGGTGTGGGTGTGGAGATCGAGCGCGGATGCCGCTGA

Upstream 100 bases:

>100_bases
GCGAGGATCGCCAGTAACCAAAACATGCTAACTATTCCGGGCGAGGACGCCCTGATTCTAACGGCGCATTGCGCCCTTGT
CGTGCAGCGGAGAAAAGTGC

Downstream 100 bases:

>100_bases
CCCAGGTCTATCTCGGGCTCGGTAGCAATATCGAGCGCGAAACCCATTTGCAGGCCGGTCTGGATGCCTTGTCCACGTTT
CTGGTGGATATACGCTGTTC

Product: dihydroneopterin aldolase family protein

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MDRVFIEGLEVDTVIGAYDWERGIRQCLRLDLSFAWDNRPAAAGDDLTLALDYASVSTRIQAFAEQSQYQLVETFAERLV
EVLMNEFKITWVRLKLTKPGAVPAAKGGVGVEIERGCR

Sequences:

>Translated_118_residues
MDRVFIEGLEVDTVIGAYDWERGIRQCLRLDLSFAWDNRPAAAGDDLTLALDYASVSTRIQAFAEQSQYQLVETFAERLV
EVLMNEFKITWVRLKLTKPGAVPAAKGGVGVEIERGCR
>Mature_118_residues
MDRVFIEGLEVDTVIGAYDWERGIRQCLRLDLSFAWDNRPAAAGDDLTLALDYASVSTRIQAFAEQSQYQLVETFAERLV
EVLMNEFKITWVRLKLTKPGAVPAAKGGVGVEIERGCR

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=116, Percent_Identity=50, Blast_Score=110, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13237; Mature: 13237

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVFIEGLEVDTVIGAYDWERGIRQCLRLDLSFAWDNRPAAAGDDLTLALDYASVSTRI
CCCEEECCCCEEHEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEHHHHHHHH
QAFAEQSQYQLVETFAERLVEVLMNEFKITWVRLKLTKPGAVPAAKGGVGVEIERGCR
HHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCCCCCCCCCEEECCCCC
>Mature Secondary Structure
MDRVFIEGLEVDTVIGAYDWERGIRQCLRLDLSFAWDNRPAAAGDDLTLALDYASVSTRI
CCCEEECCCCEEHEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEHHHHHHHH
QAFAEQSQYQLVETFAERLVEVLMNEFKITWVRLKLTKPGAVPAAKGGVGVEIERGCR
HHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]