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The map label for this gene is folK [H]

Identifier: 77461364

GI number: 77461364

Start: 5780340

End: 5780858

Strand: Reverse

Name: folK [H]

Synonym: Pfl01_5143

Alternate gene names: 77461364

Gene position: 5780858-5780340 (Counterclockwise)

Preceding gene: 77461365

Following gene: 77461352

Centisome position: 89.79

GC content: 58.57

Gene sequence:

>519_bases
ATGCCGCTGACCCAGGTCTATCTCGGGCTCGGTAGCAATATCGAGCGCGAAACCCATTTGCAGGCCGGTCTGGATGCCTT
GTCCACGTTTCTGGTGGATATACGCTGTTCGCCTGTGTTCGAAAGCCAGCCGGTGGGAATCAAGAGCGGGCCGTTCTTCA
ACTTCGTGGTGTCGGCGTTCACCGATCTGCCGTTGATCGAGCTGGATCGCCGCTTGAAGTTCATTGAAGCGGACAACGGT
CGTTATGCGCCGGATCGCAAGGGCTTGCCGCTGGACATCGACGTGTTGTTGTACGGCGATCTGGCGGGCAACTTCGACGG
GCTGATCCTGCCTCGTGCGGAAATCCTGAAAAATGCCTTTGTGCTGTGGCCGCTGTCGCTGATTGCGCCGGATCGGGTGC
ATCCCGGTGCAGGAAAAAGCTTTGCCACGTTGTGGGCCGAAGCGCAGATCGATCAGGTGCTGGCACCGGTCGGATTCGAG
TGGCGCGGTATTCAGCTCACGCCTTCAGATCTGTCTTGA

Upstream 100 bases:

>100_bases
TGATGAATGAATTCAAGATCACCTGGGTGCGCCTGAAGCTGACCAAGCCAGGTGCCGTACCGGCCGCCAAGGGTGGTGTG
GGTGTGGAGATCGAGCGCGG

Downstream 100 bases:

>100_bases
ACAGTTTGATCCGCCCTCGCGAGGGCGGATCAGGTGCTTTCAGGACGCCGCCGATTCCTTGTAAACCTTCAACGCCTTGA
GCCGTTCGCGCTTGAGTGCC

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MPLTQVYLGLGSNIERETHLQAGLDALSTFLVDIRCSPVFESQPVGIKSGPFFNFVVSAFTDLPLIELDRRLKFIEADNG
RYAPDRKGLPLDIDVLLYGDLAGNFDGLILPRAEILKNAFVLWPLSLIAPDRVHPGAGKSFATLWAEAQIDQVLAPVGFE
WRGIQLTPSDLS

Sequences:

>Translated_172_residues
MPLTQVYLGLGSNIERETHLQAGLDALSTFLVDIRCSPVFESQPVGIKSGPFFNFVVSAFTDLPLIELDRRLKFIEADNG
RYAPDRKGLPLDIDVLLYGDLAGNFDGLILPRAEILKNAFVLWPLSLIAPDRVHPGAGKSFATLWAEAQIDQVLAPVGFE
WRGIQLTPSDLS
>Mature_171_residues
PLTQVYLGLGSNIERETHLQAGLDALSTFLVDIRCSPVFESQPVGIKSGPFFNFVVSAFTDLPLIELDRRLKFIEADNGR
YAPDRKGLPLDIDVLLYGDLAGNFDGLILPRAEILKNAFVLWPLSLIAPDRVHPGAGKSFATLWAEAQIDQVLAPVGFEW
RGIQLTPSDLS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18920; Mature: 18789

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTQVYLGLGSNIERETHLQAGLDALSTFLVDIRCSPVFESQPVGIKSGPFFNFVVSAF
CCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHH
TDLPLIELDRRLKFIEADNGRYAPDRKGLPLDIDVLLYGDLAGNFDGLILPRAEILKNAF
CCCCCEEHHCEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEECHHHHHHCCH
VLWPLSLIAPDRVHPGAGKSFATLWAEAQIDQVLAPVGFEWRGIQLTPSDLS
HEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECEEECCCCCC
>Mature Secondary Structure 
PLTQVYLGLGSNIERETHLQAGLDALSTFLVDIRCSPVFESQPVGIKSGPFFNFVVSAF
CHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHH
TDLPLIELDRRLKFIEADNGRYAPDRKGLPLDIDVLLYGDLAGNFDGLILPRAEILKNAF
CCCCCEEHHCEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEECHHHHHHCCH
VLWPLSLIAPDRVHPGAGKSFATLWAEAQIDQVLAPVGFEWRGIQLTPSDLS
HEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]