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The map label for this gene is ispA [H]

Identifier: 77461227

GI number: 77461227

Start: 5641954

End: 5642841

Strand: Direct

Name: ispA [H]

Synonym: Pfl01_5006

Alternate gene names: 77461227

Gene position: 5641954-5642841 (Clockwise)

Preceding gene: 77461226

Following gene: 77461228

Centisome position: 87.63

GC content: 65.32

Gene sequence:

>888_bases
ATGATTGCAGCGTATTCGGCCACCAGCCAGGCACGGGTCAATGCGGCACTGGAAACCCTGTTCAACGCTCCGCTGCCAGA
ACTGGCGCGCCTTTATGAAGCCATGCGCTACAGCGTGATGAACGGCGGCAAACGCGTGCGCCCATTGCTGGCCTACGCGG
CGTGCGAAGCCCTTGGCGGCAAGGCCGAACAGGCCAACGGCGCGGCGTGTGCGGTTGAGCTGATCCACGCGTATTCGCTG
GTGCACGACGATTTGCCGGCGATGGACGACGACGATCTGCGTCGCGGCCAGCCGACCACTCACAAGAAATTCGACGAAGC
CTGCGCAATCCTCGCCGGCGACGGCTTGCAGAGCCTGGCGTTCAGTGCCCTGCTCGACCCGCGCCTGAGCGACCTGAGCG
CGGACATCCGCCTGCAGCAGGTCACAGCACTGGCGCACGCGGCGGGCCCGGCTGGCATGGTCGGCGGTCAGGCCATCGAC
CTCGGTTCGGTCGGCCTCAAGCTTGATCAGAAAGCGCTGGAACAGATGCACCGACACAAGACCGGCGCGCTGATCGAAGT
CAGCGTCAAGCTCGGCGCCCTGGCCAGCGGCTGTGCCGAGAAGGATGAACTCAAGTCCCTGCAGACTTATGCACAGGCCA
TCGGCCTGGCATTCCAGGTCCAGGACGACATTCTCGACGTCGAAAGCGATACCGAAACCCTCGGCAAACGCCAGGGCGCC
GACATCGCCCGCGACAAGCCGACCTACCCGGCACTGCTCGGTCTGGACGCCGCCAAGGCCTATGCGCTGGAACTGCGCGA
TCAGGCCCTGCACGCGCTGCGACCGTTTGACGCGGCTGCCGAGCCGTTGCGCGATCTGGCCCGGTATATCGTCGACCGGC
GCAACTGA

Upstream 100 bases:

>100_bases
ACTGCCAGGCGGCGCTGGCCCAGGCCGAGCAGAAGGTCCAGGTGTTGCTGGAGCGCGATGGCGAACTCGCCGAGGAACCC
TTCGACGCGGATCAGCCAGA

Downstream 100 bases:

>100_bases
AGGCTTATCTGCCAAAAAAGACCAACGCGTGGGCAGGGGGCGATGCATCAGGTAAACTGCCGCATCTTTTATACCTATAA
CGATTCGCCTGATGCCCACG

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIAAYSATSQARVNAALETLFNAPLPELARLYEAMRYSVMNGGKRVRPLLAYAACEALGGKAEQANGAACAVELIHAYSL
VHDDLPAMDDDDLRRGQPTTHKKFDEACAILAGDGLQSLAFSALLDPRLSDLSADIRLQQVTALAHAAGPAGMVGGQAID
LGSVGLKLDQKALEQMHRHKTGALIEVSVKLGALASGCAEKDELKSLQTYAQAIGLAFQVQDDILDVESDTETLGKRQGA
DIARDKPTYPALLGLDAAKAYALELRDQALHALRPFDAAAEPLRDLARYIVDRRN

Sequences:

>Translated_295_residues
MIAAYSATSQARVNAALETLFNAPLPELARLYEAMRYSVMNGGKRVRPLLAYAACEALGGKAEQANGAACAVELIHAYSL
VHDDLPAMDDDDLRRGQPTTHKKFDEACAILAGDGLQSLAFSALLDPRLSDLSADIRLQQVTALAHAAGPAGMVGGQAID
LGSVGLKLDQKALEQMHRHKTGALIEVSVKLGALASGCAEKDELKSLQTYAQAIGLAFQVQDDILDVESDTETLGKRQGA
DIARDKPTYPALLGLDAAKAYALELRDQALHALRPFDAAAEPLRDLARYIVDRRN
>Mature_295_residues
MIAAYSATSQARVNAALETLFNAPLPELARLYEAMRYSVMNGGKRVRPLLAYAACEALGGKAEQANGAACAVELIHAYSL
VHDDLPAMDDDDLRRGQPTTHKKFDEACAILAGDGLQSLAFSALLDPRLSDLSADIRLQQVTALAHAAGPAGMVGGQAID
LGSVGLKLDQKALEQMHRHKTGALIEVSVKLGALASGCAEKDELKSLQTYAQAIGLAFQVQDDILDVESDTETLGKRQGA
DIARDKPTYPALLGLDAAKAYALELRDQALHALRPFDAAAEPLRDLARYIVDRRN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=234, Percent_Identity=31.6239316239316, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786623, Length=281, Percent_Identity=53.3807829181495, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI1789578, Length=253, Percent_Identity=31.6205533596838, Blast_Score=113, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24651612, Length=224, Percent_Identity=31.25, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31516; Mature: 31516

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAAYSATSQARVNAALETLFNAPLPELARLYEAMRYSVMNGGKRVRPLLAYAACEALGG
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KAEQANGAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHKKFDEACAILAGDGLQSLA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCHHHHH
FSALLDPRLSDLSADIRLQQVTALAHAAGPAGMVGGQAIDLGSVGLKLDQKALEQMHRHK
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHC
TGALIEVSVKLGALASGCAEKDELKSLQTYAQAIGLAFQVQDDILDVESDTETLGKRQGA
CCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCHHHHHHHCCC
DIARDKPTYPALLGLDAAKAYALELRDQALHALRPFDAAAEPLRDLARYIVDRRN
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIAAYSATSQARVNAALETLFNAPLPELARLYEAMRYSVMNGGKRVRPLLAYAACEALGG
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KAEQANGAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHKKFDEACAILAGDGLQSLA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCHHHHH
FSALLDPRLSDLSADIRLQQVTALAHAAGPAGMVGGQAIDLGSVGLKLDQKALEQMHRHK
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHC
TGALIEVSVKLGALASGCAEKDELKSLQTYAQAIGLAFQVQDDILDVESDTETLGKRQGA
CCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCHHHHHHHCCC
DIARDKPTYPALLGLDAAKAYALELRDQALHALRPFDAAAEPLRDLARYIVDRRN
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]