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The map label for this gene is proY [C]

Identifier: 77461211

GI number: 77461211

Start: 5621769

End: 5623139

Strand: Direct

Name: proY [C]

Synonym: Pfl01_4990

Alternate gene names: 77461211

Gene position: 5621769-5623139 (Clockwise)

Preceding gene: 77461210

Following gene: 77461212

Centisome position: 87.32

GC content: 62.07

Gene sequence:

>1371_bases
ATGACTTCCACCACACAGCTCAAACCCACACTCGGCACCCTGCATCTCTGGGGCATTGCCGTCGGCCTGGTGATTTCCGG
CGAATACTTCGGCTGGAGTTACGGCTGGGGCACGGCAGGAACCCTGGGTTTCCTGGTCACAGCCCTGATGGTCGCGACCA
TGTACACCTGCTTCATCTTCAGTTTCACCGAACTGACCACCGCGATTCCTCACGCGGGCGGGCCGTTTGCCTACAGCCGC
CGGGCGTTCGGCGAGAAAGGCGGATTGATCGCCGGCATCGCCACCCTGATCGAATTCGTGTTCGCCCCGCCGGCCATCGC
TATGGCCATCGGCGCCTATCTGAATGTGCAATATCCGGGGCTCGATCCGAAACTCGCGGCAGTCGGCGCGTATTTCGTGT
TCATGACACTGAACATTCTTGGCGTCAGCATCGCCGCGACCTTTGAGCTGGTGGTGACCGTGCTCGCCGTCGCCGAACTG
CTGGTGTTCATGGGCGTGGTCGCGCCGGGCTTCAGCTTCAGCAACTTCGTTTTGAACGGCTGGTCAGGCGCCAATGAATT
CACGATGGGTTCGATTCCGGGCATTTTCGCGGCGATTCCCTTCGCGATCTGGTTCTTCCTCGCCATCGAAGGCGCAGCCA
TGGCGGCCGAGGAAGCCAAGGACCCGAAACGCACGATTCCACGGGCCTACGTCAGTGGCATCCTGACCCTGGTGTTCCTG
GCCATCGGCGTGATGGTGATGGCCGGCGGCGTCGGTGACTGGCGCCAACTGTCGAACATCAACGACCCGCTGCCGCAAGC
GATGAAAGCGGTGGTCGGCAACAATTCGACCTGGATGCACATGCTGGTGTGGATCGGCCTGTTCGGGCTGGTGGCGAGTT
TCCACGGGATCATCCTCGGCTACTCGCGGCAGTTCTTCGCCCTGGCCCGGGCCGGTTATCTGCCCAAAGGCCTGGCCAAA
CTCTCGCGCTTCCAGACCCCGCACCGGGCGATTCTGGCCGGCGGCGTGGTCGGCATCGCGGCGATCTACAGCGACGGCCT
GGTCAATCTGCAAGGCATGACCCTGACGGCGGCGATGATCACCATGTCGGTGTTCGGCGCCATCGTGATGTACATCATCA
GCATGCTCAGCCTGTTCAAACTGCGTAAAACCGAGCCGAACCTGGAGCGCACCTTCCGCGCGCCGGGCTATCCGGTGGTG
CCGGCCATCGCGCTGTTCCTGGCCGTGGTGTGTCTGGTGGCGATGGCCTGGTTCAACACGCTGATCGGCTGCGTGTTCCT
CGGTTTCATGGCCGCCGGCTATCTGTACTTTCAGCTGACCGCCAAGCAACGCTCCGAAGCACCGGCAGACGCTATGCTCG
AAGGTATCTAG

Upstream 100 bases:

>100_bases
AATTGCGTGAACACTGCCGCTGCGTGAACAGCATCCACCCACTCAACCGCTGCACCCGAAAGTCCAACAGATCGAACAAT
AAAAAAGACAGAGAGGACTT

Downstream 100 bases:

>100_bases
AAGTTATCCGAGCTGCACCGGCACCGGGCTTCGTGTCCGGTGCCTGCACTAAAAGCATTCAATCAGGAGGAACGCGCCCC
ATGGCCGCATTTGCCCATAC

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTSTTQLKPTLGTLHLWGIAVGLVISGEYFGWSYGWGTAGTLGFLVTALMVATMYTCFIFSFTELTTAIPHAGGPFAYSR
RAFGEKGGLIAGIATLIEFVFAPPAIAMAIGAYLNVQYPGLDPKLAAVGAYFVFMTLNILGVSIAATFELVVTVLAVAEL
LVFMGVVAPGFSFSNFVLNGWSGANEFTMGSIPGIFAAIPFAIWFFLAIEGAAMAAEEAKDPKRTIPRAYVSGILTLVFL
AIGVMVMAGGVGDWRQLSNINDPLPQAMKAVVGNNSTWMHMLVWIGLFGLVASFHGIILGYSRQFFALARAGYLPKGLAK
LSRFQTPHRAILAGGVVGIAAIYSDGLVNLQGMTLTAAMITMSVFGAIVMYIISMLSLFKLRKTEPNLERTFRAPGYPVV
PAIALFLAVVCLVAMAWFNTLIGCVFLGFMAAGYLYFQLTAKQRSEAPADAMLEGI

Sequences:

>Translated_456_residues
MTSTTQLKPTLGTLHLWGIAVGLVISGEYFGWSYGWGTAGTLGFLVTALMVATMYTCFIFSFTELTTAIPHAGGPFAYSR
RAFGEKGGLIAGIATLIEFVFAPPAIAMAIGAYLNVQYPGLDPKLAAVGAYFVFMTLNILGVSIAATFELVVTVLAVAEL
LVFMGVVAPGFSFSNFVLNGWSGANEFTMGSIPGIFAAIPFAIWFFLAIEGAAMAAEEAKDPKRTIPRAYVSGILTLVFL
AIGVMVMAGGVGDWRQLSNINDPLPQAMKAVVGNNSTWMHMLVWIGLFGLVASFHGIILGYSRQFFALARAGYLPKGLAK
LSRFQTPHRAILAGGVVGIAAIYSDGLVNLQGMTLTAAMITMSVFGAIVMYIISMLSLFKLRKTEPNLERTFRAPGYPVV
PAIALFLAVVCLVAMAWFNTLIGCVFLGFMAAGYLYFQLTAKQRSEAPADAMLEGI
>Mature_455_residues
TSTTQLKPTLGTLHLWGIAVGLVISGEYFGWSYGWGTAGTLGFLVTALMVATMYTCFIFSFTELTTAIPHAGGPFAYSRR
AFGEKGGLIAGIATLIEFVFAPPAIAMAIGAYLNVQYPGLDPKLAAVGAYFVFMTLNILGVSIAATFELVVTVLAVAELL
VFMGVVAPGFSFSNFVLNGWSGANEFTMGSIPGIFAAIPFAIWFFLAIEGAAMAAEEAKDPKRTIPRAYVSGILTLVFLA
IGVMVMAGGVGDWRQLSNINDPLPQAMKAVVGNNSTWMHMLVWIGLFGLVASFHGIILGYSRQFFALARAGYLPKGLAKL
SRFQTPHRAILAGGVVGIAAIYSDGLVNLQGMTLTAAMITMSVFGAIVMYIISMLSLFKLRKTEPNLERTFRAPGYPVVP
AIALFLAVVCLVAMAWFNTLIGCVFLGFMAAGYLYFQLTAKQRSEAPADAMLEGI

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI7657683, Length=437, Percent_Identity=24.9427917620137, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786602, Length=415, Percent_Identity=21.2048192771084, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081708, Length=486, Percent_Identity=23.4567901234568, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790653, Length=301, Percent_Identity=24.2524916943522, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI87081915, Length=362, Percent_Identity=24.3093922651934, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082250, Length=316, Percent_Identity=23.1012658227848, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786302, Length=463, Percent_Identity=21.8142548596112, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786789, Length=373, Percent_Identity=20.3753351206434, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48680; Mature: 48549

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTTQLKPTLGTLHLWGIAVGLVISGEYFGWSYGWGTAGTLGFLVTALMVATMYTCFIF
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SFTELTTAIPHAGGPFAYSRRAFGEKGGLIAGIATLIEFVFAPPAIAMAIGAYLNVQYPG
HHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCC
LDPKLAAVGAYFVFMTLNILGVSIAATFELVVTVLAVAELLVFMGVVAPGFSFSNFVLNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEC
WSGANEFTMGSIPGIFAAIPFAIWFFLAIEGAAMAAEEAKDPKRTIPRAYVSGILTLVFL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AIGVMVMAGGVGDWRQLSNINDPLPQAMKAVVGNNSTWMHMLVWIGLFGLVASFHGIILG
HHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YSRQFFALARAGYLPKGLAKLSRFQTPHRAILAGGVVGIAAIYSDGLVNLQGMTLTAAMI
CCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHH
TMSVFGAIVMYIISMLSLFKLRKTEPNLERTFRAPGYPVVPAIALFLAVVCLVAMAWFNT
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LIGCVFLGFMAAGYLYFQLTAKQRSEAPADAMLEGI
HHHHHHHHHHHHHHHHEEEEHHHCCCCCHHHHHCCC
>Mature Secondary Structure 
TSTTQLKPTLGTLHLWGIAVGLVISGEYFGWSYGWGTAGTLGFLVTALMVATMYTCFIF
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SFTELTTAIPHAGGPFAYSRRAFGEKGGLIAGIATLIEFVFAPPAIAMAIGAYLNVQYPG
HHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCC
LDPKLAAVGAYFVFMTLNILGVSIAATFELVVTVLAVAELLVFMGVVAPGFSFSNFVLNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEC
WSGANEFTMGSIPGIFAAIPFAIWFFLAIEGAAMAAEEAKDPKRTIPRAYVSGILTLVFL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AIGVMVMAGGVGDWRQLSNINDPLPQAMKAVVGNNSTWMHMLVWIGLFGLVASFHGIILG
HHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YSRQFFALARAGYLPKGLAKLSRFQTPHRAILAGGVVGIAAIYSDGLVNLQGMTLTAAMI
CCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHH
TMSVFGAIVMYIISMLSLFKLRKTEPNLERTFRAPGYPVVPAIALFLAVVCLVAMAWFNT
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LIGCVFLGFMAAGYLYFQLTAKQRSEAPADAMLEGI
HHHHHHHHHHHHHHHHEEEEHHHCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]