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The map label for this gene is holA [H]

Identifier: 77461180

GI number: 77461180

Start: 5587653

End: 5588690

Strand: Direct

Name: holA [H]

Synonym: Pfl01_4959

Alternate gene names: 77461180

Gene position: 5587653-5588690 (Clockwise)

Preceding gene: 77461179

Following gene: 77461181

Centisome position: 86.79

GC content: 64.84

Gene sequence:

>1038_bases
ATGAAGCTCGCTCCCGCCCAACTCGGCAAACACCTGCAAGGCGCCCTCGCGCCGGTCTACATCATCAGCGGCGATGACCC
GCTGCTGTGTCAGGAAGCTGCCGACGCCATTCGCTCCGCTGCCCGTCAGCAAGGGTTCGACGAACGCCAGGTCTTTGCCG
CCGACGCCAATTTCGATTGGGGTACGCTGCTGCAGGCCGGCGCCAGCATGTCGCTGTTCGCCGAAAAGCGCTTGCTGGAA
CTGCGCCTGCCTTCGGGCAAGCCCGGTGACAAGGGCGCCGCCGCGCTGATCGAGTACTGCTCGCGCCCGGCTGAAGACAC
GGTACTGTTGATCAGCCTGCCGAAGCTGGACGGTAGCGCGCAGAAGACCAAGTGGGGCAAGGCGCTGGTCGAGGGTCAGC
AGACCCAGTTCGTGCAGATCTGGCCGGTAGATGCCAACCAGCTGCCGAGCTGGATTCGTCAGCGACTGTCCCAGGCCGGC
TTGTCGGCCAGCCAGGACGCGGTCGAATTGATCGCCGCGCGGGTCGAAGGCAATCTGCTGGCTGCCGCGCAAGAGATCGA
AAAACTCAAGCTGATGGCCGAGGGCGGGCAGATCACCGTCGAAACCGTGCAGGCAGCCGTGGCCGACAGTGCGCGCTTCG
ACGTATTCGGCCTGACCGACGCAGTGCTCAACGGCGAACCGGCTCACGCCCTGCGCATGCTCGAAGGGCTGCGCGGTGAA
GGGGTCGAACCACCGGTGATCCTCTGGGCTCTGGCCCGGGAGTTGCGCTTGCTGGCCAACATCTCGTTGCAGTACAGCCA
GGGCACACCGCTGGACAAGTGCTTCAGTCAGGCCAAGCCGCCGGTCTGGGACAAGCGCAAACCGCTGATGAGCAAGGCCC
TGCAACGTTACTCGGCGCAACGCTGGGCGCAGTTGCTGCTCGAAGCCCAGCGTATCGATGCGCAGATCAAGGGCCAGGCA
GCCGGTTCGCCGTGGATGAGCCTCAGCCGGTTGGCGCTGCTGATGGCCGGTCAGCGTCTGACATTACCTGCCGAATGA

Upstream 100 bases:

>100_bases
GGCGCAGAAGGCTGAAGCGGAAACCCCGCGTCAGTCGCCGCTCGAACTGCCGCAGCAGTAAGACGTACGGGGCGCTCAGG
CGCCCCGTTCGCCCTCTCTT

Downstream 100 bases:

>100_bases
AATCCGGGATCGCGCGCGGCGGTCCCGTTGTTTACCGAGTCCATTTCCTACAGAACATCCCGCCCTCGGTCCTATAGACA
GACGCCCGAGATCGGCAGAT

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKLAPAQLGKHLQGALAPVYIISGDDPLLCQEAADAIRSAARQQGFDERQVFAADANFDWGTLLQAGASMSLFAEKRLLE
LRLPSGKPGDKGAAALIEYCSRPAEDTVLLISLPKLDGSAQKTKWGKALVEGQQTQFVQIWPVDANQLPSWIRQRLSQAG
LSASQDAVELIAARVEGNLLAAAQEIEKLKLMAEGGQITVETVQAAVADSARFDVFGLTDAVLNGEPAHALRMLEGLRGE
GVEPPVILWALARELRLLANISLQYSQGTPLDKCFSQAKPPVWDKRKPLMSKALQRYSAQRWAQLLLEAQRIDAQIKGQA
AGSPWMSLSRLALLMAGQRLTLPAE

Sequences:

>Translated_345_residues
MKLAPAQLGKHLQGALAPVYIISGDDPLLCQEAADAIRSAARQQGFDERQVFAADANFDWGTLLQAGASMSLFAEKRLLE
LRLPSGKPGDKGAAALIEYCSRPAEDTVLLISLPKLDGSAQKTKWGKALVEGQQTQFVQIWPVDANQLPSWIRQRLSQAG
LSASQDAVELIAARVEGNLLAAAQEIEKLKLMAEGGQITVETVQAAVADSARFDVFGLTDAVLNGEPAHALRMLEGLRGE
GVEPPVILWALARELRLLANISLQYSQGTPLDKCFSQAKPPVWDKRKPLMSKALQRYSAQRWAQLLLEAQRIDAQIKGQA
AGSPWMSLSRLALLMAGQRLTLPAE
>Mature_345_residues
MKLAPAQLGKHLQGALAPVYIISGDDPLLCQEAADAIRSAARQQGFDERQVFAADANFDWGTLLQAGASMSLFAEKRLLE
LRLPSGKPGDKGAAALIEYCSRPAEDTVLLISLPKLDGSAQKTKWGKALVEGQQTQFVQIWPVDANQLPSWIRQRLSQAG
LSASQDAVELIAARVEGNLLAAAQEIEKLKLMAEGGQITVETVQAAVADSARFDVFGLTDAVLNGEPAHALRMLEGLRGE
GVEPPVILWALARELRLLANISLQYSQGTPLDKCFSQAKPPVWDKRKPLMSKALQRYSAQRWAQLLLEAQRIDAQIKGQA
AGSPWMSLSRLALLMAGQRLTLPAE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=340, Percent_Identity=35.5882352941176, Blast_Score=167, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37406; Mature: 37406

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAPAQLGKHLQGALAPVYIISGDDPLLCQEAADAIRSAARQQGFDERQVFAADANFDW
CCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCH
GTLLQAGASMSLFAEKRLLELRLPSGKPGDKGAAALIEYCSRPAEDTVLLISLPKLDGSA
HHHHHCCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
QKTKWGKALVEGQQTQFVQIWPVDANQLPSWIRQRLSQAGLSASQDAVELIAARVEGNLL
HHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHH
AAAQEIEKLKLMAEGGQITVETVQAAVADSARFDVFGLTDAVLNGEPAHALRMLEGLRGE
HHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCEEEEECHHHHHCCCHHHHHHHHHHHCCC
GVEPPVILWALARELRLLANISLQYSQGTPLDKCFSQAKPPVWDKRKPLMSKALQRYSAQ
CCCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
RWAQLLLEAQRIDAQIKGQAAGSPWMSLSRLALLMAGQRLTLPAE
HHHHHHHHHHHHCHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKLAPAQLGKHLQGALAPVYIISGDDPLLCQEAADAIRSAARQQGFDERQVFAADANFDW
CCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCH
GTLLQAGASMSLFAEKRLLELRLPSGKPGDKGAAALIEYCSRPAEDTVLLISLPKLDGSA
HHHHHCCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
QKTKWGKALVEGQQTQFVQIWPVDANQLPSWIRQRLSQAGLSASQDAVELIAARVEGNLL
HHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHH
AAAQEIEKLKLMAEGGQITVETVQAAVADSARFDVFGLTDAVLNGEPAHALRMLEGLRGE
HHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCEEEEECHHHHHCCCHHHHHHHHHHHCCC
GVEPPVILWALARELRLLANISLQYSQGTPLDKCFSQAKPPVWDKRKPLMSKALQRYSAQ
CCCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
RWAQLLLEAQRIDAQIKGQAAGSPWMSLSRLALLMAGQRLTLPAE
HHHHHHHHHHHHCHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]