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The map label for this gene is thiD [H]

Identifier: 77461166

GI number: 77461166

Start: 5573405

End: 5574202

Strand: Direct

Name: thiD [H]

Synonym: Pfl01_4945

Alternate gene names: 77461166

Gene position: 5573405-5574202 (Clockwise)

Preceding gene: 77461161

Following gene: 77461167

Centisome position: 86.56

GC content: 64.79

Gene sequence:

>798_bases
ATGAATATCTACAGCTCACGCCCCGTTGTCCTCTGTCTCTCCGGCCACGACCCCAGTGGTGGCGCCGGCTTGCAGGCAGA
TATCGAAGCCCTGCTCGCTCAGGGTTGCCATGCGGCTCCGGCCGTCACCGCCCTGACCGTGCAAGACACCGTCAACGTCA
CTGACTTTCGCGTCCTCGACCGTGAGTGGGTACTGGCCCAGGCCAATGCCGTGCTCAACGACTCCGAAGTCGCGGCAGTG
AAACTGGGCATGCTCGGTTCCCTGGAAATGGTCGACACCGTCGTCGAACTGCTTCAGGCGCACCCGCACTTGCCAGTGGT
CTGCGACCCGGTGCTGCGTGCCGGCGGCGGCGGACGCCTGGGCAAGGACGAAGTCGGCTACGCCATGCGCGAACGCCTGC
TGCCGCTGTCGATCATCGCCACCCCCAACCTTCCCGAAGCCCGGATCCTTGCCGAACTGCCGGAAGGCACCGCGGACGAG
TGCGCTGAAAAACTCCTGCCGTTCATCAAGAACCTGCTGATCACTGGCGGTCACGGCGACGAAAGCGAAATCCATAACCG
CCTGTACAGCCGCGACGGCCTGCGCGAAACCTTCAAGTGCCAGCGCTTGCCGGGCAGCTATCACGGCTCCGGTTGCACCC
TGGCCAGCACGCTTGCCGGCCGCCTGGCACTGGGCGAAAACCTTGCCAGCGCCGTACGCACGGCACTGGATTACACCTGG
CGCACCCTGCGCGATGCCGAACAGCTGGGCAAAGGCCAGTTCGTGCCGCGTCGCCTGCCGCTGGATTTCTGTTCCTGA

Upstream 100 bases:

>100_bases
TCAGATTGTGACAAGCGCTGTGGATCTCGCTACCCGTGTTATCGGCCGCGCACTGCGCCACAACACCCGGAAAACAGGTT
TGGTGGTAAGCTCGCGCACC

Downstream 100 bases:

>100_bases
TGTTTCGAGCCTGAGGTCTGCGCGATGAAACTACGTGGCCTGTATGCCATCACCGACAGCCAGTTGCTGGCCGGCAAGTT
TCTGTCCTACGTGGAGGCGG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MNIYSSRPVVLCLSGHDPSGGAGLQADIEALLAQGCHAAPAVTALTVQDTVNVTDFRVLDREWVLAQANAVLNDSEVAAV
KLGMLGSLEMVDTVVELLQAHPHLPVVCDPVLRAGGGGRLGKDEVGYAMRERLLPLSIIATPNLPEARILAELPEGTADE
CAEKLLPFIKNLLITGGHGDESEIHNRLYSRDGLRETFKCQRLPGSYHGSGCTLASTLAGRLALGENLASAVRTALDYTW
RTLRDAEQLGKGQFVPRRLPLDFCS

Sequences:

>Translated_265_residues
MNIYSSRPVVLCLSGHDPSGGAGLQADIEALLAQGCHAAPAVTALTVQDTVNVTDFRVLDREWVLAQANAVLNDSEVAAV
KLGMLGSLEMVDTVVELLQAHPHLPVVCDPVLRAGGGGRLGKDEVGYAMRERLLPLSIIATPNLPEARILAELPEGTADE
CAEKLLPFIKNLLITGGHGDESEIHNRLYSRDGLRETFKCQRLPGSYHGSGCTLASTLAGRLALGENLASAVRTALDYTW
RTLRDAEQLGKGQFVPRRLPLDFCS
>Mature_265_residues
MNIYSSRPVVLCLSGHDPSGGAGLQADIEALLAQGCHAAPAVTALTVQDTVNVTDFRVLDREWVLAQANAVLNDSEVAAV
KLGMLGSLEMVDTVVELLQAHPHLPVVCDPVLRAGGGGRLGKDEVGYAMRERLLPLSIIATPNLPEARILAELPEGTADE
CAEKLLPFIKNLLITGGHGDESEIHNRLYSRDGLRETFKCQRLPGSYHGSGCTLASTLAGRLALGENLASAVRTALDYTW
RTLRDAEQLGKGQFVPRRLPLDFCS

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=248, Percent_Identity=33.0645161290323, Blast_Score=124, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6325378, Length=250, Percent_Identity=34, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324997, Length=246, Percent_Identity=35.3658536585366, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324517, Length=248, Percent_Identity=33.4677419354839, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28414; Mature: 28414

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIYSSRPVVLCLSGHDPSGGAGLQADIEALLAQGCHAAPAVTALTVQDTVNVTDFRVLD
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHEEEHH
REWVLAQANAVLNDSEVAAVKLGMLGSLEMVDTVVELLQAHPHLPVVCDPVLRAGGGGRL
HHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECHHHHCCCCCCC
GKDEVGYAMRERLLPLSIIATPNLPEARILAELPEGTADECAEKLLPFIKNLLITGGHGD
CHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCC
ESEIHNRLYSRDGLRETFKCQRLPGSYHGSGCTLASTLAGRLALGENLASAVRTALDYTW
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTLRDAEQLGKGQFVPRRLPLDFCS
HHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIYSSRPVVLCLSGHDPSGGAGLQADIEALLAQGCHAAPAVTALTVQDTVNVTDFRVLD
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHEEEHH
REWVLAQANAVLNDSEVAAVKLGMLGSLEMVDTVVELLQAHPHLPVVCDPVLRAGGGGRL
HHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECHHHHCCCCCCC
GKDEVGYAMRERLLPLSIIATPNLPEARILAELPEGTADECAEKLLPFIKNLLITGGHGD
CHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCC
ESEIHNRLYSRDGLRETFKCQRLPGSYHGSGCTLASTLAGRLALGENLASAVRTALDYTW
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTLRDAEQLGKGQFVPRRLPLDFCS
HHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]