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The map label for this gene is pgi [H]

Identifier: 77461034

GI number: 77461034

Start: 5429980

End: 5431644

Strand: Direct

Name: pgi [H]

Synonym: Pfl01_4813

Alternate gene names: 77461034

Gene position: 5429980-5431644 (Clockwise)

Preceding gene: 77461033

Following gene: 77461035

Centisome position: 84.34

GC content: 61.5

Gene sequence:

>1665_bases
ATGGCGTACTACCGCACTCCTCATGACGTTACCGCTCTGCCTGCCTGGCAAGCGTTGAAAGATCACCGCCAAGCCATGCA
GGATTTCAGCATGCGCGAAGCCTTCAACGCCGATCCGCAGCGCTTCAATCAGTTCACTCTCAGCAGCTGCGGACTGTTTC
TCGACTATTCGAAGAATCTGATCAACGCCGAGACCCGCAACCTGCTGGTGGGTCTGGCCAATGAAGTCGATCTCAAAGGC
GCGATCAAGGCGCTGTTCGACGGCGAAATCGTCAACTCCTCCGAAGGCCGCCCGGCACTGCACACCGCCCTGCGTCGCCC
GGTCGGCGACAAGCTGTCGGTCAACGGTGTCAACGTGATGCCTGAGGTACACAAGGTGCTGAACCAGATCACCGATCTCG
TGGGCCGCATCCACGACGGTCTGTGGCGCGGTTACACCGAGAAGCCGATCACTGACGTTGTGAACATCGGCATCGGCGGC
TCGTTCCTCGGCCCCGAGCTGGTCTCCGAAGCCCTGCTGTCCTACGCCCAGAAAGGCGTGCGTTGCCATTACCTGGCAAA
CATCGACGGCAGCGAATTCCACGAGCTGACGCAAAAACTGCGCGCCGAGACCACGCTGTTCATCGTTTCGTCGAAATCGT
TCAACACCCTCGAAACCCTGAAAAATGCCCAGGCCGCACGCGCCTGGTACCTGGCCCAGGGTGGTTCGGAAGCCGAGCTG
TATCGCCACTTCATCGCCGTATCGAGCAACAATGCCGCCGCCGTGGCCTTCGGTATCCGCGAAGAAAACATCTTCCCGAT
GTGGGACTGGGTCGGCGGTCGTTACTCGCTGTGGTCGGCCATCGGCCTGCCAATCGCGCTGGCCATCGGCATGTCCAACT
TCAAGGAACTGCTGTCCGGTGCCTACACCATGGACCAGCATTTCCAGAGCGCGCCGTTCGAACAGAACATGCCGGTGCTG
CTGGCCCTGCTCGGCGTGTGGTACGGCAACTTCTGGGGCGCGCAAAGCCACGCGATCCTGCCGTACGACCACTACCTGCG
TAACATCACCAAGCACTTGCAACAGCTGGACATGGAATCCAACGGCAAGAGCGTGCGTCAGGACGGCACCCCGGTGTCGA
CCGACACTGGCCCGGTGATCTGGGGCGGCGTCGGTTGCAACGGTCAGCACGCTTATCACCAGTTGCTGCACCAAGGGACC
CAACTGATCCCGGCCGACTTCATCGTGCCGATCGTCAGCTTCAACCCGGTCTCCGACCACCATCAGTGGCTGTACGCCAA
CTGCCTGTCGCAGAGCCAGGCGCTGATGCTCGGCAAGACCCTGCCGGAAGCCGAAGCGGAACTGCGCGACAAGGGCATGA
GCGAAGACCAGGTGCAGAAACTCGCACCGCACAAGGTGATCCCGGGCAACCGTCCGAGCAACACCCTGGTGGTCGAGCGC
ATCAGCCCGCGTCGTCTCGGCGCACTGGTGGCGATGTACGAACACAAAGTCTTCGTGCAAAGCGTGGTCTGGGGCATCAA
CGCCTTCGACCAGTGGGGCGTGGAGCTGGGCAAGGAACTGGGCAAGGGCGTGTACAACCGTCTGGTCGGCAGCGAAGAAA
CCGCCGCTGAAGACGCGTCCACCCAAGGCCTGATCAACTACTTCCGCGGCCGTCACCGCGGCTGA

Upstream 100 bases:

>100_bases
AAAGTAATCGTGTCGACGCAGTTGCCCCCTCGCCCAAACATGGCGGGGAGGTCTTTTCAGTGTTCAAAAGGCCGTTCAAG
TAAAAAGGAAAACCGCAGCG

Downstream 100 bases:

>100_bases
TCCCGCCCTGAACACACCCCCTCGCCATGAGGGGGTGTTTGTTCACAGGTATTGAACCCTCTCCGCTCTCGGCGCATCTT
TATCCTTGTCGCACAACAAG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MAYYRTPHDVTALPAWQALKDHRQAMQDFSMREAFNADPQRFNQFTLSSCGLFLDYSKNLINAETRNLLVGLANEVDLKG
AIKALFDGEIVNSSEGRPALHTALRRPVGDKLSVNGVNVMPEVHKVLNQITDLVGRIHDGLWRGYTEKPITDVVNIGIGG
SFLGPELVSEALLSYAQKGVRCHYLANIDGSEFHELTQKLRAETTLFIVSSKSFNTLETLKNAQAARAWYLAQGGSEAEL
YRHFIAVSSNNAAAVAFGIREENIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKELLSGAYTMDQHFQSAPFEQNMPVL
LALLGVWYGNFWGAQSHAILPYDHYLRNITKHLQQLDMESNGKSVRQDGTPVSTDTGPVIWGGVGCNGQHAYHQLLHQGT
QLIPADFIVPIVSFNPVSDHHQWLYANCLSQSQALMLGKTLPEAEAELRDKGMSEDQVQKLAPHKVIPGNRPSNTLVVER
ISPRRLGALVAMYEHKVFVQSVVWGINAFDQWGVELGKELGKGVYNRLVGSEETAAEDASTQGLINYFRGRHRG

Sequences:

>Translated_554_residues
MAYYRTPHDVTALPAWQALKDHRQAMQDFSMREAFNADPQRFNQFTLSSCGLFLDYSKNLINAETRNLLVGLANEVDLKG
AIKALFDGEIVNSSEGRPALHTALRRPVGDKLSVNGVNVMPEVHKVLNQITDLVGRIHDGLWRGYTEKPITDVVNIGIGG
SFLGPELVSEALLSYAQKGVRCHYLANIDGSEFHELTQKLRAETTLFIVSSKSFNTLETLKNAQAARAWYLAQGGSEAEL
YRHFIAVSSNNAAAVAFGIREENIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKELLSGAYTMDQHFQSAPFEQNMPVL
LALLGVWYGNFWGAQSHAILPYDHYLRNITKHLQQLDMESNGKSVRQDGTPVSTDTGPVIWGGVGCNGQHAYHQLLHQGT
QLIPADFIVPIVSFNPVSDHHQWLYANCLSQSQALMLGKTLPEAEAELRDKGMSEDQVQKLAPHKVIPGNRPSNTLVVER
ISPRRLGALVAMYEHKVFVQSVVWGINAFDQWGVELGKELGKGVYNRLVGSEETAAEDASTQGLINYFRGRHRG
>Mature_553_residues
AYYRTPHDVTALPAWQALKDHRQAMQDFSMREAFNADPQRFNQFTLSSCGLFLDYSKNLINAETRNLLVGLANEVDLKGA
IKALFDGEIVNSSEGRPALHTALRRPVGDKLSVNGVNVMPEVHKVLNQITDLVGRIHDGLWRGYTEKPITDVVNIGIGGS
FLGPELVSEALLSYAQKGVRCHYLANIDGSEFHELTQKLRAETTLFIVSSKSFNTLETLKNAQAARAWYLAQGGSEAELY
RHFIAVSSNNAAAVAFGIREENIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKELLSGAYTMDQHFQSAPFEQNMPVLL
ALLGVWYGNFWGAQSHAILPYDHYLRNITKHLQQLDMESNGKSVRQDGTPVSTDTGPVIWGGVGCNGQHAYHQLLHQGTQ
LIPADFIVPIVSFNPVSDHHQWLYANCLSQSQALMLGKTLPEAEAELRDKGMSEDQVQKLAPHKVIPGNRPSNTLVVERI
SPRRLGALVAMYEHKVFVQSVVWGINAFDQWGVELGKELGKGVYNRLVGSEETAAEDASTQGLINYFRGRHRG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=547, Percent_Identity=48.4460694698355, Blast_Score=563, Evalue=1e-160,
Organism=Homo sapiens, GI296080693, Length=547, Percent_Identity=44.9725776965265, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI1790457, Length=541, Percent_Identity=49.3530499075786, Blast_Score=559, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71996703, Length=538, Percent_Identity=49.4423791821561, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71996708, Length=538, Percent_Identity=49.4423791821561, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=44.9908925318761, Blast_Score=482, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24651916, Length=544, Percent_Identity=48.8970588235294, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24651914, Length=544, Percent_Identity=48.8970588235294, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI17737445, Length=544, Percent_Identity=48.8970588235294, Blast_Score=553, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61469; Mature: 61338

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00659 GLYCOSYL_HYDROL_F5 ; PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYYRTPHDVTALPAWQALKDHRQAMQDFSMREAFNADPQRFNQFTLSSCGLFLDYSKNL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCH
INAETRNLLVGLANEVDLKGAIKALFDGEIVNSSEGRPALHTALRRPVGDKLSVNGVNVM
HCHHHHHHHEECCCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHCCCCCCEECCCCCCC
PEVHKVLNQITDLVGRIHDGLWRGYTEKPITDVVNIGIGGSFLGPELVSEALLSYAQKGV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
RCHYLANIDGSEFHELTQKLRAETTLFIVSSKSFNTLETLKNAQAARAWYLAQGGSEAEL
EEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHEECCCCHHHH
YRHFIAVSSNNAAAVAFGIREENIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKELLSG
HHHHHEECCCCCEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AYTMDQHFQSAPFEQNMPVLLALLGVWYGNFWGAQSHAILPYDHYLRNITKHLQQLDMES
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHCCCC
NGKSVRQDGTPVSTDTGPVIWGGVGCNGQHAYHQLLHQGTQLIPADFIVPIVSFNPVSDH
CCCHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCH
HQWLYANCLSQSQALMLGKTLPEAEAELRDKGMSEDQVQKLAPHKVIPGNRPSNTLVVER
HHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCEEEEC
ISPRRLGALVAMYEHKVFVQSVVWGINAFDQWGVELGKELGKGVYNRLVGSEETAAEDAS
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCH
TQGLINYFRGRHRG
HHHHHHHHHCCCCC
>Mature Secondary Structure 
AYYRTPHDVTALPAWQALKDHRQAMQDFSMREAFNADPQRFNQFTLSSCGLFLDYSKNL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCH
INAETRNLLVGLANEVDLKGAIKALFDGEIVNSSEGRPALHTALRRPVGDKLSVNGVNVM
HCHHHHHHHEECCCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHCCCCCCEECCCCCCC
PEVHKVLNQITDLVGRIHDGLWRGYTEKPITDVVNIGIGGSFLGPELVSEALLSYAQKGV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
RCHYLANIDGSEFHELTQKLRAETTLFIVSSKSFNTLETLKNAQAARAWYLAQGGSEAEL
EEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHEECCCCHHHH
YRHFIAVSSNNAAAVAFGIREENIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKELLSG
HHHHHEECCCCCEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AYTMDQHFQSAPFEQNMPVLLALLGVWYGNFWGAQSHAILPYDHYLRNITKHLQQLDMES
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHCCCC
NGKSVRQDGTPVSTDTGPVIWGGVGCNGQHAYHQLLHQGTQLIPADFIVPIVSFNPVSDH
CCCHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCH
HQWLYANCLSQSQALMLGKTLPEAEAELRDKGMSEDQVQKLAPHKVIPGNRPSNTLVVER
HHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCEEEEC
ISPRRLGALVAMYEHKVFVQSVVWGINAFDQWGVELGKELGKGVYNRLVGSEETAAEDAS
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCH
TQGLINYFRGRHRG
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA