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The map label for this gene is lon2 [H]

Identifier: 77460800

GI number: 77460800

Start: 5175121

End: 5177544

Strand: Direct

Name: lon2 [H]

Synonym: Pfl01_4579

Alternate gene names: 77460800

Gene position: 5175121-5177544 (Clockwise)

Preceding gene: 77460799

Following gene: 77460801

Centisome position: 80.38

GC content: 60.77

Gene sequence:

>2424_bases
ATGAGCGACCAGCAAGAATTCCCCGAAAACCCCGACGACATCACCGAAACCGACGCCGAACACATCGAACACCACGTCCC
CGGCAAAGGCCTGGCCCTGCCCGGCCAGAACCTGCCGGACAAGGTCTACATCATCCCGATCCACAACCGCCCGTTCTTCC
CGGCCCAGGTCCTGCCGGTTATCGTCAACGAAGAGCCCTGGGCCGAAACCCTTGAACTGGTCAGCAAATCCGAACACCAC
TCCCTGGCCCTGTTCTTCATGGACACACCCCAGGAAGACCCGCGCCACTTCGACACCAAGGCGTTGCCGCAATACGGCAC
CCTGGTCAAGGTGCATCACGCCAGCCGCGAAAACGGCAAACTGCAATTCGTCGCGCAGGGCCTGAGCCGCGTACGCATCA
AGACCTGGCTCAAACACCATCGCCCGCCGTATCTCGTTGAAGTCGAATACCCGCACCAGCCCACCGAGCCGACCGACGAG
GTCAAGGCCTACGGAATGGCGCTGATCAACGCTATCAAGGAACTGCTGCCGCTCAACCCGCTGTACAGCGAAGAGCTGAA
GAACTACCTCAACCGCTTCAGCCCCAACGATCCGTCGCCGCTGACCGACTTCGCCGCCGCCCTCACATCGGCGACCGGCA
ATGAGCTGCAGGAAGTGCTCGACTGCGTGCCGATGCTCAAGCGCATGGAAAAAGTCCTGCCGATGCTGCGCAAGGAAGTC
GAAGTCGCGCGTCTGCAAAAAGAAATCTCCGCCGAAGTGAACCGCAAGATCGGCGAGCATCAGCGCGAGTTCTTCCTCAA
GGAACAGCTCAAGGTCATCCAGCAAGAGCTGGGCCTGACCAAGGACGACCGCAGCGCCGACCTCGAGCAGTTCGAGCAGC
GTCTGGAAGGCAAGGTCCTGCCGACGCAGGTACAAAAGCGCCTCGAAGAAGAAATGAACAAACTGTCGATCCTCGAAACC
GGATCGCCGGAGTACGCGGTCACCCGCAACTACCTCGACTGGGCAACCTCGGTACCGTGGGGCGTGTATGGCGAGGACAA
ACTCGACCTCAAGCACGCGCGCAAGGTGCTGGACAAACACCACGCCGGCCTCGACGACATCAAGGACCGGATTCTCGAAT
TCCTAGCGGTCGGTGCCTATAAAGGCGAGATCAGTGGCTCCATCGTGCTGCTGGTGGGCCCGCCGGGCGTGGGTAAAACC
AGTGTCGGCAAATCCATCGCCGAATCCCTCGGCCGGCCGTTCTACCGCTTCAGCCTCGGCGGCATGCGCGACGAAGCCGA
GATCAAGGGCCACCGCCGCACCTACATCGGCGCGCAGCCGGGCAAACTCGTGCAGGCGTTGAAAGACGTCGAAGTGATGA
ACCCGGTGATCATGCTCGACGAGATCGACAAGATGGGCCAGAGCTACCAGGGCGACCCCGCCTCGGCGCTGCTCGAAACC
CTCGACCCGGAACAGAACGTCGAATTCCTCGACCACTATCTGGACCTGCGGATGGACCTGTCGAAAGTCCTGTTCGTCTG
CACCGCCAACACCCTGGATTCGATTCCCGGCCCGTTGCTGGACCGGATGGAAGTGATTCGCCTGTCGGGCTACATCACCG
AAGAAAAAGTCGCCATCGCCAAGCGTCACCTGTGGCCGAAACTGCTGGAAAAGGCTGGCGTGTCCAAAGGCAGCCTGAGC
ATCAGCGACACGGCGCTCAAGGCTCTGATCGACGGTTATGCCCGTGAAGCCGGCGTGCGCCAGCTGGAAAAACAGATGGG
CAAACTGGTGCGCAAAGCGGTGATGAAGCTGATCGACGACCCGAAAGCGGCGATCAAGATCGGCCCGAAAGACCTCGAAG
CGTCCCTCGGCCATCCGGTGTTCCGCAACGAGCAAGTGCTGTCCGGCACTGGCGTGATCACGGGACTTGCCTGGACCAGC
ATGGGCGGCGCGACACTGCCGATTGAAGCGACGCGGATTCACACGCTCAATCGAGGTTTCAAACTCACCGGGCAACTGGG
CGATGTGATGAAGGAGTCGGCGGAGATCGCCTACAGCTACGTCAGCTCGCACCTGAAACAGTTCGGCGGTGACGCGAAAT
TCTTCGACGAAGCTTTCGTCCACCTGCACGTACCGGAAGGCGCCACACCGAAAGACGGCCCAAGCGCCGGCGTGACCATG
GCCAGCGCCCTGCTCTCCCTCGCCCGTAATCAGCCGCCGAAAAAAGGCGTGGCCATGACCGGTGAACTGACGCTGACCGG
CCATGTGCTGCCGATTGGCGGGGTGCGCGAGAAGGTGATTGCGGCGCGGCGGCAGAAGATTTTCGAGTTGATTCTGCCGG
AACCCAATCGGGGTAACTTCGAGGAACTGCCGGATTACTTGAAGGAAGGCATTACCGTGCACTTCGCCAAGAAGTTTTCG
GATGTGGCGAAGGTGCTTTTCTGA

Upstream 100 bases:

>100_bases
CTGTCAAAACCCTGAACACACAAGCAGAAACATTCACCCCCATTGAAACCACCCAACCCCTGCCCCATCTAACAGCCATA
CCCAATTGCGCAGGTGCCCC

Downstream 100 bases:

>100_bases
TTTCTTCTTGAGCTATCGAGGGGGCTGCCATCGCTCCCCCTCACCGTCACACTTTGCCTCATCTTCAGTTATGCTCGCCG
TTCGTCGCCAACGCTGGAGC

Product: PIM1 peptidase

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSDQQEFPENPDDITETDAEHIEHHVPGKGLALPGQNLPDKVYIIPIHNRPFFPAQVLPVIVNEEPWAETLELVSKSEHH
SLALFFMDTPQEDPRHFDTKALPQYGTLVKVHHASRENGKLQFVAQGLSRVRIKTWLKHHRPPYLVEVEYPHQPTEPTDE
VKAYGMALINAIKELLPLNPLYSEELKNYLNRFSPNDPSPLTDFAAALTSATGNELQEVLDCVPMLKRMEKVLPMLRKEV
EVARLQKEISAEVNRKIGEHQREFFLKEQLKVIQQELGLTKDDRSADLEQFEQRLEGKVLPTQVQKRLEEEMNKLSILET
GSPEYAVTRNYLDWATSVPWGVYGEDKLDLKHARKVLDKHHAGLDDIKDRILEFLAVGAYKGEISGSIVLLVGPPGVGKT
SVGKSIAESLGRPFYRFSLGGMRDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLET
LDPEQNVEFLDHYLDLRMDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKVAIAKRHLWPKLLEKAGVSKGSLS
ISDTALKALIDGYAREAGVRQLEKQMGKLVRKAVMKLIDDPKAAIKIGPKDLEASLGHPVFRNEQVLSGTGVITGLAWTS
MGGATLPIEATRIHTLNRGFKLTGQLGDVMKESAEIAYSYVSSHLKQFGGDAKFFDEAFVHLHVPEGATPKDGPSAGVTM
ASALLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIFELILPEPNRGNFEELPDYLKEGITVHFAKKFS
DVAKVLF

Sequences:

>Translated_807_residues
MSDQQEFPENPDDITETDAEHIEHHVPGKGLALPGQNLPDKVYIIPIHNRPFFPAQVLPVIVNEEPWAETLELVSKSEHH
SLALFFMDTPQEDPRHFDTKALPQYGTLVKVHHASRENGKLQFVAQGLSRVRIKTWLKHHRPPYLVEVEYPHQPTEPTDE
VKAYGMALINAIKELLPLNPLYSEELKNYLNRFSPNDPSPLTDFAAALTSATGNELQEVLDCVPMLKRMEKVLPMLRKEV
EVARLQKEISAEVNRKIGEHQREFFLKEQLKVIQQELGLTKDDRSADLEQFEQRLEGKVLPTQVQKRLEEEMNKLSILET
GSPEYAVTRNYLDWATSVPWGVYGEDKLDLKHARKVLDKHHAGLDDIKDRILEFLAVGAYKGEISGSIVLLVGPPGVGKT
SVGKSIAESLGRPFYRFSLGGMRDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLET
LDPEQNVEFLDHYLDLRMDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKVAIAKRHLWPKLLEKAGVSKGSLS
ISDTALKALIDGYAREAGVRQLEKQMGKLVRKAVMKLIDDPKAAIKIGPKDLEASLGHPVFRNEQVLSGTGVITGLAWTS
MGGATLPIEATRIHTLNRGFKLTGQLGDVMKESAEIAYSYVSSHLKQFGGDAKFFDEAFVHLHVPEGATPKDGPSAGVTM
ASALLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIFELILPEPNRGNFEELPDYLKEGITVHFAKKFS
DVAKVLF
>Mature_806_residues
SDQQEFPENPDDITETDAEHIEHHVPGKGLALPGQNLPDKVYIIPIHNRPFFPAQVLPVIVNEEPWAETLELVSKSEHHS
LALFFMDTPQEDPRHFDTKALPQYGTLVKVHHASRENGKLQFVAQGLSRVRIKTWLKHHRPPYLVEVEYPHQPTEPTDEV
KAYGMALINAIKELLPLNPLYSEELKNYLNRFSPNDPSPLTDFAAALTSATGNELQEVLDCVPMLKRMEKVLPMLRKEVE
VARLQKEISAEVNRKIGEHQREFFLKEQLKVIQQELGLTKDDRSADLEQFEQRLEGKVLPTQVQKRLEEEMNKLSILETG
SPEYAVTRNYLDWATSVPWGVYGEDKLDLKHARKVLDKHHAGLDDIKDRILEFLAVGAYKGEISGSIVLLVGPPGVGKTS
VGKSIAESLGRPFYRFSLGGMRDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLETL
DPEQNVEFLDHYLDLRMDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKVAIAKRHLWPKLLEKAGVSKGSLSI
SDTALKALIDGYAREAGVRQLEKQMGKLVRKAVMKLIDDPKAAIKIGPKDLEASLGHPVFRNEQVLSGTGVITGLAWTSM
GGATLPIEATRIHTLNRGFKLTGQLGDVMKESAEIAYSYVSSHLKQFGGDAKFFDEAFVHLHVPEGATPKDGPSAGVTMA
SALLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIFELILPEPNRGNFEELPDYLKEGITVHFAKKFSD
VAKVLF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=676, Percent_Identity=47.189349112426, Blast_Score=651, Evalue=0.0,
Organism=Homo sapiens, GI31377667, Length=748, Percent_Identity=36.4973262032086, Blast_Score=456, Evalue=1e-128,
Organism=Escherichia coli, GI1786643, Length=766, Percent_Identity=40.7310704960835, Blast_Score=554, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17505831, Length=703, Percent_Identity=43.5277382645804, Blast_Score=575, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17556486, Length=532, Percent_Identity=40.0375939849624, Blast_Score=417, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319449, Length=714, Percent_Identity=45.0980392156863, Blast_Score=613, Evalue=1e-176,
Organism=Drosophila melanogaster, GI24666867, Length=682, Percent_Identity=47.5073313782991, Blast_Score=656, Evalue=0.0,
Organism=Drosophila melanogaster, GI221513036, Length=682, Percent_Identity=47.5073313782991, Blast_Score=656, Evalue=0.0,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89944; Mature: 89812

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQQEFPENPDDITETDAEHIEHHVPGKGLALPGQNLPDKVYIIPIHNRPFFPAQVLPV
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCHHHEEE
IVNEEPWAETLELVSKSEHHSLALFFMDTPQEDPRHFDTKALPQYGTLVKVHHASRENGK
EECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
LQFVAQGLSRVRIKTWLKHHRPPYLVEVEYPHQPTEPTDEVKAYGMALINAIKELLPLNP
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
LYSEELKNYLNRFSPNDPSPLTDFAAALTSATGNELQEVLDCVPMLKRMEKVLPMLRKEV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVARLQKEISAEVNRKIGEHQREFFLKEQLKVIQQELGLTKDDRSADLEQFEQRLEGKVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCC
PTQVQKRLEEEMNKLSILETGSPEYAVTRNYLDWATSVPWGVYGEDKLDLKHARKVLDKH
HHHHHHHHHHHHHHEEEEECCCCCCEEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
HAGLDDIKDRILEFLAVGAYKGEISGSIVLLVGPPGVGKTSVGKSIAESLGRPFYRFSLG
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCC
GMRDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLET
CCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHH
LDPEQNVEFLDHYLDLRMDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKVAIA
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHH
KRHLWPKLLEKAGVSKGSLSISDTALKALIDGYAREAGVRQLEKQMGKLVRKAVMKLIDD
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKAAIKIGPKDLEASLGHPVFRNEQVLSGTGVITGLAWTSMGGATLPIEATRIHTLNRGF
CCCEEEECHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCEEHHHHHHHCCCE
KLTGQLGDVMKESAEIAYSYVSSHLKQFGGDAKFFDEAFVHLHVPEGATPKDGPSAGVTM
EEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCCCCCCCCCHHHHH
ASALLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIFELILPEPNRGNF
HHHHHHHHHCCCCCCCCEEECEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCH
EELPDYLKEGITVHFAKKFSDVAKVLF
HHHHHHHHCCCEEEHHHHHHHHHHHHC
>Mature Secondary Structure 
SDQQEFPENPDDITETDAEHIEHHVPGKGLALPGQNLPDKVYIIPIHNRPFFPAQVLPV
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCHHHEEE
IVNEEPWAETLELVSKSEHHSLALFFMDTPQEDPRHFDTKALPQYGTLVKVHHASRENGK
EECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
LQFVAQGLSRVRIKTWLKHHRPPYLVEVEYPHQPTEPTDEVKAYGMALINAIKELLPLNP
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
LYSEELKNYLNRFSPNDPSPLTDFAAALTSATGNELQEVLDCVPMLKRMEKVLPMLRKEV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVARLQKEISAEVNRKIGEHQREFFLKEQLKVIQQELGLTKDDRSADLEQFEQRLEGKVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCC
PTQVQKRLEEEMNKLSILETGSPEYAVTRNYLDWATSVPWGVYGEDKLDLKHARKVLDKH
HHHHHHHHHHHHHHEEEEECCCCCCEEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
HAGLDDIKDRILEFLAVGAYKGEISGSIVLLVGPPGVGKTSVGKSIAESLGRPFYRFSLG
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCC
GMRDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLET
CCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHH
LDPEQNVEFLDHYLDLRMDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKVAIA
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHH
KRHLWPKLLEKAGVSKGSLSISDTALKALIDGYAREAGVRQLEKQMGKLVRKAVMKLIDD
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKAAIKIGPKDLEASLGHPVFRNEQVLSGTGVITGLAWTSMGGATLPIEATRIHTLNRGF
CCCEEEECHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCEEHHHHHHHCCCE
KLTGQLGDVMKESAEIAYSYVSSHLKQFGGDAKFFDEAFVHLHVPEGATPKDGPSAGVTM
EEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCCCCCCCCCHHHHH
ASALLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIFELILPEPNRGNF
HHHHHHHHHCCCCCCCCEEECEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCH
EELPDYLKEGITVHFAKKFSDVAKVLF
HHHHHHHHCCCEEEHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA