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The map label for this gene is yusP [H]

Identifier: 77460700

GI number: 77460700

Start: 5050558

End: 5052075

Strand: Direct

Name: yusP [H]

Synonym: Pfl01_4479

Alternate gene names: 77460700

Gene position: 5050558-5052075 (Clockwise)

Preceding gene: 77460699

Following gene: 77460705

Centisome position: 78.44

GC content: 63.77

Gene sequence:

>1518_bases
GTGACCAATCTCAACCATCCCGAAACGCCCAAACCGGCCATTCGCAGCGTGCTGGTCGCGCTGATGATGGCGATCTTTCT
CGGCGCGCTGGACCAGACCATCGTCGCCGTTTCCATGCCGGCCATCTCCGCCCAGTTCAAGGACGTCAGCCTGTTGGCAT
GGGTGATTTCCGGCTACATGGTGGCGATGACCGTGGCGGTGCCGATCTACGGCAAGCTCGGCGATCTGTACGGGCGGCGC
AAACTGATGCTGTTCGGCATGGGCATGTTCACCCTAGCGTCGCTGTTCTGCGGCATGGCCCAGAGCATGGAGCAACTGGT
GCTGGCGCGGATTTTCCAGGGCATCGGCGCTGGCGGGATGATTTCGGTGAGTCAGGCGATCATCGGCGACATCGTGCCAC
CTCGCGAACGCGGGCGTTATCAGGGCTATTTCTCCAGCATGTACGCGGTGGCCAGTGTGGCCGGCCCGGTGCTCGGCGGT
TACATGACCGAGTACCTGTCGTGGCGCTGGGTGTTTCTGATCAACCTGCCGCTGGGCCTTGGCGCTTACTGGGTGGCGCG
ACGCAATCTGATCGGCCTGCCGATTCCGCAGCGCAAACCAGTCATCGATTATCTCGGCACGCTGTTGATGATCATCGGCC
TGACGGCACTGTTGCTGGCGATCACTCAGGTCGGCCAGGGCCATGCGTGGCGCAGCAGTGAAGTGCTCGGTCTGTTCGCT
TGCGCGATGGCAGTGTTGGCGGTGTTCGTCTGGCATGAACGACGCGCGCGGGAGCCGTTGCTGCCGATGCACTTGTTCAC
CAATCGCAGTGCGCTGCTGTGCTGGTGCACGATTTTCTTTTGCAGCTTCCAGGCGATTTCCCTGATCGTGCTGATGCCGC
TGCGCTTTCAGAGCGTAACCGGTGCCGGCGCCGACAGCGCTGCGTTGCACCTGCTGCCGCTGGCGATGGGTTTGCCGATC
GGCGCGTATTTCGCCGGACGTCGCACCTCGATCACCGGGCGCTACAAACCGCAGATTCTGACCGGCGCGCTGCTGATGCC
GGTCTCGATCCTCGGCATGGCCTTCAGCCCGCCCGATGCGACGCTGCTCAGCAGCCTGTTCATGTTGCTCAGCGGGATCG
CCGGCGGCATGCAGTTCCCGACCTCGCTGGTCGGCACCCAAAACTCGGTCGAGCAAAAGGACATTGGCGTCGCCACCAGC
ACCACCAACCTGTTCCGCTCCCTGGGCGGCGCGGTGGGCGTAGCGTTGATGTCGGCGCTGTTGCTGGCGTTGTTGCAGGA
CTCCAGTTTCGCGCACCTGGCCGGCAGCTCGCTGATGAGCGAAGGGCATTCCGGCAACGTGTTGCTCGATGGCCTGAACG
CGGCACCCGGCGATGCGCAGAATGCCTTGCGTGCCGAATTGCTGGTGACGTTCCGGCATTTGCTGATGGTCAGCGCGGCG
GTTTCGCTGCTTGGGCTGGCGGCGGCGATCGCGATGCCGAACCGGTTGCTGCGGGGCCGTGAGCACGGCGCCCGCTGA

Upstream 100 bases:

>100_bases
CCTTATGAGGCTATCGAATAGCTTCCTACCGACTTACACTGGCGAGCATCCCCGCTCGCCTGGCGATCTGCGGGACCCTC
ACTGCCCGCAGGTTTTGCCC

Downstream 100 bases:

>100_bases
TTGATGCCGATGGCTCCCACGCGCTGCGTGGGAGCGCTCACGAATCAGGCACTGTAGTAACCGACCGCCACCAGCATGTT
CCCGACCTTCTTCAGGTAGG

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTNLNHPETPKPAIRSVLVALMMAIFLGALDQTIVAVSMPAISAQFKDVSLLAWVISGYMVAMTVAVPIYGKLGDLYGRR
KLMLFGMGMFTLASLFCGMAQSMEQLVLARIFQGIGAGGMISVSQAIIGDIVPPRERGRYQGYFSSMYAVASVAGPVLGG
YMTEYLSWRWVFLINLPLGLGAYWVARRNLIGLPIPQRKPVIDYLGTLLMIIGLTALLLAITQVGQGHAWRSSEVLGLFA
CAMAVLAVFVWHERRAREPLLPMHLFTNRSALLCWCTIFFCSFQAISLIVLMPLRFQSVTGAGADSAALHLLPLAMGLPI
GAYFAGRRTSITGRYKPQILTGALLMPVSILGMAFSPPDATLLSSLFMLLSGIAGGMQFPTSLVGTQNSVEQKDIGVATS
TTNLFRSLGGAVGVALMSALLLALLQDSSFAHLAGSSLMSEGHSGNVLLDGLNAAPGDAQNALRAELLVTFRHLLMVSAA
VSLLGLAAAIAMPNRLLRGREHGAR

Sequences:

>Translated_505_residues
MTNLNHPETPKPAIRSVLVALMMAIFLGALDQTIVAVSMPAISAQFKDVSLLAWVISGYMVAMTVAVPIYGKLGDLYGRR
KLMLFGMGMFTLASLFCGMAQSMEQLVLARIFQGIGAGGMISVSQAIIGDIVPPRERGRYQGYFSSMYAVASVAGPVLGG
YMTEYLSWRWVFLINLPLGLGAYWVARRNLIGLPIPQRKPVIDYLGTLLMIIGLTALLLAITQVGQGHAWRSSEVLGLFA
CAMAVLAVFVWHERRAREPLLPMHLFTNRSALLCWCTIFFCSFQAISLIVLMPLRFQSVTGAGADSAALHLLPLAMGLPI
GAYFAGRRTSITGRYKPQILTGALLMPVSILGMAFSPPDATLLSSLFMLLSGIAGGMQFPTSLVGTQNSVEQKDIGVATS
TTNLFRSLGGAVGVALMSALLLALLQDSSFAHLAGSSLMSEGHSGNVLLDGLNAAPGDAQNALRAELLVTFRHLLMVSAA
VSLLGLAAAIAMPNRLLRGREHGAR
>Mature_504_residues
TNLNHPETPKPAIRSVLVALMMAIFLGALDQTIVAVSMPAISAQFKDVSLLAWVISGYMVAMTVAVPIYGKLGDLYGRRK
LMLFGMGMFTLASLFCGMAQSMEQLVLARIFQGIGAGGMISVSQAIIGDIVPPRERGRYQGYFSSMYAVASVAGPVLGGY
MTEYLSWRWVFLINLPLGLGAYWVARRNLIGLPIPQRKPVIDYLGTLLMIIGLTALLLAITQVGQGHAWRSSEVLGLFAC
AMAVLAVFVWHERRAREPLLPMHLFTNRSALLCWCTIFFCSFQAISLIVLMPLRFQSVTGAGADSAALHLLPLAMGLPIG
AYFAGRRTSITGRYKPQILTGALLMPVSILGMAFSPPDATLLSSLFMLLSGIAGGMQFPTSLVGTQNSVEQKDIGVATST
TNLFRSLGGAVGVALMSALLLALLQDSSFAHLAGSSLMSEGHSGNVLLDGLNAAPGDAQNALRAELLVTFRHLLMVSAAV
SLLGLAAAIAMPNRLLRGREHGAR

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=428, Percent_Identity=27.5700934579439, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI87081983, Length=323, Percent_Identity=31.2693498452012, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1788710, Length=432, Percent_Identity=28.7037037037037, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790195, Length=357, Percent_Identity=27.7310924369748, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788392, Length=294, Percent_Identity=29.2517006802721, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1788509, Length=136, Percent_Identity=30.1470588235294, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1790146, Length=137, Percent_Identity=29.1970802919708, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319770, Length=389, Percent_Identity=27.7634961439589, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323735, Length=453, Percent_Identity=27.8145695364238, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6322958, Length=472, Percent_Identity=24.5762711864407, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325455, Length=452, Percent_Identity=24.5575221238938, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321663, Length=466, Percent_Identity=24.2489270386266, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6324954, Length=242, Percent_Identity=26.0330578512397, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324264, Length=163, Percent_Identity=26.9938650306748, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53932; Mature: 53801

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLNHPETPKPAIRSVLVALMMAIFLGALDQTIVAVSMPAISAQFKDVSLLAWVISGYM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VAMTVAVPIYGKLGDLYGRRKLMLFGMGMFTLASLFCGMAQSMEQLVLARIFQGIGAGGM
HHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ISVSQAIIGDIVPPRERGRYQGYFSSMYAVASVAGPVLGGYMTEYLSWRWVFLINLPLGL
HHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCC
GAYWVARRNLIGLPIPQRKPVIDYLGTLLMIIGLTALLLAITQVGQGHAWRSSEVLGLFA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
CAMAVLAVFVWHERRAREPLLPMHLFTNRSALLCWCTIFFCSFQAISLIVLMPLRFQSVT
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GAGADSAALHLLPLAMGLPIGAYFAGRRTSITGRYKPQILTGALLMPVSILGMAFSPPDA
CCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
TLLSSLFMLLSGIAGGMQFPTSLVGTQNSVEQKDIGVATSTTNLFRSLGGAVGVALMSAL
HHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLALLQDSSFAHLAGSSLMSEGHSGNVLLDGLNAAPGDAQNALRAELLVTFRHLLMVSAA
HHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VSLLGLAAAIAMPNRLLRGREHGAR
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TNLNHPETPKPAIRSVLVALMMAIFLGALDQTIVAVSMPAISAQFKDVSLLAWVISGYM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VAMTVAVPIYGKLGDLYGRRKLMLFGMGMFTLASLFCGMAQSMEQLVLARIFQGIGAGGM
HHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ISVSQAIIGDIVPPRERGRYQGYFSSMYAVASVAGPVLGGYMTEYLSWRWVFLINLPLGL
HHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCC
GAYWVARRNLIGLPIPQRKPVIDYLGTLLMIIGLTALLLAITQVGQGHAWRSSEVLGLFA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
CAMAVLAVFVWHERRAREPLLPMHLFTNRSALLCWCTIFFCSFQAISLIVLMPLRFQSVT
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GAGADSAALHLLPLAMGLPIGAYFAGRRTSITGRYKPQILTGALLMPVSILGMAFSPPDA
CCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
TLLSSLFMLLSGIAGGMQFPTSLVGTQNSVEQKDIGVATSTTNLFRSLGGAVGVALMSAL
HHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLALLQDSSFAHLAGSSLMSEGHSGNVLLDGLNAAPGDAQNALRAELLVTFRHLLMVSAA
HHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VSLLGLAAAIAMPNRLLRGREHGAR
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]