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The map label for this gene is phoP [H]

Identifier: 77460461

GI number: 77460461

Start: 4782576

End: 4783253

Strand: Reverse

Name: phoP [H]

Synonym: Pfl01_4240

Alternate gene names: 77460461

Gene position: 4783253-4782576 (Counterclockwise)

Preceding gene: 77460462

Following gene: 77460460

Centisome position: 74.29

GC content: 61.5

Gene sequence:

>678_bases
ATGAAACTGTTGGTCGTCGAAGATGAAGCGCTGTTGCGCCATCACCTGCAAACCCGCCTGACGGAGAGCGGTCACGTGGT
CGAGTCCGTGGCCAATGCCGAAGAGGCGTTGTACCAGACCGGGCAATTCAACTTTGACCTGGCGGTGATCGACCTTGGAC
TGCCGGGCATGAGTGGCCTCGACCTGATCCGCCAGCTGCGCTCGGGCGGCAAGACGTTTCCGATCCTGATCCTCACCGCG
CGCGGCAACTGGCAAGACAAGGTCGAAGGTCTGGCAGCCGGGGCTGACGATTATCTGGTCAAGCCGTTCCAGTTCGAAGA
GCTTGAAGCGCGACTCAATGCCTTGCTGCGCCGCTCCAGCGGTTTCACCCAGTCGACCATTGTCGCCGGCCCGCTGTTGC
TCGACCTCAATCGCAAGCAGGCGACCCTCGACGAGCAACCGCTGGCGCTGACCGCCTACGAATACCGGATTCTCGAATAC
CTCATGCGTCATCACCAGCAAGTGGTGCCCAAGGATCGGCTGATGGAGCAGCTGTACCCGGATGACGACGAGCGCGATCC
GAACGTGATCGAAGTGCTGGTCGGCCGTCTGCGCCGCAAGCTCGAAGGCCCGGCCGGATTCAAGCCGATCGACACCGTGC
GCGGCCTCGGTTACCTGTTCAATGAGCGTTGCACTTGA

Upstream 100 bases:

>100_bases
TTGGCGTCAGGCCCGCGCCGGGTCGTCCTTCGAGGGGCGACCCGGCGCAGCCATGTGAGGCGAAAGCCTTTGGAGTTGTC
GATTTACCCGGGAGAGCGTC

Downstream 100 bases:

>100_bases
TCCGTTCCCTTCGCGTCCGGCTGATGCTCGCCGCCACCACCCTGGCGGTGTTGTTCATGCTCGCCTTGCTCCCGGCGATG
CAGGGCGCTTTCAGCCTGGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKLLVVEDEALLRHHLQTRLTESGHVVESVANAEEALYQTGQFNFDLAVIDLGLPGMSGLDLIRQLRSGGKTFPILILTA
RGNWQDKVEGLAAGADDYLVKPFQFEELEARLNALLRRSSGFTQSTIVAGPLLLDLNRKQATLDEQPLALTAYEYRILEY
LMRHHQQVVPKDRLMEQLYPDDDERDPNVIEVLVGRLRRKLEGPAGFKPIDTVRGLGYLFNERCT

Sequences:

>Translated_225_residues
MKLLVVEDEALLRHHLQTRLTESGHVVESVANAEEALYQTGQFNFDLAVIDLGLPGMSGLDLIRQLRSGGKTFPILILTA
RGNWQDKVEGLAAGADDYLVKPFQFEELEARLNALLRRSSGFTQSTIVAGPLLLDLNRKQATLDEQPLALTAYEYRILEY
LMRHHQQVVPKDRLMEQLYPDDDERDPNVIEVLVGRLRRKLEGPAGFKPIDTVRGLGYLFNERCT
>Mature_225_residues
MKLLVVEDEALLRHHLQTRLTESGHVVESVANAEEALYQTGQFNFDLAVIDLGLPGMSGLDLIRQLRSGGKTFPILILTA
RGNWQDKVEGLAAGADDYLVKPFQFEELEARLNALLRRSSGFTQSTIVAGPLLLDLNRKQATLDEQPLALTAYEYRILEY
LMRHHQQVVPKDRLMEQLYPDDDERDPNVIEVLVGRLRRKLEGPAGFKPIDTVRGLGYLFNERCT

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=49.7757847533632, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=40.2714932126697, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=40.7079646017699, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=40.4545454545455, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=33.6363636363636, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.7665198237885, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=33.7777777777778, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=34.2342342342342, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=33.7899543378995, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=33.6363636363636, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.0649350649351, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1787229, Length=210, Percent_Identity=31.4285714285714, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=28.3842794759825, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=33.0097087378641, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=126, Percent_Identity=30.952380952381, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693140, Length=240, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=30.5785123966942, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=28.695652173913, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790299, Length=105, Percent_Identity=31.4285714285714, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25441; Mature: 25441

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVEDEALLRHHLQTRLTESGHVVESVANAEEALYQTGQFNFDLAVIDLGLPGMSGL
CEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHH
DLIRQLRSGGKTFPILILTARGNWQDKVEGLAAGADDYLVKPFQFEELEARLNALLRRSS
HHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHCC
GFTQSTIVAGPLLLDLNRKQATLDEQPLALTAYEYRILEYLMRHHQQVVPKDRLMEQLYP
CCCHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DDDERDPNVIEVLVGRLRRKLEGPAGFKPIDTVRGLGYLFNERCT
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLLVVEDEALLRHHLQTRLTESGHVVESVANAEEALYQTGQFNFDLAVIDLGLPGMSGL
CEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHH
DLIRQLRSGGKTFPILILTARGNWQDKVEGLAAGADDYLVKPFQFEELEARLNALLRRSS
HHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHCC
GFTQSTIVAGPLLLDLNRKQATLDEQPLALTAYEYRILEYLMRHHQQVVPKDRLMEQLYP
CCCHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DDDERDPNVIEVLVGRLRRKLEGPAGFKPIDTVRGLGYLFNERCT
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA