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The map label for this gene is phoQ [H]

Identifier: 77460460

GI number: 77460460

Start: 4781233

End: 4782585

Strand: Reverse

Name: phoQ [H]

Synonym: Pfl01_4239

Alternate gene names: 77460460

Gene position: 4782585-4781233 (Counterclockwise)

Preceding gene: 77460461

Following gene: 77460459

Centisome position: 74.28

GC content: 62.68

Gene sequence:

>1353_bases
TTGCACTTGATCCGTTCCCTTCGCGTCCGGCTGATGCTCGCCGCCACCACCCTGGCGGTGTTGTTCATGCTCGCCTTGCT
CCCGGCGATGCAGGGCGCTTTCAGCCTGGCGCTGCAGGACTCGATCGAGCAACGGCTGGCGTCCGATGTCACCACGCTGA
TCTCCGCCGCACGGGTTGAAAACAACCGCTTGATGATGCCGGCACAGTTGCCCGACGAGCGCTTCAACCTCACGGACAAT
CGCCTGCTCGGCTACATCTATGACCGCGAAGGGCACCTGGTCTGGCGCTCGAAGGGCACCCAGGAAGAGAAGATCAACTA
CACGCCGCGTTACGACGGCCTCGGCAACGAGTTCGCGCGGATCCGCGAAGCCAACGGTCAGGAATTCTTCGTCTACGACG
TTGAAGTCAAACTGCTCGGCGGCAAGAGCGCGGCCTTCAGTATCGTGGCCCTGCAACCGGTGCGCGAATACGAAACCACC
CTTGAAGGCCTGCGGGAAAATCTCTACCTCGGTTTTGGCGCAGCGTTGCTGGTGCTGCTCGCACTGCTGTGGATCGGCCT
GACCTGGGGCCTGAAAGCCTTGCGCCGGCTCAGTCAGGAACTCGACGAGATCGAAGGCGGAACCCTCGAAAGCCTCAGCG
AACAACACCCGCGCGAACTGTTGCGCCTGACCGGTTCCCTCAACCGCCTGCTGCACAGCGAACGCCAGCAGCGCAGCCGT
TACCGCGATTCTCTCGACGATCTGGCCCACAGCCTGAAAACCCCGCTGGCGGTACTGCAAGGCGTCAGCGAAGACATGGC
TCAACGCCCCGAAGACCGCGATCAGGCCTGGGTGCTGCAAACCCAGATCGAACGCATGAGCCAGCAGATCGGCTACCAGT
TGCAACGCGCCAGCCTGCGCAAAAGTGGCCTGGTGCGCCATCAGGTGCGCCTGCGTCCGGTGCTGCAAAGCCTGTGCGAC
ACCCTCGACAAGGTCTACCGCGACAAACATGTGCGCGTCGCCTTCGATCTGCCGGAGCACTGTTACGTGCCGATCGAGCA
GGGCGCCTTGCTGGAGATGATGGGCAACCTGCTGGAAAACGCCTATCGCCTGTGCCTGGGCGAAGTACGCATCAGCGTGC
GTGAAAGTCTGGACGGAATCGAACTGTGCATCGAAGACGACGGCCCCGGCGTACCACCGGATCAGCGCGCACGGATTCTC
GAACGCGGCGAACGCCTGGACCGCCAGCACCCGGGGCAGGGCATCGGGCTGGCGGTGGTCAAGGACATCATCGAGAGCTA
CAGCGCGAAATTGACGCTGGGGGATTCACCGATGGGTGGGGCGGCGTTCAGGATTCATTTCCCGGCTGTGTGA

Upstream 100 bases:

>100_bases
TCGAAGTGCTGGTCGGCCGTCTGCGCCGCAAGCTCGAAGGCCCGGCCGGATTCAAGCCGATCGACACCGTGCGCGGCCTC
GGTTACCTGTTCAATGAGCG

Downstream 100 bases:

>100_bases
AGCCGAGTCTCTTTCAGGTGGCGCCGGGGTTATGGCCATTCATCGCCACTGTCAGATCTGACAGTGGTTCATTCCGCGTA
TTTCCAACACTCTGTTTTTG

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MHLIRSLRVRLMLAATTLAVLFMLALLPAMQGAFSLALQDSIEQRLASDVTTLISAARVENNRLMMPAQLPDERFNLTDN
RLLGYIYDREGHLVWRSKGTQEEKINYTPRYDGLGNEFARIREANGQEFFVYDVEVKLLGGKSAAFSIVALQPVREYETT
LEGLRENLYLGFGAALLVLLALLWIGLTWGLKALRRLSQELDEIEGGTLESLSEQHPRELLRLTGSLNRLLHSERQQRSR
YRDSLDDLAHSLKTPLAVLQGVSEDMAQRPEDRDQAWVLQTQIERMSQQIGYQLQRASLRKSGLVRHQVRLRPVLQSLCD
TLDKVYRDKHVRVAFDLPEHCYVPIEQGALLEMMGNLLENAYRLCLGEVRISVRESLDGIELCIEDDGPGVPPDQRARIL
ERGERLDRQHPGQGIGLAVVKDIIESYSAKLTLGDSPMGGAAFRIHFPAV

Sequences:

>Translated_450_residues
MHLIRSLRVRLMLAATTLAVLFMLALLPAMQGAFSLALQDSIEQRLASDVTTLISAARVENNRLMMPAQLPDERFNLTDN
RLLGYIYDREGHLVWRSKGTQEEKINYTPRYDGLGNEFARIREANGQEFFVYDVEVKLLGGKSAAFSIVALQPVREYETT
LEGLRENLYLGFGAALLVLLALLWIGLTWGLKALRRLSQELDEIEGGTLESLSEQHPRELLRLTGSLNRLLHSERQQRSR
YRDSLDDLAHSLKTPLAVLQGVSEDMAQRPEDRDQAWVLQTQIERMSQQIGYQLQRASLRKSGLVRHQVRLRPVLQSLCD
TLDKVYRDKHVRVAFDLPEHCYVPIEQGALLEMMGNLLENAYRLCLGEVRISVRESLDGIELCIEDDGPGVPPDQRARIL
ERGERLDRQHPGQGIGLAVVKDIIESYSAKLTLGDSPMGGAAFRIHFPAV
>Mature_450_residues
MHLIRSLRVRLMLAATTLAVLFMLALLPAMQGAFSLALQDSIEQRLASDVTTLISAARVENNRLMMPAQLPDERFNLTDN
RLLGYIYDREGHLVWRSKGTQEEKINYTPRYDGLGNEFARIREANGQEFFVYDVEVKLLGGKSAAFSIVALQPVREYETT
LEGLRENLYLGFGAALLVLLALLWIGLTWGLKALRRLSQELDEIEGGTLESLSEQHPRELLRLTGSLNRLLHSERQQRSR
YRDSLDDLAHSLKTPLAVLQGVSEDMAQRPEDRDQAWVLQTQIERMSQQIGYQLQRASLRKSGLVRHQVRLRPVLQSLCD
TLDKVYRDKHVRVAFDLPEHCYVPIEQGALLEMMGNLLENAYRLCLGEVRISVRESLDGIELCIEDDGPGVPPDQRARIL
ERGERLDRQHPGQGIGLAVVKDIIESYSAKLTLGDSPMGGAAFRIHFPAV

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=475, Percent_Identity=33.6842105263158, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1788393, Length=270, Percent_Identity=25.9259259259259, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=27.7153558052434, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=30.2040816326531, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=28.0542986425339, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787894, Length=341, Percent_Identity=26.6862170087977, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=23.7623762376238, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790861, Length=290, Percent_Identity=25.1724137931034, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788279, Length=228, Percent_Identity=27.1929824561404, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50872; Mature: 50872

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLIRSLRVRLMLAATTLAVLFMLALLPAMQGAFSLALQDSIEQRLASDVTTLISAARVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NNRLMMPAQLPDERFNLTDNRLLGYIYDREGHLVWRSKGTQEEKINYTPRYDGLGNEFAR
CCEEEECCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCHHHHH
IREANGQEFFVYDVEVKLLGGKSAAFSIVALQPVREYETTLEGLRENLYLGFGAALLVLL
HHHCCCCEEEEEEEEEEEECCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLWIGLTWGLKALRRLSQELDEIEGGTLESLSEQHPRELLRLTGSLNRLLHSERQQRSR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRDSLDDLAHSLKTPLAVLQGVSEDMAQRPEDRDQAWVLQTQIERMSQQIGYQLQRASLR
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KSGLVRHQVRLRPVLQSLCDTLDKVYRDKHVRVAFDLPEHCYVPIEQGALLEMMGNLLEN
HHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AYRLCLGEVRISVRESLDGIELCIEDDGPGVPPDQRARILERGERLDRQHPGQGIGLAVV
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHH
KDIIESYSAKLTLGDSPMGGAAFRIHFPAV
HHHHHHHCCEEEECCCCCCCCEEEEECCCC
>Mature Secondary Structure
MHLIRSLRVRLMLAATTLAVLFMLALLPAMQGAFSLALQDSIEQRLASDVTTLISAARVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NNRLMMPAQLPDERFNLTDNRLLGYIYDREGHLVWRSKGTQEEKINYTPRYDGLGNEFAR
CCEEEECCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCHHHHH
IREANGQEFFVYDVEVKLLGGKSAAFSIVALQPVREYETTLEGLRENLYLGFGAALLVLL
HHHCCCCEEEEEEEEEEEECCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLWIGLTWGLKALRRLSQELDEIEGGTLESLSEQHPRELLRLTGSLNRLLHSERQQRSR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRDSLDDLAHSLKTPLAVLQGVSEDMAQRPEDRDQAWVLQTQIERMSQQIGYQLQRASLR
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KSGLVRHQVRLRPVLQSLCDTLDKVYRDKHVRVAFDLPEHCYVPIEQGALLEMMGNLLEN
HHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AYRLCLGEVRISVRESLDGIELCIEDDGPGVPPDQRARILERGERLDRQHPGQGIGLAVV
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHH
KDIIESYSAKLTLGDSPMGGAAFRIHFPAV
HHHHHHHCCEEEECCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA