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The map label for this gene is lpxK

Identifier: 77460396

GI number: 77460396

Start: 4712171

End: 4713181

Strand: Reverse

Name: lpxK

Synonym: Pfl01_4175

Alternate gene names: 77460396

Gene position: 4713181-4712171 (Counterclockwise)

Preceding gene: 77460397

Following gene: 77460395

Centisome position: 73.2

GC content: 65.58

Gene sequence:

>1011_bases
ATGGCCATGTCCGATCGTCTGCTCGCCGCGTGGTACCACGGGCACCCGGCCCTGACGCTGTTGCGGCCGTTGGAGTGGCT
GTACCGCCGCGTCGTGGCCGGCAAGCGTCAGCGTTTTCTCGACGGCGAAGGTGAGATCTATCAGTCACCGGTGCCGGTGA
TCGTGGTTGGCAATATCACCGTTGGCGGCACCGGCAAGACGCCGATGATCCTGTGGTTGATCGAGCACTGCCGACGCCAC
GGGCTGCGGGTCGGTGTGGTCAGTCGTGGTTACGGCGCCAAACCGGCGCAACTGCCATGGCGAGTCCAAGCCGATCAGAC
TGCCGACATCGCCGGCGACGAACCACTGCTGATCGTGCAGCGCACCGGCGTACCGCTGATGATCGACCCCGATCGCAGCG
CCGCCGTCAGAGCCCTGCTGGACAGCGAGCCGCTGGACCTGATCCTGTCCGATGACGGCATGCAGCATTACCGCCTCGCG
CGGGATCTGGAACTGGTGCTGATCGACGCCGCCCGAGGGCTTGGCAACCGGCGCTGTCTGCCCGCCGGCCCCCTGCGCGA
ACCGGCAGAGCGCCTGCAAAGCGTTGACGGTGTGCTGTTCAACGGCGCCCTTGAGGACCGCGACGGCGGATTCGCTTTCC
GCCTCAAGCCGTCGGCGCTGGTCAATCTGCGCAGCGGCGAACGCCGGCCGCTCGATCATTTTCCGCCCGGTCAGGCCGTG
CACGCGGTAGCCGGGATCGGCAATCCGCAACGTTTCTTCAATACCCTCGAAGCGCTAGACTGGCGGCCTGTGCCCCACGC
GTTTGCCGACCACGCCGAATACAGCGTGCAGGCCTTGAGTTTCACGCCGTCATTGCCAGTGGTGATGACTGAGAAGGACG
CGGTGAAGTGCCGTGCCTTCGCCGCCGACGACTGGTGGTATCTGACGGTCGATGCCGTGCCGTCGCCGGCCTTCGTGGCC
TGGTTCGACACGCAGTTGATGCGCCTGTTGCCGGATCGTCTTTTGCCTTAA

Upstream 100 bases:

>100_bases
AGACTCAGCACCAATCCGTGATCACCGCCATGGACGCGGCCGGCAAGCTCGGTTTCAGCCATCTGCGCATGACCACGGTC
GAGGCGGCGCCCAAATCCTG

Downstream 100 bases:

>100_bases
TCCGTTTTTATCCAGGGAATGTTCATGGACACCAAATTGCTCGATATCCTCGCCTGCCCGGTCTGCAAAGGCCCGCTCAA
ACTCAGCGCCGACAAGACCG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAMSDRLLAAWYHGHPALTLLRPLEWLYRRVVAGKRQRFLDGEGEIYQSPVPVIVVGNITVGGTGKTPMILWLIEHCRRH
GLRVGVVSRGYGAKPAQLPWRVQADQTADIAGDEPLLIVQRTGVPLMIDPDRSAAVRALLDSEPLDLILSDDGMQHYRLA
RDLELVLIDAARGLGNRRCLPAGPLREPAERLQSVDGVLFNGALEDRDGGFAFRLKPSALVNLRSGERRPLDHFPPGQAV
HAVAGIGNPQRFFNTLEALDWRPVPHAFADHAEYSVQALSFTPSLPVVMTEKDAVKCRAFAADDWWYLTVDAVPSPAFVA
WFDTQLMRLLPDRLLP

Sequences:

>Translated_336_residues
MAMSDRLLAAWYHGHPALTLLRPLEWLYRRVVAGKRQRFLDGEGEIYQSPVPVIVVGNITVGGTGKTPMILWLIEHCRRH
GLRVGVVSRGYGAKPAQLPWRVQADQTADIAGDEPLLIVQRTGVPLMIDPDRSAAVRALLDSEPLDLILSDDGMQHYRLA
RDLELVLIDAARGLGNRRCLPAGPLREPAERLQSVDGVLFNGALEDRDGGFAFRLKPSALVNLRSGERRPLDHFPPGQAV
HAVAGIGNPQRFFNTLEALDWRPVPHAFADHAEYSVQALSFTPSLPVVMTEKDAVKCRAFAADDWWYLTVDAVPSPAFVA
WFDTQLMRLLPDRLLP
>Mature_335_residues
AMSDRLLAAWYHGHPALTLLRPLEWLYRRVVAGKRQRFLDGEGEIYQSPVPVIVVGNITVGGTGKTPMILWLIEHCRRHG
LRVGVVSRGYGAKPAQLPWRVQADQTADIAGDEPLLIVQRTGVPLMIDPDRSAAVRALLDSEPLDLILSDDGMQHYRLAR
DLELVLIDAARGLGNRRCLPAGPLREPAERLQSVDGVLFNGALEDRDGGFAFRLKPSALVNLRSGERRPLDHFPPGQAVH
AVAGIGNPQRFFNTLEALDWRPVPHAFADHAEYSVQALSFTPSLPVVMTEKDAVKCRAFAADDWWYLTVDAVPSPAFVAW
FDTQLMRLLPDRLLP

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=326, Percent_Identity=47.5460122699387, Blast_Score=263, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_PSEPF (Q3K8J2)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_349903.1
- ProteinModelPortal:   Q3K8J2
- STRING:   Q3K8J2
- GeneID:   3712539
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_4175
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   GNIHAGG
- ProtClustDB:   PRK00652
- BioCyc:   PFLU205922:PFL_4175-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 37304; Mature: 37173

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMSDRLLAAWYHGHPALTLLRPLEWLYRRVVAGKRQRFLDGEGEIYQSPVPVIVVGNIT
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEECCCCCEEEECCEE
VGGTGKTPMILWLIEHCRRHGLRVGVVSRGYGAKPAQLPWRVQADQTADIAGDEPLLIVQ
ECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE
RTGVPLMIDPDRSAAVRALLDSEPLDLILSDDGMQHYRLARDLELVLIDAARGLGNRRCL
ECCCEEEECCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCEEEEEECCCCCCCCCCC
PAGPLREPAERLQSVDGVLFNGALEDRDGGFAFRLKPSALVNLRSGERRPLDHFPPGQAV
CCCCCHHHHHHHHHHCCEEEECEEECCCCCEEEEECCHHEEEECCCCCCCCCCCCCCHHH
HAVAGIGNPQRFFNTLEALDWRPVPHAFADHAEYSVQALSFTPSLPVVMTEKDAVKCRAF
HHHHCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECCCCCEEEECCCCEEEEEE
AADDWWYLTVDAVPSPAFVAWFDTQLMRLLPDRLLP
ECCCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AMSDRLLAAWYHGHPALTLLRPLEWLYRRVVAGKRQRFLDGEGEIYQSPVPVIVVGNIT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEECCCCCEEEECCEE
VGGTGKTPMILWLIEHCRRHGLRVGVVSRGYGAKPAQLPWRVQADQTADIAGDEPLLIVQ
ECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE
RTGVPLMIDPDRSAAVRALLDSEPLDLILSDDGMQHYRLARDLELVLIDAARGLGNRRCL
ECCCEEEECCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCEEEEEECCCCCCCCCCC
PAGPLREPAERLQSVDGVLFNGALEDRDGGFAFRLKPSALVNLRSGERRPLDHFPPGQAV
CCCCCHHHHHHHHHHCCEEEECEEECCCCCEEEEECCHHEEEECCCCCCCCCCCCCCHHH
HAVAGIGNPQRFFNTLEALDWRPVPHAFADHAEYSVQALSFTPSLPVVMTEKDAVKCRAF
HHHHCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECCCCCEEEECCCCEEEEEE
AADDWWYLTVDAVPSPAFVAWFDTQLMRLLPDRLLP
ECCCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA