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The map label for this gene is fabD [H]

Identifier: 77460379

GI number: 77460379

Start: 4694936

End: 4695874

Strand: Reverse

Name: fabD [H]

Synonym: Pfl01_4158

Alternate gene names: 77460379

Gene position: 4695874-4694936 (Counterclockwise)

Preceding gene: 77460380

Following gene: 77460378

Centisome position: 72.94

GC content: 64.64

Gene sequence:

>939_bases
ATGTCTGCTTCCCTCGCATTCGTCTTTCCAGGACAGGGTTCGCAGTCCCTCGGCATGCTGGCCGAGCTGGGCGCGCAACA
TCCACTGATCCTCGAAACCTTCAAAGAAGCATCCGATGCTCTGGGCTATGACCTGTGGGCGCTGACCCAGCAGGGTCCGG
AAGAGCTGCTCAATCAAACCGACAAAACCCAGCCGGCCATTCTGACCGCTTCGGTCGCCTTGTGGCGTCTGTGGCTGGCG
GAAGGTGGCGCGCGTCCGGCCTTCGTTGCCGGTCACAGCCTGGGTGAATACAGCGCGCTGGTCGCTGCCGGCAGTCTGAG
CCTGGCTGACGCGGTAAAACTCGTCGAGCGCCGTGGCCAGTTGATGCAGGAAGCCGTTCCGGCCGGTCAGGGCGGCATGG
CTGCCATCCTCGGTCTGGAAGATGCCGACGTGCTGGCGGCCTGTGCTGAAGCGGCGCAAGGCGAAGTGGTCAGTGCGGTG
AACTTCAACTCCCCGGGCCAGGTGGTGATCGCCGGTGCCAAGGCAGCCGTTGAGCGCGCCATCGAAGGCTGCAAGGCCCG
TGGCGCCAAGCGTGCCATGCCGCTGCCGGTCAGCGTGCCGTCGCACTGTGAACTGATGCGCCCGGCTGCCGAGCGTTTCG
CCGAGTCCATCGCTGCCATCGACTGGCAGGCGCCGCAGATCCCGGTGGTACAGAACGTAAGCGCCCAGGTGCCGGCGGAT
CTGGAAACCCTCAAGCGTGATCTGCTGGAGCAGCTTTACAAGCCGGTCCGCTGGGTCGAGTCCGTACAGACCCTGGCCGC
CAAAGGCGCGACCAATCTGGTCGAGTGCGGCCCTGGCAAGGTGCTGGCCGGTCTGAACAAACGTTGCGCCGAAGGCGTTT
CGACTTCCAACCTCAATACCCCAGACGCTTTCGCTGCTGCTCGCGCAGCGGCTGTCTGA

Upstream 100 bases:

>100_bases
TGTGACCGCCCGGTTCAAAGGGCCATCCAACTGTCAGTTTCTTGCGTCCCTCTAGCGGGATGCCATTTTTCCGACGACAA
GATCATTAGGGGCTTGTTAC

Downstream 100 bases:

>100_bases
ATCAGGAGAAGCTTGCATGAGTCTGCAAGGTAAAGTTGCACTGGTCACCGGCGCAAGCCGTGGCATCGGCCAGGCTATCG
CACTGGAACTGGGTCGTCAG

Product: [acyl-carrier-protein] S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSASLAFVFPGQGSQSLGMLAELGAQHPLILETFKEASDALGYDLWALTQQGPEELLNQTDKTQPAILTASVALWRLWLA
EGGARPAFVAGHSLGEYSALVAAGSLSLADAVKLVERRGQLMQEAVPAGQGGMAAILGLEDADVLAACAEAAQGEVVSAV
NFNSPGQVVIAGAKAAVERAIEGCKARGAKRAMPLPVSVPSHCELMRPAAERFAESIAAIDWQAPQIPVVQNVSAQVPAD
LETLKRDLLEQLYKPVRWVESVQTLAAKGATNLVECGPGKVLAGLNKRCAEGVSTSNLNTPDAFAAARAAAV

Sequences:

>Translated_312_residues
MSASLAFVFPGQGSQSLGMLAELGAQHPLILETFKEASDALGYDLWALTQQGPEELLNQTDKTQPAILTASVALWRLWLA
EGGARPAFVAGHSLGEYSALVAAGSLSLADAVKLVERRGQLMQEAVPAGQGGMAAILGLEDADVLAACAEAAQGEVVSAV
NFNSPGQVVIAGAKAAVERAIEGCKARGAKRAMPLPVSVPSHCELMRPAAERFAESIAAIDWQAPQIPVVQNVSAQVPAD
LETLKRDLLEQLYKPVRWVESVQTLAAKGATNLVECGPGKVLAGLNKRCAEGVSTSNLNTPDAFAAARAAAV
>Mature_311_residues
SASLAFVFPGQGSQSLGMLAELGAQHPLILETFKEASDALGYDLWALTQQGPEELLNQTDKTQPAILTASVALWRLWLAE
GGARPAFVAGHSLGEYSALVAAGSLSLADAVKLVERRGQLMQEAVPAGQGGMAAILGLEDADVLAACAEAAQGEVVSAVN
FNSPGQVVIAGAKAAVERAIEGCKARGAKRAMPLPVSVPSHCELMRPAAERFAESIAAIDWQAPQIPVVQNVSAQVPADL
ETLKRDLLEQLYKPVRWVESVQTLAAKGATNLVECGPGKVLAGLNKRCAEGVSTSNLNTPDAFAAARAAAV

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=305, Percent_Identity=32.4590163934426, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI27477045, Length=114, Percent_Identity=39.4736842105263, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1787334, Length=303, Percent_Identity=62.3762376237624, Blast_Score=364, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71984332, Length=296, Percent_Identity=30.4054054054054, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=296, Percent_Identity=31.0810810810811, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24665753, Length=311, Percent_Identity=30.8681672025724, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32412; Mature: 32281

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASLAFVFPGQGSQSLGMLAELGAQHPLILETFKEASDALGYDLWALTQQGPEELLNQT
CCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCC
DKTQPAILTASVALWRLWLAEGGARPAFVAGHSLGEYSALVAAGSLSLADAVKLVERRGQ
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
LMQEAVPAGQGGMAAILGLEDADVLAACAEAAQGEVVSAVNFNSPGQVVIAGAKAAVERA
HHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECHHHHHHHH
IEGCKARGAKRAMPLPVSVPSHCELMRPAAERFAESIAAIDWQAPQIPVVQNVSAQVPAD
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCC
LETLKRDLLEQLYKPVRWVESVQTLAAKGATNLVECGPGKVLAGLNKRCAEGVSTSNLNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCCCCC
PDAFAAARAAAV
CHHHHHHHHHCC
>Mature Secondary Structure 
SASLAFVFPGQGSQSLGMLAELGAQHPLILETFKEASDALGYDLWALTQQGPEELLNQT
CCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCC
DKTQPAILTASVALWRLWLAEGGARPAFVAGHSLGEYSALVAAGSLSLADAVKLVERRGQ
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
LMQEAVPAGQGGMAAILGLEDADVLAACAEAAQGEVVSAVNFNSPGQVVIAGAKAAVERA
HHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECHHHHHHHH
IEGCKARGAKRAMPLPVSVPSHCELMRPAAERFAESIAAIDWQAPQIPVVQNVSAQVPAD
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCC
LETLKRDLLEQLYKPVRWVESVQTLAAKGATNLVECGPGKVLAGLNKRCAEGVSTSNLNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCCCCC
PDAFAAARAAAV
CHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]