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The map label for this gene is yciK [H]

Identifier: 77460304

GI number: 77460304

Start: 4614805

End: 4615545

Strand: Direct

Name: yciK [H]

Synonym: Pfl01_4083

Alternate gene names: 77460304

Gene position: 4614805-4615545 (Clockwise)

Preceding gene: 77460303

Following gene: 77460305

Centisome position: 71.68

GC content: 61.4

Gene sequence:

>741_bases
ATGTTTGATTACTCCGCTCGCCCCGAATTGCTCAAGGATCGGATCATTCTGGTCACCGGTGCCGGGCGCGGCATCGGCGC
GGCTGCCGCCAAGACCTACGCCGCCCACGGCGCGACCGTATTGCTGCTGGGCAAGACCGAAGCCAACCTGACCGAAGTCT
ACGACGAGATCGAAGCAGCCGGGCATCCACAGCCCGCCGTGATCCCGTTCAACCTCGAAACCGCCCTGCCCCATCAATAC
GATGAGCTGGCGGCGATGATCGAAACCGAGTTCGGCCACCTCGACGGTCTGCTGCACAACGCCTCGATCATCGGCCCGCG
CACGCCGATCGAGCAGTTGTCCGGTGAAAACTTCATGCGTGTCATGCAGGTCAACGTCAACGCGATGTTCATGCTCACCA
GCACGCTGTTGCCACTGCTCAAACTTTCGCAGGATGCCTCGGTGGTGTTCACCTCCAGCAGCGTCGGGCGCAAGGGTCGT
GCTTACTGGGGCGCCTATGGCGTATCGAAGTTCGCCACTGAAGGCCTGATGCAAACACTGGCCGACGAAGTCGAAAACGT
CGCTCCGGTACGCTCCAACAGCATCAATCCGGGCGCCACTCGCACCAGCATGCGTGCGCAGGCTTACCCGGGCGAAAACC
CGCTGAATAACCCGACACCGGAAGAGATCATGCCGGTCTACCTGTACCTGATGGGCCCGGACAGCACCGGTATCAATGGC
CAGGCCTTCAACGCCCAGTAG

Upstream 100 bases:

>100_bases
ACGCTCTGTGCAGTTGCTGAGTGGTGCTGCAAAGCGACCATCGCTGCATTCCCGCGCAAGACGCGGGAGCGATCAGAAGT
TAATGGATTAGAGGTTTCTT

Downstream 100 bases:

>100_bases
TGCCATACGTCGCATTTGTTGCCGTGGCGGAATACCGTCGCGGCATGCAATTGCCGCTCTGAACGCGGCAAATTCAGTCA
AATAACCACCGCCCCTCCTT

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MFDYSARPELLKDRIILVTGAGRGIGAAAAKTYAAHGATVLLLGKTEANLTEVYDEIEAAGHPQPAVIPFNLETALPHQY
DELAAMIETEFGHLDGLLHNASIIGPRTPIEQLSGENFMRVMQVNVNAMFMLTSTLLPLLKLSQDASVVFTSSSVGRKGR
AYWGAYGVSKFATEGLMQTLADEVENVAPVRSNSINPGATRTSMRAQAYPGENPLNNPTPEEIMPVYLYLMGPDSTGING
QAFNAQ

Sequences:

>Translated_246_residues
MFDYSARPELLKDRIILVTGAGRGIGAAAAKTYAAHGATVLLLGKTEANLTEVYDEIEAAGHPQPAVIPFNLETALPHQY
DELAAMIETEFGHLDGLLHNASIIGPRTPIEQLSGENFMRVMQVNVNAMFMLTSTLLPLLKLSQDASVVFTSSSVGRKGR
AYWGAYGVSKFATEGLMQTLADEVENVAPVRSNSINPGATRTSMRAQAYPGENPLNNPTPEEIMPVYLYLMGPDSTGING
QAFNAQ
>Mature_246_residues
MFDYSARPELLKDRIILVTGAGRGIGAAAAKTYAAHGATVLLLGKTEANLTEVYDEIEAAGHPQPAVIPFNLETALPHQY
DELAAMIETEFGHLDGLLHNASIIGPRTPIEQLSGENFMRVMQVNVNAMFMLTSTLLPLLKLSQDASVVFTSSSVGRKGR
AYWGAYGVSKFATEGLMQTLADEVENVAPVRSNSINPGATRTSMRAQAYPGENPLNNPTPEEIMPVYLYLMGPDSTGING
QAFNAQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=207, Percent_Identity=28.5024154589372, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=25.1012145748988, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40548397, Length=200, Percent_Identity=27.5, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI214010158, Length=200, Percent_Identity=27.5, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI214010156, Length=200, Percent_Identity=27.5, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI22758144, Length=200, Percent_Identity=27.5, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI19743808, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI109715829, Length=229, Percent_Identity=26.2008733624454, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787526, Length=243, Percent_Identity=52.2633744855967, Blast_Score=231, Evalue=3e-62,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=29.4354838709677, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082100, Length=220, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787335, Length=191, Percent_Identity=27.7486910994764, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=258, Percent_Identity=26.3565891472868, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=212, Percent_Identity=26.4150943396226, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=222, Percent_Identity=26.5765765765766, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71997402, Length=225, Percent_Identity=28, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=241, Percent_Identity=24.896265560166, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=193, Percent_Identity=29.5336787564767, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=208, Percent_Identity=27.8846153846154, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=205, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=210, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=197, Percent_Identity=29.9492385786802, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=203, Percent_Identity=27.5862068965517, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=199, Percent_Identity=31.6582914572864, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322861, Length=249, Percent_Identity=29.718875502008, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=219, Percent_Identity=26.027397260274, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644339, Length=196, Percent_Identity=33.6734693877551, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571526, Length=201, Percent_Identity=33.8308457711443, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI23397609, Length=196, Percent_Identity=33.6734693877551, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24643142, Length=243, Percent_Identity=31.6872427983539, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=27.5303643724696, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357041, Length=197, Percent_Identity=31.4720812182741, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281364892, Length=207, Percent_Identity=29.4685990338164, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640492, Length=195, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355631, Length=232, Percent_Identity=25, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=26.2376237623762, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26470; Mature: 26470

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDYSARPELLKDRIILVTGAGRGIGAAAAKTYAAHGATVLLLGKTEANLTEVYDEIEAA
CCCCCCCCHHHHCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHC
GHPQPAVIPFNLETALPHQYDELAAMIETEFGHLDGLLHNASIIGPRTPIEQLSGENFMR
CCCCCEEEEEECHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHCCCCEEE
VMQVNVNAMFMLTSTLLPLLKLSQDASVVFTSSSVGRKGRAYWGAYGVSKFATEGLMQTL
EEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHH
ADEVENVAPVRSNSINPGATRTSMRAQAYPGENPLNNPTPEEIMPVYLYLMGPDSTGING
HHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHEEEEEEEECCCCCCCCC
QAFNAQ
EECCCC
>Mature Secondary Structure
MFDYSARPELLKDRIILVTGAGRGIGAAAAKTYAAHGATVLLLGKTEANLTEVYDEIEAA
CCCCCCCCHHHHCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHC
GHPQPAVIPFNLETALPHQYDELAAMIETEFGHLDGLLHNASIIGPRTPIEQLSGENFMR
CCCCCEEEEEECHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHCCCCEEE
VMQVNVNAMFMLTSTLLPLLKLSQDASVVFTSSSVGRKGRAYWGAYGVSKFATEGLMQTL
EEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHH
ADEVENVAPVRSNSINPGATRTSMRAQAYPGENPLNNPTPEEIMPVYLYLMGPDSTGING
HHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHEEEEEEEECCCCCCCCC
QAFNAQ
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]