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The map label for this gene is abcA [H]

Identifier: 77460269

GI number: 77460269

Start: 4572536

End: 4573852

Strand: Reverse

Name: abcA [H]

Synonym: Pfl01_4048

Alternate gene names: 77460269

Gene position: 4573852-4572536 (Counterclockwise)

Preceding gene: 77460270

Following gene: 77460268

Centisome position: 71.04

GC content: 54.82

Gene sequence:

>1317_bases
ATGTCCTCTGATTCGGATATTGCGATCAAGGTTGAAAATCTGAGCAAGTGTTACCAGATTTACGACCAGCCCCACGATCG
TCTGAAGCAGTTCCTGGTGAAGGGCCGCAAATTCTATCGAGAGTTCTGGGCGCTCAACGACGTTTCCTTTGAGATCAGGA
AAGGTGAGACAGTCGGTATCATCGGTCGTAACGGCAGTGGCAAGTCCACGCTGTTGCAGATGATTTGCGGCACGCTCAAT
CCAACCAGCGGCAGTGTACAGACCCATGGTCGTATCGCTGCGCTTCTGGAGCTGGGTTCAGGGTTCAACCCCGAGTTCAC
CGGACGCGAAAACATCTACATGAATGCTGCGGTGCTGGGTTTGAGCACCGAGGAAACCGACGCCCGCTACGACAGAATCG
TCGAGTTCGCGGACATCGGCAGCTTTATCGAACAGCCTGTCAAAACCTATTCCAGCGGGATGATGGTGCGTCTGGCGTTC
TCGGTGGCGATTCACGTGGAACCGGACATCCTGATCGTCGATGAAGCGTTGTCGGTCGGCGACGCCTACTTCCAGGCCAA
GTGCGCAAAAATGATCCAGGGGATCATCGCGGCAGGCTCGACGGTCTTGTTCGTCAGCCATGACACCGCCTCAGTCAAGT
CACTTTGCAGTCGGGCCCTGTTGCTCGAGTCCGGGCGAAGTCAGTATCTGGGCGATGTGAACACGGCAGTGGAAAAGTAT
TACTCTGCCTTGATCGAAAGCCAGCGTGTGGACCGAGGCCCCGAGGAAGTTGTCAAGCAGACTGCGGCGGTGGCGTCGGA
ATATACCGATGGTGTCGAGTCATTCCAGTCCATGGCCAGTTTTCAGCGGATACAGAACGGTGTTGCCGAATTCATCAACG
TAGCGTTGCTGAACGAAAGCGGTCTGATGATCGACACTGTGGACTTCGGGCAGAAGGTGGTGCTGCGCCAGGTAGTGCAG
GTCCACAAGTCTGTTCCCAGCCTTGGCCTGGCGTACCACATCCGTGACAAGAATGGGCAGGACATCATCTACTCCGATAC
CGGTATCGAAGGTAACCGGCATCTGGTCGATGTCAAGGCCGGCAGTGTGCACGTGATTGAGTGGACGTTTACCGCGCATC
TGAGAGAAGGACACTACTCTGTTTCTTCCATGCTCGCAGAACCGGTCAATCTGAATATCGGTGAGGTCGTCGTCGCGGAC
TTTGTTCCCATTTCGACGAAGTTCTCACTTTCCAGCGCGGGACATCCACAGATTTACGGAGCCGCGTACTGGGGTAACAA
GGTAAGCATGCGAGAAATCAAAAATGGCACAGACTGA

Upstream 100 bases:

>100_bases
GCTCCGGATTTTTCAATTATCGGTATTTATTTCCTTATAGGGCTGCTGGTCATGTGGTTAGGCTTTGCCTGGTTCCAGAA
AACACGCAAGGGGTTTGCCG

Downstream 100 bases:

>100_bases
TCAGAAACTTCACCTCGGATGTGGCTCGGTCACATTCCCCGGCTGGATCAATATCGATCTTGACTCCCCCACGGCCGATC
GATTGCTCGATCTCACTGAG

Product: ABC transporter-like protein

Products: Ni2; [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSSDSDIAIKVENLSKCYQIYDQPHDRLKQFLVKGRKFYREFWALNDVSFEIRKGETVGIIGRNGSGKSTLLQMICGTLN
PTSGSVQTHGRIAALLELGSGFNPEFTGRENIYMNAAVLGLSTEETDARYDRIVEFADIGSFIEQPVKTYSSGMMVRLAF
SVAIHVEPDILIVDEALSVGDAYFQAKCAKMIQGIIAAGSTVLFVSHDTASVKSLCSRALLLESGRSQYLGDVNTAVEKY
YSALIESQRVDRGPEEVVKQTAAVASEYTDGVESFQSMASFQRIQNGVAEFINVALLNESGLMIDTVDFGQKVVLRQVVQ
VHKSVPSLGLAYHIRDKNGQDIIYSDTGIEGNRHLVDVKAGSVHVIEWTFTAHLREGHYSVSSMLAEPVNLNIGEVVVAD
FVPISTKFSLSSAGHPQIYGAAYWGNKVSMREIKNGTD

Sequences:

>Translated_438_residues
MSSDSDIAIKVENLSKCYQIYDQPHDRLKQFLVKGRKFYREFWALNDVSFEIRKGETVGIIGRNGSGKSTLLQMICGTLN
PTSGSVQTHGRIAALLELGSGFNPEFTGRENIYMNAAVLGLSTEETDARYDRIVEFADIGSFIEQPVKTYSSGMMVRLAF
SVAIHVEPDILIVDEALSVGDAYFQAKCAKMIQGIIAAGSTVLFVSHDTASVKSLCSRALLLESGRSQYLGDVNTAVEKY
YSALIESQRVDRGPEEVVKQTAAVASEYTDGVESFQSMASFQRIQNGVAEFINVALLNESGLMIDTVDFGQKVVLRQVVQ
VHKSVPSLGLAYHIRDKNGQDIIYSDTGIEGNRHLVDVKAGSVHVIEWTFTAHLREGHYSVSSMLAEPVNLNIGEVVVAD
FVPISTKFSLSSAGHPQIYGAAYWGNKVSMREIKNGTD
>Mature_437_residues
SSDSDIAIKVENLSKCYQIYDQPHDRLKQFLVKGRKFYREFWALNDVSFEIRKGETVGIIGRNGSGKSTLLQMICGTLNP
TSGSVQTHGRIAALLELGSGFNPEFTGRENIYMNAAVLGLSTEETDARYDRIVEFADIGSFIEQPVKTYSSGMMVRLAFS
VAIHVEPDILIVDEALSVGDAYFQAKCAKMIQGIIAAGSTVLFVSHDTASVKSLCSRALLLESGRSQYLGDVNTAVEKYY
SALIESQRVDRGPEEVVKQTAAVASEYTDGVESFQSMASFQRIQNGVAEFINVALLNESGLMIDTVDFGQKVVLRQVVQV
HKSVPSLGLAYHIRDKNGQDIIYSDTGIEGNRHLVDVKAGSVHVIEWTFTAHLREGHYSVSSMLAEPVNLNIGEVVVADF
VPISTKFSLSSAGHPQIYGAAYWGNKVSMREIKNGTD

Specific function: Influences the expression of the surface array protein gene (vapA). May have both regulatory and transport activities [H]

COG id: COG1134

COG function: function code GM; ABC-type polysaccharide/polyol phosphate transport system, ATPase component

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=211, Percent_Identity=28.9099526066351, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6005701, Length=205, Percent_Identity=30.2439024390244, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI27436953, Length=246, Percent_Identity=27.6422764227642, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI27477115, Length=205, Percent_Identity=28.2926829268293, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI45446740, Length=243, Percent_Identity=25.9259259259259, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI47078218, Length=243, Percent_Identity=25.9259259259259, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI31657092, Length=211, Percent_Identity=27.0142180094787, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI105990541, Length=310, Percent_Identity=22.5806451612903, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI27881501, Length=207, Percent_Identity=24.6376811594203, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI30795238, Length=207, Percent_Identity=24.6376811594203, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI27262624, Length=289, Percent_Identity=24.5674740484429, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI27262626, Length=289, Percent_Identity=24.5674740484429, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI116734710, Length=210, Percent_Identity=25.7142857142857, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI150417984, Length=199, Percent_Identity=24.1206030150754, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI157502201, Length=234, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI157502203, Length=234, Percent_Identity=25.6410256410256, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI21536376, Length=204, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789891, Length=211, Percent_Identity=29.3838862559242, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1787758, Length=212, Percent_Identity=27.3584905660377, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787089, Length=226, Percent_Identity=25.2212389380531, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790467, Length=216, Percent_Identity=26.3888888888889, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87081782, Length=207, Percent_Identity=28.5024154589372, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788761, Length=196, Percent_Identity=26.0204081632653, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI48994943, Length=220, Percent_Identity=25.4545454545455, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081791, Length=207, Percent_Identity=24.1545893719807, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081709, Length=198, Percent_Identity=23.7373737373737, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787029, Length=205, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082267, Length=214, Percent_Identity=22.4299065420561, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788897, Length=250, Percent_Identity=26, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787712, Length=204, Percent_Identity=25.9803921568627, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786703, Length=205, Percent_Identity=27.8048780487805, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786319, Length=193, Percent_Identity=24.3523316062176, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789032, Length=243, Percent_Identity=24.2798353909465, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787164, Length=195, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788210, Length=199, Percent_Identity=26.6331658291457, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786398, Length=202, Percent_Identity=26.7326732673267, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789751, Length=234, Percent_Identity=23.5042735042735, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081834, Length=199, Percent_Identity=29.1457286432161, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI48995001, Length=205, Percent_Identity=23.9024390243902, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1790190, Length=205, Percent_Identity=26.3414634146341, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=330, Percent_Identity=24.8484848484848, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17565586, Length=242, Percent_Identity=26.0330578512397, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17569081, Length=195, Percent_Identity=28.7179487179487, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71983523, Length=197, Percent_Identity=25.3807106598985, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983510, Length=197, Percent_Identity=25.3807106598985, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983516, Length=197, Percent_Identity=25.3807106598985, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565938, Length=231, Percent_Identity=27.7056277056277, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25146765, Length=151, Percent_Identity=30.4635761589404, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71992066, Length=151, Percent_Identity=30.4635761589404, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71992070, Length=151, Percent_Identity=30.4635761589404, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI86564969, Length=151, Percent_Identity=30.4635761589404, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24643674, Length=237, Percent_Identity=24.0506329113924, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI116007184, Length=189, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221500365, Length=189, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221512771, Length=227, Percent_Identity=25.5506607929515, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666092, Length=232, Percent_Identity=22.8448275862069, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574150, Length=218, Percent_Identity=26.605504587156, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI116007328, Length=218, Percent_Identity=26.605504587156, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573571, Length=200, Percent_Identity=23.5, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573573, Length=200, Percent_Identity=23.5, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648314, Length=214, Percent_Identity=23.3644859813084, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 48020; Mature: 47889

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDSDIAIKVENLSKCYQIYDQPHDRLKQFLVKGRKFYREFWALNDVSFEIRKGETVGI
CCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEE
IGRNGSGKSTLLQMICGTLNPTSGSVQTHGRIAALLELGSGFNPEFTGRENIYMNAAVLG
EECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHEEHHHCCCCCCCCCCCCCEEEEEEEEE
LSTEETDARYDRIVEFADIGSFIEQPVKTYSSGMMVRLAFSVAIHVEPDILIVDEALSVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCEEEEECHHHHH
DAYFQAKCAKMIQGIIAAGSTVLFVSHDTASVKSLCSRALLLESGRSQYLGDVNTAVEKY
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHH
YSALIESQRVDRGPEEVVKQTAAVASEYTDGVESFQSMASFQRIQNGVAEFINVALLNES
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
GLMIDTVDFGQKVVLRQVVQVHKSVPSLGLAYHIRDKNGQDIIYSDTGIEGNRHLVDVKA
CCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCCEEEEEEC
GSVHVIEWTFTAHLREGHYSVSSMLAEPVNLNIGEVVVADFVPISTKFSLSSAGHPQIYG
CCEEEEEEEEEEEHHCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCEEECCCCCCCCEEE
AAYWGNKVSMREIKNGTD
EEECCCCCCHHHHCCCCC
>Mature Secondary Structure 
SSDSDIAIKVENLSKCYQIYDQPHDRLKQFLVKGRKFYREFWALNDVSFEIRKGETVGI
CCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEE
IGRNGSGKSTLLQMICGTLNPTSGSVQTHGRIAALLELGSGFNPEFTGRENIYMNAAVLG
EECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHEEHHHCCCCCCCCCCCCCEEEEEEEEE
LSTEETDARYDRIVEFADIGSFIEQPVKTYSSGMMVRLAFSVAIHVEPDILIVDEALSVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCEEEEECHHHHH
DAYFQAKCAKMIQGIIAAGSTVLFVSHDTASVKSLCSRALLLESGRSQYLGDVNTAVEKY
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHH
YSALIESQRVDRGPEEVVKQTAAVASEYTDGVESFQSMASFQRIQNGVAEFINVALLNES
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
GLMIDTVDFGQKVVLRQVVQVHKSVPSLGLAYHIRDKNGQDIIYSDTGIEGNRHLVDVKA
CCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCCEEEEEEC
GSVHVIEWTFTAHLREGHYSVSSMLAEPVNLNIGEVVVADFVPISTKFSLSSAGHPQIYG
CCEEEEEEEEEEEHHCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCEEECCCCCCCCEEE
AAYWGNKVSMREIKNGTD
EEECCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; ATP; H2O [C]

Specific reaction: Ni2+ [Periplasm] + ATP + H2O = Ni2+ [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8491726 [H]