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The map label for this gene is mrdA [H]

Identifier: 77460124

GI number: 77460124

Start: 4414407

End: 4416299

Strand: Reverse

Name: mrdA [H]

Synonym: Pfl01_3903

Alternate gene names: 77460124

Gene position: 4416299-4414407 (Counterclockwise)

Preceding gene: 77460127

Following gene: 77460122

Centisome position: 68.59

GC content: 59.75

Gene sequence:

>1893_bases
ATGCCTGAACCCATCCCTATCAAGGACCACGAAAAAGAAACGCGGCTGGTCAACAAACGCCTGATCGCCTGTGCCTTGTT
CGTTTTCGCCATCAGTTGTGCCCTGGTGGTACGCCTGTACATCCTGCAAGTCGTCGAGTTCGATTACCACTCGACCATCT
CTGAAAACAATCGCGTCCATGTCCTGCCGATCCCGCCGACACGCGGCCTGATTTACGATCGCAACGGCGTGTTGCTGGCC
GATAATCGTCCCAGCTACAACCTGACCATCACCCGCGAACGGGCGACTGACGTCAATCAAGAGCTGGATGAAGTCATCAA
CCTCCTGCACCTGCCCGCCGAAGACCGCGCAGTCTTTGACAAAGCCATGAAGCAGTCGCGTCATCCGTTTACACCCGTAA
CGCTGTTCTATGAGCTAACCGAAGAACAGATCGCCGTGCTGGCAGTTAACGAGTTCCGTCTACCGGGCCTGGATGTCGAG
CCACAATTCGTTCGTAACTACCCGTTGGGTGCGCACTTCGCACACTCGATCGGTTACGTTGGCCGTATCAACGAAAAAGA
ATCCAAAACCCTCGACTCCGTCGAATACCGTGGCACCCAATCCATCGGCAAGACGGGTATCGAACGCTTCTACGAGCCAC
AGCTGCACGGCCACGTCGGTTACGAGGAGGTAGAGACCAACGCACAAGGTCGAGTACTACGGGTCCTGAAACACACCGAT
CCAATACCAGGCAAAAACATTGTCCTGAGCCTCGACGTCAAACTCCAGGAAGCCGCCGAAGCCGCACTGGGCGACCGTCG
CGGCTCGGTCGTTGCACTGGACCCCTCTACCGGCGAAGTGCTGGCCATGGTCAGCAACCCGAGCTTCGACCCCAATCTGT
TCGTGACCGGTATCAGCTCCAAGGAATATTCCGCGCTGCGCGACTCCATCGACCGTCCGCTATTCAACCGCGTGCTGCGC
GGTCTGTATGCACCCGGTTCGACGATCAAGCCGGAAGTGGCCATCGCTGGCCTCGACGCCGGTGTCGTCACTCCACAAAC
CCGAGTCTTCGATCCGGGCTACTACCAACTGCCGGATTTCGACCACAAGTATCGCAACTGGAACCACAGCGGCGACGGTT
GGGTAGACATGGATGCAGCGATCATGCGGTCCAACGACACCTACTTCTACGACCTGGCGCACAAGCTCGGCATCGATCGC
CTTCACGACTACATGGCGATGTTCGGCCTTGGCGAGAAAGTCTCGCTCGACATGTTCGAGGAGTCACCGGGCTTGATGCC
GTCCCAGGCGTGGAAGCGCGCCACCCGGCGTCAGGCCTGGTTCCCCGGCGAAACCGTGATCCTCGGCATAGGCCAGGGCT
ATATGCAAGTCACGCCGCTGCAACTGGCTCAAGCCACCGCACTGATCGCCAACAAGGGCGTCTGGAACCGTCCGCACCTG
GCCAAGACCGTCGACGGTGTGGCGCCGGTGGACGAGCACCCGATGCCGAACATCCTGCTCAAGGATCCGCGTGACTGGGA
GCAGGTCAACCACGGCATGCAGATGGTGATGCACGATGCCCGCGGCATTGCTCGTGCGGCAGCGGCCGGTGCGCAATACC
GCATCGCCGGCAAGAGTGGTACGGCGCAAGTGGTGGCGATCAAGCAGGGTGAGCGCTACAACCGCGAGAAAACCCTCGAA
CGTCACCGTGACAACGCCTTGTTCGTTGGCTTTGCGCCCGCCGAACATCCGAAAATCGCGATCTCGGTAATGATCGAAAA
CGGCGAGGCTGGTGGCCGAGTCGCAGGTCCGGTGGTGCGGCAGATCATGGACGCCTGGCTACTCGACCAGGACGGTCACC
TCAAGCCGCAATACGCGGCGCCGACCAAAGCGCCGGGCGATCCTCACGTGTAA

Upstream 100 bases:

>100_bases
ATGACCGCCCGGTTTTTGGTATGGTGCAGCTCGTTTTTTAACGGACTGATGTCATGCCCAAGGATCGGCGCTTATTTTTT
GTCAAAGAGTGGCTGCAGAA

Downstream 100 bases:

>100_bases
CCCGCTAAAGCTTCACAGCACAGGCTCACGCAAGCTGAGCATGTGCTGGAAGCTGTCGAGGAATACCGTTTCCGCCTGAG
TCATCTTCTGCTCGCGGTTC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MPEPIPIKDHEKETRLVNKRLIACALFVFAISCALVVRLYILQVVEFDYHSTISENNRVHVLPIPPTRGLIYDRNGVLLA
DNRPSYNLTITRERATDVNQELDEVINLLHLPAEDRAVFDKAMKQSRHPFTPVTLFYELTEEQIAVLAVNEFRLPGLDVE
PQFVRNYPLGAHFAHSIGYVGRINEKESKTLDSVEYRGTQSIGKTGIERFYEPQLHGHVGYEEVETNAQGRVLRVLKHTD
PIPGKNIVLSLDVKLQEAAEAALGDRRGSVVALDPSTGEVLAMVSNPSFDPNLFVTGISSKEYSALRDSIDRPLFNRVLR
GLYAPGSTIKPEVAIAGLDAGVVTPQTRVFDPGYYQLPDFDHKYRNWNHSGDGWVDMDAAIMRSNDTYFYDLAHKLGIDR
LHDYMAMFGLGEKVSLDMFEESPGLMPSQAWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATALIANKGVWNRPHL
AKTVDGVAPVDEHPMPNILLKDPRDWEQVNHGMQMVMHDARGIARAAAAGAQYRIAGKSGTAQVVAIKQGERYNREKTLE
RHRDNALFVGFAPAEHPKIAISVMIENGEAGGRVAGPVVRQIMDAWLLDQDGHLKPQYAAPTKAPGDPHV

Sequences:

>Translated_630_residues
MPEPIPIKDHEKETRLVNKRLIACALFVFAISCALVVRLYILQVVEFDYHSTISENNRVHVLPIPPTRGLIYDRNGVLLA
DNRPSYNLTITRERATDVNQELDEVINLLHLPAEDRAVFDKAMKQSRHPFTPVTLFYELTEEQIAVLAVNEFRLPGLDVE
PQFVRNYPLGAHFAHSIGYVGRINEKESKTLDSVEYRGTQSIGKTGIERFYEPQLHGHVGYEEVETNAQGRVLRVLKHTD
PIPGKNIVLSLDVKLQEAAEAALGDRRGSVVALDPSTGEVLAMVSNPSFDPNLFVTGISSKEYSALRDSIDRPLFNRVLR
GLYAPGSTIKPEVAIAGLDAGVVTPQTRVFDPGYYQLPDFDHKYRNWNHSGDGWVDMDAAIMRSNDTYFYDLAHKLGIDR
LHDYMAMFGLGEKVSLDMFEESPGLMPSQAWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATALIANKGVWNRPHL
AKTVDGVAPVDEHPMPNILLKDPRDWEQVNHGMQMVMHDARGIARAAAAGAQYRIAGKSGTAQVVAIKQGERYNREKTLE
RHRDNALFVGFAPAEHPKIAISVMIENGEAGGRVAGPVVRQIMDAWLLDQDGHLKPQYAAPTKAPGDPHV
>Mature_629_residues
PEPIPIKDHEKETRLVNKRLIACALFVFAISCALVVRLYILQVVEFDYHSTISENNRVHVLPIPPTRGLIYDRNGVLLAD
NRPSYNLTITRERATDVNQELDEVINLLHLPAEDRAVFDKAMKQSRHPFTPVTLFYELTEEQIAVLAVNEFRLPGLDVEP
QFVRNYPLGAHFAHSIGYVGRINEKESKTLDSVEYRGTQSIGKTGIERFYEPQLHGHVGYEEVETNAQGRVLRVLKHTDP
IPGKNIVLSLDVKLQEAAEAALGDRRGSVVALDPSTGEVLAMVSNPSFDPNLFVTGISSKEYSALRDSIDRPLFNRVLRG
LYAPGSTIKPEVAIAGLDAGVVTPQTRVFDPGYYQLPDFDHKYRNWNHSGDGWVDMDAAIMRSNDTYFYDLAHKLGIDRL
HDYMAMFGLGEKVSLDMFEESPGLMPSQAWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATALIANKGVWNRPHLA
KTVDGVAPVDEHPMPNILLKDPRDWEQVNHGMQMVMHDARGIARAAAAGAQYRIAGKSGTAQVVAIKQGERYNREKTLER
HRDNALFVGFAPAEHPKIAISVMIENGEAGGRVAGPVVRQIMDAWLLDQDGHLKPQYAAPTKAPGDPHV

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=613, Percent_Identity=42.9037520391517, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1786272, Length=619, Percent_Identity=27.3021001615509, Blast_Score=159, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70231; Mature: 70100

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPIPIKDHEKETRLVNKRLIACALFVFAISCALVVRLYILQVVEFDYHSTISENNRVH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEE
VLPIPPTRGLIYDRNGVLLADNRPSYNLTITRERATDVNQELDEVINLLHLPAEDRAVFD
EEECCCCCCEEECCCCEEEECCCCCEEEEEEECHHCCHHHHHHHHHHHHCCCCCHHHHHH
KAMKQSRHPFTPVTLFYELTEEQIAVLAVNEFRLPGLDVEPQFVRNYPLGAHFAHSIGYV
HHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHCCCCCHHHHHHCCCC
GRINEKESKTLDSVEYRGTQSIGKTGIERFYEPQLHGHVGYEEVETNAQGRVLRVLKHTD
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCEEEEEHHCC
PIPGKNIVLSLDVKLQEAAEAALGDRRGSVVALDPSTGEVLAMVSNPSFDPNLFVTGISS
CCCCCCEEEEEECHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCEEEEECCC
KEYSALRDSIDRPLFNRVLRGLYAPGSTIKPEVAIAGLDAGVVTPQTRVFDPGYYQLPDF
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCC
DHKYRNWNHSGDGWVDMDAAIMRSNDTYFYDLAHKLGIDRLHDYMAMFGLGEKVSLDMFE
CHHHCCCCCCCCCEEECCHHEEECCCCEEEECHHHHCHHHHHHHHHHHCCCCCEEEEECC
ESPGLMPSQAWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATALIANKGVWNRPHL
CCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHCCCCCCCCCH
AKTVDGVAPVDEHPMPNILLKDPRDWEQVNHGMQMVMHDARGIARAAAAGAQYRIAGKSG
HHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
TAQVVAIKQGERYNREKTLERHRDNALFVGFAPAEHPKIAISVMIENGEAGGRVAGPVVR
CEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHH
QIMDAWLLDQDGHLKPQYAAPTKAPGDPHV
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PEPIPIKDHEKETRLVNKRLIACALFVFAISCALVVRLYILQVVEFDYHSTISENNRVH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEE
VLPIPPTRGLIYDRNGVLLADNRPSYNLTITRERATDVNQELDEVINLLHLPAEDRAVFD
EEECCCCCCEEECCCCEEEECCCCCEEEEEEECHHCCHHHHHHHHHHHHCCCCCHHHHHH
KAMKQSRHPFTPVTLFYELTEEQIAVLAVNEFRLPGLDVEPQFVRNYPLGAHFAHSIGYV
HHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHCCCCCHHHHHHCCCC
GRINEKESKTLDSVEYRGTQSIGKTGIERFYEPQLHGHVGYEEVETNAQGRVLRVLKHTD
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCEEEEEHHCC
PIPGKNIVLSLDVKLQEAAEAALGDRRGSVVALDPSTGEVLAMVSNPSFDPNLFVTGISS
CCCCCCEEEEEECHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCEEEEECCC
KEYSALRDSIDRPLFNRVLRGLYAPGSTIKPEVAIAGLDAGVVTPQTRVFDPGYYQLPDF
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCC
DHKYRNWNHSGDGWVDMDAAIMRSNDTYFYDLAHKLGIDRLHDYMAMFGLGEKVSLDMFE
CHHHCCCCCCCCCEEECCHHEEECCCCEEEECHHHHCHHHHHHHHHHHCCCCCEEEEECC
ESPGLMPSQAWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATALIANKGVWNRPHL
CCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHCCCCCCCCCH
AKTVDGVAPVDEHPMPNILLKDPRDWEQVNHGMQMVMHDARGIARAAAAGAQYRIAGKSG
HHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
TAQVVAIKQGERYNREKTLERHRDNALFVGFAPAEHPKIAISVMIENGEAGGRVAGPVVR
CEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHH
QIMDAWLLDQDGHLKPQYAAPTKAPGDPHV
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]