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The map label for this gene is yoeA [H]

Identifier: 77459763

GI number: 77459763

Start: 4016618

End: 4018093

Strand: Reverse

Name: yoeA [H]

Synonym: Pfl01_3541

Alternate gene names: 77459763

Gene position: 4018093-4016618 (Counterclockwise)

Preceding gene: 77459764

Following gene: 77459762

Centisome position: 62.41

GC content: 62.13

Gene sequence:

>1476_bases
ATGAACTCATCTTCGTCCGCTTTTAATCAGACAGAAAAACCTTCACCGCTATTACCTCCGACAAGTCGCAAAACATCTAG
CGTAATATCCAGGCAATCCTCCACCCGAGACGGATCCTCAATGCAAACCCCCGCTCAATCCCCCCTCTGGAAAACCTACC
TGCTGTTCCTGGCCCCGATGGTGCTGTCGAACTTCCTGCAATCGATGTCGGGCACGGTCAACAGCATCTACATCGGCCAG
ATGCTCGGTACGCAGGCGCTGGCGGCGGTGTCGGGGATGTTTCCGATCATCTTTTTCTTTATCGCGCTGGTCATCGGCCT
GGGCGCCGGGGCAGGGGTGTTGATCGGTCAGGCGTGGGGCGCGCGTGAGTCGCACATGGTCAAGGCAATTGCCGGGGCGA
CGTTGTTGCTGGGGGTATTGATCGGGCTGGTGGCGGCGGTGCTGGGCAGTGTGTTTGCGCGCCAGGCCTTGCAGGGTTTG
GGGACGCCGGCGGATGTGTTGGATGATGCGGTGGCCTATGCCCGGGTGATGATGTGGACCTTGCCGGTTGTGCTGGTGTA
CGTGCTGTTCACCCAGTTGTTGCGCGGAGTGAGCGATACGCTGTCGCCGATGCTGGCGCTGTTGCTGTCGACCGTGGTCG
GGCTGGCGCTGACCCCGGCGTTCATTCGCGGCTGGATCGGCTTGCCACAACTGGGCATTCAGAGCGCGGCAATTGCGGGT
CTGGTCGGTACGTTGACATCGATGGCGTGGCTGTCATGGCGCCTGATCCGCAAGGGCCATCCGCTGGCGCCGGATCGCGA
GTTTTTCGCGGCGCTGCGACTGGACGGCGCGATTCTCGGCAAGGTGTTGCGCATCGGCCTGCCGACCGGGGTGCAGATGA
TTGTGCTGTCGCTGTCGGAGCTGGTGATTCTGGCGCTGGTCAACCAGCACGGCTCGCAGGCGACGGCGGCCTATGGCGCG
GTGACGCAGATCGTCAACTACGTGCAGTTTCCGGCGCTGTCGATTGCGATCACCGCGTCGATCCTCGGCGCCCAGGCGAT
CGGTGCCGGGCGGCTGGAGCGAATGGGTCCGATTCTGCGCACTGGATTGTGGATCAACGTGTGCCTGACCGGTGGTTTGA
TCCTGGCGGGCTACCTGTTGTCGCACTGGTTGCTGGGGCTGTTCCTGACCGAAGACTCGACCCGGGCGATGGCCGAGCAT
CTGCTGCACATCATGCTGTGGAGCCTGTTGATCTTCGGTTTCCAGGCGATCATCGGCGGCATCATGCGCGCCAGCGGCAC
GGTGCTGGTGCCGGTGGGCGTGGCGATCATCTGCGTGCTCGGCGTGCAGTTGCCGGCGGCCTACTGGCTGGACGGGCAGT
TCGGTCTGCAGGGTGTGTGGATGGCGTTTCCGATCGCGTATCTGGGGATGCTGGTTTTGCAGACGCTGTATTACACACGG
GTCTGGAAGCATCAGAAGATTGAGCGGTTGGTGTGA

Upstream 100 bases:

>100_bases
CGAGCAGGTTCCTCGCCGAGAAGCATTCGATCTATCTGGAGCGCGTCCGCGCCAAGTGCTGGCATCTTGATTGGCCACTT
TTGCAGATCATGATGGAACG

Downstream 100 bases:

>100_bases
CGGACTGATCCGGTTGGGCGTTGGCGGAACTGGCACAAGTGCCGGATGTTTGCTTAAGTCATTCGAGACCCATCGGGCGC
CGGAGCATTGCATGTCGATT

Product: multi anti extrusion protein MatE

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNSSSSAFNQTEKPSPLLPPTSRKTSSVISRQSSTRDGSSMQTPAQSPLWKTYLLFLAPMVLSNFLQSMSGTVNSIYIGQ
MLGTQALAAVSGMFPIIFFFIALVIGLGAGAGVLIGQAWGARESHMVKAIAGATLLLGVLIGLVAAVLGSVFARQALQGL
GTPADVLDDAVAYARVMMWTLPVVLVYVLFTQLLRGVSDTLSPMLALLLSTVVGLALTPAFIRGWIGLPQLGIQSAAIAG
LVGTLTSMAWLSWRLIRKGHPLAPDREFFAALRLDGAILGKVLRIGLPTGVQMIVLSLSELVILALVNQHGSQATAAYGA
VTQIVNYVQFPALSIAITASILGAQAIGAGRLERMGPILRTGLWINVCLTGGLILAGYLLSHWLLGLFLTEDSTRAMAEH
LLHIMLWSLLIFGFQAIIGGIMRASGTVLVPVGVAIICVLGVQLPAAYWLDGQFGLQGVWMAFPIAYLGMLVLQTLYYTR
VWKHQKIERLV

Sequences:

>Translated_491_residues
MNSSSSAFNQTEKPSPLLPPTSRKTSSVISRQSSTRDGSSMQTPAQSPLWKTYLLFLAPMVLSNFLQSMSGTVNSIYIGQ
MLGTQALAAVSGMFPIIFFFIALVIGLGAGAGVLIGQAWGARESHMVKAIAGATLLLGVLIGLVAAVLGSVFARQALQGL
GTPADVLDDAVAYARVMMWTLPVVLVYVLFTQLLRGVSDTLSPMLALLLSTVVGLALTPAFIRGWIGLPQLGIQSAAIAG
LVGTLTSMAWLSWRLIRKGHPLAPDREFFAALRLDGAILGKVLRIGLPTGVQMIVLSLSELVILALVNQHGSQATAAYGA
VTQIVNYVQFPALSIAITASILGAQAIGAGRLERMGPILRTGLWINVCLTGGLILAGYLLSHWLLGLFLTEDSTRAMAEH
LLHIMLWSLLIFGFQAIIGGIMRASGTVLVPVGVAIICVLGVQLPAAYWLDGQFGLQGVWMAFPIAYLGMLVLQTLYYTR
VWKHQKIERLV
>Mature_491_residues
MNSSSSAFNQTEKPSPLLPPTSRKTSSVISRQSSTRDGSSMQTPAQSPLWKTYLLFLAPMVLSNFLQSMSGTVNSIYIGQ
MLGTQALAAVSGMFPIIFFFIALVIGLGAGAGVLIGQAWGARESHMVKAIAGATLLLGVLIGLVAAVLGSVFARQALQGL
GTPADVLDDAVAYARVMMWTLPVVLVYVLFTQLLRGVSDTLSPMLALLLSTVVGLALTPAFIRGWIGLPQLGIQSAAIAG
LVGTLTSMAWLSWRLIRKGHPLAPDREFFAALRLDGAILGKVLRIGLPTGVQMIVLSLSELVILALVNQHGSQATAAYGA
VTQIVNYVQFPALSIAITASILGAQAIGAGRLERMGPILRTGLWINVCLTGGLILAGYLLSHWLLGLFLTEDSTRAMAEH
LLHIMLWSLLIFGFQAIIGGIMRASGTVLVPVGVAIICVLGVQLPAAYWLDGQFGLQGVWMAFPIAYLGMLVLQTLYYTR
VWKHQKIERLV

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 52332; Mature: 52332

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]