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The map label for this gene is yeiA [H]

Identifier: 77459665

GI number: 77459665

Start: 3927892

End: 3929166

Strand: Direct

Name: yeiA [H]

Synonym: Pfl01_3443

Alternate gene names: 77459665

Gene position: 3927892-3929166 (Clockwise)

Preceding gene: 77459664

Following gene: 77459667

Centisome position: 61.01

GC content: 62.35

Gene sequence:

>1275_bases
ATGGCCGATCTCTCGATAGTCTTCGCCGGTATCAAAGCCCCCAACCCGTTCTGGCTGGCCTCCGCGCCGCCGACCGACAA
GGCCTACAACGTGGTGCGCGCCTTCGAGGCCGGCTGGGGCGGCGTGGTCTGGAAAACCCTGGGTGAAGACCCGGCGGCGG
TCAACGTGTCGTCGCGTTATTCGGCGCATTACGGCGCCAACCGCGAAGTGCTGGGCATCAACAACATCGAACTGATCACC
GACCGCTCGCTGGAAATCAACCTGCGGGAAATCACCCAGGTGAAAAAGGACTGGCCGGATCGCGCGCTGATCGTGTCGCT
GATGGTGCCCTGCGTCGAAGAGTCGTGGAAACACATCCTGCCGTTGGTGGAAGCCACCGGCGCCGACGGCATCGAGCTGA
ATTTCGGCTGCCCCCACGGCATGCCCGAGCGCGGCATGGGCGCGGCGGTCGGTCAGGTGCCGGAGTACGTCGAGCAGGTC
ACGCGCTGGTGCAAGACCTATTGCTCGCTGCCGGTGATCGTCAAACTCACACCGAACATCACCGACATCCGCGTCGCCGC
CCGAGCCGCACACCGGGGCGGCGCCGATGCGGTGTCGCTGATCAACACCATCAACTCGATCACCAGCGTCGACCTCGAAC
ACATGGTCGCCCTGCCCACCGTCGGCAGCAAAAGCACCCACGGCGGTTATTGCGGCTCGGCGGTCAAGCCGATCGCGCTG
AACATGGTCGCGGAAATCGCCCGTGACCCGCAGACCCAGGGCCTGCCGATCTGCGGCATTGGCGGCATTGGCAGCTGGCG
TGACGCGGCGGAGTTCATCGCACTGGGCAGCGGCGCGGTGCAAGTGTGCACGGCGGCGATGCTGCACGGCTTCCGGATTG
TCGATGAGATGAAGGATGGCCTGTCGCGGTGGATGGACAGTCAGGGTTACGCCAGCATTGCCGAGTTTTCCGGGCGCGCG
GTGGGCAACACCACGGACTGGAAGTATTTGGACATCAACTATCAGGTCATCGCGAAGATCGATCAGGAAGCGTGTATCGG
ATGCGGGCGTTGCCACATTGCCTGCGAAGACACTTCACACCAGGCGATCAGCAGTCTGAAACAGGCCGATGGCACGCATA
AATATGAAGTGATCGATGATGAGTGTGTGGGGTGCAATCTGTGCCAGATCACCTGTCCGGTGGCGGACTGCATCGAGATG
GTGCCGATGGAAACGGGCAAGCCGTTTCTGGACTGGAATCATGATCCGAGGAATCCGTATCACGTTGCGGTCTAG

Upstream 100 bases:

>100_bases
CAGCCTCGATCAGGACCTGACCGTGCAAGCGGTGCAACACGGCAAGCGCGCCGCCGAGGCGATCAACGCTCAACTGATGC
TCAACGTGGAGGCTGCGTAA

Downstream 100 bases:

>100_bases
ATCGCCTGTGGATCCGGAAGCCCCCTCACCCTAGCCCTCTCCCAAAGGGAGAGGGAACCGACCGGGGAATATTGATGAAC
TGCACCGACGTGAAAGTTTT

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MADLSIVFAGIKAPNPFWLASAPPTDKAYNVVRAFEAGWGGVVWKTLGEDPAAVNVSSRYSAHYGANREVLGINNIELIT
DRSLEINLREITQVKKDWPDRALIVSLMVPCVEESWKHILPLVEATGADGIELNFGCPHGMPERGMGAAVGQVPEYVEQV
TRWCKTYCSLPVIVKLTPNITDIRVAARAAHRGGADAVSLINTINSITSVDLEHMVALPTVGSKSTHGGYCGSAVKPIAL
NMVAEIARDPQTQGLPICGIGGIGSWRDAAEFIALGSGAVQVCTAAMLHGFRIVDEMKDGLSRWMDSQGYASIAEFSGRA
VGNTTDWKYLDINYQVIAKIDQEACIGCGRCHIACEDTSHQAISSLKQADGTHKYEVIDDECVGCNLCQITCPVADCIEM
VPMETGKPFLDWNHDPRNPYHVAV

Sequences:

>Translated_424_residues
MADLSIVFAGIKAPNPFWLASAPPTDKAYNVVRAFEAGWGGVVWKTLGEDPAAVNVSSRYSAHYGANREVLGINNIELIT
DRSLEINLREITQVKKDWPDRALIVSLMVPCVEESWKHILPLVEATGADGIELNFGCPHGMPERGMGAAVGQVPEYVEQV
TRWCKTYCSLPVIVKLTPNITDIRVAARAAHRGGADAVSLINTINSITSVDLEHMVALPTVGSKSTHGGYCGSAVKPIAL
NMVAEIARDPQTQGLPICGIGGIGSWRDAAEFIALGSGAVQVCTAAMLHGFRIVDEMKDGLSRWMDSQGYASIAEFSGRA
VGNTTDWKYLDINYQVIAKIDQEACIGCGRCHIACEDTSHQAISSLKQADGTHKYEVIDDECVGCNLCQITCPVADCIEM
VPMETGKPFLDWNHDPRNPYHVAV
>Mature_423_residues
ADLSIVFAGIKAPNPFWLASAPPTDKAYNVVRAFEAGWGGVVWKTLGEDPAAVNVSSRYSAHYGANREVLGINNIELITD
RSLEINLREITQVKKDWPDRALIVSLMVPCVEESWKHILPLVEATGADGIELNFGCPHGMPERGMGAAVGQVPEYVEQVT
RWCKTYCSLPVIVKLTPNITDIRVAARAAHRGGADAVSLINTINSITSVDLEHMVALPTVGSKSTHGGYCGSAVKPIALN
MVAEIARDPQTQGLPICGIGGIGSWRDAAEFIALGSGAVQVCTAAMLHGFRIVDEMKDGLSRWMDSQGYASIAEFSGRAV
GNTTDWKYLDINYQVIAKIDQEACIGCGRCHIACEDTSHQAISSLKQADGTHKYEVIDDECVGCNLCQITCPVADCIEMV
PMETGKPFLDWNHDPRNPYHVAV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=439, Percent_Identity=32.8018223234624, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI87082059, Length=398, Percent_Identity=43.21608040201, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71984108, Length=327, Percent_Identity=39.7553516819572, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322633, Length=249, Percent_Identity=27.3092369477912, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24640763, Length=301, Percent_Identity=42.8571428571429, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI18858217, Length=301, Percent_Identity=42.8571428571429, Blast_Score=234, Evalue=7e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 45840; Mature: 45709

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLSIVFAGIKAPNPFWLASAPPTDKAYNVVRAFEAGWGGVVWKTLGEDPAAVNVSSRY
CCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHCCCCCEEHHCCCCCCCEEEECCCC
SAHYGANREVLGINNIELITDRSLEINLREITQVKKDWPDRALIVSLMVPCVEESWKHIL
CCCCCCCCEEEECCCEEEEECCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
PLVEATGADGIELNFGCPHGMPERGMGAAVGQVPEYVEQVTRWCKTYCSLPVIVKLTPNI
HHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
TDIRVAARAAHRGGADAVSLINTINSITSVDLEHMVALPTVGSKSTHGGYCGSAVKPIAL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHEEECCCCCCCCCCCCCCCCCCHHHH
NMVAEIARDPQTQGLPICGIGGIGSWRDAAEFIALGSGAVQVCTAAMLHGFRIVDEMKDG
HHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LSRWMDSQGYASIAEFSGRAVGNTTDWKYLDINYQVIAKIDQEACIGCGRCHIACEDTSH
HHHHHCCCCCHHHHHHCCCCCCCCCCCEEEECCCEEEEEECHHHHCCCCEEEEEECCCHH
QAISSLKQADGTHKYEVIDDECVGCNLCQITCPVADCIEMVPMETGKPFLDWNHDPRNPY
HHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCE
HVAV
EECC
>Mature Secondary Structure 
ADLSIVFAGIKAPNPFWLASAPPTDKAYNVVRAFEAGWGGVVWKTLGEDPAAVNVSSRY
CCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHCCCCCEEHHCCCCCCCEEEECCCC
SAHYGANREVLGINNIELITDRSLEINLREITQVKKDWPDRALIVSLMVPCVEESWKHIL
CCCCCCCCEEEECCCEEEEECCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
PLVEATGADGIELNFGCPHGMPERGMGAAVGQVPEYVEQVTRWCKTYCSLPVIVKLTPNI
HHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
TDIRVAARAAHRGGADAVSLINTINSITSVDLEHMVALPTVGSKSTHGGYCGSAVKPIAL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHEEECCCCCCCCCCCCCCCCCCHHHH
NMVAEIARDPQTQGLPICGIGGIGSWRDAAEFIALGSGAVQVCTAAMLHGFRIVDEMKDG
HHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LSRWMDSQGYASIAEFSGRAVGNTTDWKYLDINYQVIAKIDQEACIGCGRCHIACEDTSH
HHHHHCCCCCHHHHHHCCCCCCCCCCCEEEECCCEEEEEECHHHHCCCCEEEEEECCCHH
QAISSLKQADGTHKYEVIDDECVGCNLCQITCPVADCIEMVPMETGKPFLDWNHDPRNPY
HHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCE
HVAV
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]