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The map label for this gene is map [H]

Identifier: 77459467

GI number: 77459467

Start: 3726036

End: 3726827

Strand: Reverse

Name: map [H]

Synonym: Pfl01_3245

Alternate gene names: 77459467

Gene position: 3726827-3726036 (Counterclockwise)

Preceding gene: 77459468

Following gene: 77459461

Centisome position: 57.88

GC content: 58.71

Gene sequence:

>792_bases
ATGAGAAATCCGATCAAGATCAACACCCAGGCCGAAATCGCCCAATCCCGAGAGGCCGGCAGACTGGCCGCCGAGGTGCT
GGCAATGCTGGTGCCGCACGTCAAGGCTGGCGTCACCACCGACCAGCTCGACCAGTTGTGCAACGACTACATCGTCAATG
TGCAGAAGGCGATTCCGGCCAACGTCGGTTATCACGGCTTTCCGAAAACCGTTTGTGCGTCAGTCAACGAAGTGGTCTGC
CACGGCATTCCTTCGAAGCGCGTGTTGAAGGATGGCGACATCGTCAACCTCGACATCGCGGTGATCAAGAACGGCTGGTT
CGGCGATACCAGCCGCATGTACGTGGTCGGTGAGCCGACGCCCGAGGCTCGGCACCTGATCAAGACAACCTACGACGCGA
TGTGCGCGGGCATCCGCGTCGTCCGACCGGGCGCCACGTTGGGTGACATCGGTCATGCGATCCAGACGTTGGCGGAAAAA
GAAGGGTTCAGCGTGGTGCGCGAGTATTGCGGGCACGGGATTGGCAAGGTTTATCACGATGAGCCGCAGGTGCTGCATTA
CGGTTATCCGGAGCAGGGCTTGAAGCTGAAGGCGGGGATGATTTTCACCATCGAGCCGATGCTCAATGCCGGCAAGCGGC
ATGTGAAGAGTCTGGCGGATGGCTGGACGGTGGTGACCAAGGATCATTCATTGTCGGCGCAGTGGGAGCACATGATTGCG
GTGACTGACGACGGGTTTGAAGTGTTGACGGCTTGGCCGGATGAGATTGAGGGCTTTAAAGCCATTGTCTGA

Upstream 100 bases:

>100_bases
TGCTGATTCGCGCCGAGCAGTCGGGCGGTCTGGATCTGCAGCAGGTCTGCGCACTGGCGGATGCCGCGCAGAACGCCTCG
GTCAAAGAGGCGGCCAAGGC

Downstream 100 bases:

>100_bases
AAAAATGGCCACCGCAACCCGACGTTGCGGTGGCCAGAAGTGACACGCAGTCTCTATTGAATCAGTGCGCGCCGGCGGCT
TTGTTCAAATCACTCTCGGC

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MRNPIKINTQAEIAQSREAGRLAAEVLAMLVPHVKAGVTTDQLDQLCNDYIVNVQKAIPANVGYHGFPKTVCASVNEVVC
HGIPSKRVLKDGDIVNLDIAVIKNGWFGDTSRMYVVGEPTPEARHLIKTTYDAMCAGIRVVRPGATLGDIGHAIQTLAEK
EGFSVVREYCGHGIGKVYHDEPQVLHYGYPEQGLKLKAGMIFTIEPMLNAGKRHVKSLADGWTVVTKDHSLSAQWEHMIA
VTDDGFEVLTAWPDEIEGFKAIV

Sequences:

>Translated_263_residues
MRNPIKINTQAEIAQSREAGRLAAEVLAMLVPHVKAGVTTDQLDQLCNDYIVNVQKAIPANVGYHGFPKTVCASVNEVVC
HGIPSKRVLKDGDIVNLDIAVIKNGWFGDTSRMYVVGEPTPEARHLIKTTYDAMCAGIRVVRPGATLGDIGHAIQTLAEK
EGFSVVREYCGHGIGKVYHDEPQVLHYGYPEQGLKLKAGMIFTIEPMLNAGKRHVKSLADGWTVVTKDHSLSAQWEHMIA
VTDDGFEVLTAWPDEIEGFKAIV
>Mature_263_residues
MRNPIKINTQAEIAQSREAGRLAAEVLAMLVPHVKAGVTTDQLDQLCNDYIVNVQKAIPANVGYHGFPKTVCASVNEVVC
HGIPSKRVLKDGDIVNLDIAVIKNGWFGDTSRMYVVGEPTPEARHLIKTTYDAMCAGIRVVRPGATLGDIGHAIQTLAEK
EGFSVVREYCGHGIGKVYHDEPQVLHYGYPEQGLKLKAGMIFTIEPMLNAGKRHVKSLADGWTVVTKDHSLSAQWEHMIA
VTDDGFEVLTAWPDEIEGFKAIV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=246, Percent_Identity=43.9024390243902, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI40385867, Length=253, Percent_Identity=37.9446640316205, Blast_Score=190, Evalue=1e-48,
Organism=Escherichia coli, GI1786364, Length=252, Percent_Identity=58.7301587301587, Blast_Score=316, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=41.2955465587045, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6323273, Length=250, Percent_Identity=41.6, Blast_Score=209, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=41.4634146341463, Blast_Score=203, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=39.1836734693878, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28782; Mature: 28782

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPIKINTQAEIAQSREAGRLAAEVLAMLVPHVKAGVTTDQLDQLCNDYIVNVQKAIPA
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
NVGYHGFPKTVCASVNEVVCHGIPSKRVLKDGDIVNLDIAVIKNGWFGDTSRMYVVGEPT
CCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEEEEECCCCCCCCEEEEEECCC
PEARHLIKTTYDAMCAGIRVVRPGATLGDIGHAIQTLAEKEGFSVVREYCGHGIGKVYHD
HHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEECC
EPQVLHYGYPEQGLKLKAGMIFTIEPMLNAGKRHVKSLADGWTVVTKDHSLSAQWEHMIA
CCCEEECCCCCCCCEEECCEEEEEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEE
VTDDGFEVLTAWPDEIEGFKAIV
EECCCCEEEECCCHHHCCCCCCC
>Mature Secondary Structure
MRNPIKINTQAEIAQSREAGRLAAEVLAMLVPHVKAGVTTDQLDQLCNDYIVNVQKAIPA
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
NVGYHGFPKTVCASVNEVVCHGIPSKRVLKDGDIVNLDIAVIKNGWFGDTSRMYVVGEPT
CCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEEEEECCCCCCCCEEEEEECCC
PEARHLIKTTYDAMCAGIRVVRPGATLGDIGHAIQTLAEKEGFSVVREYCGHGIGKVYHD
HHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEECC
EPQVLHYGYPEQGLKLKAGMIFTIEPMLNAGKRHVKSLADGWTVVTKDHSLSAQWEHMIA
CCCEEECCCCCCCCEEECCEEEEEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEE
VTDDGFEVLTAWPDEIEGFKAIV
EECCCCEEEECCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]