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The map label for this gene is acrE [H]

Identifier: 77458983

GI number: 77458983

Start: 3183639

End: 3184796

Strand: Reverse

Name: acrE [H]

Synonym: Pfl01_2758

Alternate gene names: 77458983

Gene position: 3184796-3183639 (Counterclockwise)

Preceding gene: 77458988

Following gene: 77458982

Centisome position: 49.47

GC content: 64.08

Gene sequence:

>1158_bases
ATGGGCAATTTGCGTGCAGTAGGGATGGCGGGGTCGTTGGCAGTTGCCATTGCGCTGGCCGGGTGTGGACCAGCGAATGA
ACAGGCGGATATGGCTGAAGTGGCGCGTCCGGTAGAGGTGCTTGCAGTGAAGACTGAGCCACTGGCACTGACGTCAGAGC
TGCCGGGGCGGGTGGAACCGATGCGCGTTGCGGAAGTGCGTGCGCGGGTGCCGGGCATCGTGATGCAGAAGCGTTTTGAA
GAGGGCGCTGATGTCAAAGCCGGCGACCTGCTGTTCCAGATCGACCCGGCACCGCTGAAAGCAGCCTTGTCTCGCGCCGA
GGGTGAACTGGCCCGTGCGCAATCCGTTGCCCTTGAGGCTCAGGCGCGGGTCAAGCGTTATGAACCGTTGGTGAAGATCG
AAGCGGTCAGCCAGCAGGACTACGACAGCGCCATGGCCGATTTGCGCAGTGCTCAGGCGGCCACGCGTTCAGCCCAGGCT
GATCTGCAAAGCGCCCGGTTGAACCTGGGTTATGCCTCGGTGACCGCGCCGATTTCCGGGCGTGTCGGCCGCGCACTGGT
CACAGAAGGCGCCTTGGTCGGTCAGGGTGACGCAACGTTGATGGCGCGGATTCAGCAGCTGGATCCGGTGTATGTCGACT
TCACCCAATCGGCCGCTGACGCGCTGCGTCTGCGCGAATCACTCAAGGGCGGCAAACTCTCCGCCGACGACAACAAGGCG
TTGTCGATTCGTGTCGACGGCACTGCTTACGAGCGTCAGGGCGCCCTGATGTTTACCGATGTCGCCGTTGACCGTGGCAC
CGGCCAGGTGTCGTTGCGTGGCAAGTTCGCCAACAGTGACGGCGTGTTGCTGCCGGGCATGTTCGTGCGCGTGCGCACAC
CTCAAGGCACCGACAATCAGGCCATTCTCGTGCCACAGCGCTCGGTGCAGCGCGGCAGCGATGGCGGGGCGCAAGTCATG
GTGGTCGGCGCCGACGGCCGCGCCGAAGCGCGCACTGTGGTGACCGGTTCCATGCAGGGTTCGCGCTGGCAGATCAGTGA
AGGCCTGAAGGCTGGCGATCAGGTGATTGTCAACGGCCTGAGTGGCCTGCAGGCAGGCGCCAAGGTCGCGCCTGCTCAGC
CTCAAGCCCAGGCGCTGACGCCTGAGTCGAAACAGTAA

Upstream 100 bases:

>100_bases
GTAATGTAAGATTCATATATTTCTCACATGAGACATTATTGACTCATTAGGATTTGAAAAGTAGCATTCGCACCAAATTC
AATCAAGCCTTGGGTGAGTT

Downstream 100 bases:

>100_bases
GGGCGCCGTCGCCGCGAGGATATTCCGATGTCTCAGTTTTTCATCAAACGCCCGAACTTCGCCTGGGTGGTGGCGTTGTT
CATCTCTCTGGCCGGTCTGC

Product: secretion protein HlyD

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MGNLRAVGMAGSLAVAIALAGCGPANEQADMAEVARPVEVLAVKTEPLALTSELPGRVEPMRVAEVRARVPGIVMQKRFE
EGADVKAGDLLFQIDPAPLKAALSRAEGELARAQSVALEAQARVKRYEPLVKIEAVSQQDYDSAMADLRSAQAATRSAQA
DLQSARLNLGYASVTAPISGRVGRALVTEGALVGQGDATLMARIQQLDPVYVDFTQSAADALRLRESLKGGKLSADDNKA
LSIRVDGTAYERQGALMFTDVAVDRGTGQVSLRGKFANSDGVLLPGMFVRVRTPQGTDNQAILVPQRSVQRGSDGGAQVM
VVGADGRAEARTVVTGSMQGSRWQISEGLKAGDQVIVNGLSGLQAGAKVAPAQPQAQALTPESKQ

Sequences:

>Translated_385_residues
MGNLRAVGMAGSLAVAIALAGCGPANEQADMAEVARPVEVLAVKTEPLALTSELPGRVEPMRVAEVRARVPGIVMQKRFE
EGADVKAGDLLFQIDPAPLKAALSRAEGELARAQSVALEAQARVKRYEPLVKIEAVSQQDYDSAMADLRSAQAATRSAQA
DLQSARLNLGYASVTAPISGRVGRALVTEGALVGQGDATLMARIQQLDPVYVDFTQSAADALRLRESLKGGKLSADDNKA
LSIRVDGTAYERQGALMFTDVAVDRGTGQVSLRGKFANSDGVLLPGMFVRVRTPQGTDNQAILVPQRSVQRGSDGGAQVM
VVGADGRAEARTVVTGSMQGSRWQISEGLKAGDQVIVNGLSGLQAGAKVAPAQPQAQALTPESKQ
>Mature_384_residues
GNLRAVGMAGSLAVAIALAGCGPANEQADMAEVARPVEVLAVKTEPLALTSELPGRVEPMRVAEVRARVPGIVMQKRFEE
GADVKAGDLLFQIDPAPLKAALSRAEGELARAQSVALEAQARVKRYEPLVKIEAVSQQDYDSAMADLRSAQAATRSAQAD
LQSARLNLGYASVTAPISGRVGRALVTEGALVGQGDATLMARIQQLDPVYVDFTQSAADALRLRESLKGGKLSADDNKAL
SIRVDGTAYERQGALMFTDVAVDRGTGQVSLRGKFANSDGVLLPGMFVRVRTPQGTDNQAILVPQRSVQRGSDGGAQVMV
VGADGRAEARTVVTGSMQGSRWQISEGLKAGDQVIVNGLSGLQAGAKVAPAQPQAQALTPESKQ

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=361, Percent_Identity=48.7534626038781, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1786668, Length=376, Percent_Identity=46.8085106382979, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1789929, Length=378, Percent_Identity=38.8888888888889, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082036, Length=335, Percent_Identity=31.9402985074627, Blast_Score=168, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40263; Mature: 40132

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLRAVGMAGSLAVAIALAGCGPANEQADMAEVARPVEVLAVKTEPLALTSELPGRVEP
CCCEEEECCCCHHEEEEEEECCCCCCCCHHHHHHCCCEEEEEEECCCEEECCCCCCCCCC
MRVAEVRARVPGIVMQKRFEEGADVKAGDLLFQIDPAPLKAALSRAEGELARAQSVALEA
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QARVKRYEPLVKIEAVSQQDYDSAMADLRSAQAATRSAQADLQSARLNLGYASVTAPISG
HHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECCCCC
RVGRALVTEGALVGQGDATLMARIQQLDPVYVDFTQSAADALRLRESLKGGKLSADDNKA
CCCHHHHCCCCEECCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCE
LSIRVDGTAYERQGALMFTDVAVDRGTGQVSLRGKFANSDGVLLPGMFVRVRTPQGTDNQ
EEEEECCCEECCCCCEEEEEEEEECCCCEEEEEEEECCCCCEECCCEEEEEECCCCCCCC
AILVPQRSVQRGSDGGAQVMVVGADGRAEARTVVTGSMQGSRWQISEGLKAGDQVIVNGL
EEEECCHHHCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEHHHCCCCCCCEEEECH
SGLQAGAKVAPAQPQAQALTPESKQ
HHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GNLRAVGMAGSLAVAIALAGCGPANEQADMAEVARPVEVLAVKTEPLALTSELPGRVEP
CCEEEECCCCHHEEEEEEECCCCCCCCHHHHHHCCCEEEEEEECCCEEECCCCCCCCCC
MRVAEVRARVPGIVMQKRFEEGADVKAGDLLFQIDPAPLKAALSRAEGELARAQSVALEA
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QARVKRYEPLVKIEAVSQQDYDSAMADLRSAQAATRSAQADLQSARLNLGYASVTAPISG
HHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECCCCC
RVGRALVTEGALVGQGDATLMARIQQLDPVYVDFTQSAADALRLRESLKGGKLSADDNKA
CCCHHHHCCCCEECCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCE
LSIRVDGTAYERQGALMFTDVAVDRGTGQVSLRGKFANSDGVLLPGMFVRVRTPQGTDNQ
EEEEECCCEECCCCCEEEEEEEEECCCCEEEEEEEECCCCCEECCCEEEEEECCCCCCCC
AILVPQRSVQRGSDGGAQVMVVGADGRAEARTVVTGSMQGSRWQISEGLKAGDQVIVNGL
EEEECCHHHCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEHHHCCCCCCCEEEECH
SGLQAGAKVAPAQPQAQALTPESKQ
HHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]