Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 77458972

GI number: 77458972

Start: 3165875

End: 3167158

Strand: Reverse

Name: acdA [H]

Synonym: Pfl01_2747

Alternate gene names: 77458972

Gene position: 3167158-3165875 (Counterclockwise)

Preceding gene: 77458973

Following gene: 77458971

Centisome position: 49.19

GC content: 61.29

Gene sequence:

>1284_bases
ATGATCTCGCTCAAGTCGACACTTACCCTGCCAGCCGCCGGACTCTCCGGATTCGAAACACCGCTGACAGAAGAGGAGGC
TGCAATACAGGCCTCCGTCCACCGCTTCGCCAAAGAGGTGTTACGCCCGCTGGGTCGAGAGCTGGACCGGATGACCCCGG
AAGAAGTCGTTGCCCCGGGCTCGCCTTACTATTCGTTGTTCGGCGAATTCGCCAAGCTCGGTCTTGACCCGGCACTGTTG
GCGCAGTTACCGCCGGAAATGGCAGTGCGGATCGAATCTCTGATAGGCGAAGAACTCGGCTGGGGCGATGCAGGCCTGGC
TGTCTCGCTGGGTTGCGCCGACTTCCCTCTGCAAATGGCCATCGCCGCTGGCAATGCCGAGTTGGTCGAACTCTGCCAAG
GCCGGATCGGCTGCTGGATGGCCACTCAACCTGATCGTGGCAGCGACAACCAGATCTTCGACATGGCGCGAGACTGGCCG
GCAGGTAAGCTCGGCAATATCGGCAATCTGACCGCTAAAGTGGTCGGCGATGAAGTCATCCTCAATGGCCAAAGCTCCGC
GTGGGTCTCCAACGGAGCCATTGCACAGGTTGCACTGGGCTTGATGTGCGCTGATTACGGCGACGGTTTCTACGATGAGA
ACGGCCGGCCGCACGGTATTGCGCTGATTATCCCCCTCGACCTCAAAGGTGTGTCCAAAGGCAAGCCCCTGGACAAGATC
GGGCAGCGTTCCTTGCCCCAAGGCGAAATCTACTTCGACAGTGTACGAGTGCCACGTCGCTTCGCTATTGCCGAGCGCGA
CCAGTACTACGGTGCTGTCAGCTCCTCCTGGTCCTTCGCCGGCACCCACATGAGTCAGGTGTTCACCGGTGTCGCACGTG
CCGCCTTCGAGATGGCGCTGCAGTACTGCCATGAGCGCCGCCAGGGCGGTCATCCATTGATCGATCACCAGATGACCCGT
CTGCGCCTCGGCGAAATGTTGCGTCGGGTCGAGGCAGCGCGTGCGGTTGCCCGACGTTCGTTGAGCTTCGCGCGCCTGTC
GCCGCAAACCCACCCGTACGCCACAGCCTCCGCCAAGGTCACGGTGACCGAAGAGGCAATGGCCGTTGTGCAAGAGGCTT
TCCGCCTGTTCGGCGGCAATGGCACCACGCGCGAATACCCGATCGAAAAACTGCTGCGCGACACCCAGTCGTCATTGATC
GAGGACGGCGAAAACCGGGTCCTGACCATGCGACTGGGGCTGCTTGCCCAGCAGCTGTATGCCGAAGGCTGGGCGAACAA
CTGA

Upstream 100 bases:

>100_bases
TGTTGCGTTAAATAATTTTGCTTGTTAGAGTCGATTGCAAATAACAAGACGCAGAACGCTGCAAAGCGCAGCGACCTGCG
ATTTCGATGGAGGTACTCTG

Downstream 100 bases:

>100_bases
CTCTGCAGATTCACCCGACATCACTCATCCAAAAACAACAAATGAGGTAAATCCCGATGGCCAAATATCCAGTAGTTGTC
TACGGCGCCAGTGGTTACAC

Product: acyl-CoA dehydrogenase-like protein

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MISLKSTLTLPAAGLSGFETPLTEEEAAIQASVHRFAKEVLRPLGRELDRMTPEEVVAPGSPYYSLFGEFAKLGLDPALL
AQLPPEMAVRIESLIGEELGWGDAGLAVSLGCADFPLQMAIAAGNAELVELCQGRIGCWMATQPDRGSDNQIFDMARDWP
AGKLGNIGNLTAKVVGDEVILNGQSSAWVSNGAIAQVALGLMCADYGDGFYDENGRPHGIALIIPLDLKGVSKGKPLDKI
GQRSLPQGEIYFDSVRVPRRFAIAERDQYYGAVSSSWSFAGTHMSQVFTGVARAAFEMALQYCHERRQGGHPLIDHQMTR
LRLGEMLRRVEAARAVARRSLSFARLSPQTHPYATASAKVTVTEEAMAVVQEAFRLFGGNGTTREYPIEKLLRDTQSSLI
EDGENRVLTMRLGLLAQQLYAEGWANN

Sequences:

>Translated_427_residues
MISLKSTLTLPAAGLSGFETPLTEEEAAIQASVHRFAKEVLRPLGRELDRMTPEEVVAPGSPYYSLFGEFAKLGLDPALL
AQLPPEMAVRIESLIGEELGWGDAGLAVSLGCADFPLQMAIAAGNAELVELCQGRIGCWMATQPDRGSDNQIFDMARDWP
AGKLGNIGNLTAKVVGDEVILNGQSSAWVSNGAIAQVALGLMCADYGDGFYDENGRPHGIALIIPLDLKGVSKGKPLDKI
GQRSLPQGEIYFDSVRVPRRFAIAERDQYYGAVSSSWSFAGTHMSQVFTGVARAAFEMALQYCHERRQGGHPLIDHQMTR
LRLGEMLRRVEAARAVARRSLSFARLSPQTHPYATASAKVTVTEEAMAVVQEAFRLFGGNGTTREYPIEKLLRDTQSSLI
EDGENRVLTMRLGLLAQQLYAEGWANN
>Mature_427_residues
MISLKSTLTLPAAGLSGFETPLTEEEAAIQASVHRFAKEVLRPLGRELDRMTPEEVVAPGSPYYSLFGEFAKLGLDPALL
AQLPPEMAVRIESLIGEELGWGDAGLAVSLGCADFPLQMAIAAGNAELVELCQGRIGCWMATQPDRGSDNQIFDMARDWP
AGKLGNIGNLTAKVVGDEVILNGQSSAWVSNGAIAQVALGLMCADYGDGFYDENGRPHGIALIIPLDLKGVSKGKPLDKI
GQRSLPQGEIYFDSVRVPRRFAIAERDQYYGAVSSSWSFAGTHMSQVFTGVARAAFEMALQYCHERRQGGHPLIDHQMTR
LRLGEMLRRVEAARAVARRSLSFARLSPQTHPYATASAKVTVTEEAMAVVQEAFRLFGGNGTTREYPIEKLLRDTQSSLI
EDGENRVLTMRLGLLAQQLYAEGWANN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=402, Percent_Identity=26.1194029850746, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI187960098, Length=402, Percent_Identity=26.1194029850746, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4557233, Length=276, Percent_Identity=25.7246376811594, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI21361497, Length=245, Percent_Identity=28.1632653061224, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4501859, Length=411, Percent_Identity=25.0608272506083, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI7656849, Length=253, Percent_Identity=26.8774703557312, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI226958412, Length=402, Percent_Identity=22.8855721393035, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501857, Length=291, Percent_Identity=25.085910652921, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI226958414, Length=330, Percent_Identity=23.6363636363636, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI4557235, Length=393, Percent_Identity=23.9185750636132, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI76496475, Length=393, Percent_Identity=23.9185750636132, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87081958, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508101, Length=412, Percent_Identity=25.7281553398058, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17570075, Length=422, Percent_Identity=25.1184834123223, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17506239, Length=422, Percent_Identity=25.5924170616114, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17534899, Length=414, Percent_Identity=23.9130434782609, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17569725, Length=423, Percent_Identity=25.7683215130024, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17533517, Length=288, Percent_Identity=23.6111111111111, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538396, Length=414, Percent_Identity=22.9468599033816, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17551932, Length=239, Percent_Identity=28.0334728033473, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17505929, Length=248, Percent_Identity=28.2258064516129, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71985184, Length=368, Percent_Identity=23.6413043478261, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71990804, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534353, Length=285, Percent_Identity=23.5087719298246, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24660351, Length=417, Percent_Identity=24.4604316546763, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21355753, Length=417, Percent_Identity=24.4604316546763, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24666513, Length=430, Percent_Identity=25.3488372093023, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24646207, Length=402, Percent_Identity=25.8706467661692, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356377, Length=276, Percent_Identity=26.0869565217391, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281363737, Length=243, Percent_Identity=23.8683127572016, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 46443; Mature: 46443

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLKSTLTLPAAGLSGFETPLTEEEAAIQASVHRFAKEVLRPLGRELDRMTPEEVVAPG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
SPYYSLFGEFAKLGLDPALLAQLPPEMAVRIESLIGEELGWGDAGLAVSLGCADFPLQMA
CCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEE
IAAGNAELVELCQGRIGCWMATQPDRGSDNQIFDMARDWPAGKLGNIGNLTAKVVGDEVI
EECCCHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHEECCEEE
LNGQSSAWVSNGAIAQVALGLMCADYGDGFYDENGRPHGIALIIPLDLKGVSKGKPLDKI
ECCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHH
GQRSLPQGEIYFDSVRVPRRFAIAERDQYYGAVSSSWSFAGTHMSQVFTGVARAAFEMAL
HCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QYCHERRQGGHPLIDHQMTRLRLGEMLRRVEAARAVARRSLSFARLSPQTHPYATASAKV
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
TVTEEAMAVVQEAFRLFGGNGTTREYPIEKLLRDTQSSLIEDGENRVLTMRLGLLAQQLY
EEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
AEGWANN
HHCCCCC
>Mature Secondary Structure
MISLKSTLTLPAAGLSGFETPLTEEEAAIQASVHRFAKEVLRPLGRELDRMTPEEVVAPG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
SPYYSLFGEFAKLGLDPALLAQLPPEMAVRIESLIGEELGWGDAGLAVSLGCADFPLQMA
CCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEE
IAAGNAELVELCQGRIGCWMATQPDRGSDNQIFDMARDWPAGKLGNIGNLTAKVVGDEVI
EECCCHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHEECCEEE
LNGQSSAWVSNGAIAQVALGLMCADYGDGFYDENGRPHGIALIIPLDLKGVSKGKPLDKI
ECCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHH
GQRSLPQGEIYFDSVRVPRRFAIAERDQYYGAVSSSWSFAGTHMSQVFTGVARAAFEMAL
HCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QYCHERRQGGHPLIDHQMTRLRLGEMLRRVEAARAVARRSLSFARLSPQTHPYATASAKV
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
TVTEEAMAVVQEAFRLFGGNGTTREYPIEKLLRDTQSSLIEDGENRVLTMRLGLLAQQLY
EEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
AEGWANN
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]