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The map label for this gene is yfcY [C]

Identifier: 77458969

GI number: 77458969

Start: 3161863

End: 3163101

Strand: Reverse

Name: yfcY [C]

Synonym: Pfl01_2744

Alternate gene names: 77458969

Gene position: 3163101-3161863 (Counterclockwise)

Preceding gene: 77458970

Following gene: 77458968

Centisome position: 49.13

GC content: 60.53

Gene sequence:

>1239_bases
ATGGAACCTATTTACATCGCCGGCATTGCCATGACCGAGTTCGGTCGCCACCTGGAACGCAGTCTCCAGGATTTAGCGCT
GGAAGCTTTGCAGGGCGCACTCGCCGACTCCGGCGCCTTGCGCGCTGATATCGGTGCGGTGTTCTACGCCGGCATCACCA
ACGGTCATCTGCAAGGACAACTGTCGATTCCCGGGCAGGTGCTGTGCAGCAAGATCGGCCTCGAAGGGGTGCCGGTGTAC
AACGTCGAAAACGCCTGCGCCTCGGGCAGTACAGCGGTTCATCTGGCAGTGCAGAGCTTGCGCTCAGGGGCTACCGACGT
GGCCCTGGCGTTGGGCGCGGAGAAAATGAACGTGCCGGACAAGTCGCGGGCACTGGCCCTGTTCGAAACCGGTTGGGACG
TTTCCACTGCCGAAGAGAACTACGCGACGCTGGTGAAAATGGGGGAGGGCATCATTGTTCCGCCAGGCTCGGAATCTGAT
CGTCCGTACAGTAAATTCATGGCCATTTATGCTGCCATGTGTCGCTGGCATATGAAGACCTATGGCACCACTCAACGGCA
GATTGCGGCGGTGTGTGCCAAGAACCATCAACACTCGGTGCACAACCCCTATTCGCAATTTCGCAAGACCTTCAGCATCG
AAGAAGTTCTGGCGGCGCCTCCAATTACCTATCCGATCACATTGCCCATGTGCGCGCCGCTGTCCGACGGTGCGGCCGCC
GCGATCCTTTGCACCGAGGCGGGACTGAAACGCATTGGTGCCGATCCAAAACGTTGTGTGCGAATCGCCGCCAGCGTGAT
CCGCAGCTTCACCCTGCGCGGGCTCGACGAGCCGCACAAGCACGTCAGCCTGTTGGCGGCGCGTGAAGCCTACGAAATCG
CCGGCCTCGGCCCGCAGGACATGCACGTGGCCGAGGTACACGACGCCTCGGCAATGGGGGAAATCATCCAGTCGGAAAAT
CTCGGACTTGCACCGCTGGGAGAGGGTGGGGTTTGTGCAGAACGGGGAGATTTCACTCTAGGTGGCCGTCTTCCGATCAA
TACCTCCGGCGGCCTGGAATCCAAAGGTCATCCACTTGGCGCGACGGGGATCGGGCAGTTGTACGAGTTGGTCACCCAAT
TGCGCGGGGAGGCCGGGCCGCGTCAAGTCCACGGCGCGCGGCATGCCATCCAGGAAAACGGTGGCGGTCTTCAAGGTGTC
GAGGAAGCAGCAGTCGCTATTCACATCCTGAGTCGATAG

Upstream 100 bases:

>100_bases
GATGCATTGCCGCGCAGCCCGGTCGGCAAGGTGCTGAAGAAAGATCTGCGTGCCCATTACTGGCAAAACGTTGACCGGCG
TATCTGAGGGGAACGATCTG

Downstream 100 bases:

>100_bases
GAGCGCATCACATGTCCATGGCCTATCAAGCACAAGAGTTGGAACGCCATTTTGCAGGCGGACATTTCCGTCGGTTGGGT
GGCTGGGTCGAAAGTCCGGT

Product: thiolase

Products: CoA; oxoacyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MEPIYIAGIAMTEFGRHLERSLQDLALEALQGALADSGALRADIGAVFYAGITNGHLQGQLSIPGQVLCSKIGLEGVPVY
NVENACASGSTAVHLAVQSLRSGATDVALALGAEKMNVPDKSRALALFETGWDVSTAEENYATLVKMGEGIIVPPGSESD
RPYSKFMAIYAAMCRWHMKTYGTTQRQIAAVCAKNHQHSVHNPYSQFRKTFSIEEVLAAPPITYPITLPMCAPLSDGAAA
AILCTEAGLKRIGADPKRCVRIAASVIRSFTLRGLDEPHKHVSLLAAREAYEIAGLGPQDMHVAEVHDASAMGEIIQSEN
LGLAPLGEGGVCAERGDFTLGGRLPINTSGGLESKGHPLGATGIGQLYELVTQLRGEAGPRQVHGARHAIQENGGGLQGV
EEAAVAIHILSR

Sequences:

>Translated_412_residues
MEPIYIAGIAMTEFGRHLERSLQDLALEALQGALADSGALRADIGAVFYAGITNGHLQGQLSIPGQVLCSKIGLEGVPVY
NVENACASGSTAVHLAVQSLRSGATDVALALGAEKMNVPDKSRALALFETGWDVSTAEENYATLVKMGEGIIVPPGSESD
RPYSKFMAIYAAMCRWHMKTYGTTQRQIAAVCAKNHQHSVHNPYSQFRKTFSIEEVLAAPPITYPITLPMCAPLSDGAAA
AILCTEAGLKRIGADPKRCVRIAASVIRSFTLRGLDEPHKHVSLLAAREAYEIAGLGPQDMHVAEVHDASAMGEIIQSEN
LGLAPLGEGGVCAERGDFTLGGRLPINTSGGLESKGHPLGATGIGQLYELVTQLRGEAGPRQVHGARHAIQENGGGLQGV
EEAAVAIHILSR
>Mature_412_residues
MEPIYIAGIAMTEFGRHLERSLQDLALEALQGALADSGALRADIGAVFYAGITNGHLQGQLSIPGQVLCSKIGLEGVPVY
NVENACASGSTAVHLAVQSLRSGATDVALALGAEKMNVPDKSRALALFETGWDVSTAEENYATLVKMGEGIIVPPGSESD
RPYSKFMAIYAAMCRWHMKTYGTTQRQIAAVCAKNHQHSVHNPYSQFRKTFSIEEVLAAPPITYPITLPMCAPLSDGAAA
AILCTEAGLKRIGADPKRCVRIAASVIRSFTLRGLDEPHKHVSLLAAREAYEIAGLGPQDMHVAEVHDASAMGEIIQSEN
LGLAPLGEGGVCAERGDFTLGGRLPINTSGGLESKGHPLGATGIGQLYELVTQLRGEAGPRQVHGARHAIQENGGGLQGV
EEAAVAIHILSR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=405, Percent_Identity=38.0246913580247, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI302344760, Length=405, Percent_Identity=36.0493827160494, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI302344767, Length=332, Percent_Identity=40.0602409638554, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI302344762, Length=405, Percent_Identity=34.320987654321, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI55956775, Length=373, Percent_Identity=32.171581769437, Blast_Score=145, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17537653, Length=414, Percent_Identity=35.5072463768116, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24585051, Length=402, Percent_Identity=37.0646766169154, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI19921506, Length=402, Percent_Identity=36.318407960199, Blast_Score=222, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16 [C]

Molecular weight: Translated: 43456; Mature: 43456

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIYIAGIAMTEFGRHLERSLQDLALEALQGALADSGALRADIGAVFYAGITNGHLQGQ
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEECCCCCEEEEE
LSIPGQVLCSKIGLEGVPVYNVENACASGSTAVHLAVQSLRSGATDVALALGAEKMNVPD
ECCCHHHHHHHHCCCCCCEECCCHHHCCCCHHHHHHHHHHHCCCCCEEHEECCHHCCCCC
KSRALALFETGWDVSTAEENYATLVKMGEGIIVPPGSESDRPYSKFMAIYAAMCRWHMKT
CCCEEEEEECCCCCCCCCHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
YGTTQRQIAAVCAKNHQHSVHNPYSQFRKTFSIEEVLAAPPITYPITLPMCAPLSDGAAA
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCCCCEE
AILCTEAGLKRIGADPKRCVRIAASVIRSFTLRGLDEPHKHVSLLAAREAYEIAGLGPQD
EEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCC
MHVAEVHDASAMGEIIQSENLGLAPLGEGGVCAERGDFTLGGRLPINTSGGLESKGHPLG
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCEECCCCCCCCCCCCCCCC
ATGIGQLYELVTQLRGEAGPRQVHGARHAIQENGGGLQGVEEAAVAIHILSR
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHEEEECC
>Mature Secondary Structure
MEPIYIAGIAMTEFGRHLERSLQDLALEALQGALADSGALRADIGAVFYAGITNGHLQGQ
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEECCCCCEEEEE
LSIPGQVLCSKIGLEGVPVYNVENACASGSTAVHLAVQSLRSGATDVALALGAEKMNVPD
ECCCHHHHHHHHCCCCCCEECCCHHHCCCCHHHHHHHHHHHCCCCCEEHEECCHHCCCCC
KSRALALFETGWDVSTAEENYATLVKMGEGIIVPPGSESDRPYSKFMAIYAAMCRWHMKT
CCCEEEEEECCCCCCCCCHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
YGTTQRQIAAVCAKNHQHSVHNPYSQFRKTFSIEEVLAAPPITYPITLPMCAPLSDGAAA
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCCCCEE
AILCTEAGLKRIGADPKRCVRIAASVIRSFTLRGLDEPHKHVSLLAAREAYEIAGLGPQD
EEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCC
MHVAEVHDASAMGEIIQSENLGLAPLGEGGVCAERGDFTLGGRLPINTSGGLESKGHPLG
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCEECCCCCCCCCCCCCCCC
ATGIGQLYELVTQLRGEAGPRQVHGARHAIQENGGGLQGVEEAAVAIHILSR
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acyl-CoA; acetyl-CoA [C]

Specific reaction: Acyl-CoA + acetyl-CoA = CoA + oxoacyl-CoA [C]

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]