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The map label for this gene is qor [C]

Identifier: 77458662

GI number: 77458662

Start: 2790226

End: 2791218

Strand: Reverse

Name: qor [C]

Synonym: Pfl01_2437

Alternate gene names: 77458662

Gene position: 2791218-2790226 (Counterclockwise)

Preceding gene: 77458663

Following gene: 77458660

Centisome position: 43.35

GC content: 66.97

Gene sequence:

>993_bases
ATGCAAACCGATTACGCTGCCTGGGCCTGGACGTCCGGCCAAGGGCTGGATGGCCTGACACTGACCCGCAAGCCTCTCCG
GCAACCCGGCCCCGGGCAAGTGCTGGTGGCCAACCGCGCCATCGCCTTGAACCCGGTGGACTGGAAGATCATCGAGTGGG
GCCACTCCGCGTGGCACACCGGCCGTGTGCCGGGTGTCGACGGCATGGGCGTGGTGGTCGCAGCCGGCGCCGGCGTGACA
CTGCAACCCGGCAGTCGCGTGGCGTATCACCAATCACTGGCGAACGATGGCAGCTTCGCCGAGTACTGCCTGCTCGACGC
CGCCACCGTGCTGTCGGTGCCCGCCGCGCTCGATGATGCCGCGGCGGCGTCACTGCCCTGCCCCGGACTGACCGCGTGGC
AAGCCGTGGAAAAAGTCCCAGCGAATGGCGCAGCCGATGTGCTGGTGATCGGCGCCGGCGGCGCGGTCGGCCTGCTGCTG
GTGCAACTGGCGGTACAACGTGGATGGCGGGTCTGGGCGACCGCATCCGGCGCGCATCATGAAAAGCTCAAGGCCCTGGG
CGCAGTCGGCGTATTCGATTACCGCGAACTGGACTGGCAAAGCGCACTCGCAGCCAGCCTCGGCGAACGTCGTTTGCATG
CCGTGTTCGACACGGTCAGCGGCGCTCACGCGGCGAAAATGGCCGACCTGCTGGGCTACAACGGCCATCTGGTGTGCATT
CAGGATCGTCAGGAAAGCGCGCCCCTGCCGGCGTTCACCACCGCGATTTCGCTGCATGAAGTGGCATTGAACAGCTTCCA
CGTCCACGCCAGCCTGCACGATCGCCAGACCTTGCGCCGCAACGGCGAGCAGTTGCTGCAAGCGCTGCTCGACGGCAGCC
TGATCGGCCCGGCGCTGCAGATGTTCGACTTCGATGAATTGCCCCAGGCCTTGCGCGCCCTGAAGGACGGCGCGGGTGGC
GGGAAATGGGTGACGCGTCTGCCCGTCGTTTGA

Upstream 100 bases:

>100_bases
TGCTGACTTTTACGCAAAACACCTTTGACCCAGGGCCGGTTCTTCTCATGCCCGTTGCCACCGATACTGGCGGCCATTGA
CAGTCATGGGAAACCGCACA

Downstream 100 bases:

>100_bases
ATCGCGTCAGTCGAGGCCTTCCCCAGTGCCTTGACTGACCTCCCGGGTCAAACAATCAATCAGCGCCCGCGCCGAAGCCG
ACAGCTGCCGGTGCGGCGGG

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MQTDYAAWAWTSGQGLDGLTLTRKPLRQPGPGQVLVANRAIALNPVDWKIIEWGHSAWHTGRVPGVDGMGVVVAAGAGVT
LQPGSRVAYHQSLANDGSFAEYCLLDAATVLSVPAALDDAAAASLPCPGLTAWQAVEKVPANGAADVLVIGAGGAVGLLL
VQLAVQRGWRVWATASGAHHEKLKALGAVGVFDYRELDWQSALAASLGERRLHAVFDTVSGAHAAKMADLLGYNGHLVCI
QDRQESAPLPAFTTAISLHEVALNSFHVHASLHDRQTLRRNGEQLLQALLDGSLIGPALQMFDFDELPQALRALKDGAGG
GKWVTRLPVV

Sequences:

>Translated_330_residues
MQTDYAAWAWTSGQGLDGLTLTRKPLRQPGPGQVLVANRAIALNPVDWKIIEWGHSAWHTGRVPGVDGMGVVVAAGAGVT
LQPGSRVAYHQSLANDGSFAEYCLLDAATVLSVPAALDDAAAASLPCPGLTAWQAVEKVPANGAADVLVIGAGGAVGLLL
VQLAVQRGWRVWATASGAHHEKLKALGAVGVFDYRELDWQSALAASLGERRLHAVFDTVSGAHAAKMADLLGYNGHLVCI
QDRQESAPLPAFTTAISLHEVALNSFHVHASLHDRQTLRRNGEQLLQALLDGSLIGPALQMFDFDELPQALRALKDGAGG
GKWVTRLPVV
>Mature_330_residues
MQTDYAAWAWTSGQGLDGLTLTRKPLRQPGPGQVLVANRAIALNPVDWKIIEWGHSAWHTGRVPGVDGMGVVVAAGAGVT
LQPGSRVAYHQSLANDGSFAEYCLLDAATVLSVPAALDDAAAASLPCPGLTAWQAVEKVPANGAADVLVIGAGGAVGLLL
VQLAVQRGWRVWATASGAHHEKLKALGAVGVFDYRELDWQSALAASLGERRLHAVFDTVSGAHAAKMADLLGYNGHLVCI
QDRQESAPLPAFTTAISLHEVALNSFHVHASLHDRQTLRRNGEQLLQALLDGSLIGPALQMFDFDELPQALRALKDGAGG
GKWVTRLPVV

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=219, Percent_Identity=28.7671232876712, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI13236495, Length=219, Percent_Identity=28.7671232876712, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI47519420, Length=335, Percent_Identity=27.1641791044776, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI194239676, Length=175, Percent_Identity=32, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1790485, Length=216, Percent_Identity=29.1666666666667, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71987554, Length=368, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 34776; Mature: 34776

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDYAAWAWTSGQGLDGLTLTRKPLRQPGPGQVLVANRAIALNPVDWKIIEWGHSAWHT
CCCCCEEEEEECCCCCCCCEECHHHCCCCCCCEEEEECCEEEECCCCEEEEECCCCCCCC
GRVPGVDGMGVVVAAGAGVTLQPGSRVAYHQSLANDGSFAEYCLLDAATVLSVPAALDDA
CCCCCCCCCCEEEEECCCEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCH
AAASLPCPGLTAWQAVEKVPANGAADVLVIGAGGAVGLLLVQLAVQRGWRVWATASGAHH
HHCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCHH
EKLKALGAVGVFDYRELDWQSALAASLGERRLHAVFDTVSGAHAAKMADLLGYNGHLVCI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEE
QDRQESAPLPAFTTAISLHEVALNSFHVHASLHDRQTLRRNGEQLLQALLDGSLIGPALQ
ECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHCHHHHHHHHHCCCHHHHHHH
MFDFDELPQALRALKDGAGGGKWVTRLPVV
HCCHHHHHHHHHHHHCCCCCCCEEEECCCC
>Mature Secondary Structure
MQTDYAAWAWTSGQGLDGLTLTRKPLRQPGPGQVLVANRAIALNPVDWKIIEWGHSAWHT
CCCCCEEEEEECCCCCCCCEECHHHCCCCCCCEEEEECCEEEECCCCEEEEECCCCCCCC
GRVPGVDGMGVVVAAGAGVTLQPGSRVAYHQSLANDGSFAEYCLLDAATVLSVPAALDDA
CCCCCCCCCCEEEEECCCEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCH
AAASLPCPGLTAWQAVEKVPANGAADVLVIGAGGAVGLLLVQLAVQRGWRVWATASGAHH
HHCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCHH
EKLKALGAVGVFDYRELDWQSALAASLGERRLHAVFDTVSGAHAAKMADLLGYNGHLVCI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEE
QDRQESAPLPAFTTAISLHEVALNSFHVHASLHDRQTLRRNGEQLLQALLDGSLIGPALQ
ECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHCHHHHHHHHHCCCHHHHHHH
MFDFDELPQALRALKDGAGGGKWVTRLPVV
HCCHHHHHHHHHHHHCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA