Click here to switch to the map view.

The map label for this gene is yrhP [H]

Identifier: 77458447

GI number: 77458447

Start: 2543611

End: 2544252

Strand: Direct

Name: yrhP [H]

Synonym: Pfl01_2220

Alternate gene names: 77458447

Gene position: 2543611-2544252 (Clockwise)

Preceding gene: 77458442

Following gene: 77458448

Centisome position: 39.51

GC content: 59.03

Gene sequence:

>642_bases
ATGGATTCTCACTCGATTCTGGCCTTTACCCTGGTTGCCGCGATTGCGATCGCCAGCCCGGGGCCCGCGACCCTGATGGC
GATCAACAACAGCCTGGCCCATGGTCAACGCAGTGCAATCTGGTCATCCCTCGGCAATGCCAGTGGCCTGTTCTGCCTCT
CGGCTGCCGCGATGCTGGGACTTGGGGCCTTGCTGGCCAGCTCCGAAATGCTGTTCAACGCGGTGAAAATCATCGGTGCC
GGTTATCTGTTCTACCTCGGGATCCGGCAGTTGTTCAAAAAAGGTTCGATGCTCCCGGAGAACGTTGAAGATGAGTCGAA
AAAGGTCCGGCCTACTCGCAGCAAACTGTACAAGTCAGCGTTCCTGACGGCCGTGACCAATCCCAAGGCGACAATGTTCT
TCACCGCACTGTTTCCGCAGTTCATCGATCAGGGCGCGACATTGCTGCCGCAGTTTCTGATCCTCACCTCGATTTTCATG
GCGTTGTCGGTGACGTCGCTGACGCTTTATGCAGCGCTCGCCTCGCGGGCCAAGGGCGTGCTGACCCGGCCTGCGCTGTC
CCGCTGGGTCAGTCGGGTTGTCGGAACTACGTTTATCGGTTTCGGGGCTGCGATTCTGACGATGCGTCGGCAGGCCGCGT
AA

Upstream 100 bases:

>100_bases
TTGGGCTGCTGACACCGAGAAGTAAAGCGTAGCGGCCGGAGGTCCGTTGGCTCCCGCGCTCCTGTAATATGCGGCCACCT
CACCCCAACGAGCATGGAAA

Downstream 100 bases:

>100_bases
GTAAAAGCTGTCCGACTGAAATCAGTCATCCATTCAAGGAAGTATTGCGTGGCACTCAGGGTTTTAGTGGTCGGCGGTTA
TGGAAATTTCGGCAGCATTG

Product: lysine exporter protein LysE/YggA

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MDSHSILAFTLVAAIAIASPGPATLMAINNSLAHGQRSAIWSSLGNASGLFCLSAAAMLGLGALLASSEMLFNAVKIIGA
GYLFYLGIRQLFKKGSMLPENVEDESKKVRPTRSKLYKSAFLTAVTNPKATMFFTALFPQFIDQGATLLPQFLILTSIFM
ALSVTSLTLYAALASRAKGVLTRPALSRWVSRVVGTTFIGFGAAILTMRRQAA

Sequences:

>Translated_213_residues
MDSHSILAFTLVAAIAIASPGPATLMAINNSLAHGQRSAIWSSLGNASGLFCLSAAAMLGLGALLASSEMLFNAVKIIGA
GYLFYLGIRQLFKKGSMLPENVEDESKKVRPTRSKLYKSAFLTAVTNPKATMFFTALFPQFIDQGATLLPQFLILTSIFM
ALSVTSLTLYAALASRAKGVLTRPALSRWVSRVVGTTFIGFGAAILTMRRQAA
>Mature_213_residues
MDSHSILAFTLVAAIAIASPGPATLMAINNSLAHGQRSAIWSSLGNASGLFCLSAAAMLGLGALLASSEMLFNAVKIIGA
GYLFYLGIRQLFKKGSMLPENVEDESKKVRPTRSKLYKSAFLTAVTNPKATMFFTALFPQFIDQGATLLPQFLILTSIFM
ALSVTSLTLYAALASRAKGVLTRPALSRWVSRVVGTTFIGFGAAILTMRRQAA

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=203, Percent_Identity=30.5418719211823, Blast_Score=90, Evalue=9e-20,
Organism=Escherichia coli, GI1788099, Length=207, Percent_Identity=31.8840579710145, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI48994978, Length=207, Percent_Identity=24.1545893719807, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 22671; Mature: 22671

Theoretical pI: Translated: 11.10; Mature: 11.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSHSILAFTLVAAIAIASPGPATLMAINNSLAHGQRSAIWSSLGNASGLFCLSAAAMLG
CCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
LGALLASSEMLFNAVKIIGAGYLFYLGIRQLFKKGSMLPENVEDESKKVRPTRSKLYKSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHH
FLTAVTNPKATMFFTALFPQFIDQGATLLPQFLILTSIFMALSVTSLTLYAALASRAKGV
HHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTRPALSRWVSRVVGTTFIGFGAAILTMRRQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDSHSILAFTLVAAIAIASPGPATLMAINNSLAHGQRSAIWSSLGNASGLFCLSAAAMLG
CCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
LGALLASSEMLFNAVKIIGAGYLFYLGIRQLFKKGSMLPENVEDESKKVRPTRSKLYKSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHH
FLTAVTNPKATMFFTALFPQFIDQGATLLPQFLILTSIFMALSVTSLTLYAALASRAKGV
HHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTRPALSRWVSRVVGTTFIGFGAAILTMRRQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]