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The map label for this gene is macA [H]

Identifier: 77458441

GI number: 77458441

Start: 2534757

End: 2535905

Strand: Direct

Name: macA [H]

Synonym: Pfl01_2214

Alternate gene names: 77458441

Gene position: 2534757-2535905 (Clockwise)

Preceding gene: 77458440

Following gene: 77458442

Centisome position: 39.37

GC content: 61.71

Gene sequence:

>1149_bases
ATGGAACAGTCGAAGTTGCGCAAAGTCGGTCTGGGAGTCGCGTTGACGCTGGTGGCCGGGTTGGTGTTCTACACGGTGCA
GGCGCCGGCCGAAGCACCGCAATACCTGACCGCCACGGTCGAACGTGGCGACATTGAAAACGCGGTGCTCGCCACCGGTT
TGCTGGAGGGCATCAAGCAGGTGGACGTCGGTGCCCAGGTCTCGGGGCAGTTGAAGTCGCTCAAGGTCAAGGTTGGCGAC
AAGGTCAAGAAGGGTCAGTGGCTGGCGGAAATCGACCCGCTGGTGCTGCAGAACACGCTGCGCCAGGCTCAGGTCGATGA
GGAAAACCTGCAAGCCCAGCGCCGTGCGACTCAGGCTCAGTTACGCCAGACCAAGGCGATCTACGAGCGCTATCAGAATC
TGCAGGAGGACGCCTCGATCTCGCGGCAGGATTTCGAAACCGCGCAATCGAACTATGAAGTGCAGCAGGCCAACCTGATG
TCGCTGGATGCACAGATCAAGAGTGCGCACATCCAGATCGACACGGCCAAGGTCAATCTGGCCTACACGCGGATCGTCGC
GCCCATCGATGGCGACGTGGTGGGCATCGTCACCCAGGAAGGCCAGACCGTGATTGCCAGCCAACTGGCGCCGGTTCTGC
TGAAACTGGCGGATCTGGACACCATGACCGTCAAGGCTCAGGTGTCGGAGGCCGACGTCATTCATATCGCACCGGGGCAA
GAGGTGTATTTCACCATTCTGGGCGAGGACAAGCGTTATTACGGCAAGCTGCGCGGCACCGACCCTGCGCCGCAGAACTT
CCTTGAAGCGCCGCCAGCCGGGACACCGAAGCAGAACACGGCGGTGTTCTACAACGCGCTGTTCGACGTGCCCAATCCTG
ATCACCGCTTGCGCATCTCCATGACGGCCCAGGTGCGGGTGGTGCTCGACACCGCCAAATCGGTGCTGACGATTCCGGTA
GCGGCGCTGGGCCCGCGCAACAACGATGGCAGTTTCCCGGTGCGAGTGCTGGATGCCAAAGGCCAGGCGCAGTCGCGCAA
TGTCCAGACCGGGATCAACAACAACGTCAAGGTGCAGGTCAACGACGGCCTGGCCGAAGGCGACCGGGTGGTGATCGGTG
ATCCGGTGACGAAAGTGGCAGGGGCATGA

Upstream 100 bases:

>100_bases
GTTGACGGTGGCGGCGGGTCAAGTGTTGTCCTGATTGAAGTTTTTATCCTGGAACCCGGCCGCTGGCCGGGCTCAACCCT
GAACGGAATTGTGGTCATTT

Downstream 100 bases:

>100_bases
GCATGAGCGAACCTCTGCTGCAACTGACCGGCATCAGCCGCAGTTTCACTGCCGGCGACCGTGAATTTCTGGCGCTGAAG
AATATCGACCTGACGATCCA

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MEQSKLRKVGLGVALTLVAGLVFYTVQAPAEAPQYLTATVERGDIENAVLATGLLEGIKQVDVGAQVSGQLKSLKVKVGD
KVKKGQWLAEIDPLVLQNTLRQAQVDEENLQAQRRATQAQLRQTKAIYERYQNLQEDASISRQDFETAQSNYEVQQANLM
SLDAQIKSAHIQIDTAKVNLAYTRIVAPIDGDVVGIVTQEGQTVIASQLAPVLLKLADLDTMTVKAQVSEADVIHIAPGQ
EVYFTILGEDKRYYGKLRGTDPAPQNFLEAPPAGTPKQNTAVFYNALFDVPNPDHRLRISMTAQVRVVLDTAKSVLTIPV
AALGPRNNDGSFPVRVLDAKGQAQSRNVQTGINNNVKVQVNDGLAEGDRVVIGDPVTKVAGA

Sequences:

>Translated_382_residues
MEQSKLRKVGLGVALTLVAGLVFYTVQAPAEAPQYLTATVERGDIENAVLATGLLEGIKQVDVGAQVSGQLKSLKVKVGD
KVKKGQWLAEIDPLVLQNTLRQAQVDEENLQAQRRATQAQLRQTKAIYERYQNLQEDASISRQDFETAQSNYEVQQANLM
SLDAQIKSAHIQIDTAKVNLAYTRIVAPIDGDVVGIVTQEGQTVIASQLAPVLLKLADLDTMTVKAQVSEADVIHIAPGQ
EVYFTILGEDKRYYGKLRGTDPAPQNFLEAPPAGTPKQNTAVFYNALFDVPNPDHRLRISMTAQVRVVLDTAKSVLTIPV
AALGPRNNDGSFPVRVLDAKGQAQSRNVQTGINNNVKVQVNDGLAEGDRVVIGDPVTKVAGA
>Mature_382_residues
MEQSKLRKVGLGVALTLVAGLVFYTVQAPAEAPQYLTATVERGDIENAVLATGLLEGIKQVDVGAQVSGQLKSLKVKVGD
KVKKGQWLAEIDPLVLQNTLRQAQVDEENLQAQRRATQAQLRQTKAIYERYQNLQEDASISRQDFETAQSNYEVQQANLM
SLDAQIKSAHIQIDTAKVNLAYTRIVAPIDGDVVGIVTQEGQTVIASQLAPVLLKLADLDTMTVKAQVSEADVIHIAPGQ
EVYFTILGEDKRYYGKLRGTDPAPQNFLEAPPAGTPKQNTAVFYNALFDVPNPDHRLRISMTAQVRVVLDTAKSVLTIPV
AALGPRNNDGSFPVRVLDAKGQAQSRNVQTGINNNVKVQVNDGLAEGDRVVIGDPVTKVAGA

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=376, Percent_Identity=45.4787234042553, Blast_Score=300, Evalue=7e-83,
Organism=Escherichia coli, GI87082036, Length=351, Percent_Identity=29.6296296296296, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786668, Length=315, Percent_Identity=27.9365079365079, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789929, Length=324, Percent_Identity=25.6172839506173, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787013, Length=296, Percent_Identity=26.6891891891892, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41353; Mature: 41353

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQSKLRKVGLGVALTLVAGLVFYTVQAPAEAPQYLTATVERGDIENAVLATGLLEGIKQ
CCHHHHHHHCCHHHHHHHHHHHHEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
VDVGAQVSGQLKSLKVKVGDKVKKGQWLAEIDPLVLQNTLRQAQVDEENLQAQRRATQAQ
HCCCCCCCCCEEEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LRQTKAIYERYQNLQEDASISRQDFETAQSNYEVQQANLMSLDAQIKSAHIQIDTAKVNL
HHHHHHHHHHHHCHHHHHCCCHHHHHHHHCCCEEHHHHHEECCCEEEEEEEEEEEEEEEE
AYTRIVAPIDGDVVGIVTQEGQTVIASQLAPVLLKLADLDTMTVKAQVSEADVIHIAPGQ
EEEEEEECCCCCEEEEEECCCCEEHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCC
EVYFTILGEDKRYYGKLRGTDPAPQNFLEAPPAGTPKQNTAVFYNALFDVPNPDHRLRIS
EEEEEEEECCCEEEEECCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEE
MTAQVRVVLDTAKSVLTIPVAALGPRNNDGSFPVRVLDAKGQAQSRNVQTGINNNVKVQV
EEEEEEEEEECCCHHEEEEHEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEE
NDGLAEGDRVVIGDPVTKVAGA
CCCCCCCCEEEECCCHHHHCCC
>Mature Secondary Structure
MEQSKLRKVGLGVALTLVAGLVFYTVQAPAEAPQYLTATVERGDIENAVLATGLLEGIKQ
CCHHHHHHHCCHHHHHHHHHHHHEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
VDVGAQVSGQLKSLKVKVGDKVKKGQWLAEIDPLVLQNTLRQAQVDEENLQAQRRATQAQ
HCCCCCCCCCEEEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LRQTKAIYERYQNLQEDASISRQDFETAQSNYEVQQANLMSLDAQIKSAHIQIDTAKVNL
HHHHHHHHHHHHCHHHHHCCCHHHHHHHHCCCEEHHHHHEECCCEEEEEEEEEEEEEEEE
AYTRIVAPIDGDVVGIVTQEGQTVIASQLAPVLLKLADLDTMTVKAQVSEADVIHIAPGQ
EEEEEEECCCCCEEEEEECCCCEEHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCC
EVYFTILGEDKRYYGKLRGTDPAPQNFLEAPPAGTPKQNTAVFYNALFDVPNPDHRLRIS
EEEEEEEECCCEEEEECCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEE
MTAQVRVVLDTAKSVLTIPVAALGPRNNDGSFPVRVLDAKGQAQSRNVQTGINNNVKVQV
EEEEEEEEEECCCHHEEEEHEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEE
NDGLAEGDRVVIGDPVTKVAGA
CCCCCCCCEEEECCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]