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The map label for this gene is adiA [H]

Identifier: 77458415

GI number: 77458415

Start: 2471552

End: 2473807

Strand: Direct

Name: adiA [H]

Synonym: Pfl01_2188

Alternate gene names: 77458415

Gene position: 2471552-2473807 (Clockwise)

Preceding gene: 77458414

Following gene: 77458416

Centisome position: 38.39

GC content: 61.97

Gene sequence:

>2256_bases
ATGTACAAAGATTTGAAGTTCCCGGTGTTGATCGTCCACCGCGACATCAAGGCCGACACGGTTGCCGGTGACCGCATCCG
CGGCATTGCCCGAGAGCTGGAGCTGGAAGGTTTCAGTATCGTTTCGGCCACCGACTACACCGAAGGCCGGCTCGTGGCGT
CGACCCACCATGGTCTGGCGTGCATGCTGATCGCCGCGGAAGACGCCAGCACCAACTCCCATCTGTTGCAGAACATGGCC
GAACTGATCGGTCTGGCCCGGGTGCGGGCGCCGGATCTGCCGATCTTTGCACTCGGCGAGCAAGTAACCCTGGAAAACGC
CCCGGCCGATGCGATGGCCGAACTCAACCAGTTACGCGGCATTCTCTACCTGTTCGAAGACACCGTGCCGTTTCTCGCCC
GACAAGTGGCGCGGGCAGCGCGCAAATACCTGGACGGCCTGTTGCCGCCATTCTTCAAGGCGCTGGTCCAGCACACCGCC
GATTCCAACTATTCCTGGCACACCCCCGGTCACGGCGGCGGGGTGGCCTATCACAAGAGTCCGGTGGGGCAGGCGTTTCA
TCAGTTCTTCGGGGAAAACACCCTGCGCTCCGATTTATCGGTCTCGGTGCCGGAGCTGGGTTCCTTGCTCGATCACACCG
GGCCGCTGGCCGAGGCGGAAGCGCGGGCCGCGCGCAATTTCGGCGCCGATCACACCTTTTTCGTGATCAATGGCACCTCG
ACCGCCAACAAGATCGTCTGGCACTCGATGGTCGGGCGCGATGATCTGGTGCTGGTGGATCGCAACTGCCACAAGTCGGT
GCTGCACGCGATCATCATGACCGGCGCGATTCCGCTGTACCTGTGCCCGGAGCGCAACGAGCTGGGGATCATCGGGCCGA
TCCCGCTCAGTGAATTCAGTCGTGAATCGATCCAGGCCAAGATCGACGCCAGCCCGTTGACCAAGGGCCGCGAACCGAAA
GTCAAACTGGCGGTGATCACCAACTCCACTTACGACGGCCTCTGCTACAACGCCGAGCTGATCAAGCAGAGCCTGGGCAA
CAGTGTCGAAGTGTTGCATTTCGACGAGGCCTGGTACGCCTACGCCGCGTTTCACGAATTCTTTGCCGGCCGTTACGGCA
TGGCCACCTCGCGCAGCGAGGACAGTCCGCTGGTGTTTACCACCCACTCCACCCACAAACTGTTGGCGGCGTTCAGTCAG
GCCTCGATGATTCATGTTCAGGACGGTGGGGCGCGGCAGCTGGATCGCGACCGGTTCAACGAAGCGTTCATGATGCACAT
CTCGACGTCGCCGCAGTACAGCATCATTGCTTCGCTGGACGTCGCCTCGGCGATGATGGAAGGCCCGGCCGGACGCTCGC
TGCTGCAGGAAACCTTCGACGAAGCCCTGAGCTTTCGCCGGGCCTTGGCCAATCTGCGTCAGCACATCGCCGCTGACGAT
TGGTGGTTCTCGATCTGGCAGCCGCCGGGTGTCGAGGGCATCGACCGGGTGCAGACCGAGGACTGGCTGCTGCAACCCGA
TGCGGACTGGCACGGTTTCGGCGAGGTCAGCGACGACTACGTACTGCTCGACCCGATCAAGGTCACCCTGGTCATGCCGG
GCCTGACCGCCGGCGGCGCTTTGAGCGACAAGGGCATCCCGGCGGCCGTGGTCAGCCGTTTCCTCTGGGAGCGCGGGCTG
GTGGTGGAGAAAACCGGTCTGTATTCATTTCTGGTGCTGTTCTCCATGGGCATCACCAAGGGCAAGTGGAGCACGCTCCT
GACCGAACTGCTGGAGTTCAAGCGCAGCTACGACGCCAACATCAGTCTCGACACCTGCCTGAAGTGTGTCGAGCAGGAAG
ATCCTGTGCGCTATCGCGGCATGGGCCTGCGCGATTTGTGCGATCAGCTTCACGCCTGCTATCGCAGCAACGCGACCGCC
AGACACCTCAAGCGCATGTACACGGTGCTGCCGGAAATCGCGATGAAACCGGCCCACGCTTACGATCAATTGGTGCGCGG
CGAAGTCGAGGCGGTGCCGATCGATGAGCTGGAAGGCCGGGTGGCGGCGGTGATGCTGGTGCCGTACCCGCCGGGCATTC
CGCTGATCATGCCCGGCGAACGGTTTACCGAATCCACGCGCTCGATCATCGAATACCTCAGGTTTGCCCGCACGTTCGAC
ACAACGTTTCCGGGGTTCGTGGTCGATGTGCACGGTCTGCAACACGAAGATGAGGGCAATGGGCGGCACTACACCGTCGA
TTGCGTCAAGGAATGA

Upstream 100 bases:

>100_bases
GGCAGTACTGACAACTGGCCACCCTCGCCACATCGGCTCCGACCCTCTAACCTGAGGACATTGGCAGATCACTCTCCGCC
GCCTCAGGACACTGAGCCTC

Downstream 100 bases:

>100_bases
GGGCTTTTCCGAGTATGCAACCGGTCATTAATCCGAAATACCCAGGGCTGTCGGTGCGGGTCGCCGACGACGGTTTTGCC
GCGTATATCTGGGGCAGCGA

Product: ornithine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 751; Mature: 751

Protein sequence:

>751_residues
MYKDLKFPVLIVHRDIKADTVAGDRIRGIARELELEGFSIVSATDYTEGRLVASTHHGLACMLIAAEDASTNSHLLQNMA
ELIGLARVRAPDLPIFALGEQVTLENAPADAMAELNQLRGILYLFEDTVPFLARQVARAARKYLDGLLPPFFKALVQHTA
DSNYSWHTPGHGGGVAYHKSPVGQAFHQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTS
TANKIVWHSMVGRDDLVLVDRNCHKSVLHAIIMTGAIPLYLCPERNELGIIGPIPLSEFSRESIQAKIDASPLTKGREPK
VKLAVITNSTYDGLCYNAELIKQSLGNSVEVLHFDEAWYAYAAFHEFFAGRYGMATSRSEDSPLVFTTHSTHKLLAAFSQ
ASMIHVQDGGARQLDRDRFNEAFMMHISTSPQYSIIASLDVASAMMEGPAGRSLLQETFDEALSFRRALANLRQHIAADD
WWFSIWQPPGVEGIDRVQTEDWLLQPDADWHGFGEVSDDYVLLDPIKVTLVMPGLTAGGALSDKGIPAAVVSRFLWERGL
VVEKTGLYSFLVLFSMGITKGKWSTLLTELLEFKRSYDANISLDTCLKCVEQEDPVRYRGMGLRDLCDQLHACYRSNATA
RHLKRMYTVLPEIAMKPAHAYDQLVRGEVEAVPIDELEGRVAAVMLVPYPPGIPLIMPGERFTESTRSIIEYLRFARTFD
TTFPGFVVDVHGLQHEDEGNGRHYTVDCVKE

Sequences:

>Translated_751_residues
MYKDLKFPVLIVHRDIKADTVAGDRIRGIARELELEGFSIVSATDYTEGRLVASTHHGLACMLIAAEDASTNSHLLQNMA
ELIGLARVRAPDLPIFALGEQVTLENAPADAMAELNQLRGILYLFEDTVPFLARQVARAARKYLDGLLPPFFKALVQHTA
DSNYSWHTPGHGGGVAYHKSPVGQAFHQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTS
TANKIVWHSMVGRDDLVLVDRNCHKSVLHAIIMTGAIPLYLCPERNELGIIGPIPLSEFSRESIQAKIDASPLTKGREPK
VKLAVITNSTYDGLCYNAELIKQSLGNSVEVLHFDEAWYAYAAFHEFFAGRYGMATSRSEDSPLVFTTHSTHKLLAAFSQ
ASMIHVQDGGARQLDRDRFNEAFMMHISTSPQYSIIASLDVASAMMEGPAGRSLLQETFDEALSFRRALANLRQHIAADD
WWFSIWQPPGVEGIDRVQTEDWLLQPDADWHGFGEVSDDYVLLDPIKVTLVMPGLTAGGALSDKGIPAAVVSRFLWERGL
VVEKTGLYSFLVLFSMGITKGKWSTLLTELLEFKRSYDANISLDTCLKCVEQEDPVRYRGMGLRDLCDQLHACYRSNATA
RHLKRMYTVLPEIAMKPAHAYDQLVRGEVEAVPIDELEGRVAAVMLVPYPPGIPLIMPGERFTESTRSIIEYLRFARTFD
TTFPGFVVDVHGLQHEDEGNGRHYTVDCVKE
>Mature_751_residues
MYKDLKFPVLIVHRDIKADTVAGDRIRGIARELELEGFSIVSATDYTEGRLVASTHHGLACMLIAAEDASTNSHLLQNMA
ELIGLARVRAPDLPIFALGEQVTLENAPADAMAELNQLRGILYLFEDTVPFLARQVARAARKYLDGLLPPFFKALVQHTA
DSNYSWHTPGHGGGVAYHKSPVGQAFHQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTS
TANKIVWHSMVGRDDLVLVDRNCHKSVLHAIIMTGAIPLYLCPERNELGIIGPIPLSEFSRESIQAKIDASPLTKGREPK
VKLAVITNSTYDGLCYNAELIKQSLGNSVEVLHFDEAWYAYAAFHEFFAGRYGMATSRSEDSPLVFTTHSTHKLLAAFSQ
ASMIHVQDGGARQLDRDRFNEAFMMHISTSPQYSIIASLDVASAMMEGPAGRSLLQETFDEALSFRRALANLRQHIAADD
WWFSIWQPPGVEGIDRVQTEDWLLQPDADWHGFGEVSDDYVLLDPIKVTLVMPGLTAGGALSDKGIPAAVVSRFLWERGL
VVEKTGLYSFLVLFSMGITKGKWSTLLTELLEFKRSYDANISLDTCLKCVEQEDPVRYRGMGLRDLCDQLHACYRSNATA
RHLKRMYTVLPEIAMKPAHAYDQLVRGEVEAVPIDELEGRVAAVMLVPYPPGIPLIMPGERFTESTRSIIEYLRFARTFD
TTFPGFVVDVHGLQHEDEGNGRHYTVDCVKE

Specific function: ADC can be found in two forms:biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI221142684, Length=765, Percent_Identity=39.8692810457516, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI1786384, Length=631, Percent_Identity=45.1664025356577, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1790573, Length=729, Percent_Identity=40.7407407407407, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI87082193, Length=625, Percent_Identity=36.48, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI1786909, Length=662, Percent_Identity=33.3836858006042, Blast_Score=349, Evalue=3e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 83339; Mature: 83339

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKDLKFPVLIVHRDIKADTVAGDRIRGIARELELEGFSIVSATDYTEGRLVASTHHGLA
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCEE
CMLIAAEDASTNSHLLQNMAELIGLARVRAPDLPIFALGEQVTLENAPADAMAELNQLRG
EEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCHHHHHHHHHHHH
ILYLFEDTVPFLARQVARAARKYLDGLLPPFFKALVQHTADSNYSWHTPGHGGGVAYHKS
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEECCC
PVGQAFHQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTS
HHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCC
TANKIVWHSMVGRDDLVLVDRNCHKSVLHAIIMTGAIPLYLCPERNELGIIGPIPLSEFS
CHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCHHHHH
RESIQAKIDASPLTKGREPKVKLAVITNSTYDGLCYNAELIKQSLGNSVEVLHFDEAWYA
HHHHHEEECCCCCCCCCCCCEEEEEEECCCCCCEEECHHHHHHHCCCCEEEEEECCHHHH
YAAFHEFFAGRYGMATSRSEDSPLVFTTHSTHKLLAAFSQASMIHVQDGGARQLDRDRFN
HHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCEEEEECCCCCHHHHHHCC
EAFMMHISTSPQYSIIASLDVASAMMEGPAGRSLLQETFDEALSFRRALANLRQHIAADD
CEEEEEEECCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WWFSIWQPPGVEGIDRVQTEDWLLQPDADWHGFGEVSDDYVLLDPIKVTLVMPGLTAGGA
CEEEECCCCCCCCHHHCCCCCEEECCCCCCCCCCCCCCCEEEECCEEEEEEECCCCCCCC
LSDKGIPAAVVSRFLWERGLVVEKTGLYSFLVLFSMGITKGKWSTLLTELLEFKRSYDAN
CCCCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
ISLDTCLKCVEQEDPVRYRGMGLRDLCDQLHACYRSNATARHLKRMYTVLPEIAMKPAHA
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHH
YDQLVRGEVEAVPIDELEGRVAAVMLVPYPPGIPLIMPGERFTESTRSIIEYLRFARTFD
HHHHHCCCCCCCCHHHHCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHC
TTFPGFVVDVHGLQHEDEGNGRHYTVDCVKE
CCCCCEEEEECCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MYKDLKFPVLIVHRDIKADTVAGDRIRGIARELELEGFSIVSATDYTEGRLVASTHHGLA
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCEE
CMLIAAEDASTNSHLLQNMAELIGLARVRAPDLPIFALGEQVTLENAPADAMAELNQLRG
EEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCHHHHHHHHHHHH
ILYLFEDTVPFLARQVARAARKYLDGLLPPFFKALVQHTADSNYSWHTPGHGGGVAYHKS
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEECCC
PVGQAFHQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTS
HHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCC
TANKIVWHSMVGRDDLVLVDRNCHKSVLHAIIMTGAIPLYLCPERNELGIIGPIPLSEFS
CHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCHHHHH
RESIQAKIDASPLTKGREPKVKLAVITNSTYDGLCYNAELIKQSLGNSVEVLHFDEAWYA
HHHHHEEECCCCCCCCCCCCEEEEEEECCCCCCEEECHHHHHHHCCCCEEEEEECCHHHH
YAAFHEFFAGRYGMATSRSEDSPLVFTTHSTHKLLAAFSQASMIHVQDGGARQLDRDRFN
HHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCEEEEECCCCCHHHHHHCC
EAFMMHISTSPQYSIIASLDVASAMMEGPAGRSLLQETFDEALSFRRALANLRQHIAADD
CEEEEEEECCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WWFSIWQPPGVEGIDRVQTEDWLLQPDADWHGFGEVSDDYVLLDPIKVTLVMPGLTAGGA
CEEEECCCCCCCCHHHCCCCCEEECCCCCCCCCCCCCCCEEEECCEEEEEEECCCCCCCC
LSDKGIPAAVVSRFLWERGLVVEKTGLYSFLVLFSMGITKGKWSTLLTELLEFKRSYDAN
CCCCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
ISLDTCLKCVEQEDPVRYRGMGLRDLCDQLHACYRSNATARHLKRMYTVLPEIAMKPAHA
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHH
YDQLVRGEVEAVPIDELEGRVAAVMLVPYPPGIPLIMPGERFTESTRSIIEYLRFARTFD
HHHHHCCCCCCCCHHHHCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHC
TTFPGFVVDVHGLQHEDEGNGRHYTVDCVKE
CCCCCEEEEECCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8383109; 7610040; 9278503; 2830169; 4204273 [H]