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The map label for this gene is uvrB [H]

Identifier: 77458102

GI number: 77458102

Start: 2137616

End: 2139631

Strand: Direct

Name: uvrB [H]

Synonym: Pfl01_1875

Alternate gene names: 77458102

Gene position: 2137616-2139631 (Clockwise)

Preceding gene: 77458099

Following gene: 77458105

Centisome position: 33.2

GC content: 62.05

Gene sequence:

>2016_bases
ATGTCTGAATTCCAGCTCGTCACCCGTTTCGACCCCGCCGGCGATCAACCCGAAGCCATTCGCCTGATGGTCGAAGGCAT
CGAAGCCGGGCTGTCGCACCAGACGCTGCTCGGGGTGACCGGGTCGGGCAAGACCTTCAGCATCGCCAATGTGATCGCCC
AGGTGCAGCGTCCGACGCTGGTGCTGGCGCCGAACAAGACCCTGGCCGCGCAGTTGTACGGCGAGTTCAAGTCGTTCTTC
CCGAACAACGCCGTCGAATACTTCGTTTCCTACTACGACTACTACCAGCCCGAAGCCTATGTGCCGTCGTCCGACACCTT
TATCGAGAAGGATGCGTCGATCAACGACCATATCGAGCAGATGCGGCTGTCGGCGACCAAGGCACTGCTCGAGCGCAAGG
ACGCGATCATCGTCACCACGGTGTCGTGCATCTACGGTCTGGGCAGCCCGGAAACCTATTTGAAAATGGTCCTGCACGTC
GATCGCGGCGACAAGCTCGATCAACGTGCGCTGGTGAGGCGCCTGGCCGACCTGCAATACACCCGCAACGACATGGATTT
CGCCCGTGCGACCTTCCGTGTGCGCGGCGATGTGATCGACATCTACCCGGCGGAATCCGACCTGGAAGCGATCCGCATCG
AGCTGTTCGATGACGAGGTGGAGAGCATTTCTGCGTTCGACCCGCTGACCGGCGAAGTCATCCGCAAGCTGCCGCGCTTC
ACCTTCTACCCGAAGAGCCACTACGTGACGCCCCGGGAAACCCTGCTCGACGCCATCGAGGGGATCAAGGTCGAGTTGCA
GGAGCGCCTGGAATACCTGCGCAACAACAACAAACTGGTGGAAGCCCAGCGTCTTGAGCAGCGCACCCGGTTCGACCTGG
AGATGATCCTCGAACTCGGCTACTGCAACGGCATCGAAAACTACTCGCGCTACCTGTCCGGACGCCCGGCTGGTGCGGCG
CCGCCGACGCTCTACGATTACCTGCCGGCCGATGCGTTGCTGGTGATCGACGAATCCCACGTCAGCGTGCCGCAAGTCGG
CGCGATGTATAAGGGCGACCGCTCGCGCAAAGAAACTCTCGTGGAGTACGGCTTCCGCCTGCCGTCGGCGCTGGACAACC
GGCCGATGCGCTTCGACGAGTGGGAAGGGGTGAGCCCACAGACGATTTTCGTCTCGGCCACGCCCGGCAACTACGAAGCC
GAGCATGCCGGGCGGGTGATCGAACAGGTTGTGCGCCCGACCGGTCTGGTCGACCCGCAGGTCGAAGTGCGGCCGGCGCT
GACTCAGGTTGACGATCTATTGTCGGAAATCACCAAGCGTGTGGCGGTGGAGGAGCGGGTGCTGGTTACCACGCTGACCA
AGCGCATGGCCGAAGACCTGACCGATTACCTGGCCGATCACGGCGTACGCGTGCGTTATCTGCACTCGGACATCGACACC
GTCGAGCGGGTCGAAATCATCCGCGACCTGCGTTTGGGCACGTTCGATGTGCTGGTGGGGATCAACCTGCTGCGTGAAGG
TCTGGACATGCCGGAAGTGTCGCTGGTGGCGATTCTCGACGCGGACAAGGAAGGCTTCCTGCGTTCCGAGCGTTCGCTGA
TCCAGACCATCGGCCGGGCGGCACGTAACCTCAATGGCCGGGCGATTCTCTACGCGGATCGCATCACCGGTTCGATGGAG
CGCGCCATCGGCGAAACCGAACGCCGTCGTGACAAACAGATCGCCTTCAATCTGGCCAACGGCATCACGCCGAAGGGCGT
GTTCAAGGACGTCGCCGACATCATGGAAGGCGCCACCGTGCCCGGTTCGCGCAGCAAGAAGCGCAAAGGCATGGCCAAGG
CCGCCGAAGAGAACGCCAAGTACGAAGCCGAACTGCGCTCGCCGAGCGAGATCACCAAGCGCATCCGCCAACTGGAAGAG
AAGATGTACCAGCTGGCCCGCGACCTGGAATTCGAAGCGGCAGCACAGATGCGCGACGAAATCGCCAAGCTGCGTGAGCG
GCTGTTGGCCGTTTAA

Upstream 100 bases:

>100_bases
ATTCAGCACAATCTTCGTTTTTCCTTGCGCGACATCGGTCGTTTGCGGTCTTTCTCGTGGTGCTGCGGTTGCCCGCCGCG
TCGCGATTCCAGAGGTGTTT

Downstream 100 bases:

>100_bases
CGGATCGTTCCCACGCTCTGCGTGGGAATGCAGCCCTGGACGCTCTGCGTCCGCTCAAGATTAATGTGCCTCGCCGGCCT
TCAGTCCGGCGGGCAATTTC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MSEFQLVTRFDPAGDQPEAIRLMVEGIEAGLSHQTLLGVTGSGKTFSIANVIAQVQRPTLVLAPNKTLAAQLYGEFKSFF
PNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERKDAIIVTTVSCIYGLGSPETYLKMVLHV
DRGDKLDQRALVRRLADLQYTRNDMDFARATFRVRGDVIDIYPAESDLEAIRIELFDDEVESISAFDPLTGEVIRKLPRF
TFYPKSHYVTPRETLLDAIEGIKVELQERLEYLRNNNKLVEAQRLEQRTRFDLEMILELGYCNGIENYSRYLSGRPAGAA
PPTLYDYLPADALLVIDESHVSVPQVGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFDEWEGVSPQTIFVSATPGNYEA
EHAGRVIEQVVRPTGLVDPQVEVRPALTQVDDLLSEITKRVAVEERVLVTTLTKRMAEDLTDYLADHGVRVRYLHSDIDT
VERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGRAILYADRITGSME
RAIGETERRRDKQIAFNLANGITPKGVFKDVADIMEGATVPGSRSKKRKGMAKAAEENAKYEAELRSPSEITKRIRQLEE
KMYQLARDLEFEAAAQMRDEIAKLRERLLAV

Sequences:

>Translated_671_residues
MSEFQLVTRFDPAGDQPEAIRLMVEGIEAGLSHQTLLGVTGSGKTFSIANVIAQVQRPTLVLAPNKTLAAQLYGEFKSFF
PNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERKDAIIVTTVSCIYGLGSPETYLKMVLHV
DRGDKLDQRALVRRLADLQYTRNDMDFARATFRVRGDVIDIYPAESDLEAIRIELFDDEVESISAFDPLTGEVIRKLPRF
TFYPKSHYVTPRETLLDAIEGIKVELQERLEYLRNNNKLVEAQRLEQRTRFDLEMILELGYCNGIENYSRYLSGRPAGAA
PPTLYDYLPADALLVIDESHVSVPQVGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFDEWEGVSPQTIFVSATPGNYEA
EHAGRVIEQVVRPTGLVDPQVEVRPALTQVDDLLSEITKRVAVEERVLVTTLTKRMAEDLTDYLADHGVRVRYLHSDIDT
VERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGRAILYADRITGSME
RAIGETERRRDKQIAFNLANGITPKGVFKDVADIMEGATVPGSRSKKRKGMAKAAEENAKYEAELRSPSEITKRIRQLEE
KMYQLARDLEFEAAAQMRDEIAKLRERLLAV
>Mature_670_residues
SEFQLVTRFDPAGDQPEAIRLMVEGIEAGLSHQTLLGVTGSGKTFSIANVIAQVQRPTLVLAPNKTLAAQLYGEFKSFFP
NNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERKDAIIVTTVSCIYGLGSPETYLKMVLHVD
RGDKLDQRALVRRLADLQYTRNDMDFARATFRVRGDVIDIYPAESDLEAIRIELFDDEVESISAFDPLTGEVIRKLPRFT
FYPKSHYVTPRETLLDAIEGIKVELQERLEYLRNNNKLVEAQRLEQRTRFDLEMILELGYCNGIENYSRYLSGRPAGAAP
PTLYDYLPADALLVIDESHVSVPQVGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFDEWEGVSPQTIFVSATPGNYEAE
HAGRVIEQVVRPTGLVDPQVEVRPALTQVDDLLSEITKRVAVEERVLVTTLTKRMAEDLTDYLADHGVRVRYLHSDIDTV
ERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGRAILYADRITGSMER
AIGETERRRDKQIAFNLANGITPKGVFKDVADIMEGATVPGSRSKKRKGMAKAAEENAKYEAELRSPSEITKRIRQLEEK
MYQLARDLEFEAAAQMRDEIAKLRERLLAV

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=669, Percent_Identity=69.9551569506726, Blast_Score=950, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=324, Percent_Identity=23.1481481481481, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75895; Mature: 75764

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFQLVTRFDPAGDQPEAIRLMVEGIEAGLSHQTLLGVTGSGKTFSIANVIAQVQRPTL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEHHHHHHHHHCCCEE
VLAPNKTLAAQLYGEFKSFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQ
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
MRLSATKALLERKDAIIVTTVSCIYGLGSPETYLKMVLHVDRGDKLDQRALVRRLADLQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
TRNDMDFARATFRVRGDVIDIYPAESDLEAIRIELFDDEVESISAFDPLTGEVIRKLPRF
CCCHHHHHHHHHEEECCEEEEECCCCCCCEEEEEEEHHHHHHHHHCCCCHHHHHHHCCCC
TFYPKSHYVTPRETLLDAIEGIKVELQERLEYLRNNNKLVEAQRLEQRTRFDLEMILELG
EECCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHH
YCNGIENYSRYLSGRPAGAAPPTLYDYLPADALLVIDESHVSVPQVGAMYKGDRSRKETL
CCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCHHCCCCHHHHHH
VEYGFRLPSALDNRPMRFDEWEGVSPQTIFVSATPGNYEAEHAGRVIEQVVRPTGLVDPQ
HHHHCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
VEVRPALTQVDDLLSEITKRVAVEERVLVTTLTKRMAEDLTDYLADHGVRVRYLHSDIDT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
VERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARNLNGRAILYADRITGSMERAIGETERRRDKQIAFNLANGITPKGVFKDVADIMEGATV
HHCCCCCEEEEEHHHCCHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
PGSRSKKRKGMAKAAEENAKYEAELRSPSEITKRIRQLEEKMYQLARDLEFEAAAQMRDE
CCCCHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IAKLRERLLAV
HHHHHHHHHCC
>Mature Secondary Structure 
SEFQLVTRFDPAGDQPEAIRLMVEGIEAGLSHQTLLGVTGSGKTFSIANVIAQVQRPTL
CCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEHHHHHHHHHCCCEE
VLAPNKTLAAQLYGEFKSFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQ
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
MRLSATKALLERKDAIIVTTVSCIYGLGSPETYLKMVLHVDRGDKLDQRALVRRLADLQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
TRNDMDFARATFRVRGDVIDIYPAESDLEAIRIELFDDEVESISAFDPLTGEVIRKLPRF
CCCHHHHHHHHHEEECCEEEEECCCCCCCEEEEEEEHHHHHHHHHCCCCHHHHHHHCCCC
TFYPKSHYVTPRETLLDAIEGIKVELQERLEYLRNNNKLVEAQRLEQRTRFDLEMILELG
EECCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHH
YCNGIENYSRYLSGRPAGAAPPTLYDYLPADALLVIDESHVSVPQVGAMYKGDRSRKETL
CCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCHHCCCCHHHHHH
VEYGFRLPSALDNRPMRFDEWEGVSPQTIFVSATPGNYEAEHAGRVIEQVVRPTGLVDPQ
HHHHCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
VEVRPALTQVDDLLSEITKRVAVEERVLVTTLTKRMAEDLTDYLADHGVRVRYLHSDIDT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
VERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARNLNGRAILYADRITGSMERAIGETERRRDKQIAFNLANGITPKGVFKDVADIMEGATV
HHCCCCCEEEEEHHHCCHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
PGSRSKKRKGMAKAAEENAKYEAELRSPSEITKRIRQLEEKMYQLARDLEFEAAAQMRDE
CCCCHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IAKLRERLLAV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA