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The map label for this gene is bvgA [H]

Identifier: 77458090

GI number: 77458090

Start: 2123792

End: 2124421

Strand: Direct

Name: bvgA [H]

Synonym: Pfl01_1863

Alternate gene names: 77458090

Gene position: 2123792-2124421 (Clockwise)

Preceding gene: 77458089

Following gene: 77458091

Centisome position: 32.99

GC content: 55.56

Gene sequence:

>630_bases
ATGGGTTCAGCATTGATCGTTGATGATCATCCAGTGGTGGTGGGTGCCCTACGCCTGGTTCTGGAGTCTGCGGGTTACAC
ACCGATCCATGTGACTGGCAGAGGTGTCGATGTGGTGCCGATGCTGCGTGAGCACGCGCCGAAACTGGTAGTGCTCGACC
TGAAACTCGATGGCTTCGGCGGCCTGGAGGTGTTAGCCCGCATCAGAGCCGTCGGGCTGGTCTGCAATGTGGTGATTTTC
ACCTCGGCCGACCCTGAACACTATCTGATGCGCTGTCGACGTGCAGGGGCGATGGCTTTTGTCGCCAAATCCGCCTCGAT
GCAGCATTTGCAAAATGCAATCAAAGCCGTCCGTTCGGGTTATACCTACTTCCCCGAAATGCCTGTGGTCAATACCGGGC
AATCCGAAGCACATCGCGATGAACGAGAGTTGATTGCACTTCTGTCCACTCGCGAAATGGAGATCATGCTGAAGCTGGCC
AGAGGCGAGTCCAACAAGCACATTGCGCTTGCGATGAACCTTAGCCACAAAACCATCAGCACCTACAAGACCCGCCTGAT
GCTGAAGCTCGGGGTAAGCTCACTGGTGGTGTTGCGAGAGTTTGTCAAACGCAACGGTCTGCTTCCATAG

Upstream 100 bases:

>100_bases
TTCAGGGTGCATACCGTGCAACAGTTGTAGCGCAGCTACCAATAGTCCCGTTCAAGCCAGATCGGTGGCGTCGTGTCATG
TATTCGCCCCGGGAGTGATC

Downstream 100 bases:

>100_bases
GCTGCCCATGATATGGCCTCTGCGGTTCGTTCTTCTGTCGATACTGATGCTTGCAAGCACAGTGCACGCGACCGAGGCAC
AACGGCTGGAAATCGTCTCC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGSALIVDDHPVVVGALRLVLESAGYTPIHVTGRGVDVVPMLREHAPKLVVLDLKLDGFGGLEVLARIRAVGLVCNVVIF
TSADPEHYLMRCRRAGAMAFVAKSASMQHLQNAIKAVRSGYTYFPEMPVVNTGQSEAHRDERELIALLSTREMEIMLKLA
RGESNKHIALAMNLSHKTISTYKTRLMLKLGVSSLVVLREFVKRNGLLP

Sequences:

>Translated_209_residues
MGSALIVDDHPVVVGALRLVLESAGYTPIHVTGRGVDVVPMLREHAPKLVVLDLKLDGFGGLEVLARIRAVGLVCNVVIF
TSADPEHYLMRCRRAGAMAFVAKSASMQHLQNAIKAVRSGYTYFPEMPVVNTGQSEAHRDERELIALLSTREMEIMLKLA
RGESNKHIALAMNLSHKTISTYKTRLMLKLGVSSLVVLREFVKRNGLLP
>Mature_208_residues
GSALIVDDHPVVVGALRLVLESAGYTPIHVTGRGVDVVPMLREHAPKLVVLDLKLDGFGGLEVLARIRAVGLVCNVVIFT
SADPEHYLMRCRRAGAMAFVAKSASMQHLQNAIKAVRSGYTYFPEMPVVNTGQSEAHRDERELIALLSTREMEIMLKLAR
GESNKHIALAMNLSHKTISTYKTRLMLKLGVSSLVVLREFVKRNGLLP

Specific function: Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788712, Length=205, Percent_Identity=32.6829268292683, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786747, Length=202, Percent_Identity=30.1980198019802, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=30.1435406698565, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788521, Length=193, Percent_Identity=29.5336787564767, Blast_Score=88, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22982; Mature: 22850

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSALIVDDHPVVVGALRLVLESAGYTPIHVTGRGVDVVPMLREHAPKLVVLDLKLDGFG
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHCCCCEEEEEEEECCCC
GLEVLARIRAVGLVCNVVIFTSADPEHYLMRCRRAGAMAFVAKSASMQHLQNAIKAVRSG
HHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
YTYFPEMPVVNTGQSEAHRDERELIALLSTREMEIMLKLARGESNKHIALAMNLSHKTIS
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHH
TYKTRLMLKLGVSSLVVLREFVKRNGLLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GSALIVDDHPVVVGALRLVLESAGYTPIHVTGRGVDVVPMLREHAPKLVVLDLKLDGFG
CCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHCCCCEEEEEEEECCCC
GLEVLARIRAVGLVCNVVIFTSADPEHYLMRCRRAGAMAFVAKSASMQHLQNAIKAVRSG
HHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
YTYFPEMPVVNTGQSEAHRDERELIALLSTREMEIMLKLARGESNKHIALAMNLSHKTIS
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHH
TYKTRLMLKLGVSSLVVLREFVKRNGLLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1791760; 12910271 [H]