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The map label for this gene is macA [H]

Identifier: 77458084

GI number: 77458084

Start: 2115751

End: 2116923

Strand: Reverse

Name: macA [H]

Synonym: Pfl01_1857

Alternate gene names: 77458084

Gene position: 2116923-2115751 (Counterclockwise)

Preceding gene: 77458092

Following gene: 77458083

Centisome position: 32.88

GC content: 63.43

Gene sequence:

>1173_bases
ATGAAACGTCCCCGCCCCGCCCGACGCGCCCTGCTCATCGCCCTTTGCCTTATCCCCGTCATTGCTATTGCCGCCTGGCA
GGTGTTGCCGCCCGGTCGGGACAAATTCACCACCGTGCAGGTCTCTCGCGGCGATATAGAAAGCAGCGTGACCGCACTCG
GCACCCTCCAGCCTCGCCGGTATGTAGATGTCGGCGCCCAGGCGTCGGGGCAGATTCGCAAGATCCACGTGGAAGTCGGC
GACGTGGTCAAGGAGGGTCAGTTGCTGGTAGAGATCGACCCGGCCACGCAAAAGGCCAAACTCGACGCCAGCCAGTTTTC
CATCGAGAACCTGAAGGCGCAGTTGCAGGAACAACAGGCCCAACATGAACTGGCGCGTCAGAAGTATCAGCGCCAGCAGA
ACCTGGCTGCCGGCGGCGCCACCCGTGAAGAAGACGTGCAAACCGCCCGCGCCGAACTGAAAGCCACGCAGGCGCGCATC
GACATGTTCCAGGCGCAGATCCGTCAGGCACAGGCGAGCCTGCGCAGCGATCAGGCCGAGCTCGGTTACACCCGGATCTA
CGCACCGATGGCCGGTACCGTGGTCGCACTGGACGCTCGCGAAGGCCAGACACTCAACGCCCAGCAACAGACACCGCTGA
TCCTGCGGATCGCCAAGCTGTCGCCAATGACGGTCTGGGCTGAAGTCTCCGAAGCCGACATCGGCCACGTCAAACCGGGC
ATGAGCGCTTATTTCACCACCCTCAGTGGCGGCAACCGGCGCTGGAGCAGCACCGTGCGGCAGATCCTGCCGGTGCCGCC
CAAACCGCTGGACCAGACCAGCCAGGGCGGTGGCAGCCCGACCAGCACCAGCAAAAGCGGTGCCGGTCGTGTGGTGCTGT
ACACCGTATTGCTGGATGTCGATAACGCCGACAACGCGCTGATGGCGGAAATGACCACACAAGTGTTCTTCGTCTCCAAC
GAGGCAAAAAACGTCCTCACCGCACCGGTTGCCGCCCTGCACGGCAGCGCCAAACCCGACAGTCAGGTTGCCCGGGTCGT
GGCGCAGAACGGCGACATTGAGCAACGCACCGTGCGTACCGGCATCAGCGACCGTTTGAAGGTGCAGATTCTCGACGGTC
TCAGCGAAGGCGATCATCTGTTGATCGGCCCGGTCGACGGCAGCGGAGGCTGA

Upstream 100 bases:

>100_bases
ACAGCCCCCGTATCTGTCGCGTCCTGCGACAGCGTTCGACCGTGGCCCGCTCGCGGTGCCTGCTGAACGACGGGCCTATT
TCCACTGGCCGGAACCCTGC

Downstream 100 bases:

>100_bases
ATGCAAACGCCCCTGATCGACCTGCAGGACATCCGCAAATCCTACGGCGGCGGCGACACGCCCGAAGTTCACGTGTTGCG
TGGCATCGATCTGTCGATCC

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKRPRPARRALLIALCLIPVIAIAAWQVLPPGRDKFTTVQVSRGDIESSVTALGTLQPRRYVDVGAQASGQIRKIHVEVG
DVVKEGQLLVEIDPATQKAKLDASQFSIENLKAQLQEQQAQHELARQKYQRQQNLAAGGATREEDVQTARAELKATQARI
DMFQAQIRQAQASLRSDQAELGYTRIYAPMAGTVVALDAREGQTLNAQQQTPLILRIAKLSPMTVWAEVSEADIGHVKPG
MSAYFTTLSGGNRRWSSTVRQILPVPPKPLDQTSQGGGSPTSTSKSGAGRVVLYTVLLDVDNADNALMAEMTTQVFFVSN
EAKNVLTAPVAALHGSAKPDSQVARVVAQNGDIEQRTVRTGISDRLKVQILDGLSEGDHLLIGPVDGSGG

Sequences:

>Translated_390_residues
MKRPRPARRALLIALCLIPVIAIAAWQVLPPGRDKFTTVQVSRGDIESSVTALGTLQPRRYVDVGAQASGQIRKIHVEVG
DVVKEGQLLVEIDPATQKAKLDASQFSIENLKAQLQEQQAQHELARQKYQRQQNLAAGGATREEDVQTARAELKATQARI
DMFQAQIRQAQASLRSDQAELGYTRIYAPMAGTVVALDAREGQTLNAQQQTPLILRIAKLSPMTVWAEVSEADIGHVKPG
MSAYFTTLSGGNRRWSSTVRQILPVPPKPLDQTSQGGGSPTSTSKSGAGRVVLYTVLLDVDNADNALMAEMTTQVFFVSN
EAKNVLTAPVAALHGSAKPDSQVARVVAQNGDIEQRTVRTGISDRLKVQILDGLSEGDHLLIGPVDGSGG
>Mature_390_residues
MKRPRPARRALLIALCLIPVIAIAAWQVLPPGRDKFTTVQVSRGDIESSVTALGTLQPRRYVDVGAQASGQIRKIHVEVG
DVVKEGQLLVEIDPATQKAKLDASQFSIENLKAQLQEQQAQHELARQKYQRQQNLAAGGATREEDVQTARAELKATQARI
DMFQAQIRQAQASLRSDQAELGYTRIYAPMAGTVVALDAREGQTLNAQQQTPLILRIAKLSPMTVWAEVSEADIGHVKPG
MSAYFTTLSGGNRRWSSTVRQILPVPPKPLDQTSQGGGSPTSTSKSGAGRVVLYTVLLDVDNADNALMAEMTTQVFFVSN
EAKNVLTAPVAALHGSAKPDSQVARVVAQNGDIEQRTVRTGISDRLKVQILDGLSEGDHLLIGPVDGSGG

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=383, Percent_Identity=37.0757180156658, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87082036, Length=340, Percent_Identity=25.2941176470588, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87081951, Length=190, Percent_Identity=30, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42033; Mature: 42033

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRPRPARRALLIALCLIPVIAIAAWQVLPPGRDKFTTVQVSRGDIESSVTALGTLQPRR
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCC
YVDVGAQASGQIRKIHVEVGDVVKEGQLLVEIDPATQKAKLDASQFSIENLKAQLQEQQA
EEECCCCCCCCEEEEEEEHHHHHHCCCEEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHH
QHELARQKYQRQQNLAAGGATREEDVQTARAELKATQARIDMFQAQIRQAQASLRSDQAE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LGYTRIYAPMAGTVVALDAREGQTLNAQQQTPLILRIAKLSPMTVWAEVSEADIGHVKPG
CCEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCC
MSAYFTTLSGGNRRWSSTVRQILPVPPKPLDQTSQGGGSPTSTSKSGAGRVVLYTVLLDV
CHHEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEC
DNADNALMAEMTTQVFFVSNEAKNVLTAPVAALHGSAKPDSQVARVVAQNGDIEQRTVRT
CCCCCHHHHHHEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHC
GISDRLKVQILDGLSEGDHLLIGPVDGSGG
CCCCCEEEEEECCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MKRPRPARRALLIALCLIPVIAIAAWQVLPPGRDKFTTVQVSRGDIESSVTALGTLQPRR
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCC
YVDVGAQASGQIRKIHVEVGDVVKEGQLLVEIDPATQKAKLDASQFSIENLKAQLQEQQA
EEECCCCCCCCEEEEEEEHHHHHHCCCEEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHH
QHELARQKYQRQQNLAAGGATREEDVQTARAELKATQARIDMFQAQIRQAQASLRSDQAE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LGYTRIYAPMAGTVVALDAREGQTLNAQQQTPLILRIAKLSPMTVWAEVSEADIGHVKPG
CCEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCC
MSAYFTTLSGGNRRWSSTVRQILPVPPKPLDQTSQGGGSPTSTSKSGAGRVVLYTVLLDV
CHHEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEC
DNADNALMAEMTTQVFFVSNEAKNVLTAPVAALHGSAKPDSQVARVVAQNGDIEQRTVRT
CCCCCHHHHHHEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHC
GISDRLKVQILDGLSEGDHLLIGPVDGSGG
CCCCCEEEEEECCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]