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The map label for this gene is plsC [H]

Identifier: 77457970

GI number: 77457970

Start: 1936238

End: 1936972

Strand: Reverse

Name: plsC [H]

Synonym: Pfl01_1743

Alternate gene names: 77457970

Gene position: 1936972-1936238 (Counterclockwise)

Preceding gene: 77457971

Following gene: 77457969

Centisome position: 30.08

GC content: 57.69

Gene sequence:

>735_bases
ATGGGCCTGAAAATGCTGTTTGTGTTTCGTATGTTATTGATGGGCCTGCACTTTATTCTGGCGGGGATACTCGGAGTGAT
CCTCGGGCTGTGCCGGCCATTTAATCCGGACAACAGTCGCCTGTGTGCCCGTCTCTATGCACTGCCGGCCATGTGCATTT
TGCGTCTGCGGGTGAAGGCCGATGTTGGCGCGCTAATGAACAAACCCGACAGCTGCGTGATCATCGCCAACCATCAGTCC
AACTACGACCTGTTCGTGTTCGGTAACGTGGTGCCGCATCGTACCGTGTGCATCGGCAAGAAAAGCCTGAAGTGGGTACC
GCTGTTCGGGCAGCTGTTCTGGCTGGCGGGCAATGTGTTGATCGATCGTGGGAACGCGCACAAGGCGCGCCAGTCGATGC
TGACCACCACCGACACCTTGCAGCACAAAGACACCTCGATCTGGGTCTTTCCAGAAGGCACCCGCAACCTGGGTGAAGAA
CTGCTGCCGTTCAAGAAAGGCGCTTTCCAGATGGCCATTGCCGCCGGGGTGCCGATCGTTCCGGTGTGTGTCAGCAGCTA
CATCAAGCACATGCGCCTGAACCGCTGGCACAGCGGGAAAATTCTTATACGCTCACTACCGGCGATTCCTACGGCCGGCC
TGACCATGGACGACATGCCCATGCTCATCAACCAATGCCGCGAGCAGATGCGCGAATGCATCGATGCGATGGATCGGCAG
CTGCAAGCCGCGTGA

Upstream 100 bases:

>100_bases
AAGTCGGAAACATGCGCTTAAACATCGCCCATCTCCAGACTCTATAGCGGCAATTGCCGAAAACAGTGCACATCCGTACA
CTGCGCCACCTTTTGTCCCG

Downstream 100 bases:

>100_bases
AAAAGAAGCCCGCCCTGTGCGGGTTTTCTTTTGCCCGCTGAACTGTGCAGATTTCACTGACTCTCAAGCAGCGACACGGC
TAAGCTGAAGCCATGTCTCT

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MGLKMLFVFRMLLMGLHFILAGILGVILGLCRPFNPDNSRLCARLYALPAMCILRLRVKADVGALMNKPDSCVIIANHQS
NYDLFVFGNVVPHRTVCIGKKSLKWVPLFGQLFWLAGNVLIDRGNAHKARQSMLTTTDTLQHKDTSIWVFPEGTRNLGEE
LLPFKKGAFQMAIAAGVPIVPVCVSSYIKHMRLNRWHSGKILIRSLPAIPTAGLTMDDMPMLINQCREQMRECIDAMDRQ
LQAA

Sequences:

>Translated_244_residues
MGLKMLFVFRMLLMGLHFILAGILGVILGLCRPFNPDNSRLCARLYALPAMCILRLRVKADVGALMNKPDSCVIIANHQS
NYDLFVFGNVVPHRTVCIGKKSLKWVPLFGQLFWLAGNVLIDRGNAHKARQSMLTTTDTLQHKDTSIWVFPEGTRNLGEE
LLPFKKGAFQMAIAAGVPIVPVCVSSYIKHMRLNRWHSGKILIRSLPAIPTAGLTMDDMPMLINQCREQMRECIDAMDRQ
LQAA
>Mature_243_residues
GLKMLFVFRMLLMGLHFILAGILGVILGLCRPFNPDNSRLCARLYALPAMCILRLRVKADVGALMNKPDSCVIIANHQSN
YDLFVFGNVVPHRTVCIGKKSLKWVPLFGQLFWLAGNVLIDRGNAHKARQSMLTTTDTLQHKDTSIWVFPEGTRNLGEEL
LPFKKGAFQMAIAAGVPIVPVCVSSYIKHMRLNRWHSGKILIRSLPAIPTAGLTMDDMPMLINQCREQMRECIDAMDRQL
QAA

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=226, Percent_Identity=36.283185840708, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI15100175, Length=226, Percent_Identity=36.283185840708, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI6041665, Length=168, Percent_Identity=38.0952380952381, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI69122971, Length=168, Percent_Identity=29.7619047619048, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789395, Length=237, Percent_Identity=40.084388185654, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17564032, Length=161, Percent_Identity=38.5093167701863, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17568319, Length=235, Percent_Identity=31.9148936170213, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320151, Length=243, Percent_Identity=33.7448559670782, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24641614, Length=242, Percent_Identity=33.4710743801653, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24641612, Length=242, Percent_Identity=33.4710743801653, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI281364648, Length=242, Percent_Identity=31.8181818181818, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24582856, Length=242, Percent_Identity=31.8181818181818, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24582854, Length=242, Percent_Identity=31.8181818181818, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27345; Mature: 27214

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
9.0 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
8.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLKMLFVFRMLLMGLHFILAGILGVILGLCRPFNPDNSRLCARLYALPAMCILRLRVKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DVGALMNKPDSCVIIANHQSNYDLFVFGNVVPHRTVCIGKKSLKWVPLFGQLFWLAGNVL
HHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCEEEECCCCCEEHHHHHHHHHHHCCCE
IDRGNAHKARQSMLTTTDTLQHKDTSIWVFPEGTRNLGEELLPFKKGAFQMAIAAGVPIV
EECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHCCCCHH
PVCVSSYIKHMRLNRWHSGKILIRSLPAIPTAGLTMDDMPMLINQCREQMRECIDAMDRQ
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQAA
HCCC
>Mature Secondary Structure 
GLKMLFVFRMLLMGLHFILAGILGVILGLCRPFNPDNSRLCARLYALPAMCILRLRVKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DVGALMNKPDSCVIIANHQSNYDLFVFGNVVPHRTVCIGKKSLKWVPLFGQLFWLAGNVL
HHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCEEEECCCCCEEHHHHHHHHHHHCCCE
IDRGNAHKARQSMLTTTDTLQHKDTSIWVFPEGTRNLGEELLPFKKGAFQMAIAAGVPIV
EECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHCCCCHH
PVCVSSYIKHMRLNRWHSGKILIRSLPAIPTAGLTMDDMPMLINQCREQMRECIDAMDRQ
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQAA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1557036; 9278503 [H]