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The map label for this gene is purM [H]

Identifier: 77457860

GI number: 77457860

Start: 1823825

End: 1824883

Strand: Reverse

Name: purM [H]

Synonym: Pfl01_1633

Alternate gene names: 77457860

Gene position: 1824883-1823825 (Counterclockwise)

Preceding gene: 77457866

Following gene: 77457859

Centisome position: 28.34

GC content: 63.46

Gene sequence:

>1059_bases
ATGAGCAAGCAACCCTCCCTGAGCTACAAGGACGCCGGTGTAGACATCGACGCCGGTGAAGCATTGGTCGAACGCATCAA
GAGCGTCGCCAAGCGCACTGCGCGCCCGGAAGTCATGGGCGGCCTGGGCGGTTTCGGCGCCCTCTGCGAGATCCCGGCCG
GTTACAAGCAGCCGGTGCTGGTTTCCGGTACTGACGGCGTCGGCACCAAACTGCGCCTGGCGCTGAACCTGAACAAGCAC
GACAGCATCGGCCAGGACCTGGTCGCCATGTGCGTCAACGATCTGGTGGTGTGCGGCGCCGAGCCGCTGTTCTTCCTCGA
CTACTACGCCACCGGCAAGCTGAACGTCGACGTAGCGGCCACCGTGGTTACCGGTATCGGTGCAGGCTGCGAACTGGCTG
GCTGCTCGCTGGTCGGCGGCGAAACCGCTGAAATGCCTGGCATGTACGAAGGCGAAGACTACGACCTGGCCGGCTTCTGC
GTCGGCGTCGTGGAAAAAGCCGAAATCATCGACGGCTCGAAAGTCGCCACCGGTGACGCCCTGATCGCCCTGCCATCGTC
CGGCCCGCACTCCAACGGTTACTCGCTGATCCGCAAGATCATCGAAGTGTCCGGTGCCGATATCGAAACCGTTCAGCTCG
ACGGCAAGCCGCTGACCGAACTGCTGATGGCCCCGACCCGCATCTACGTGAAGCCGCTGCTCAAGCTGATCAAGGACACC
GGCGCGGTCAAGGCCATGGCCCACATCACCGGTGGCGGTTTGCTCGACAACATCCCGCGCGTTCTGCCAAAAGGCGCTCA
GGCCGTGGTTGACGTGGCCAGCTGGAACCGCCCGGCCGTCTTCGACTGGCTGCAAGAGAAAGGCAACGTCGACGAAACCG
AAATGCACCGCGTGCTGAACTGCGGCGTGGGCATGGTGATCTGCGTGGCTCAGGAGCACGTTGAAGTTGCGCTGAACACC
CTGCGTGACGCCGGCGAGCAGCCTTGGGTCATCGGTCAGATCGCTGCCGCTGCCGAAGGCGCGGCCCAGGTCGAACTGAA
GAACCTCAAGGCTCACTGA

Upstream 100 bases:

>100_bases
CACCCCGAACTCCGCGTGAGGCAATCGCCCCCTGTCGGATTCGGCGTTCCCGCTGAACTCGGTCGTTACCCCTGAATCCC
CTCCCCTAAAGGCCTGGATC

Downstream 100 bases:

>100_bases
TGTCCCAGACCTGTGATGTCGTGGTGCTGTTGTCCGGCACCGGCAGTAACTTGCAGGCCCTGATCGACAGCACGCGGACC
GGCGACAGCCCGGTCCGCAT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSKQPSLSYKDAGVDIDAGEALVERIKSVAKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKH
DSIGQDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFC
VGVVEKAEIIDGSKVATGDALIALPSSGPHSNGYSLIRKIIEVSGADIETVQLDGKPLTELLMAPTRIYVKPLLKLIKDT
GAVKAMAHITGGGLLDNIPRVLPKGAQAVVDVASWNRPAVFDWLQEKGNVDETEMHRVLNCGVGMVICVAQEHVEVALNT
LRDAGEQPWVIGQIAAAAEGAAQVELKNLKAH

Sequences:

>Translated_352_residues
MSKQPSLSYKDAGVDIDAGEALVERIKSVAKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKH
DSIGQDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFC
VGVVEKAEIIDGSKVATGDALIALPSSGPHSNGYSLIRKIIEVSGADIETVQLDGKPLTELLMAPTRIYVKPLLKLIKDT
GAVKAMAHITGGGLLDNIPRVLPKGAQAVVDVASWNRPAVFDWLQEKGNVDETEMHRVLNCGVGMVICVAQEHVEVALNT
LRDAGEQPWVIGQIAAAAEGAAQVELKNLKAH
>Mature_351_residues
SKQPSLSYKDAGVDIDAGEALVERIKSVAKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHD
SIGQDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCV
GVVEKAEIIDGSKVATGDALIALPSSGPHSNGYSLIRKIIEVSGADIETVQLDGKPLTELLMAPTRIYVKPLLKLIKDTG
AVKAMAHITGGGLLDNIPRVLPKGAQAVVDVASWNRPAVFDWLQEKGNVDETEMHRVLNCGVGMVICVAQEHVEVALNTL
RDAGEQPWVIGQIAAAAEGAAQVELKNLKAH

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=353, Percent_Identity=51.2747875354108, Blast_Score=352, Evalue=2e-97,
Organism=Homo sapiens, GI209869995, Length=353, Percent_Identity=51.2747875354108, Blast_Score=352, Evalue=2e-97,
Organism=Homo sapiens, GI209869993, Length=353, Percent_Identity=51.2747875354108, Blast_Score=352, Evalue=2e-97,
Organism=Escherichia coli, GI1788845, Length=337, Percent_Identity=69.1394658753709, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17567511, Length=347, Percent_Identity=44.3804034582133, Blast_Score=260, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6321203, Length=354, Percent_Identity=45.1977401129944, Blast_Score=291, Evalue=7e-80,
Organism=Drosophila melanogaster, GI24582400, Length=308, Percent_Identity=43.1818181818182, Blast_Score=242, Evalue=3e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36861; Mature: 36730

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQPSLSYKDAGVDIDAGEALVERIKSVAKRTARPEVMGGLGGFGALCEIPAGYKQPVL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHCCCCCCCCCEE
VSGTDGVGTKLRLALNLNKHDSIGQDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDVAA
EECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEECCHHHH
TVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSKVATGDA
HHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCE
LIALPSSGPHSNGYSLIRKIIEVSGADIETVQLDGKPLTELLMAPTRIYVKPLLKLIKDT
EEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHCC
GAVKAMAHITGGGLLDNIPRVLPKGAQAVVDVASWNRPAVFDWLQEKGNVDETEMHRVLN
CHHHHHHHHCCCCHHHHHHHHCCCCHHHHEEHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
CGVGMVICVAQEHVEVALNTLRDAGEQPWVIGQIAAAAEGAAQVELKNLKAH
CCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCEEEECCCCCC
>Mature Secondary Structure 
SKQPSLSYKDAGVDIDAGEALVERIKSVAKRTARPEVMGGLGGFGALCEIPAGYKQPVL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHCCCCCCCCCEE
VSGTDGVGTKLRLALNLNKHDSIGQDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDVAA
EECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEECCHHHH
TVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSKVATGDA
HHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCE
LIALPSSGPHSNGYSLIRKIIEVSGADIETVQLDGKPLTELLMAPTRIYVKPLLKLIKDT
EEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHCC
GAVKAMAHITGGGLLDNIPRVLPKGAQAVVDVASWNRPAVFDWLQEKGNVDETEMHRVLN
CHHHHHHHHCCCCHHHHHHHHCCCCHHHHEEHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
CGVGMVICVAQEHVEVALNTLRDAGEQPWVIGQIAAAAEGAAQVELKNLKAH
CCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA