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The map label for this gene is 77457750

Identifier: 77457750

GI number: 77457750

Start: 1711800

End: 1712852

Strand: Direct

Name: 77457750

Synonym: Pfl01_1523

Alternate gene names: NA

Gene position: 1711800-1712852 (Clockwise)

Preceding gene: 77457749

Following gene: 77457751

Centisome position: 26.59

GC content: 62.68

Gene sequence:

>1053_bases
ATGAGCAGTTTCAAGATCGGCAACCGTCAGATCGGTGCCGATGCGCCGCCGTTCATCATCGCGGAAATGAGCGGCAACCA
TAACCAGTCGCTGGACGTAGCCCTGCAGATTGTCGAAGCGGCAGCAAAGGCCGGTGCGCACGCCCTGAAGCTGCAAACCT
ACACCGCCGAAACCATGACTCTGGATCTGGCGCAAGGCGAGTTCTTCATCAAGGATCCGAACAGTCTCTGGGCGGGCACC
TCGCTCTACGACCTGTATGAAAAGGCCCACACACCCTGGGAATGGCATGCGCCGATCTTCGCCCGGGCCAGAGAATTGGG
CATGCTCGCGTTTTCCACGCCGTTCGATGACAGCGCCGTGGACTTTCTCGAAAGCCTCGATGTGCCGGCCTACAAGATCG
CCAGTTTCGAAAATACCGATCTGCCGTTGATTCGCCGTGTCGCGGCGACCGGCAAACCGCTGATCATTTCCACCGGCATG
GCCAGCATCGCCGAACTCGATGAAACCGTGCGCGCTGCCCGTGAGGCAGGTTGCAAGGATCTGGTGCTGCTCAAATGCAC
CAGCACCTACCCGGCGACGCCGCTCAACAGCCACGTGCGCACGATTCCGCATCTGCGTGAGCTGTTTGGCTGCGAGGTCG
GGCTGTCCGATCACTCGATGGGTGTAGGCGTGTCGGTGGCGGCGGTGGCACTCGGCGCGACCGTGGTGGAAAAACACTTC
ACCCTCGACCGTTCAGCCGGAGGGGTGGACGCCAGTTTCTCGCTGGAGCCGGCGGAACTGGCCAGCCTGGTGGTCGAGAC
CGAACGTGCCTGGCAGGCCATGGGCCAGGTGCATTACGGGGTGACCGAGGCTGAGCAGAAGTCGCTGGTTTACCGTCGGT
CGCTGTACGTCACGACCGATATGGCGGCCGGCGAACCCTTCACGGCGGCCAACCTGCGCGCCATTCGTCCCGGTCTCGGT
CTGCCGCCCAAGCACACCGATGCGGTCCTCGGGCGCCGTGCGCGCCAGCCGATCAAGCGTGGTACACCGCTGGACTGGTC
ATTGGTCGAATGA

Upstream 100 bases:

>100_bases
AGGTGTTGCCGGCCAATCGGCCCTCGATGAATGTTTTTCGTGACGCCGGGTTCACCCAGAGTGCCTGTGCGTTCACCAAG
GTATTGAAGGAATCCTGTCA

Downstream 100 bases:

>100_bases
CCCAATCTGCCACCGATTCGGCAAAATAGCGTGACCTGCGAGTCATAACGCGCATCTTCACTGTATTGTAATGACCGGGG
GAGATGGCGCCTGGCCCGTT

Product: N-acetylneuraminate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSSFKIGNRQIGADAPPFIIAEMSGNHNQSLDVALQIVEAAAKAGAHALKLQTYTAETMTLDLAQGEFFIKDPNSLWAGT
SLYDLYEKAHTPWEWHAPIFARARELGMLAFSTPFDDSAVDFLESLDVPAYKIASFENTDLPLIRRVAATGKPLIISTGM
ASIAELDETVRAAREAGCKDLVLLKCTSTYPATPLNSHVRTIPHLRELFGCEVGLSDHSMGVGVSVAAVALGATVVEKHF
TLDRSAGGVDASFSLEPAELASLVVETERAWQAMGQVHYGVTEAEQKSLVYRRSLYVTTDMAAGEPFTAANLRAIRPGLG
LPPKHTDAVLGRRARQPIKRGTPLDWSLVE

Sequences:

>Translated_350_residues
MSSFKIGNRQIGADAPPFIIAEMSGNHNQSLDVALQIVEAAAKAGAHALKLQTYTAETMTLDLAQGEFFIKDPNSLWAGT
SLYDLYEKAHTPWEWHAPIFARARELGMLAFSTPFDDSAVDFLESLDVPAYKIASFENTDLPLIRRVAATGKPLIISTGM
ASIAELDETVRAAREAGCKDLVLLKCTSTYPATPLNSHVRTIPHLRELFGCEVGLSDHSMGVGVSVAAVALGATVVEKHF
TLDRSAGGVDASFSLEPAELASLVVETERAWQAMGQVHYGVTEAEQKSLVYRRSLYVTTDMAAGEPFTAANLRAIRPGLG
LPPKHTDAVLGRRARQPIKRGTPLDWSLVE
>Mature_349_residues
SSFKIGNRQIGADAPPFIIAEMSGNHNQSLDVALQIVEAAAKAGAHALKLQTYTAETMTLDLAQGEFFIKDPNSLWAGTS
LYDLYEKAHTPWEWHAPIFARARELGMLAFSTPFDDSAVDFLESLDVPAYKIASFENTDLPLIRRVAATGKPLIISTGMA
SIAELDETVRAAREAGCKDLVLLKCTSTYPATPLNSHVRTIPHLRELFGCEVGLSDHSMGVGVSVAAVALGATVVEKHFT
LDRSAGGVDASFSLEPAELASLVVETERAWQAMGQVHYGVTEAEQKSLVYRRSLYVTTDMAAGEPFTAANLRAIRPGLGL
PPKHTDAVLGRRARQPIKRGTPLDWSLVE

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=270, Percent_Identity=34.4444444444444, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21357081, Length=247, Percent_Identity=34.8178137651822, Blast_Score=147, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 37860; Mature: 37729

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFKIGNRQIGADAPPFIIAEMSGNHNQSLDVALQIVEAAAKAGAHALKLQTYTAETMT
CCCCCCCCEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECEEE
LDLAQGEFFIKDPNSLWAGTSLYDLYEKAHTPWEWHAPIFARARELGMLAFSTPFDDSAV
EEEECCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCEEEECCCCCHHHH
DFLESLDVPAYKIASFENTDLPLIRRVAATGKPLIISTGMASIAELDETVRAAREAGCKD
HHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCE
LVLLKCTSTYPATPLNSHVRTIPHLRELFGCEVGLSDHSMGVGVSVAAVALGATVVEKHF
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TLDRSAGGVDASFSLEPAELASLVVETERAWQAMGQVHYGVTEAEQKSLVYRRSLYVTTD
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEC
MAAGEPFTAANLRAIRPGLGLPPKHTDAVLGRRARQPIKRGTPLDWSLVE
CCCCCCCCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure 
SSFKIGNRQIGADAPPFIIAEMSGNHNQSLDVALQIVEAAAKAGAHALKLQTYTAETMT
CCCCCCCEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECEEE
LDLAQGEFFIKDPNSLWAGTSLYDLYEKAHTPWEWHAPIFARARELGMLAFSTPFDDSAV
EEEECCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCEEEECCCCCHHHH
DFLESLDVPAYKIASFENTDLPLIRRVAATGKPLIISTGMASIAELDETVRAAREAGCKD
HHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCE
LVLLKCTSTYPATPLNSHVRTIPHLRELFGCEVGLSDHSMGVGVSVAAVALGATVVEKHF
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TLDRSAGGVDASFSLEPAELASLVVETERAWQAMGQVHYGVTEAEQKSLVYRRSLYVTTD
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEC
MAAGEPFTAANLRAIRPGLGLPPKHTDAVLGRRARQPIKRGTPLDWSLVE
CCCCCCCCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]