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The map label for this gene is neuA [H]

Identifier: 77457748

GI number: 77457748

Start: 1709609

End: 1710304

Strand: Direct

Name: neuA [H]

Synonym: Pfl01_1521

Alternate gene names: 77457748

Gene position: 1709609-1710304 (Clockwise)

Preceding gene: 77457747

Following gene: 77457749

Centisome position: 26.55

GC content: 62.5

Gene sequence:

>696_bases
TTGAACAACGTCGCAATCATCCCGGCCCGCGGGGGCAGCAAACGCATCCCGCGCAAGAATCTCAAGCCGTTCGACGGTGT
GCCGATGATTGTCCGTTCGATTCGCACGGCCCTCGATTCTGGGTTGTTCGAGCAAGTGGTGGTCAGCACCGACGACGCAG
AGATCGCCGACGTGGCGCGGGCCAACGGTGCCCACGTGCCGTTCATGCGTCCGGCGGAGCTGGCCGATGATTTCACCGGC
ACTGCGGCGGTGATCGTGCATGCCTTGCAGCAACTGCCGGCCTTCGAATACGCCTGCTGTGTGTACGCCACGGCGCCGCT
GTTGCAGGCGCGCTTTCTGCGTCAGGGCTTTGAATTGCTGGCGCAGCATCCGGACAAGTCCTTTGCTTTTTCGGTCACCG
ATTTCGGCTTTCCTGTGCAGCGCGCCTTGACCCTCGACGGGCAGGGCGGCCTGACGGCGTTGTACCCCGAATTTCGCAAT
ACCCGTTCGCAGGATCTGCCGGCTGCCTTTCAGGATGCCGGCCAGTTCTATTGGGGCCGTAGTCAGGCCTGGCTGGGTGG
CGAGGTGCTGTATTCGCCGGCAAGTCTGCCGGTGATCCTGCCCCGGTATCTGGTGCAGGACATCGATACCGTCGAAGACT
GGAAGCGTGCCGAGTACCTTTACGCGGCACTCAAGGCGGGCGGAGAACTGCAATGA

Upstream 100 bases:

>100_bases
GCTATCCCGATCTGCAACTGCTGGATTACGGCTTCGGTTATCACCGCGATCCGCAATTTCCGGTGGACGACATCACCTGG
TTCCTGCTGGAAAAACGTCC

Downstream 100 bases:

>100_bases
GAGTGCTGATCCGCGCCGACGCCTCGCCGACCATCGGCAGCGGCCACATCGCCCGGTGCCTGACGCTGGCGCGGGTATTG
CGCACGCAAGGCAGTCATGT

Product: acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNNVAIIPARGGSKRIPRKNLKPFDGVPMIVRSIRTALDSGLFEQVVVSTDDAEIADVARANGAHVPFMRPAELADDFTG
TAAVIVHALQQLPAFEYACCVYATAPLLQARFLRQGFELLAQHPDKSFAFSVTDFGFPVQRALTLDGQGGLTALYPEFRN
TRSQDLPAAFQDAGQFYWGRSQAWLGGEVLYSPASLPVILPRYLVQDIDTVEDWKRAEYLYAALKAGGELQ

Sequences:

>Translated_231_residues
MNNVAIIPARGGSKRIPRKNLKPFDGVPMIVRSIRTALDSGLFEQVVVSTDDAEIADVARANGAHVPFMRPAELADDFTG
TAAVIVHALQQLPAFEYACCVYATAPLLQARFLRQGFELLAQHPDKSFAFSVTDFGFPVQRALTLDGQGGLTALYPEFRN
TRSQDLPAAFQDAGQFYWGRSQAWLGGEVLYSPASLPVILPRYLVQDIDTVEDWKRAEYLYAALKAGGELQ
>Mature_231_residues
MNNVAIIPARGGSKRIPRKNLKPFDGVPMIVRSIRTALDSGLFEQVVVSTDDAEIADVARANGAHVPFMRPAELADDFTG
TAAVIVHALQQLPAFEYACCVYATAPLLQARFLRQGFELLAQHPDKSFAFSVTDFGFPVQRALTLDGQGGLTALYPEFRN
TRSQDLPAAFQDAGQFYWGRSQAWLGGEVLYSPASLPVILPRYLVQDIDTVEDWKRAEYLYAALKAGGELQ

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=217, Percent_Identity=31.7972350230415, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 25379; Mature: 25379

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVAIIPARGGSKRIPRKNLKPFDGVPMIVRSIRTALDSGLFEQVVVSTDDAEIADVAR
CCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ANGAHVPFMRPAELADDFTGTAAVIVHALQQLPAFEYACCVYATAPLLQARFLRQGFELL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQHPDKSFAFSVTDFGFPVQRALTLDGQGGLTALYPEFRNTRSQDLPAAFQDAGQFYWGR
HHCCCCCEEEEECCCCCCHHHEEEECCCCCEEEECHHHHCCCCCCCCHHHHHHCHHHCCC
SQAWLGGEVLYSPASLPVILPRYLVQDIDTVEDWKRAEYLYAALKAGGELQ
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNNVAIIPARGGSKRIPRKNLKPFDGVPMIVRSIRTALDSGLFEQVVVSTDDAEIADVAR
CCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ANGAHVPFMRPAELADDFTGTAAVIVHALQQLPAFEYACCVYATAPLLQARFLRQGFELL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQHPDKSFAFSVTDFGFPVQRALTLDGQGGLTALYPEFRNTRSQDLPAAFQDAGQFYWGR
HHCCCCCEEEEECCCCCCHHHEEEECCCCCEEEECHHHHCCCCCCCCHHHHHHCHHHCCC
SQAWLGGEVLYSPASLPVILPRYLVQDIDTVEDWKRAEYLYAALKAGGELQ
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]