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The map label for this gene is aroP [H]

Identifier: 77457720

GI number: 77457720

Start: 1671884

End: 1673302

Strand: Direct

Name: aroP [H]

Synonym: Pfl01_1493

Alternate gene names: 77457720

Gene position: 1671884-1673302 (Clockwise)

Preceding gene: 77457719

Following gene: 77457721

Centisome position: 25.97

GC content: 59.9

Gene sequence:

>1419_bases
ATGAGTGGACAAAACTCGCAATCAGGCGAGCTGAAACGCGGCCTGAAAAATCGCCACATTCAACTGATCGCCCTCGGTGG
CGCGATCGGTACCGGATTGTTCCTCGGTTCGGCCGGGGTGCTGAAATCCGCCGGCCCGTCGATGATCCTCGGCTATGCCA
TCTGCGGCTTCATCGCCTTCATGATCATGCGCCAGCTGGGCGAAATGATCGTCGAAGAGCCGGTGGCCGGATCCTTCAGC
CACTTTGCGCACAAATACTGGGGCGGTTTCGCCGGCTTCCTGTCGGGCTGGAACTGCTGGATCCTGTACATCCTGGTGGG
CATGTCGGAGCTGACCGCGGTCGGCAAATACATCCACTACTGGGCGCCGGAGATCCCGAGTTGGGTCACTGCCGCGGCGT
TCTTCGTGCTGATCAATGCGATCAACCTGGCCAACGTCAAAGTCTTCGGTGAAGCCGAATTCTGGTTCGCGATCATCAAG
GTCGTGGCGATCGTCGGCATGATCGCCCTGGGCAGCTACCTGCTGGTCAGCGGCCATGGCGGCCCGCAGGCTTCGGTCAG
CAACCTGTGGTCCCACGGTGGTTTCTTCCCGAACGGCGTCAGCGGTCTGGTGATGGCCATGGCGATCATAATGTTCTCCT
TTGGCGGTCTGGAAATGCTCGGTTTCACCGCAGCCGAAGCCGACAAGCCGAAAACCGTGATCCCGAAAGCGATCAACCAG
GTGATCTACCGGATCCTGATTTTCTACATCGGCGCACTGGTGATCCTGTTGTCGCTGACTCCGTGGGACAGTCTGCTGGA
AACCCTCAACGCTTCTGGCGATTCCTACAGCGGCAGCCCGTTCGTGCAGGTGTTCTCGATGCTCGGCAGCAACACCGCTG
CGCACATCCTCAACTTCGTGGTCCTGACCGCGGCATTGTCGGTGTACAACAGCGGCACCTACTGCAACAGCCGCATGCTG
CTGGGCATGGCCGAGCAGGGCGATGCGCCGAAAGCGCTGGCGAAGATCGACAAGCGCGGCGTGCCGGTGCGTTCGATCCT
GGCCTCGGCGGCCGTGACTCTGGTGGCGGTGCTGCTCAACTACCTGATCCCGCAACACGCGCTGGAACTGCTGATGTCGC
TGGTGGTTGCAACGCTGGTGATCAATTGGGCGATGATCAGCTTCTCGCACTTCAAGTTCCGCCAGCACATGAACAAGACC
CACCAGAAGCCGCTGTTCAAGGCGCTGTGGTACCCGTACGGCAATTACATCTGCCTGGCGTTCGTCCTGTTCATCCTCGG
CGTGATGCTGCTGATCCCGGGCATTCAGATCTCGGTGTACGCGATTCCGGTGTGGGTGGTGTTCATGTGGATCTGCTACG
TGATCAAGAACAAACGTGGCGCGCAGCAGGCACTGCACGCAGCGAGCGCAGCCAAGTAA

Upstream 100 bases:

>100_bases
TTCCTGGTGCCTGCGCTGGGGTTTGATCAGGGTTGGCTGAAATCGCAACCTTGCAGCAACGTCTACTGAACATCATCAAA
CCTTGCGTGAGACCTTTTTC

Downstream 100 bases:

>100_bases
GCGTCGTTGCAAAAACAACAAACCCGGCCAAGTGCCGGGTTTTTTGTACTTTCGCGGTATCCTGCGGGTTCTGATCAGGG
ACGCTTTTCCATGCTGGTGA

Product: amino acid permease-associated protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSGQNSQSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAFMIMRQLGEMIVEEPVAGSFS
HFAHKYWGGFAGFLSGWNCWILYILVGMSELTAVGKYIHYWAPEIPSWVTAAAFFVLINAINLANVKVFGEAEFWFAIIK
VVAIVGMIALGSYLLVSGHGGPQASVSNLWSHGGFFPNGVSGLVMAMAIIMFSFGGLEMLGFTAAEADKPKTVIPKAINQ
VIYRILIFYIGALVILLSLTPWDSLLETLNASGDSYSGSPFVQVFSMLGSNTAAHILNFVVLTAALSVYNSGTYCNSRML
LGMAEQGDAPKALAKIDKRGVPVRSILASAAVTLVAVLLNYLIPQHALELLMSLVVATLVINWAMISFSHFKFRQHMNKT
HQKPLFKALWYPYGNYICLAFVLFILGVMLLIPGIQISVYAIPVWVVFMWICYVIKNKRGAQQALHAASAAK

Sequences:

>Translated_472_residues
MSGQNSQSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAFMIMRQLGEMIVEEPVAGSFS
HFAHKYWGGFAGFLSGWNCWILYILVGMSELTAVGKYIHYWAPEIPSWVTAAAFFVLINAINLANVKVFGEAEFWFAIIK
VVAIVGMIALGSYLLVSGHGGPQASVSNLWSHGGFFPNGVSGLVMAMAIIMFSFGGLEMLGFTAAEADKPKTVIPKAINQ
VIYRILIFYIGALVILLSLTPWDSLLETLNASGDSYSGSPFVQVFSMLGSNTAAHILNFVVLTAALSVYNSGTYCNSRML
LGMAEQGDAPKALAKIDKRGVPVRSILASAAVTLVAVLLNYLIPQHALELLMSLVVATLVINWAMISFSHFKFRQHMNKT
HQKPLFKALWYPYGNYICLAFVLFILGVMLLIPGIQISVYAIPVWVVFMWICYVIKNKRGAQQALHAASAAK
>Mature_471_residues
SGQNSQSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAFMIMRQLGEMIVEEPVAGSFSH
FAHKYWGGFAGFLSGWNCWILYILVGMSELTAVGKYIHYWAPEIPSWVTAAAFFVLINAINLANVKVFGEAEFWFAIIKV
VAIVGMIALGSYLLVSGHGGPQASVSNLWSHGGFFPNGVSGLVMAMAIIMFSFGGLEMLGFTAAEADKPKTVIPKAINQV
IYRILIFYIGALVILLSLTPWDSLLETLNASGDSYSGSPFVQVFSMLGSNTAAHILNFVVLTAALSVYNSGTYCNSRMLL
GMAEQGDAPKALAKIDKRGVPVRSILASAAVTLVAVLLNYLIPQHALELLMSLVVATLVINWAMISFSHFKFRQHMNKTH
QKPLFKALWYPYGNYICLAFVLFILGVMLLIPGIQISVYAIPVWVVFMWICYVIKNKRGAQQALHAASAAK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=368, Percent_Identity=24.7282608695652, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI258614003, Length=405, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI258614005, Length=405, Percent_Identity=21.9753086419753, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI115648063, Length=481, Percent_Identity=22.8690228690229, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI115648022, Length=481, Percent_Identity=22.8690228690229, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258645169, Length=404, Percent_Identity=21.039603960396, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786302, Length=467, Percent_Identity=66.8094218415418, Blast_Score=615, Evalue=1e-177,
Organism=Escherichia coli, GI1786789, Length=455, Percent_Identity=56.7032967032967, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI1790653, Length=471, Percent_Identity=38.6411889596603, Blast_Score=345, Evalue=5e-96,
Organism=Escherichia coli, GI48994972, Length=444, Percent_Identity=41.6666666666667, Blast_Score=338, Evalue=6e-94,
Organism=Escherichia coli, GI1786602, Length=465, Percent_Identity=42.5806451612903, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI87081915, Length=399, Percent_Identity=39.8496240601504, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1789017, Length=438, Percent_Identity=35.1598173515982, Blast_Score=274, Evalue=9e-75,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=32.409381663113, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788480, Length=394, Percent_Identity=34.7715736040609, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87082023, Length=362, Percent_Identity=23.7569060773481, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87081869, Length=175, Percent_Identity=27.4285714285714, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=384, Percent_Identity=24.21875, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531343, Length=385, Percent_Identity=23.6363636363636, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=481, Percent_Identity=23.2848232848233, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=434, Percent_Identity=33.6405529953917, Blast_Score=223, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6324061, Length=448, Percent_Identity=33.0357142857143, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324924, Length=454, Percent_Identity=31.057268722467, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321053, Length=430, Percent_Identity=29.7674418604651, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320717, Length=402, Percent_Identity=31.592039800995, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6319824, Length=432, Percent_Identity=30.5555555555556, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6322892, Length=395, Percent_Identity=31.8987341772152, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=33.25, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324059, Length=449, Percent_Identity=32.0712694877506, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319608, Length=450, Percent_Identity=29.3333333333333, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320251, Length=476, Percent_Identity=27.1008403361345, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6321629, Length=409, Percent_Identity=30.3178484107579, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=363, Percent_Identity=33.0578512396694, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=400, Percent_Identity=27.5, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6322967, Length=445, Percent_Identity=29.2134831460674, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=398, Percent_Identity=28.643216080402, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324981, Length=445, Percent_Identity=28.7640449438202, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=499, Percent_Identity=26.0521042084168, Blast_Score=109, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51151; Mature: 51020

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQNSQSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAF
CCCCCCCCCHHHHHHHHCCEEEEEECCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHH
MIMRQLGEMIVEEPVAGSFSHFAHKYWGGFAGFLSGWNCWILYILVGMSELTAVGKYIHY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
WAPEIPSWVTAAAFFVLINAINLANVKVFGEAEFWFAIIKVVAIVGMIALGSYLLVSGHG
HCCCCCHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHEEEEECCC
GPQASVSNLWSHGGFFPNGVSGLVMAMAIIMFSFGGLEMLGFTAAEADKPKTVIPKAINQ
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCHHCCCCCCHHHHHHHHH
VIYRILIFYIGALVILLSLTPWDSLLETLNASGDSYSGSPFVQVFSMLGSNTAAHILNFV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
VLTAALSVYNSGTYCNSRMLLGMAEQGDAPKALAKIDKRGVPVRSILASAAVTLVAVLLN
HHHHHHHHHCCCCEECCHHEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YLIPQHALELLMSLVVATLVINWAMISFSHFKFRQHMNKTHQKPLFKALWYPYGNYICLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
FVLFILGVMLLIPGIQISVYAIPVWVVFMWICYVIKNKRGAQQALHAASAAK
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SGQNSQSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAF
CCCCCCCCHHHHHHHHCCEEEEEECCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHH
MIMRQLGEMIVEEPVAGSFSHFAHKYWGGFAGFLSGWNCWILYILVGMSELTAVGKYIHY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
WAPEIPSWVTAAAFFVLINAINLANVKVFGEAEFWFAIIKVVAIVGMIALGSYLLVSGHG
HCCCCCHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHEEEEECCC
GPQASVSNLWSHGGFFPNGVSGLVMAMAIIMFSFGGLEMLGFTAAEADKPKTVIPKAINQ
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCHHCCCCCCHHHHHHHHH
VIYRILIFYIGALVILLSLTPWDSLLETLNASGDSYSGSPFVQVFSMLGSNTAAHILNFV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
VLTAALSVYNSGTYCNSRMLLGMAEQGDAPKALAKIDKRGVPVRSILASAAVTLVAVLLN
HHHHHHHHHCCCCEECCHHEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YLIPQHALELLMSLVVATLVINWAMISFSHFKFRQHMNKTHQKPLFKALWYPYGNYICLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
FVLFILGVMLLIPGIQISVYAIPVWVVFMWICYVIKNKRGAQQALHAASAAK
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]