Click here to switch to the map view.

The map label for this gene is ppiA [H]

Identifier: 77457655

GI number: 77457655

Start: 1604361

End: 1604924

Strand: Reverse

Name: ppiA [H]

Synonym: Pfl01_1428

Alternate gene names: 77457655

Gene position: 1604924-1604361 (Counterclockwise)

Preceding gene: 77457656

Following gene: 77457654

Centisome position: 24.93

GC content: 59.57

Gene sequence:

>564_bases
ATGCTGAAAAAACTCGCCCTCGCCGCCGGCACCGTGCTGTTCGCTGCCAACCTGATGGCTGCCACGCCGGCAAAAGCACC
GCACGTGCTGCTGGACACCACCAACGGCCAGATCGAAATCGAGCTGGACCCGGTCAAGGCGCCGATCAGTACCAAGAATT
TCCTCGAGTACGTCGACAGCGGCTTTTACAACAACACGATTTTCCACCGCGTGATCCCGGGCTTCATGGCCCAGGGCGGC
GGCTTCACCCAGCAGATGCAGCAAAAAGACACCAAGGCGCCGATCAAGAACGAAGCCAGCAACGGCCTGCATAACGTTCG
TGGCACCCTGTCGATGGCCCGTACTTCCAACCCGGATTCGGCCACCAGCCAGTTCTTCATCAACGTCGCCGACAACGCTT
TCCTCGATCCGGGCCGTGACGCCGGTTACGCGGTGTTCGCCAAAGTGGTCAAGGGCATGGACGTGGTCGACATCATCGTC
AACTCCCAGACCACCACCAAACAGGGCATGCAAAACGTGCCGGTCGACCCTGTGATCATCAAGTCGGCCAAGCGCATCGA
CTAA

Upstream 100 bases:

>100_bases
CTCGCGCCATGCCACCCCGCTCGATCAGCCCGAACGCTTCAATCAAACGCTGCTGGAGTTCCTCGCCACAGCCGATAATC
ACCCTCAGGATCACTGACCC

Downstream 100 bases:

>100_bases
GCTTTACAGGGCATATCGAGCGGCGCTGACCTGATGTCACGCCGCTCACACTGATAAAAGGAGAGCCCGTGCTCCGGGCG
GTTATCTGATGCTCTATCGC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MLKKLALAAGTVLFAANLMAATPAKAPHVLLDTTNGQIEIELDPVKAPISTKNFLEYVDSGFYNNTIFHRVIPGFMAQGG
GFTQQMQQKDTKAPIKNEASNGLHNVRGTLSMARTSNPDSATSQFFINVADNAFLDPGRDAGYAVFAKVVKGMDVVDIIV
NSQTTTKQGMQNVPVDPVIIKSAKRID

Sequences:

>Translated_187_residues
MLKKLALAAGTVLFAANLMAATPAKAPHVLLDTTNGQIEIELDPVKAPISTKNFLEYVDSGFYNNTIFHRVIPGFMAQGG
GFTQQMQQKDTKAPIKNEASNGLHNVRGTLSMARTSNPDSATSQFFINVADNAFLDPGRDAGYAVFAKVVKGMDVVDIIV
NSQTTTKQGMQNVPVDPVIIKSAKRID
>Mature_187_residues
MLKKLALAAGTVLFAANLMAATPAKAPHVLLDTTNGQIEIELDPVKAPISTKNFLEYVDSGFYNNTIFHRVIPGFMAQGG
GFTQQMQQKDTKAPIKNEASNGLHNVRGTLSMARTSNPDSATSQFFINVADNAFLDPGRDAGYAVFAKVVKGMDVVDIIV
NSQTTTKQGMQNVPVDPVIIKSAKRID

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=173, Percent_Identity=34.6820809248555, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI19557636, Length=132, Percent_Identity=38.6363636363636, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI64276486, Length=172, Percent_Identity=33.7209302325581, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI24308049, Length=158, Percent_Identity=34.8101265822785, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=33.9393939393939, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=33.9393939393939, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI22547215, Length=165, Percent_Identity=33.9393939393939, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI310110104, Length=130, Percent_Identity=37.6923076923077, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=38.28125, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1789763, Length=185, Percent_Identity=65.4054054054054, Blast_Score=225, Evalue=1e-60,
Organism=Escherichia coli, GI1786736, Length=159, Percent_Identity=59.1194968553459, Blast_Score=170, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI71980594, Length=156, Percent_Identity=38.4615384615385, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=134, Percent_Identity=41.044776119403, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=135, Percent_Identity=37.7777777777778, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=159, Percent_Identity=33.9622641509434, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=138, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=196, Percent_Identity=33.1632653061224, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17986117, Length=174, Percent_Identity=37.9310344827586, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922376, Length=163, Percent_Identity=32.5153374233129, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922912, Length=142, Percent_Identity=37.3239436619718, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20130249, Length=169, Percent_Identity=33.7278106508876, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20125; Mature: 20125

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKLALAAGTVLFAANLMAATPAKAPHVLLDTTNGQIEIELDPVKAPISTKNFLEYVDS
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHC
GFYNNTIFHRVIPGFMAQGGGFTQQMQQKDTKAPIKNEASNGLHNVRGTLSMARTSNPDS
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
ATSQFFINVADNAFLDPGRDAGYAVFAKVVKGMDVVDIIVNSQTTTKQGMQNVPVDPVII
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCEEE
KSAKRID
CCCCCCC
>Mature Secondary Structure
MLKKLALAAGTVLFAANLMAATPAKAPHVLLDTTNGQIEIELDPVKAPISTKNFLEYVDS
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHC
GFYNNTIFHRVIPGFMAQGGGFTQQMQQKDTKAPIKNEASNGLHNVRGTLSMARTSNPDS
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
ATSQFFINVADNAFLDPGRDAGYAVFAKVVKGMDVVDIIVNSQTTTKQGMQNVPVDPVII
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCEEE
KSAKRID
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]